Expression of p15ink4b gene during megakaryocytic differentiation of normal and myelodysplastic hematopoietic progenitors

Blood

Volumn 98, Issue 2, 2001, Pages 495-497

  Teofili, Luciana ^a   Martini, Maurizio ^a   Di Mario, Antonella ^a   Rutella, Sergio ^a   Urbano, Raffaella ^a   Luongo, Myriam ^a   Leone, Giuseppe ^a   Larocca, Luigi Maria ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 DEOXYAZACYTIDINE; CYCLIN DEPENDENT KINASE INHIBITOR; CYTIDINE DERIVATIVE; PROTEIN P15; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CELL SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; DEMETHYLATION; DNA METHYLATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MEGAKARYOCYTE; MEGAKARYOPOIESIS; MOLECULAR CLONING; MYELODYSPLASTIC SYNDROME; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN SYNTHESIS; STEM CELL;

EID: 0035880261     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V98.2.495     Document Type: Article

References (15)

1. Teofili L, Rutella S, Chiusolo P, et al. Expression of p15INK4B in normal hematopoiesis. Exp Hematol. 1998;26:1133-1139.
2. Teofili L, Morosetti R, Martini M, et al. Expression of cyclin-dependent kinase inhibitor p15(INK4B) during normal and leukemic myeloid differentiation. Exp Hematol. 2000;28:519-526.
3. Uchida T, Kinoshita T, Nagai H, et al. Hypermethylation of the p15INK4B gene in myelodysplastic syndrome. Blood. 1997;90:1403-1409.
4. Quesnel B, Guillerm G, Vereecque R, et al. Methylation of the p15(INK4b) gene in myelodysplastic syndromes is frequent and acquired during disease progression. Blood. 1998;91:2985-2990.
5. Harmon GJ, Beach D. p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. Nature. 1994;371:257-261.
6. Fortunel NO, Hatzfeld A, Hatzfeld JA. Transforming growth factor-beta: pleiotropic role in the regulation of hematopoiesis. Blood. 2000;96:2022-2036.
7. Kuter DJ, Gminski DM, Rosenberg RD. Transforming growth factor beta inhibits megakaryocyte growth and endomitosis. Blood. 1992;79:619-626.
8. Berthier R, Valiron O, Schweitzer A, Marguerie G. Serum-free medium allows the optimal growth of human megakaryocyte progenitors compared with human plasma supplemented cultures: role of TGF beta. Stem Cells. 1993;11:120-129.
9. Jackson H, Williams N, Westcott KR, Green R. Differential effects of transforming growth factor-beta 1 on distinct developmental stages of murine megakaryocytopoiesis. J Cell Physiol. 1994;161:312-318.
10. Bennett JM, Catovsky D, Daniel MT, et al. Proposals for the classification of the myelodysplastic syndromes. Br J Haematol. 1982;51:189-199.
11. Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci U S A. 1996;93:9821-9826.
12. Larocca LM, Teofili L, Sica S, et al. Quercetin inhibits the growth of leukemic progenitors and induces the expression of transforming growth factor-beta 1 in these cells. Blood. 1995;85:3654-3661.
13. Heaney ML, Golde DW. Myelodysplasia. N Engl J Med. 1999;340:1649-1660.
14. Rajapaksa R, Ginzton N, Rott LS, Greenberg PL. Altered oncoprotein expression and apoptosis in myelodysplastic syndrome marrow cells. Blood. 1996;88:4275-4287.
15. Parker JE, Mufti GJ, Rasool F, Mijovic A, Devereux S, Pagliuca A. The role of apoptosis, proliferation, and the bcl-2-related proteins in the myelodysplastic syndromes and acute myeloid leukemia secondary to MDS. Blood. 2000;96:3932-3938.