Role of DNA methyltransferase 3A mRNA expression in Egyptian patients with idiopathic thrombocytopenic purpura

International Journal of Laboratory Hematology

Volumn 34, Issue 4, 2012, Pages 369-376

  El Shiekh, E H ^a   Bessa, S S ^a   Abdou, S M ^a   El Refaey, W A ^a  

^a TANTA UNIVERSITY   (Egypt)

Author keywords

DNA methyltransferase 3A; Epigenetics; Gene expression; Idiopathic thrombocytopenic purpura; S adenosylhomocysteine

Indexed keywords

DNA METHYLTRANSFERASE 3A; S ADENOSYLHOMOCYSTEINE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; EGYPT; FEMALE; GENE EXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; MALE; PATHOGENESIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION;

ADULT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; EGYPT; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MALE; POLYMERASE CHAIN REACTION; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; RNA, MESSENGER;

EID: 84862835989     PISSN: 17515521     EISSN: 1751553X     Source Type: Journal    
DOI: 10.1111/j.1751-553X.2012.01404.x     Document Type: Article

References (39)

1. Andrews L., Andersen R.F., Webster D., Dunachie S., Walther R.M., Bejon P., Hunt-Cooke A., Bergson G., Sanderson F., Hill A.V. & Gilbert S.C. (2005) Quantitative real-time polymerase chain reaction for malaria diagnosis and its use in malaria vaccine clinical trials. The American Journal of Tropical Medicine and Hygiene 73, 191-198.
2. + T cells from patients with systemic lupus erythematosus. Immunology 124, 339-347.
3. Bird A. (2002) DNA methylation patterns and epigenetic memory. Genes and Development 16, 6-21.
4. Boyum A. (1968) Isolation of mononuclear cells and granulocytes from human blood. Scandinavian Journal of Clinical and Laboratory Investigation 21, 77-89.
5. Chen Z., Zhou Z., Chen X., Xu J., Liu A., Du W., Gu D., Ge J., Guo Z., Wang X., Dong X., Ren Q. & Yang R. (2008) Single nucleotide polymorphism in DNMT3B promoter and the risk for idiopathic thrombocytopenic purpura in Chinese population. Journal of Clinical Immunology 28, 399-404.
6. Cines D.B. & Blanchette V.S. (2002) Immune thrombocytopenic purpura. New England Journal of Medicine 346, 995-1008.
7. De Cabo S.F., Santos J. & Fernández-Piqueras J. (1995) Molecular and cytological evidence of S-adenosyl-L-homocysteine as an innocuous undermethylating agent in vivo. Cytogenetics and Cell Genetics 71, 187-192.
8. Fitzpatrick D.R. & Wilson C.B. (2003) Methylation and demethylation in the regulation of genes, cells, and responses in the immune system. Clinical Immunology 109, 37-45.
9. Gellekink H., van Oppenraaij-Emmerzaal D., van Rooij A., Struys E.A., den Heijer M. & Blom H.J. (2005) Stable-isotope dilution liquid chromatography-electrospray injection tandem mass spectrometry method for fast, selective measurement of S-adenosylmethionine and S-adenosylhomocysteine in plasma. Clinical Chemistry 51, 1487-1492.
10. George J.N., Woolf S.H., Raskob G.E., Wasser J.S., Aledort L.M., Ballem P.J., Blanchette V.S., Bussel J.B., Cines D.B., Kelton J.G., Lichtin A.E., McMillan R., Okerbloom J.A., Regan D.H. & Warrier I. (1996) Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American society of hematology. Blood 88, 3-40.
11. Gernsheimer T. (2009) Chronic idiopathic thrombocytopenic purpura: mechanisms of pathogenesis. The Oncologist 14, 12-21.
12. Hermann A., Gowher H. & Jeltsch A. (2004) Biochemistry and biology of mammalian DNA methyltransferases. Cellular and Molecular Life Sciences 61, 2571-2587.
13. Januchowski R., Prokop J. & Jagodzinski P. (2004) Role of epigenetic DNA alterations in the pathogenesis of systemic lupus erythematosus. Journal of Applied Genetics 45, 237-248.
14. Loehrer F.M., Angst C.P., Brunner F.P., Haefeli W.E. & Fowler B. (1998) Evidence for disturbed S-adenosylmethionine: S-adenosylhomocysteine ratio in patients with end-stage renal failure: a cause for disturbed methylation reactions. Nephrology Dialysis Transplantation 13, 656-661.
15. Loehrer F.M., Tschopl M., Angst C.P., Litynski P., Jäger K., Fowler B. & Haefeli W.E. (2001) Disturbed ratio of erythrocyte and plasma S-adenosylmethionine/S-adenosylhomocysteine in peripheral arterial occlusive disease. Atherosclerosis 154, 147-154.
16. Meyer V. (2004) Reversed-phase chromatography. In: (ed. V. Meyer ), Practical High Performance Liquid Chromatography, 4th edn, 40. John Wiley & Sons, Hoboken, NJ.
17. Okada M., Ogasawara H., Kaneko H., Hishikawa T., Sekigawa I., Hashimoto H., Maruyama N., Kaneko Y. & Yamamoto N. (2002) Role of DNA methylation in transcription of human endogenous retrovirus in the pathogenesis of systemic lupus erythematosus. Journal of Rheumatology 29, 1678-1682.
18. Olsson B., Andersson P.O., Jernas M., Jacobsson S., Carlsson B., Carlsson L.M. & Wadenvik H. (2003) T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura. Nature Medicine 9, 1123-1124.
19. Richardson B. (2003) DNA methylation and autoimmune disease. Clinical Immunology 109, 72-79.
20. Richardson B. (2007) Primer: epigenetics of autoimmunity. Nature Clinical Practice Rheumatology 3, 521-527.
21. Richardson B., Scheinbart L., Strahler J., Gross L., Hanash S. & Johnson M. (1990) Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis. Arthritis and Rheumatism 33, 1665-1673.
22. Rodenhiser D. & Mann M. (2006) Epigenetics and human disease: translating basic biology into clinical applications. Canadian Medical Association Journal 174, 341-348.
23. t method. Nature Protocols 3, 1101-1108.
24. Sekigawa I., Okada M., Ogasawara H., Kaneko H., Hishikawa T. & Hashimoto H. (2003) DNA methylation in systemic lupus erythematosus. Lupus 12, 79-85.
25. Sekigawa I., Kawasaki M., Ogasawara H., Kaneda K., Kaneko H., Takasaki Y. & Ogawa H. (2006) DNA methylation: its contribution to systemic lupus erythematosus. Clinical and Experimental Medicine 6, 99-106.
26. Stasi R. & Provan D. (2004) Management of immune thrombocytopenic purpura in adults. Mayo Clinic Proceedings 79, 504-522.
27. Stasi R., Evangelista M.L., Stipa E., Buccisano F., Venditti A. & Amadori S. (2008) Idiopathic thrombocytopenic purpura: current concepts in pathophysiology and management. Thrombosis and Haemostasis 99, 4-13.
28. Strickland F. & Richardson B. (2008) Epigenetics in human autoimmunity: DNA methylation in systemic lupus erythematosus and beyond. Journal of Autoimmunity 41, 278-286.
29. Tao J., Yang M., Chen Z., Huang Y., Zhao Q., Xu J., Ren H., Zhao H., Chen Z., Ren Q. & Yang R. (2008) Decreased DNA methyltransferase 3A and 3B mRNA expression in peripheral blood mononuclear cells and increased plasma SAH concentration in adult patients with idiopathic thrombocytopenic purpura. Journal of Clinical Immunology 28, 432-439.
30. Vandesompele J., De Preter K., Pattyn F., Poppe B., Van Roy N., De Paepe A. & Speleman F. (2002) Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biology 3, 1-12.
31. Wang T., Zhao H., Ren H., Guo J., Xu M., Yang R. & Han Z.C. (2005) Type 1 and type 2 T-cell profiles in idiopathic thrombocytopenic purpura. Haematologica 90, 914-923.
32. Wilson C.B., Makar K.W., Shnyreva M. & Fitzpatrick D.R. (2005) DNA methylation and the expanding epigenetics of T cell lineage commitment. Seminars in Immunology 17, 105-119.
33. Yang J., Deng C., Hemati N., Hanash S.M. & Richardson B.C. (1997) Effect of mitogenic stimulation and DNA methylation on human T cell DNA methyltransferase expression and activity. Journal of Immunology 159, 1303-1309.
34. Yeon S. & Lawrence L. (2002) Idiopathic thrombocytopenic purpura: pathophysiology and management. International Journal of Hematology 76, 123-131.
35. Yi P., Melnyk S., Pogribna M., Pogribny I.P., Hine R.J. & James S.J. (2000) Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation. Journal of Biological Chemistry 275, 29318-29323.
36. Yung R.L. & Richadson B.C. (1994) Role of T cell DNA methylation in lupus syndromes. Lupus 3, 487-491.
37. Zhao H., Du W., Gu D., Wang D., Xue F., Ge J., Sui T. & Yang R. (2009) DNMT3B 579G>T promoter polymorphism and the risk for idiopathic thrombocytopenic purpura in a Chinese population. Acta Haematologica 122, 31-35.
38. Zhao H., Du W., Wang D., Gu D., Xue F., Ge J., Sui T. & Yang R. (2010) Single nucleotide polymorphism in the methyl-CpG binding domain 4 gene and the risk for immune thrombocytopenic purpura in Chinese population. Platelets 21, 132-136.
39. Zhou B., Zhao H., Yang R.C. & Han Z.C. (2005) Multi-dysfunctional pathophysiology in ITP. Critical Reviews in Oncology/Hematology 54, 107-116.