Low-dose decitabine promotes megakaryocyte maturation and platelet production in healthy controls and immune thrombocytopenia

Thrombosis and Haemostasis

Volumn 113, Issue 5, 2015, Pages 1021-1034

  Zhou, Hai ^a   Hou, Yu ^a   Liu, Xuena ^a   Qiu, Jihua ^a   Feng, Qi ^a   Wang, Yawen ^a   Zhang, Xu ^a   Min, Yanan ^a   Shao, Linlin ^a   Liu, Xinguang ^a   Li, Guosheng ^a   Li, Lizhen ^a   Yang, Lei ^b   Xu, Shuqian ^a   Ni, Heyu ^c   Peng, Jun ^a   Hou, Ming ^a  

^a SHANDONG UNIVERSITY   (China)

^b WUXI PEOPLE S HOSPITAL AFFILIATED TO NANJING MEDICAL UNIVERSITY   (China)

^c ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

Decitabine; Immune thrombocytopenia; Megakaryocyte; Platelet; TRAIL

Indexed keywords

CASPASE 3; CASPASE 8; CD34 ANTIGEN; DECITABINE; LIPOCORTIN 5; MESSENGER RNA; PROTEIN BCL 2; PROTEIN BCL XL; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; AZACITIDINE; ENZYME INHIBITOR; TNFSF10 PROTEIN, HUMAN;

ADULT; AGED; APOPTOSIS; ARTICLE; CD34 SELECTION; CELL MATURATION; CLINICAL ARTICLE; CONTROLLED STUDY; DNA METHYLATION ASSAY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; LOW DRUG DOSE; MALE; MEGAKARYOCYTE; MIDDLE AGED; MONONUCLEAR CELL; POLYPLOIDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; THROMBOCYTE RELEASE REACTION; THROMBOCYTOPENIA; THROMBOCYTOPOIESIS; UMBILICAL CORD BLOOD; WESTERN BLOTTING; YOUNG ADULT; ADOLESCENT; ANALOGS AND DERIVATIVES; BLOOD; CASE CONTROL STUDY; CELL DIFFERENTIATION; CPG ISLAND; CYTOLOGY; DNA METHYLATION; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROMOTER REGION; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; THROMBOCYTE;

ADOLESCENT; ADULT; AGED; AZACITIDINE; BASE SEQUENCE; BLOOD PLATELETS; CASE-CONTROL STUDIES; CELL DIFFERENTIATION; CPG ISLANDS; DNA METHYLATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; FLOW CYTOMETRY; HUMANS; MALE; MEGAKARYOCYTES; MIDDLE AGED; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS, GENETIC; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; THROMBOCYTOPENIA; TNF-RELATED APOPTOSIS-INDUCING LIGAND; YOUNG ADULT;

EID: 84931270171     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH14-04-0342     Document Type: Article

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