Influence of particle size and antacid on release and stability of plasmid DNA from uniform PLGA microspheres

Journal of Controlled Release

Volumn 124, Issue 3, 2007, Pages 172-180

  Varde, Neelesh K ^a   Pack, Daniel W ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

DNA delivery; Magnesium hydroxide; Microspheres; Plasmid DNA; Poly (lactide co glycolide)

Indexed keywords

BIODEGRADABILITY; DNA; DRUG DELIVERY; ENCAPSULATION; IMAGE ANALYSIS; PARTICLE SIZE; PORE SIZE;

ANTACID CONCENTRATIONS; ENHANCING PROTEIN STABILITY; POLYMER DEGRADES; VISUALIZE THE SURFACE;

MICROSPHERES;

ANTACID AGENT; MAGNESIUM HYDROXIDE; MICROSPHERE; PLASMID DNA; POLYGLACTIN;

ARTICLE; DRUG DEGRADATION; DRUG RELEASE; DRUG STRUCTURE; ENCAPSULATION; GENETIC STABILITY; IMAGE ANALYSIS; PARTICLE SIZE; POROSITY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SCANNING ELECTRON MICROSCOPY; SURFACE PROPERTY;

ANTACIDS; BIOCOMPATIBLE MATERIALS; DELAYED-ACTION PREPARATIONS; DNA; DRUG COMPOUNDING; LACTIC ACID; MAGNESIUM HYDROXIDE; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; NUCLEIC ACID CONFORMATION; PARTICLE SIZE; PLASMIDS; POLYGLYCOLIC ACID; POLYMERS; POROSITY; SURFACE PROPERTIES;

EID: 36048967968     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2007.09.005     Document Type: Article

References (29)

1. Vile R.G., Tuszynski A., and Castleden S. Retroviral vectors: from laboratory tools to molecular medicines. Mol. Biotechnol. 5 (1996) 139-158
2. Felgner P.L., and Ringold G.M. Cationic liposome-mediated transfection. Nature 337 (1989) 387
3. Wasungu L., and Hoekstra D. Cationic lipids lipoplexes and intracellular delivery of genes. J. Control. Release 116 (2006) 255-264
4. Pack D.W., Hoffman A.S., Pun S., and Stayton P.S. Design and development of polymers for gene delivery. Nat. Rev. Drug Disc. 4 (2005) 581-593
5. Wang D., Robinson D.R., Kwon G.S., and Samuel J. Encapsulation of plasmid DNA in biodegradable poly(d,l-lactic-co-glycolic acid) microspheres as a novel approach for immunogene delivery. J. Control. Release 57 (1999) 9-18
6. Oster C.G., Kim N., Grode L., Barbu-Tudoran L., Schaper A.K., Kaufmann S.H.E., and Kissel T. Cationic microparticles consisting of poly(lactide-co-glycolide) and polyethylenimine as carriers systems for parental DNA vaccination. J. Control. Release 104 (2005) 359-377
7. Jang J.H., and Shea L.D. Intramuscular delivery of DNA releasing microspheres: microsphere properties and transgene expression. J. Control. Release 112 (2006) 120-128
8. Mathiowitz E., Jacob J.S., Jong Y.S., Carino G.P., Chickering D.E., Chaturvedi P., Santos C.A., Vijayaraghavan K., Montgomery S., Bassett M., and Morrell C. Biologically erodable microspheres as potential oral drug delivery systems. Nature 386 (1997) 410-414
9. *0201-restricted T-cell epitopes of Mycobacterium tuberculosis. Vaccine 22 (2004) 1609-1615
10. Hedley M.L., Curley J., and Urban R. Microspheres containing plasmid-encoded antigens elicit cytotoxic T-cell responses. Nat. Med. 4 (1998) 365-368
11. Eniola A.O., and Hammer D.A. Characterization of biodegradable drug delivery vehicles with the adhesive properties of leukocytes II: effect of degradation on targeting activity. Biomaterials 26 (2004) 661-670
12. Berkland C., Kim K., and Pack D.W. PLG microsphere size controls drug release rate through several competing factors. Pharm. Res. 20 (2003) 1055-1062
13. Berkland C., King M., Cox A., Kim K., and Pack D.W. Precise control of PLG microsphere size provides enhanced control of drug release rate. J. Control. Release 82 (2002) 137-147
14. Berkland C., Pollauf E.J., Varde N.K., Pack D.W., and Kim K.K. Monodisperse liquid-filled biodegradable microcapsules. Pharm. Res. 24 (2007) 1007-1013
15. Luo D., Woodrow-Mumford K., Belcheva N., and Saltzman W.M. Controlled DNA delivery systems. Pharm. Res. 16 (1999) 1300-1308
16. Cohen H., Levy R.J., Gao J., Fishbein I., Kousaev V., Sosnowski S., Slomkowski S., and Golomb G. Sustained delivery and expression of DNA encapsulated in polymeric nanoparticles. Gene Ther. 7 (2000) 1896-1905
17. Ando S., Putnam D., Pack D.W., and Langer R. PLGA microspheres containing plasmid DNA: preservation of supercoiled DNA via cryopreparation and carbohydrate stabilization. J. Pharm. Sci. 88 (1999) 126-130
18. Remaut K., Sanders N.N., Fayazpour F., Demeester J., and DeSmedt S.C. Influence of plasmid DNA topology on the transfection properties of DOTAP/DOPE lipoplexes. J. Control. Release 115 (2006) 335-343
19. Shenderova A., Burke T.G., and Schwendeman S.P. The acidic microclimate in poly(lactide-co-glycolide) microspheres stabilizes camptothecins. Pharm. Res. 16 (1999) 241-248
20. Fu K., Pack D.W., Klibanov A.M., and Langer R. Visual evidence of acidic environment within degrading poly(lactic-co-glycolic acid) (PLGA) microspheres. Pharm. Res. 171 (2000) 100-106
21. Zhu G., and Schwendeman S.P. Stabilization of proteins encapsulated in cylindrical poly(lactide-co-glycolide) implants: mechanism of stabilization by basic additives. Pharm. Res. 17 (2000) 351-357
22. 2 and sucrose on the stability of bovine serum albumin encapsulated in injectable poly(d,l-lactide-co-glycolide) implants. Biomaterials 23 (2001) 239-245
23. Jaganathan K.S., Rao Y.U.B., Singh P., Prabakaran D., Gupta S., Jain A., and Vyas S.P. Development of a single dose tetanus toxoid formulation based on polymeric microspheres: a comparative study of poly(d,l-lactic-co-glycolic acid) versus chitosan microspheres. Int. J. Pharm. 294 (2005) 23-32
24. Berkland C., Kim K., and Pack D.W. Fabrication of PLG microspheres with precisely controlled and monodisperse size distributions. J. Control. Release 73 (2001) 59-74
25. Zhu G.Z., Mallery S.R., and Schwendeman S.P. Stabilization of proteins encapsulated in injectable poly(lactide-co-glycolide). Nat. Biotechnol. 18 (2000) 52-57
26. O'Donnell P.B., and McGinity J.W. Preparation of microspheres by the solvent evaporation technique. Adv. Drug Del. Rev. 28 (1997) 25-42
27. Klose D., Siepmann F., Elkharraz K., Krenzlin S., and Siepmann J. How porosity and size affect the drug release mechanisms from PLGA-based microparticles. Int. J. Pharm. 314 (2006) 198-206
28. Jang J.H., and Shea L.D. Controllable delivery of non-viral DNA from porous scaffolds. J. Control. Release 86 (2003) 157-168
29. Kim T.H., and Park T.G. Critical effect of freezing/freeze-drying on sustained release of FITC-dextran encapsulated within PLGA microspheres. Int. J. Pharm. 271 (2004) 207-214