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Volumn 28, Issue 5, 2008, Pages 432-439

Decreased DNA methyltransferase 3A and 3B mRNA expression in peripheral blood mononuclear cells and increased plasma SAH concentration in adult patients with idiopathic thrombocytopenic purpura

Author keywords

DNA methyltransferases; Idiopathic thrombocytopenic purpura; S adenosylhomocysteine; S adenosylmethionine

Indexed keywords

DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; MESSENGER RNA; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE;

EID: 51349088958     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-008-9223-2     Document Type: Article
Times cited : (29)

References (49)
  • 1
    • 0033654452 scopus 로고    scopus 로고
    • Pathogenesis and management of chronic idiopathic thrombocytopenic purpura: An update
    • 1
    • R Yang ZC Han 2000 Pathogenesis and management of chronic idiopathic thrombocytopenic purpura: an update Int J Hematol 71 1 18 24
    • (2000) Int J Hematol , vol.71 , pp. 18-24
    • Yang, R.1    Han, Z.C.2
  • 2
    • 0037187949 scopus 로고    scopus 로고
    • Immune thrombocytopenic purpura
    • 13
    • DB Cines VS Blanchette 2002 Immune thrombocytopenic purpura N Engl J Med 346 13 995 1008
    • (2002) N Engl J Med , vol.346 , pp. 995-1008
    • Cines, D.B.1    Blanchette, V.S.2
  • 3
    • 0043245959 scopus 로고    scopus 로고
    • Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro
    • 3
    • M Chang PA Nakagawa SA Williams MR Schwartz KL Imfeld JS Buzby 2003 Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro Blood 102 3 887 95
    • (2003) Blood , vol.102 , pp. 887-95
    • Chang, M.1    Nakagawa, P.A.2    Williams, S.A.3    Schwartz, M.R.4    Imfeld, K.L.5    Buzby, J.S.6
  • 4
    • 0842328846 scopus 로고    scopus 로고
    • Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult patients with chronic ITP
    • 4
    • R McMillan L Wang A Tomer J Nichol J Pistillo 2004 Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult patients with chronic ITP Blood 103 4 1364 1369
    • (2004) Blood , vol.103 , pp. 1364-1369
    • McMillan, R.1    Wang, L.2    Tomer, A.3    Nichol, J.4    Pistillo, J.5
  • 5
    • 0141684568 scopus 로고    scopus 로고
    • T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura
    • 9
    • B Olsson PO Andersson M Jernas S Jacobsson B Carlsson LM Carlsson 2003 T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura Nat Med 9 9 1123 1124
    • (2003) Nat Med , vol.9 , pp. 1123-1124
    • Olsson, B.1    Andersson, P.O.2    Jernas, M.3    Jacobsson, S.4    Carlsson, B.5    Carlsson, L.M.6
  • 7
    • 0038638583 scopus 로고    scopus 로고
    • An epigenetic view of helper T cell differentiation
    • 7
    • KM Ansel DU Lee A Rao 2003 An epigenetic view of helper T cell differentiation Nat Immunol 4 7 616 623
    • (2003) Nat Immunol , vol.4 , pp. 616-623
    • Ansel, K.M.1    Lee, D.U.2    Rao, A.3
  • 8
    • 0035093826 scopus 로고    scopus 로고
    • Evolution of imprinting mechanisms: The battle of the sexes begins in the zygote
    • 3
    • W Reik J Walter 2001 Evolution of imprinting mechanisms: the battle of the sexes begins in the zygote Nat Genet 27 3 255 256
    • (2001) Nat Genet , vol.27 , pp. 255-256
    • Reik, W.1    Walter, J.2
  • 9
    • 0142247168 scopus 로고    scopus 로고
    • DNA methylation and autoimmune disease
    • 1
    • B Richardson 2003 DNA methylation and autoimmune disease Clin Immunol 109 1 72 79
    • (2003) Clin Immunol , vol.109 , pp. 72-79
    • Richardson, B.1
  • 10
    • 0036144048 scopus 로고    scopus 로고
    • DNA methylation patterns and epigenetic memory
    • 1
    • A Bird 2002 DNA methylation patterns and epigenetic memory Genes Dev 16 1 6 21
    • (2002) Genes Dev , vol.16 , pp. 6-21
    • Bird, A.1
  • 11
    • 2942755745 scopus 로고    scopus 로고
    • Role of epigenetic DNA alterations in the pathogenesis of systemic lupus erythematosus
    • 2
    • R Januchowski J Prokop PP Jagodzinski 2004 Role of epigenetic DNA alterations in the pathogenesis of systemic lupus erythematosus J Appl Genet 45 2 237 248
    • (2004) J Appl Genet , vol.45 , pp. 237-248
    • Januchowski, R.1    Prokop, J.2    Jagodzinski, P.P.3
  • 12
    • 0142216213 scopus 로고    scopus 로고
    • Methylation and demethylation in the regulation of genes, cells, and responses in the immune system
    • 1
    • DR Fitzpatrick CB Wilson 2003 Methylation and demethylation in the regulation of genes, cells, and responses in the immune system Clin Immunol 109 1 37 45
    • (2003) Clin Immunol , vol.109 , pp. 37-45
    • Fitzpatrick, D.R.1    Wilson, C.B.2
  • 13
    • 0036415141 scopus 로고    scopus 로고
    • Dnmt3a and Dnmt1 functionally cooperate during de novo methylation of DNA
    • 20
    • M Fatemi A Hermann H Gowher A Jeltsch 2002 Dnmt3a and Dnmt1 functionally cooperate during de novo methylation of DNA Eur J Biochem 269 20 4981 4984
    • (2002) Eur J Biochem , vol.269 , pp. 4981-4984
    • Fatemi, M.1    Hermann, A.2    Gowher, H.3    Jeltsch, A.4
  • 14
    • 0035930660 scopus 로고    scopus 로고
    • Dnmt3L and the establishment of maternal genomic imprints
    • 5551
    • D Bourc'his GL Xu CS Lin B Bollman TH Bestor 2001 Dnmt3L and the establishment of maternal genomic imprints Science 294 5551 2536 2539
    • (2001) Science , vol.294 , pp. 2536-2539
    • Bourc'His, D.1    Xu, G.L.2    Lin, C.S.3    Bollman, B.4    Bestor, T.H.5
  • 15
    • 0037168587 scopus 로고    scopus 로고
    • The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a
    • 26
    • F Chedin MR Lieber CL Hsieh 2002 The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a Proc Natl Acad Sci USA 99 26 16916 16921
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 16916-16921
    • Chedin, F.1    Lieber, M.R.2    Hsieh, C.L.3
  • 17
    • 0036095885 scopus 로고    scopus 로고
    • Demethylation of ITGAL (CD11a) regulatory sequences in systemic lupus erythematosus
    • 5
    • Q Lu M Kaplan D Ray D Ray S Zacharek D Gutsch 2002 Demethylation of ITGAL (CD11a) regulatory sequences in systemic lupus erythematosus Arthritis Rheum 46 5 1282 1291
    • (2002) Arthritis Rheum , vol.46 , pp. 1282-1291
    • Lu, Q.1    Kaplan, M.2    Ray, D.3    Ray, D.4    Zacharek, S.5    Gutsch, D.6
  • 18
    • 0030985363 scopus 로고    scopus 로고
    • Mechanisms of drug-induced lupus. IV. Comparison of procainamide and hydralazine with analogs in vitro and in vivo
    • 8
    • R Yung S Chang N Hemati K Johnson B Richardson 1997 Mechanisms of drug-induced lupus. IV. Comparison of procainamide and hydralazine with analogs in vitro and in vivo Arthritis Rheum 40 8 1436 1443
    • (1997) Arthritis Rheum , vol.40 , pp. 1436-1443
    • Yung, R.1    Chang, S.2    Hemati, N.3    Johnson, K.4    Richardson, B.5
  • 19
  • 20
    • 0037333972 scopus 로고    scopus 로고
    • Hydralazine may induce autoimmunity by inhibiting extracellular signal-regulated kinase pathway signaling
    • 3
    • C Deng Q Lu Z Zhang T Rao J Attwood R Yung 2003 Hydralazine may induce autoimmunity by inhibiting extracellular signal-regulated kinase pathway signaling Arthritis Rheum 48 3 746 756
    • (2003) Arthritis Rheum , vol.48 , pp. 746-756
    • Deng, C.1    Lu, Q.2    Zhang, Z.3    Rao, T.4    Attwood, J.5    Yung, R.6
  • 21
    • 0026741293 scopus 로고
    • Phenotypic and functional similarities between 5-azacytidine-treated T cells and a T cell subset in patients with active systemic lupus erythematosus
    • 6
    • BC Richardson JR Strahler TS Pivirotto J Quddus GE Bayliss LA Gross 1992 Phenotypic and functional similarities between 5-azacytidine-treated T cells and a T cell subset in patients with active systemic lupus erythematosus Arthritis Rheum 35 6 647 662
    • (1992) Arthritis Rheum , vol.35 , pp. 647-662
    • Richardson, B.C.1    Strahler, J.R.2    Pivirotto, T.S.3    Quddus, J.4    Bayliss, G.E.5    Gross, L.A.6
  • 22
    • 0025666735 scopus 로고
    • Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis
    • 11
    • B Richardson L Scheinbart J Strahler L Gross S Hanash M Johnson 1990 Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis Arthritis Rheum 33 11 1665 1673
    • (1990) Arthritis Rheum , vol.33 , pp. 1665-1673
    • Richardson, B.1    Scheinbart, L.2    Strahler, J.3    Gross, L.4    Hanash, S.5    Johnson, M.6
  • 23
    • 0035096761 scopus 로고    scopus 로고
    • Decreased Ras-mitogen-activated protein kinase signaling may cause DNA hypomethylation in T lymphocytes from lupus patients
    • 2
    • C Deng MJ Kaplan J Yang D Ray Z Zhang WJ McCune 2001 Decreased Ras-mitogen-activated protein kinase signaling may cause DNA hypomethylation in T lymphocytes from lupus patients Arthritis Rheum 44 2 397 407
    • (2001) Arthritis Rheum , vol.44 , pp. 397-407
    • Deng, C.1    Kaplan, M.J.2    Yang, J.3    Ray, D.4    Zhang, Z.5    McCune, W.J.6
  • 24
    • 22544456923 scopus 로고    scopus 로고
    • Type 1 and type 2 T-cell profiles in idiopathic thrombocytopenic purpura
    • 7
    • T Wang H Zhao H Ren J Guo M Xu R Yang 2005 Type 1 and type 2 T-cell profiles in idiopathic thrombocytopenic purpura Haematologica 90 7 914 923
    • (2005) Haematologica , vol.90 , pp. 914-923
    • Wang, T.1    Zhao, H.2    Ren, H.3    Guo, J.4    Xu, M.5    Yang, R.6
  • 25
    • 0033981770 scopus 로고    scopus 로고
    • Measurement of plasma and intracellular S-adenosylmethionine and S-adenosylhomocysteine utilizing coulometric electrochemical detection: Alterations with plasma homocysteine and pyridoxal 5′-phosphate concentrations
    • 2
    • S Melnyk M Pogribna IP Pogribny P Yi SJ James 2000 Measurement of plasma and intracellular S-adenosylmethionine and S-adenosylhomocysteine utilizing coulometric electrochemical detection: alterations with plasma homocysteine and pyridoxal 5′-phosphate concentrations Clin Chem 46 2 265 272
    • (2000) Clin Chem , vol.46 , pp. 265-272
    • Melnyk, S.1    Pogribna, M.2    Pogribny, I.P.3    Yi, P.4    James, S.J.5
  • 26
    • 0033753779 scopus 로고    scopus 로고
    • The DNA methyltransferases of mammals
    • 16
    • TH Bestor 2000 The DNA methyltransferases of mammals Hum Mol Genet 9 16 2395 2402
    • (2000) Hum Mol Genet , vol.9 , pp. 2395-2402
    • Bestor, T.H.1
  • 27
    • 0035980617 scopus 로고    scopus 로고
    • Epigenetics: Interaction of DNA methylation and chromatin
    • 1-2
    • M Nakao 2001 Epigenetics: interaction of DNA methylation and chromatin Gene 278 1-2 25 31
    • (2001) Gene , vol.278 , pp. 25-31
    • Nakao, M.1
  • 28
    • 2942755745 scopus 로고    scopus 로고
    • Role of epigenetic DNA alterations in the pathogenesis of systemic lupus erythematosus
    • 2
    • R Januchowski J Prokop PP Jagodzinski 2004 Role of epigenetic DNA alterations in the pathogenesis of systemic lupus erythematosus J Appl Genet 45 2 237 248
    • (2004) J Appl Genet , vol.45 , pp. 237-248
    • Januchowski, R.1    Prokop, J.2    Jagodzinski, P.P.3
  • 29
    • 0036021150 scopus 로고    scopus 로고
    • Role of DNA methylation in transcription of human endogenous retrovirus in the pathogenesis of systemic lupus erythematosus
    • 8
    • M Okada H Ogasawara H Kaneko T Hishikawa I Sekigawa H Hashimoto 2002 Role of DNA methylation in transcription of human endogenous retrovirus in the pathogenesis of systemic lupus erythematosus J Rheumatol 29 8 1678 1682
    • (2002) J Rheumatol , vol.29 , pp. 1678-1682
    • Okada, M.1    Ogasawara, H.2    Kaneko, H.3    Hishikawa, T.4    Sekigawa, I.5    Hashimoto, H.6
  • 31
    • 0028567717 scopus 로고
    • Role of T cell DNA methylation in lupus syndromes
    • 6
    • RL Yung BC Richardson 1994 Role of T cell DNA methylation in lupus syndromes Lupus 3 6 487 491
    • (1994) Lupus , vol.3 , pp. 487-491
    • Yung, R.L.1    Richardson, B.C.2
  • 32
    • 0038645801 scopus 로고    scopus 로고
    • Mechanisms of drug-induced lupus. II. T cells overexpressing lymphocyte function-associated antigen 1 become autoreactive and cause a lupuslike disease in syngeneic mice
    • 12
    • R Yung D Powers K Johnson E Amento D Carr T Laing 1996 Mechanisms of drug-induced lupus. II. T cells overexpressing lymphocyte function-associated antigen 1 become autoreactive and cause a lupuslike disease in syngeneic mice J Clin Invest 97 12 2866 2871
    • (1996) J Clin Invest , vol.97 , pp. 2866-2871
    • Yung, R.1    Powers, D.2    Johnson, K.3    Amento, E.4    Carr, D.5    Laing, T.6
  • 33
    • 0027257146 scopus 로고
    • Treating activated CD4+ T cells with either of two distinct DNA methyltransferase inhibitors, 5-azacytidine or procainamide, is sufficient to cause a lupus-like disease in syngeneic mice
    • 1
    • J Quddus KJ Johnson J Gavalchin EP Amento CE Chrisp RL Yung 1993 Treating activated CD4+ T cells with either of two distinct DNA methyltransferase inhibitors, 5-azacytidine or procainamide, is sufficient to cause a lupus-like disease in syngeneic mice J Clin Invest 92 1 38 53
    • (1993) J Clin Invest , vol.92 , pp. 38-53
    • Quddus, J.1    Johnson, K.J.2    Gavalchin, J.3    Amento, E.P.4    Chrisp, C.E.5    Yung, R.L.6
  • 34
    • 0036098657 scopus 로고    scopus 로고
    • Age-dependent DNA methylation changes in the ITGAL (CD11a) promoter
    • 9
    • Z Zhang C Deng Q Lu B Richardson 2002 Age-dependent DNA methylation changes in the ITGAL (CD11a) promoter Mech Ageing Dev 123 9 1257 1268
    • (2002) Mech Ageing Dev , vol.123 , pp. 1257-1268
    • Zhang, Z.1    Deng, C.2    Lu, Q.3    Richardson, B.4
  • 35
    • 0031201474 scopus 로고    scopus 로고
    • Effect of mitogenic stimulation and DNA methylation on human T cell DNA methyltransferase expression and activity
    • 3
    • J Yang C Deng N Hemati SM Hanash BC Richardson 1997 Effect of mitogenic stimulation and DNA methylation on human T cell DNA methyltransferase expression and activity J Immunol 159 3 1303 1309
    • (1997) J Immunol , vol.159 , pp. 1303-1309
    • Yang, J.1    Deng, C.2    Hemati, N.3    Hanash, S.M.4    Richardson, B.C.5
  • 36
    • 0020528862 scopus 로고
    • Tissue levels of S-adenosylmethionine and S-adenosylhomocysteine in rats fed methyl-deficient, amino acid-defined diets for one to five weeks
    • 8
    • N Shivapurkar LA Poirier 1983 Tissue levels of S-adenosylmethionine and S-adenosylhomocysteine in rats fed methyl-deficient, amino acid-defined diets for one to five weeks Carcinogenesis 4 8 1051 1057
    • (1983) Carcinogenesis , vol.4 , pp. 1051-1057
    • Shivapurkar, N.1    Poirier, L.A.2
  • 37
    • 0029896088 scopus 로고    scopus 로고
    • Low whole-blood S-adenosylmethionine and correlation between 5-methyltetrahydrofolate and homocysteine in coronary artery disease
    • 6
    • FM Loehrer CP Angst WE Haefeli PP Jordan R Ritz B Fowler 1996 Low whole-blood S-adenosylmethionine and correlation between 5- methyltetrahydrofolate and homocysteine in coronary artery disease Arterioscler Thromb Vasc Biol 16 6 727 733
    • (1996) Arterioscler Thromb Vasc Biol , vol.16 , pp. 727-733
    • Loehrer, F.M.1    Angst, C.P.2    Haefeli, W.E.3    Jordan, P.P.4    Ritz, R.5    Fowler, B.6
  • 38
    • 0034703084 scopus 로고    scopus 로고
    • Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation
    • 38
    • P Yi S Melnyk M Pogribna IP Pogribny RJ Hine SJ James 2000 Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation J Biol Chem 275 38 29318 29323
    • (2000) J Biol Chem , vol.275 , pp. 29318-29323
    • Yi, P.1    Melnyk, S.2    Pogribna, M.3    Pogribny, I.P.4    Hine, R.J.5    James, S.J.6
  • 40
    • 0018378083 scopus 로고
    • Relationship between tissue levels of S-adenosylmethionine, S-adenylhomocysteine, and transmethylation reactions
    • 1
    • DR Hoffman WE Cornatzer JA Duerre 1979 Relationship between tissue levels of S-adenosylmethionine, S-adenylhomocysteine, and transmethylation reactions Can J Biochem 57 1 56 65
    • (1979) Can J Biochem , vol.57 , pp. 56-65
    • Hoffman, D.R.1    Cornatzer, W.E.2    Duerre, J.A.3
  • 41
    • 0029122613 scopus 로고
    • Molecular and cytological evidence of S-adenosyl-L-homocysteine as an innocuous undermethylating agent in vivo
    • 2
    • SF De Cabo J Santos J Fernández-Piqueras 1995 Molecular and cytological evidence of S-adenosyl-L-homocysteine as an innocuous undermethylating agent in vivo Cytogenet Cell Genet 71 2 187 192
    • (1995) Cytogenet Cell Genet , vol.71 , pp. 187-192
    • De Cabo, S.F.1    Santos, J.2    Fernández-Piqueras, J.3
  • 43
    • 0031910413 scopus 로고    scopus 로고
    • Evidence for disturbed S-adenosylmethionine: S-adenosylhomocysteine ratio in patients with end-stage renal failure: A cause for disturbed methylation reactions?
    • 3
    • FM Loehrer CP Angst FP Brunner WE Haefeli B Fowler 1998 Evidence for disturbed S-adenosylmethionine: S-adenosylhomocysteine ratio in patients with end-stage renal failure: a cause for disturbed methylation reactions? Nephrol Dial Transplant 13 3 656 661
    • (1998) Nephrol Dial Transplant , vol.13 , pp. 656-661
    • Loehrer, F.M.1    Angst, C.P.2    Brunner, F.P.3    Haefeli, W.E.4    Fowler, B.5
  • 44
    • 0031816123 scopus 로고    scopus 로고
    • Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women
    • 7
    • RA Jacob DM Gretz PC Taylor SJ James IP Pogribny BJ Miller 1998 Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women J Nutr 128 7 1204 1204
    • (1998) J Nutr , vol.128 , pp. 1204-1204
    • Jacob, R.A.1    Gretz, D.M.2    Taylor, P.C.3    James, S.J.4    Pogribny, I.P.5    Miller, B.J.6
  • 45
    • 0025362827 scopus 로고
    • Methionine metabolism in mammals
    • 5
    • JD Finkelstein 1990 Methionine metabolism in mammals J Nutr Biochem 1 5 228 237
    • (1990) J Nutr Biochem , vol.1 , pp. 228-237
    • Finkelstein, J.D.1
  • 46
    • 0017717986 scopus 로고
    • Role of S-adenosylhomocysteine in adenosine-mediated toxicity in cultured mouse T lymphoma cells
    • 4
    • NM Kredich DW Martin 1977 Role of S-adenosylhomocysteine in adenosine-mediated toxicity in cultured mouse T lymphoma cells Cell 12 4 931 938
    • (1977) Cell , vol.12 , pp. 931-938
    • Kredich, N.M.1    Martin, D.W.2
  • 47
    • 0022309434 scopus 로고
    • The role of S-adenosylhomocysteine in the biological utilization of S-adenosylmethionine
    • GL Cantoni 1985 The role of S-adenosylhomocysteine in the biological utilization of S-adenosylmethionine Prog Clin Biol Res 198 47 65
    • (1985) Prog Clin Biol Res , vol.198 , pp. 47-65
    • Cantoni, G.L.1
  • 48
    • 0026579875 scopus 로고
    • Methyl groups in carcinogenesis: Effects on DNA methylation and gene expression
    • Suppl 7
    • E Wainfan LA Poirier 1992 Methyl groups in carcinogenesis: effects on DNA methylation and gene expression Cancer Res 52 Suppl 7 2071s 2077s
    • (1992) Cancer Res , vol.52
    • Wainfan, E.1    Poirier, L.A.2
  • 49
    • 0018756907 scopus 로고
    • Perturbation of biochemical transmethylations by 3-deazaadenosine in vivo
    • 12
    • PK Chiang GL Cantoni 1979 Perturbation of biochemical transmethylations by 3-deazaadenosine in vivo Biochem Pharmacol 28 12 1897 1902
    • (1979) Biochem Pharmacol , vol.28 , pp. 1897-1902
    • Chiang, P.K.1    Cantoni, G.L.2


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