Searching phase II enzymes inducers, from Michael acceptor-[1,2]dithiolethione hybrids, as cancer chemopreventive agents

Future Medicinal Chemistry

Volumn 7, Issue 7, 2015, Pages 857-871

  Couto, Marcos ^a   Ovalle, Stefani De ^a   Cabrera, Mauricio ^a   Cerecetto, Hugo ^a   Gonzalez, Mercedes ^a  

^a UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DITHIOLE 3 THIONE DERIVATIVE; 4' BROMOFLAVONE; 5 [4 (2 PHENYLETHANOYLOXY)PHENYL] 3H [1,2]DITHIOLE 3 THIONE; 5 [4 (3 PHENYL 2 PROPENOYLOXY)PHENYL] 3H [1,2]DITHIOLE 3 THIONE; 5 [4 [4 (3 OXO 3 PHENYL 5 [4 [4 (3 OXO 3 PHENYL 1 PROPENYL)]BENZOYLOXY]PHENYL] 3H [1,2]DITHIOLE 3 THIONE; 5 [4 [4 [3 (2 HYDROXYPHENYL) 3 OXO 1 PROPENYL)] BENZOYLOXY]PHENYL] 3H [1,2]DITHIOLE 3 THIONE; ANTINEOPLASTIC AGENT; CYTOTOXIC AGENT; ENZYME INDUCING AGENT; GLUTATHIONE S TRANSFERASE INDUCER; GLUTATHIONE TRANSFERASE; QUINONE REDUCTASE INDUCER; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); TERT BUTYLHYDROQUINONE; UNCLASSIFIED DRUG; 5-(4-(3-PHENYL-2-PROPENOYLOXY)PHENYL)-3H-(1,2)DITHIOLE-3-THIONE; CINNAMIC ACID DERIVATIVE; SINGLE HETEROCYCLIC RINGS;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER PREVENTION; CELL MUTANT; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG HALF LIFE; DRUG METABOLISM; DRUG STABILITY; DRUG SYNTHESIS; ENZYME ACTIVITY; HEPA 1C1C7 CELL LINE; HEPATOCELLULAR CARCINOMA CELL LINE; IC50; IN VITRO STUDY; MICHAEL ADDITION; MOLECULAR DOCKING; MOLECULAR MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; ANIMAL; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; ENZYME INDUCTION; METABOLISM; SYNTHESIS; TUMOR CELL CULTURE;

ANIMALS; ANTICARCINOGENIC AGENTS; CELL PROLIFERATION; CINNAMATES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; GLUTATHIONE TRANSFERASE; HETEROCYCLIC COMPOUNDS, 1-RING; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; QUINONE REDUCTASES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84931092534     PISSN: 17568919     EISSN: 17568927     Source Type: Journal    
DOI: 10.4155/fmc.15.32     Document Type: Article

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