Computer modeling assisted design of monodisperse PLGA microspheres with controlled porosity affords zero order release of an encapsulated macromolecule for 3 months

Pharmaceutical Research

Volumn 31, Issue 10, 2014, Pages 2844-2856

  Kazazi Hyseni, Filis ^a   Landin, Mariana ^b   Lathuile, Audrey ^c   Veldhuis, Gert J ^c   Rahimian, Sima ^a   Hennink, Wim E ^a   Kok, Robbert Jan ^a   Van Nostrum, Cornelus F ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^c NANOMI B V   (Netherlands)

Author keywords

controlled release; membrane emulsification; microspheres; PLGA; porosity

Indexed keywords

BLUE DEXTRAN; DEXTRAN; DRUG CARRIER; LACTIC ACID; MICROSPHERE; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

CHEMISTRY; COMPUTER SIMULATION; DEVICES; DRUG DESIGN; DRUG FORMULATION; DRUG RELEASE; EQUIPMENT DESIGN; PARTICLE SIZE; POROSITY; PROCEDURES; SCANNING ELECTRON MICROSCOPY; SURFACE PROPERTY; TIME;

COMPUTER SIMULATION; DEXTRANS; DRUG CARRIERS; DRUG COMPOUNDING; DRUG DESIGN; DRUG LIBERATION; EQUIPMENT DESIGN; LACTIC ACID; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; PARTICLE SIZE; POLYGLYCOLIC ACID; POROSITY; SURFACE PROPERTIES; TIME FACTORS;

EID: 84931076510     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-014-1381-8     Document Type: Article

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