Novel function of rev-erbα in promoting brown adipogenesis

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Nam, Deokhwa ^a   Chatterjee, Somik ^a   Yin, Hongshan ^b   Liu, Ruya ^c   Lee, Jeongkyung ^c   Yechoor, Vijay K ^b   Ma, Ke ^a  

^a HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

^b HEBEI MEDICAL UNIVERSITY   (China)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

REV PROTEIN;

ANIMAL; BROWN ADIPOSE TISSUE; C57BL MOUSE; CELL DIFFERENTIATION; CYTOLOGY; GROWTH, DEVELOPMENT AND AGING; MOUSE; PHYSIOLOGY;

ADIPOSE TISSUE, BROWN; ANIMALS; CELL DIFFERENTIATION; GENE PRODUCTS, REV; MICE; MICE, INBRED C57BL;

EID: 84931291907     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep11239     Document Type: Article

References (51)

1. Duez, H. & Staels, B. The nuclear receptors Rev-erbs and RORs integrate circadian rhythms and metabolism. Diab Vasc Dis Res 5, 82-88 (2008).
2. Yin, L., Wu, N. & Lazar, M. A. Nuclear receptor Rev-erbalpha: a heme receptor that coordinates circadian rhythm and metabolism. Nucl Recept Signal 8, e001 (2010).
3. Harding, H. P. & Lazar, M. A. The monomer-binding orphan receptor Rev-Erb represses transcription as a dimer on a novel direct repeat. Mol Cell Biol 15, 4791-4802 (1995).
4. Giguere, V., McBroom, L. D. & Flock, G. Determinants of target gene specificity for ROR alpha 1: monomeric DNA binding by an orphan nuclear receptor. Mol Cell Biol 15, 2517-2526 (1995).
5. Yin, L. & Lazar, M. A. The orphan nuclear receptor Rev-erbalpha recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene. Mol Endocrinol 19, 1452-1459 (2005).
6. Preitner, N. et al. The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell 110, 251-260 (2002).
7. Stratmann, M. & Schibler, U. REV-ERBs: more than the sum of the individual parts. Cell Metab 15, 791-793 (2012).
8. Sahar, S. & Sassone-Corsi, P. Regulation of metabolism: the circadian clock dictates the time. Trends Endocrinol Metab 23, 1-8 (2012).
9. Pan, A., Schernhammer, E. S., Sun, Q. & Hu, F. B. Rotating night shift work and risk of type 2 diabetes: two prospective cohort studies in women. PLoS Med 8, e1001141 (2011).
10. Roenneberg, T., Allebrandt, K. V., Merrow, M. & Vetter, C. Social jetlag and obesity. Curr Biol 22, 939-943 (2012).
11. Cannon, B. & Nedergaard, J. Brown adipose tissue: function and physiological significance. Physiol Rev 84, 277-359 (2004).
12. Saito, M. et al. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes 58, 1526-1531 (2009).
13. Van Marken Lichtenbelt, W. D. et al. Cold-activated brown adipose tissue in healthy men. N Engl J Med 360, 1500-1508 (2009).
14. Cypess, A. M. et al. Identification and importance of brown adipose tissue in adult humans. N Engl J Med 360, 1509-1517 (2009).
15. Virtanen, K. A. et al. Functional brown adipose tissue in healthy adults. N Engl J Med 360, 1518-1525 (2009).
16. Cristancho, A. G. & Lazar, M. A. Forming functional fat: a growing understanding of adipocyte differentiation. Nat Rev Mol Cell Biol 12, 722-734 (2011).
17. Peirce, V., Carobbio, S. & Vidal-Puig, A. The different shades of fat. Nature 510, 76-83 (2014).
18. Seale, P. et al. PRDM16 controls a brown fat/skeletal muscle switch. Nature 454, 961-967 (2008).
19. Chawla, A. & Lazar, M. A. Induction of Rev-ErbA alpha, an orphan receptor encoded on the opposite strand of the alpha-thyroid hormone receptor gene, during adipocyte differentiation. J Biol Chem 268, 16265-16269 (1993).
20. Fontaine, C. et al. The orphan nuclear receptor Rev-Erbalpha is a peroxisome proliferator-activated receptor (PPAR) gamma target gene and promotes PPARgamma-induced adipocyte differentiation. J Biol Chem 278, 37672-37680 (2003).
21. Wang, J. & Lazar, M. A. Bifunctional role of Rev-erbalpha in adipocyte differentiation. Mol Cell Biol 28, 2213-2220 (2008).
22. Goumidi, L. et al. Impact of REV-ERB alpha gene polymorphisms on obesity phenotypes in adult and adolescent samples. Int J Obes (Lond) 37, 666-672 (2014).
23. Chomez, P. et al. Increased cell death and delayed development in the cerebellum of mice lacking the rev-erbA(alpha) orphan receptor. Development 127, 1489-1498 (2000).
24. Atit, R. et al. Beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse. Dev Biol 296, 164-176 (2006).
25. Kumar, N. et al. Regulation of adipogenesis by natural and synthetic REV-ERB ligands. Endocrinology 151, 3015-3025 (2010).
26. Gesta, S., Tseng, Y. H. & Kahn, C. R. Developmental origin of fat: tracking obesity to its source. Cell 131, 242-256 (2007).
27. Kojetin, D., Wang, Y., Kamenecka, T. M. & Burris, T. P. Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB. ACS Chem Biol 6, 131-134 (2011).
28. Cho, H. et al. Regulation of circadian behaviour and metabolism by REV-ERB-alpha and REV-ERB-beta. Nature 485, 123-127 (2012).
29. Solt, L. A. et al. Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature 485, 62-68 (2012).
30. Fournier, B. et al. Blockade of the activin receptor IIb activates functional brown adipogenesis and thermogenesis by inducing mitochondrial oxidative metabolism. Mol Cell Biol 32, 2871-2879 (2012).
31. Koncarevic, A. et al. A novel therapeutic approach to treating obesity through modulation of TGFbeta signaling. Endocrinology 153, 3133-3146 (2012).
32. Yadav, H. et al. Protection from obesity and diabetes by blockade of TGF-beta/Smad3 signaling. Cell Metab 14, 67-79 (2011).
33. Janich, P. et al. The circadian molecular clock creates epidermal stem cell heterogeneity. Nature (2011).
34. Karpowicz, P., Zhang, Y., Hogenesch, J. B., Emery, P. & Perrimon, N. The circadian clock gates the intestinal stem cell regenerative state. Cell Rep 3, 996-1004 (2013).
35. Massague, J. & Wotton, D. Transcriptional control by the TGF-beta/Smad signaling system. Embo J 19, 1745-1754 (2000).
36. Kim, W. K. et al. Myostatin inhibits brown adipocyte differentiation via regulation of Smad3-mediated beta-catenin stabilization. Int J Biochem Cell Biol 44, 327-334 (2012).
37. Zhang, C. et al. Inhibition of myostatin protects against diet-induced obesity by enhancing fatty acid oxidation and promoting a brown adipose phenotype in mice. Diabetologia 55, 183-193 (2012).
38. Sato, F. et al. Smad3 and Snail show circadian expression in human gingival fibroblasts, human mesenchymal stem cell, and in mouse liver. Biochem Biophys Res Commun 419, 441-446 (2012).
39. Beynon, A. L., Thome, J. & Coogan, A. N. Age and time of day influences on the expression of transforming growth factor-beta and phosphorylated SMAD3 in the mouse suprachiasmatic and paraventricular nuclei. Neuroimmunomodulation 16, 392-399 (2009).
40. Gaarenstroom, T. & Hill, C. S. TGF-beta signaling to chromatin: how Smads regulate transcription during self-renewal and differentiation. Semin Cell Dev Biol 32, 107-118 (2014).
41. Ignotz, R. A. & Massague, J. Type beta transforming growth factor controls the adipogenic differentiation of 3T3 fibroblasts. Proc Natl Acad Sci U S A 82, 8530-8534 (1985).
42. Clouthier, D. E., Comerford, S. A. & Hammer, R. E. Hepatic fibrosis, glomerulosclerosis, and a lipodystrophy-like syndrome in PEPCK-TGF-beta1 transgenic mice. J Clin Invest 100, 2697-2713 (1997).
43. Choy, L. & Derynck, R. Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function. J Biol Chem 278, 9609-9619 (2003).
44. Choy, L., Skillington, J. & Derynck, R. Roles of autocrine TGF-beta receptor and Smad signaling in adipocyte differentiation. J Cell Biol 149, 667-682 (2000).
45. Gerhart-Hines, Z. et al. The nuclear receptor Rev-erbalpha controls circadian thermogenic plasticity. Nature 503, 410-413 (2013).
46. Nedergaard, J. & Cannon, B. The changed metabolic world with human brown adipose tissue: therapeutic visions. Cell Metab 11, 268-272 (2010).
47. Tseng, Y. H. et al. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature 454, 1000-1004 (2008).
48. Timmons, J. A. et al. Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages. Proc Natl Acad Sci U S A 104, 4401-4406 (2007).
49. Guo, B. et al. The clock gene, brain and muscle Arnt-like 1, regulates adipogenesis via Wnt signaling pathway. FASEB J 26, 3453-3463 (2012).
50. Chatterjee, S. et al. Brain and muscle Arnt-like 1 is a key regulator of myogenesis. J Cell Sci 126, 2213-2224 (2013).
51. Zawel, L. et al. Human Smad3 and Smad4 are sequence-specific transcription activators. Mol Cell 1, 611-617 (1998).