Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 14, 2010, Pages 5391-5399

  Cabrera, Mauricio ^a   Lavaggi, María Laura ^a   Croce, Fiorela ^a   Celano, Laura ^b   Thomson, Leonor ^b   Fernández, Marcelo ^b   Pintos, Cristina ^c   Raymondo, Stella ^c   Bollati, Mariela ^d   Monge, Antonio ^e   López De Ceráin, Adela ^e   Piro, Oscar E ^f   Cerecetto, Hugo ^a   González, Mercedes ^a  

^a UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^b Facultad de Ciencias   (Uruguay)

^c UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^d INSTITUT PASTEUR DE MONTEVIDEO   (Uruguay)

^e UNIVERSITY OF NAVARRA   (Spain)

^f UNIVERSIDAD NACIONAL DE LA PLATA   (Argentina)

Author keywords

Chalcones; Chemopreventive agents; Phase II enzyme inducers

Indexed keywords

CARCINOGEN; CHALCONE DERIVATIVE; CYTOCHROME P450 1A1; ENZYME INDUCING AGENT; GLUTATHIONE TRANSFERASE; LIVER ENZYME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE);

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER PREVENTION; CONTROLLED STUDY; CYTOTOXICITY; DNA STRAND BREAKAGE; DRUG ACTIVITY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INDUCTION; FEMALE; HUMAN; HUMAN CELL; MUTAGENICITY; NONHUMAN; RAT;

ANIMALS; ANTICARCINOGENIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; CHALCONES; COMET ASSAY; CYTOCHROME P-450 CYP1A1; FEMALE; HUMANS; LIVER; LIVER NEOPLASMS; MODELS, MOLECULAR; NAD(P)H DEHYDROGENASE (QUINONE); RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR;

EID: 77955336343     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.05.033     Document Type: Article

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