Hydrogen peroxide is a second messenger in phase 2 enzyme induction by cancer chemopreventive dithiolethiones

Chemical Research in Toxicology

Volumn 22, Issue 8, 2009, Pages 1427-1434

  Holland, Ryan ^a   Navamal, Mettachit ^a   Velayutham, Murugesan ^b   Zweier, Jay L ^b   Kensler, Thomas W ^c   Fishbein, James C ^a  

^a UNIVERSITY OF MARYLAND BALTIMORE COUNTY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DITHIOLE 3 THIONE; 5,5 DIMETHYL 1 PYRROLINE 1 OXIDE; ALCOHOL; ANETHOLEDITHIONE; ANTINEOPLASTIC AGENT; ARGON; CATALASE; CHLORINE DERIVATIVE; DRUG METABOLITE; GLUTATHIONE; HYDROETHIDINE; HYDROGEN PEROXIDE; NITRONE; NQO1 ENZYME; OLTIPRAZ; OXYGEN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; SODIUM BOROHYDRIDE; SODIUM DERIVATIVE; SUPEROXIDE DISMUTASE; THIOL DERIVATIVE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANIMAL CELL; AQUEOUS SOLUTION; ARTICLE; CANCER CHEMOTHERAPY; CANCER PREVENTION; CELL PROTECTION; CHEMICAL BOND; CHEMICAL MODIFICATION; CONTROLLED STUDY; CYCLOADDITION; DECOMPOSITION; ELECTRON SPIN RESONANCE; ENZYME INACTIVATION; ENZYME INDUCTION; ENZYME REGULATION; FLUORESCENCE ANALYSIS; ISOLATION PROCEDURE; LYSIS; MOUSE; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; REDUCTION KINETICS; SECOND MESSENGER; SPIN TRAPPING; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; CYCLIC N-OXIDES; DIGLYCERIDES; ENZYME INDUCTION; HEPATOCYTES; HUMANS; HYDROGEN PEROXIDE; NAD(P)H DEHYDROGENASE (QUINONE); NEOPLASMS; PYRAZINES; SECOND MESSENGER SYSTEMS; THIONES; THIOPHENES;

EID: 68949092109     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx900110n     Document Type: Article

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