메뉴 건너뛰기




Volumn 6, Issue 16, 2015, Pages 13925-13934

DNA methylation and cognitive aging

Author keywords

Bisulfite DNA methyl sequencing; Epigenetics; Neurodegeneration; Neuronal genes; Transcriptional regulation

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; HISTONE DEACETYLASE; HISTONE H3; HISTONE H3K27ME3; HISTONE H3K9ME3; HISTONE H4; HISTONE H4K12AC; HISTONE METHYLTRANSFERASE; HISTONE METHYLTRANSFERASE EZH2; MAMMALIAN TARGET OF RAPAMYCIN; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR NANOG; UNCLASSIFIED DRUG; DNA; DNA FRAGMENT; GENOMIC DNA;

EID: 84931065087     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.4215     Document Type: Article
Times cited : (46)

References (96)
  • 1
    • 84931072319 scopus 로고    scopus 로고
    • Single cell transcriptome study in brain aging
    • Xu X. Single cell transcriptome study in brain aging. Single Cell Biol 1:e111
    • Single Cell Biol , vol.1
    • Xu, X.1
  • 2
    • 34247204182 scopus 로고    scopus 로고
    • Dementia syndromes: evaluation and treatment
    • Apr
    • Scott KR, Barrett AM. Dementia syndromes: evaluation and treatment. Expert Rev Neurother. 2007 Apr 7:407-22.
    • (2007) Expert Rev Neurother. , vol.7 , pp. 407-422
    • Scott, K.R.1    Barrett, A.M.2
  • 3
    • 0033609045 scopus 로고    scopus 로고
    • Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway
    • Bach ME, Barad M, Son H, Zhuo M, Lu YF, Shih R, Mansuy I, Hawkins RD, Kandel ER. Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway. Proc Natl Acad Sci U S A, 1999. 96:5280-5.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 5280-5285
    • Bach, M.E.1    Barad, M.2    Son, H.3    Zhuo, M.4    Lu, Y.F.5    Shih, R.6    Mansuy, I.7    Hawkins, R.D.8    Kandel, E.R.9
  • 4
    • 0037936789 scopus 로고    scopus 로고
    • Impact of aging on hippocampal function: plasticity, network dynamics, and cognition
    • Rosenzweig ES and Barnes CA. Impact of aging on hippocampal function: plasticity, network dynamics, and cognition. Prog Neurobiol, 2003. 69:143-79.
    • (2003) Prog Neurobiol , vol.69 , pp. 143-179
    • Rosenzweig, E.S.1    Barnes, C.A.2
  • 5
    • 77049202076 scopus 로고
    • Organization of the cerebral cortex. III. A study of aging in the human cerebral cortex
    • Brody H. Organization of the cerebral cortex. III. A study of aging in the human cerebral cortex. J Comp Neurol, 1955. 102:511-6.
    • (1955) J Comp Neurol , vol.102 , pp. 511-516
    • Brody, H.1
  • 7
    • 0018218935 scopus 로고
    • The hippocampus: organizational patterns in health and senescence
    • Scheibel AB. The hippocampus: organizational patterns in health and senescence. Mech Ageing Dev, 1979. 9:89-102.
    • (1979) Mech Ageing Dev , vol.9 , pp. 89-102
    • Scheibel, A.B.1
  • 8
    • 29244439038 scopus 로고    scopus 로고
    • Neural plasticity in the ageing brain
    • Burke SN and Barnes CA. Neural plasticity in the ageing brain. Nat Rev Neurosci, 2006. 7:30-40.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 30-40
    • Burke, S.N.1    Barnes, C.A.2
  • 9
    • 84908568670 scopus 로고    scopus 로고
    • Plasticity of the aging brain: new directions in cognitive neuroscience
    • Oct 31
    • Gutchess A. Plasticity of the aging brain: new directions in cognitive neuroscience. Science. 2014 Oct 31;346:579-82
    • (2014) Science , vol.346 , pp. 579-582
    • Gutchess, A.1
  • 10
    • 79959989592 scopus 로고    scopus 로고
    • Neural Protein Synthesis during Aging: Effects on Plasticity and Memory.
    • Aug 6, pii:26
    • Schimanski LA, Barnes CA. Neural Protein Synthesis during Aging: Effects on Plasticity and Memory. Front Aging Neurosci. 2010 Aug 6;2. pii: 26.
    • (2010) Front Aging Neurosci. , vol.2
    • Schimanski, L.A.1    Barnes, C.A.2
  • 11
    • 53349103842 scopus 로고    scopus 로고
    • Diet and the epigenetic (re)programming of phenotypic differences in behavior
    • Oct 27
    • McGowan PO, Meaney MJ, Szyf M. Diet and the epigenetic (re)programming of phenotypic differences in behavior. Brain Res. 2008 Oct 27;1237:12-24
    • (2008) Brain Res , vol.1237 , pp. 12-24
    • McGowan, P.O.1    Meaney, M.J.2    Szyf, M.3
  • 12
    • 3943092621 scopus 로고    scopus 로고
    • Pathways towards and away from Alzheimer's disease
    • Aug 5
    • Mattson MP. Pathways towards and away from Alzheimer's disease. Nature. 2004 Aug 5;430:631-9.
    • (2004) Nature , vol.430 , pp. 631-639
    • Mattson, M.P.1
  • 13
    • 84923327084 scopus 로고    scopus 로고
    • Progress in unraveling the genetic etiology of Parkinson disease in a genomic era
    • Mar
    • Verstraeten A, Theuns J, Van Broeckhoven C. Progress in unraveling the genetic etiology of Parkinson disease in a genomic era. Trends Genet. 2015 Mar;31:140-9.
    • (2015) Trends Genet , vol.31 , pp. 140-149
    • Verstraeten, A.1    Theuns, J.2    Van Broeckhoven, C.3
  • 16
    • 33947534891 scopus 로고    scopus 로고
    • Hippocampal expression analyses reveal selective association of immediate-early, neuroenergetic, and myelinogenic pathways with cognitive impairment in aged rats
    • Rowe WB, Blalock EM, Chen KC, Kadish I, Wang D, Barrett JE, Thibault O, Porter NM, Rose GM, Landfield PW. Hippocampal expression analyses reveal selective association of immediate-early, neuroenergetic, and myelinogenic pathways with cognitive impairment in aged rats. J Neurosci, 2007. 27:3098-110.
    • (2007) J Neurosci , vol.27 , pp. 3098-3110
    • Rowe, W.B.1    Blalock, E.M.2    Chen, K.C.3    Kadish, I.4    Wang, D.5    Barrett, J.E.6    Thibault, O.7    Porter, N.M.8    Rose, G.M.9    Landfield, P.W.10
  • 17
    • 0000103011 scopus 로고
    • The Croonian Lecture: La Fine Structure des Centres Nerveux
    • Cajal RY. The Croonian Lecture: La Fine Structure des Centres Nerveux. Proc Roy Soc London, 1894. 55:444-448.
    • (1894) Proc Roy Soc London , vol.55 , pp. 444-448
    • Cajal, R.Y.1
  • 18
    • 84877142544 scopus 로고    scopus 로고
    • Region-specific genetic alterations in the aging hippocampus: implications for cognitive aging
    • Burger C. Region-specific genetic alterations in the aging hippocampus: implications for cognitive aging. Front Aging Neurosci. 2:140.
    • Front Aging Neurosci. , vol.2 , pp. 140
    • Burger, C.1
  • 19
    • 79251599573 scopus 로고    scopus 로고
    • Gene expression in the hippocampus: regionally specific effects of aging and caloric restriction
    • Zeier Z, Madorsky I, Xu Y, Ogle WO, Notterpek L, Foster TC. Gene expression in the hippocampus: regionally specific effects of aging and caloric restriction. Mech Ageing Dev. 132:8-19.
    • Mech Ageing Dev. , vol.132 , pp. 8-19
    • Zeier, Z.1    Madorsky, I.2    Xu, Y.3    Ogle, W.O.4    Notterpek, L.5    Foster, T.C.6
  • 20
    • 78650000995 scopus 로고    scopus 로고
    • Selective neuronal vulnerability to oxidative stress in the brain
    • Mar 30
    • Wang X, Michaelis EK. Selective neuronal vulnerability to oxidative stress in the brain. Front Aging Neurosci. 2010 Mar 30;2:12.
    • (2010) Front Aging Neurosci , vol.2 , pp. 12
    • Wang, X.1    Michaelis, E.K.2
  • 21
    • 78649981260 scopus 로고    scopus 로고
    • Functional genomics of brain aging and Alzheimer's disease: focus on selective neuronal vulnerability
    • Dec
    • Wang X, Michaelis ML, Michaelis EK. Functional genomics of brain aging and Alzheimer's disease: focus on selective neuronal vulnerability. Curr Genomics. 2010 Dec;11:618-33.
    • (2010) Curr Genomics , vol.11 , pp. 618-633
    • Wang, X.1    Michaelis, M.L.2    Michaelis, E.K.3
  • 22
    • 0015145985 scopus 로고
    • The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat
    • O'Keefe J and Dostrovsky J. The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. Brain Res, 1971. 34:171-5.
    • (1971) Brain Res , vol.34 , pp. 171-175
    • O'Keefe, J.1    Dostrovsky, J.2
  • 23
    • 0027156030 scopus 로고
    • Spatial selectivity of unit activity in the hippocampal granular layer
    • Jung MW and McNaughton BL. Spatial selectivity of unit activity in the hippocampal granular layer. Hippocampus, 1993. 3:165-82.
    • (1993) Hippocampus , vol.3 , pp. 165-182
    • Jung, M.W.1    McNaughton, B.L.2
  • 24
    • 0027440875 scopus 로고
    • Dynamics of the hippocampal ensemble code for space
    • Wilson MA and McNaughton BL. Dynamics of the hippocampal ensemble code for space. Science, 1993. 261:1055-8.
    • (1993) Science , vol.261 , pp. 1055-1058
    • Wilson, M.A.1    McNaughton, B.L.2
  • 25
    • 24744449934 scopus 로고    scopus 로고
    • Heterogeneity among hippocampal pyramidal neurons revealed by their relation to theta-band oscillation and synchrony
    • Bland BH, Konopacki J, and Dyck R. Heterogeneity among hippocampal pyramidal neurons revealed by their relation to theta-band oscillation and synchrony. Exp Neurol, 2005. 195:458-74.
    • (2005) Exp Neurol , vol.195 , pp. 458-474
    • Bland, B.H.1    Konopacki, J.2    Dyck, R.3
  • 27
    • 34247115941 scopus 로고    scopus 로고
    • Genome dynamics and transcriptional deregulation in aging
    • Apr 14
    • Busuttil R, Bahar R, Vijg J. Genome dynamics and transcriptional deregulation in aging. Neuroscience. 2007 Apr 14;145:1341-7.
    • (2007) Neuroscience , vol.145 , pp. 1341-1347
    • Busuttil, R.1    Bahar, R.2    Vijg, J.3
  • 28
    • 0037418339 scopus 로고    scopus 로고
    • Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice
    • Duan W, Guo Z, Jiang H, Ware M, Li XJ, Mattson MP. Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice. Proc Natl Acad Sci U S A, 2003. 100:2911-6.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 2911-2916
    • Duan, W.1    Guo, Z.2    Jiang, H.3    Ware, M.4    Li, X.J.5    Mattson, M.P.6
  • 29
    • 33947264635 scopus 로고    scopus 로고
    • Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease
    • Halagappa VK, Guo Z, Pearson M, Matsuoka Y, Cutler RG, Laferla FM, Mattson MP. Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease. Neurobiol Dis, 2007. 26:212-20.
    • (2007) Neurobiol Dis , vol.26 , pp. 212-220
    • Halagappa, V.K.1    Guo, Z.2    Pearson, M.3    Matsuoka, Y.4    Cutler, R.G.5    Laferla, F.M.6    Mattson, M.P.7
  • 30
    • 60749090581 scopus 로고    scopus 로고
    • The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies
    • Maalouf M, Rho JM and Mattson MP. The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies. Brain Res Rev, 2009. 59:293-315.
    • (2009) Brain Res Rev , vol.59 , pp. 293-315
    • Maalouf, M.1    Rho, J.M.2    Mattson, M.P.3
  • 31
    • 70349262248 scopus 로고    scopus 로고
    • Voluntary exercise and caloric restriction enhance hippocampal dendritic spine density and BDNF levels in diabetic mice
    • Stranahan AM, Lee K, Martin B, Maudsley S, Golden E, Cutler RG, Mattson MP. Voluntary exercise and caloric restriction enhance hippocampal dendritic spine density and BDNF levels in diabetic mice. Hippocampus, 2009. 19:951-61.
    • (2009) Hippocampus , vol.19 , pp. 951-961
    • Stranahan, A.M.1    Lee, K.2    Martin, B.3    Maudsley, S.4    Golden, E.5    Cutler, R.G.6    Mattson, M.P.7
  • 35
    • 3042648746 scopus 로고    scopus 로고
    • Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
    • May 25
    • Kapahi P, Zid BM, Harper T, Koslover D, Sapin V, Benzer S. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol. 2004 May 25;14:885-90.
    • (2004) Curr Biol , vol.14 , pp. 885-890
    • Kapahi, P.1    Zid, B.M.2    Harper, T.3    Koslover, D.4    Sapin, V.5    Benzer, S.6
  • 36
    • 35648995939 scopus 로고    scopus 로고
    • MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae
    • Oct 2
    • Medvedik O, Lamming DW, Kim KD, Sinclair DA.MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae. PLoS Biol. 2007 Oct 2;5:e261.
    • (2007) PLoS Biol. , vol.5
    • Medvedik, O.1    Lamming, D.W.2    Kim, K.D.3    Sinclair, D.A.4
  • 38
    • 67650944993 scopus 로고    scopus 로고
    • Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
    • Jul 16
    • Harrison DE, et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature. 2009 Jul 16;460:392-5.
    • (2009) Nature , vol.460 , pp. 392-395
    • Harrison, D.E.1
  • 45
    • 84899578932 scopus 로고    scopus 로고
    • Reduction in DNA methyltransferases and alteration of DNA methylation pattern associate with mouse skin ageing
    • May
    • Qian H, Xu X. Reduction in DNA methyltransferases and alteration of DNA methylation pattern associate with mouse skin ageing. Exp Dermatol. 2014 May;23:357-9.
    • (2014) Exp Dermatol , vol.23 , pp. 357-359
    • Qian, H.1    Xu, X.2
  • 46
    • 77956095231 scopus 로고    scopus 로고
    • Active DNA demethylation: Many roads lead to Rome
    • Sep
    • Wu SC, Zhang Y. Active DNA demethylation: Many roads lead to Rome. Nat Rev Mol Cell Biol. 2010; Sep;11:607-20.
    • (2010) Nat Rev Mol Cell Biol. , vol.11 , pp. 607-620
    • Wu, S.C.1    Zhang, Y.2
  • 47
    • 79952535972 scopus 로고    scopus 로고
    • Regulation and function of DNA methylation in plants and animals
    • Mar
    • He XJ, Chen T, Zhu JK. Regulation and function of DNA methylation in plants and animals. Cell Res. 2011 Mar;21:442-65.
    • (2011) Cell Res , vol.21 , pp. 442-465
    • He, X.J.1    Chen, T.2    Zhu, J.K.3
  • 48
    • 77950187447 scopus 로고    scopus 로고
    • Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons
    • Apr
    • Feng J, Zhou Y, Campbell SL, Le T, Li E, Sweatt JD, Silva AJ, Fan G. Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons. Nat Neurosci. 2010 Apr 13:423-30.
    • (2010) Nat Neurosci , vol.13 , pp. 423-430
    • Feng, J.1    Zhou, Y.2    Campbell, S.L.3    Le, T.4    Li, E.5    Sweatt, J.D.6    Silva, A.J.7    Fan, G.8
  • 49
    • 0021132637 scopus 로고
    • 5-Methylcytosine is not detectable in Saccharomyces cerevisiae DNA
    • May
    • Proffitt JH, Davie JR, Swinton D, Hattman S. 5-Methylcytosine is not detectable in Saccharomyces cerevisiae DNA. Mol Cell Biol. 1984 May;4:985-8.
    • (1984) Mol Cell Biol , vol.4 , pp. 985-988
    • Proffitt, J.H.1    Davie, J.R.2    Swinton, D.3    Hattman, S.4
  • 50
    • 0023057540 scopus 로고
    • Caenorhabditis elegans DNA does not contain 5-methylcytosine at any time during development or aging
    • V J Simpson, T E Johnson, and R F Hammen. Caenorhabditis elegans DNA does not contain 5-methylcytosine at any time during development or aging. Nucleic Acids Res. 1986; 14: 6711-6719.
    • (1986) Nucleic Acids Res. , vol.14 , pp. 6711-6719
    • Simpson, V.J.1    Johnson, T.E.2    Hammen, R.F.3
  • 51
    • 0020691774 scopus 로고
    • DNA methylation and gene activity
    • Doerfler W. DNA methylation and gene activity. Annu Rev Biochem. 1983;52:93-124.
    • (1983) Annu Rev Biochem. , vol.52 , pp. 93-124
    • Doerfler, W.1
  • 52
    • 80052461558 scopus 로고    scopus 로고
    • Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
    • Sep 2
    • Ito S, Shen L, Dai Q, Wu SC, Collins LB, Swenberg JA, He C, Zhang Y. Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science. 2011 Sep 2;333:1300-3.
    • (2011) Science , vol.333 , pp. 1300-1303
    • Ito, S.1    Shen, L.2    Dai, Q.3    Wu, S.C.4    Collins, L.B.5    Swenberg, J.A.6    He, C.7    Zhang, Y.8
  • 54
    • 80052476744 scopus 로고    scopus 로고
    • Molecular biology. Demystifying DNA demethylation
    • Sep 2
    • Nabel CS, Kohli RM. Molecular biology. Demystifying DNA demethylation. Science. 2011 Sep 2;333:1229-30.
    • (2011) Science , vol.333 , pp. 1229-1230
    • Nabel, C.S.1    Kohli, R.M.2
  • 55
    • 0023664725 scopus 로고
    • Genomic 5-methyldeoxycytidine decreases with age
    • Jul 25
    • Wilson VL, Smith RA, Ma S, Cutler RG. Genomic 5-methyldeoxycytidine decreases with age. J Biol Chem. 1987 Jul 25;262:9948-51.
    • (1987) J Biol Chem , vol.262 , pp. 9948-9951
    • Wilson, V.L.1    Smith, R.A.2    Ma, S.3    Cutler, R.G.4
  • 57
    • 0020638422 scopus 로고
    • DNA methylation decreases in aging but not in immortal cells
    • Jun 3
    • Wilson VL, Jones PA. DNA methylation decreases in aging but not in immortal cells. Science. 1983 Jun 3;220:1055-7.
    • (1983) Science , vol.220 , pp. 1055-1057
    • Wilson, V.L.1    Jones, P.A.2
  • 58
    • 78449250771 scopus 로고    scopus 로고
    • Valproate induces DNA demethylation in nuclear extracts from adult mouse brain
    • Nov-Dec
    • Dong E1, Chen Y, Gavin DP, Grayson DR, Guidotti A. Valproate induces DNA demethylation in nuclear extracts from adult mouse brain. Epigenetics. 2010 Nov-Dec;5:730-5.
    • (2010) Epigenetics , vol.5 , pp. 730-735
    • Dong, E1.1    Chen, Y.2    Gavin, D.P.3    Grayson, D.R.4    Guidotti, A.5
  • 59
    • 79957623760 scopus 로고    scopus 로고
    • Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss
    • Klein CJ, Botuyan MV, Wu Y, et al. Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss. Nat Genet 2011, 43:595-600.
    • (2011) Nat Genet , vol.43 , pp. 595-600
    • Klein, C.J.1    Botuyan, M.V.2    Wu, Y.3
  • 60
    • 84884471932 scopus 로고    scopus 로고
    • TET1 controls CNS 5-methylcytosine hydroxylation, active DNA demethylation, gene transcription, and memory formation
    • Sep 18
    • Kaas GA, Zhong C, Eason DE, Ross DL, Vachhani RV, Ming GL, King JR, Song H, Sweatt JD. TET1 controls CNS 5-methylcytosine hydroxylation, active DNA demethylation, gene transcription, and memory formation. Neuron. 2013 Sep 18;79:1086-93.
    • (2013) Neuron , vol.79 , pp. 1086-1093
    • Kaas, G.A.1    Zhong, C.2    Eason, D.E.3    Ross, D.L.4    Vachhani, R.V.5    Ming, G.L.6    King, J.R.7    Song, H.8    Sweatt, J.D.9
  • 61
    • 79957623760 scopus 로고    scopus 로고
    • Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss
    • Klein CJ, Botuyan MV, Wu Y, et al. Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss. Nat Genet 2011, 43:595-600.
    • (2011) Nat Genet , vol.43 , pp. 595-600
    • Klein, C.J.1    Botuyan, M.V.2    Wu, Y.3
  • 62
    • 84864461542 scopus 로고    scopus 로고
    • Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilities
    • Jul 1
    • Oliveira AM, Hemstedt TJ, Bading H. Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilities. Nat Neurosci. 2012 Jul 1;15:1111-3
    • (2012) Nat Neurosci , vol.15 , pp. 1111-1113
    • Oliveira, A.M.1    Hemstedt, T.J.2    Bading, H.3
  • 63
    • 84864475139 scopus 로고    scopus 로고
    • DNA methylation in cognition comes of age
    • Jul 26
    • Su SC, Tsai LH. DNA methylation in cognition comes of age. Nat Neurosci. 2012 Jul 26;15:1061-2.
    • (2012) Nat Neurosci , vol.15 , pp. 1061-1062
    • Su, S.C.1    Tsai, L.H.2
  • 65
    • 84878798054 scopus 로고    scopus 로고
    • Epigenetic determinants of healthy and diseased brain aging and cognition
    • Jun
    • Akbarian S, Beeri MS, Haroutunian V. Epigenetic determinants of healthy and diseased brain aging and cognition. JAMA Neurol. 2013 Jun;70:711-8.
    • (2013) JAMA Neurol , vol.70 , pp. 711-718
    • Akbarian, S.1    Beeri, M.S.2    Haroutunian, V.3
  • 67
    • 33847047461 scopus 로고    scopus 로고
    • Epigenetics: a landscape takes shape
    • Feb 23
    • Goldberg AD, Allis CD, Bernstein E. Epigenetics: a landscape takes shape. Cell. 2007 Feb 23;128:635-8.
    • (2007) Cell , vol.128 , pp. 635-638
    • Goldberg, A.D.1    Allis, C.D.2    Bernstein, E.3
  • 70
    • 79957999588 scopus 로고    scopus 로고
    • Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity
    • Haggarty SJ and Tsai LH. Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity. Neurobiol Learn Mem 96: 41-52.
    • Neurobiol Learn Mem , vol.96 , pp. 41-52
    • Haggarty, S.J.1    Tsai, L.H.2
  • 72
    • 79958770713 scopus 로고    scopus 로고
    • Non-coding RNA networks underlying cognitive disorders across the lifespan
    • Jun
    • Qureshi IA1, Mehler MF. Non-coding RNA networks underlying cognitive disorders across the lifespan. Trends Mol Med. 2011 Jun;17:337-46.
    • (2011) Trends Mol Med , vol.17 , pp. 337-346
    • Qureshi, I.A1.1    Mehler, M.F.2
  • 73
    • 84931029036 scopus 로고    scopus 로고
    • Histone modifications change with age, dietary restriction and rapamycin treatment in mouse brain
    • (in press)
    • Gong H, Qian H, Ertl R, Astle MC, Wang GG, Harrison DE, Xu X. Histone modifications change with age, dietary restriction and rapamycin treatment in mouse brain. Oncotarget (in press)
    • Oncotarget
    • Gong, H.1    Qian, H.2    Ertl, R.3    Astle, M.C.4    Wang, G.G.5    Harrison, D.E.6    Xu, X.7
  • 74
    • 23044514626 scopus 로고    scopus 로고
    • Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells
    • Aug
    • Weber M, Davies JJ, Wittig D, Oakeley EJ, Haase M, Lam WL, Schübeler D. Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells. Nat Genet. 2005 Aug;37:853-62.
    • (2005) Nat Genet , vol.37 , pp. 853-862
    • Weber, M.1    Davies, J.J.2    Wittig, D.3    Oakeley, E.J.4    Haase, M.5    Lam, W.L.6    Schübeler, D.7
  • 75
    • 27144500218 scopus 로고    scopus 로고
    • Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis
    • Oct 13
    • Meissner A, Gnirke A, Bell GW, Ramsahoye B, Lander ES, Jaenisch R. Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis. Nucleic Acids Res. 2005 Oct 13;33:5868-77.
    • (2005) Nucleic Acids Res , vol.33 , pp. 5868-5877
    • Meissner, A.1    Gnirke, A.2    Bell, G.W.3    Ramsahoye, B.4    Lander, E.S.5    Jaenisch, R.6
  • 76
    • 79956330964 scopus 로고    scopus 로고
    • CpG islands and the regulation of transcription
    • May 15
    • Deaton AM, Bird A. CpG islands and the regulation of transcription. Genes Dev. 2011 May 15;25:1010-22
    • (2011) Genes Dev , vol.25 , pp. 1010-1022
    • Deaton, A.M.1    Bird, A.2
  • 77
    • 84867539667 scopus 로고    scopus 로고
    • Genome-wide analysis of DNA methylation in low cell numbers by reduced representation bisulfite sequencing
    • Smallwood SA, Kelsey G. Genome-wide analysis of DNA methylation in low cell numbers by reduced representation bisulfite sequencing. Methods Mol Biol. 2012;925:187-97.
    • (2012) Methods Mol Biol. , vol.925 , pp. 187-197
    • Smallwood, S.A.1    Kelsey, G.2
  • 79
    • 84884829249 scopus 로고    scopus 로고
    • Mapping human epigenomes
    • Sep 26
    • Rivera CM, Ren B. Mapping human epigenomes. Cell. 2013 Sep 26;155:39-55.
    • (2013) Cell , vol.155 , pp. 39-55
    • Rivera, C.M.1    Ren, B.2
  • 81
    • 84929463154 scopus 로고    scopus 로고
    • Profiling DNA methylome landscapes of mammalian cells with single-cell reduced-representation bisulfite sequencing
    • May
    • Guo H, Zhu P, Guo F, Li X, Wu X, Fan X, Wen L, Tang F. Profiling DNA methylome landscapes of mammalian cells with single-cell reduced-representation bisulfite sequencing. Nat Protoc. 2015 May;10:645-59.
    • (2015) Nat Protoc , vol.10 , pp. 645-659
    • Guo, H.1    Zhu, P.2    Guo, F.3    Li, X.4    Wu, X.5    Fan, X.6    Wen, L.7    Tang, F.8
  • 82
    • 84890526238 scopus 로고    scopus 로고
    • Single-cell methylome landscapes of mouse embryonic stem cells and early embryos analyzed using reduced representation bisulfite sequencing
    • Dec
    • Guo H, Zhu P, Wu X, Li X, Wen L, Tang F. Single-cell methylome landscapes of mouse embryonic stem cells and early embryos analyzed using reduced representation bisulfite sequencing. Genome Res. 2013 Dec;23:2126-35.
    • (2013) Genome Res , vol.23 , pp. 2126-2135
    • Guo, H.1    Zhu, P.2    Wu, X.3    Li, X.4    Wen, L.5    Tang, F.6
  • 84
    • 80054800740 scopus 로고    scopus 로고
    • BDNF polymorphism predicts the rate of decline in skilled task performance and hippocampal volume in healthy individuals
    • Oct 25
    • Sanchez MM, Das D, Taylor JL, et al. BDNF polymorphism predicts the rate of decline in skilled task performance and hippocampal volume in healthy individuals. Transl Psychiatry. 2011 Oct 25;1:e51.
    • (2011) Transl Psychiatry , vol.1
    • Sanchez, M.M.1    Das, D.2    Taylor, J.L.3
  • 85
    • 15244354999 scopus 로고    scopus 로고
    • Maturation but not survival of dopaminergic nigrostriatal neurons is affected in developing and aging BDNF-deficient mice
    • Mar 28
    • Baker SA, Stanford LE, Brown RE, Hagg T. Maturation but not survival of dopaminergic nigrostriatal neurons is affected in developing and aging BDNF-deficient mice. Brain Res. 2005 Mar 28;1039:177-88.
    • (2005) Brain Res , vol.1039 , pp. 177-188
    • Baker, S.A.1    Stanford, L.E.2    Brown, R.E.3    Hagg, T.4
  • 86
    • 34247856252 scopus 로고    scopus 로고
    • Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories
    • Jul
    • Heldt SA, Stanek L, Chhatwal JP, Ressler KJ. Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories. Mol Psychiatry. 2007 Jul;12:656-70.
    • (2007) Mol Psychiatry , vol.12 , pp. 656-670
    • Heldt, S.A.1    Stanek, L.2    Chhatwal, J.P.3    Ressler, K.J.4
  • 87
    • 36649022067 scopus 로고    scopus 로고
    • Female CREBalphadelta- deficient mice show earlier age-related cognitive deficits than males
    • Dec 5
    • Hebda-Bauer EK, Luo J, Watson SJ, Akil H. Female CREBalphadelta- deficient mice show earlier age-related cognitive deficits than males. Neuroscience. 2007 Dec 5;150:260-72.
    • (2007) Neuroscience , vol.150 , pp. 260-272
    • Hebda-Bauer, E.K.1    Luo, J.2    Watson, S.J.3    Akil, H.4
  • 88
    • 80052560599 scopus 로고    scopus 로고
    • Age-related changes in Arc transcription and DNA methylation within the hippocampus
    • Dec
    • Penner MR, Roth TL, Chawla MK, et al. Age-related changes in Arc transcription and DNA methylation within the hippocampus. Neurobiol Aging. 2011 Dec;32:2198-210.
    • (2011) Neurobiol Aging , vol.32 , pp. 2198-2210
    • Penner, M.R.1    Roth, T.L.2    Chawla, M.K.3
  • 89
    • 70450217879 scopus 로고    scopus 로고
    • Human DNA methylomes at base resolution show widespread epigenomic differences
    • Nov 19
    • Lister R, Pelizzola M, Dowen RH, et al. Human DNA methylomes at base resolution show widespread epigenomic differences. Nature. 2009 Nov 19;462:315-22.
    • (2009) Nature , vol.462 , pp. 315-322
    • Lister, R.1    Pelizzola, M.2    Dowen, R.H.3
  • 90
    • 77952888250 scopus 로고    scopus 로고
    • The role of REST in transcriptional and epigenetic dysregulation in Huntington's disease
    • Jul
    • Buckley NJ, Johnson R, Zuccato C, et al. The role of REST in transcriptional and epigenetic dysregulation in Huntington's disease. Neurobiol Dis. 2010 Jul;39:28-39.
    • (2010) Neurobiol Dis , vol.39 , pp. 28-39
    • Buckley, N.J.1    Johnson, R.2    Zuccato, C.3
  • 92
    • 84923347203 scopus 로고    scopus 로고
    • Lifelong brain health is a lifelong challenge: from evolutionary principles to empirical evidence
    • Mar
    • Mattson MP. Lifelong brain health is a lifelong challenge: from evolutionary principles to empirical evidence. Ageing Res Rev. 2015 Mar;20:37-45
    • (2015) Ageing Res Rev , vol.20 , pp. 37-45
    • Mattson, M.P.1
  • 93
    • 84916630473 scopus 로고    scopus 로고
    • Histone deacetylases in memory and cognition
    • Dec 9
    • Penney J, Tsai LH. Histone deacetylases in memory and cognition. Sci Signal. 2014 Dec 9;7:re12
    • (2014) Sci Signal , vol.7 , pp. re12
    • Penney, J.1    Tsai, L.H.2
  • 94
    • 84863647710 scopus 로고    scopus 로고
    • Mechanisms of age-related cognitive change and targets for intervention: epigenetics
    • Jun
    • Kosik KS, Rapp PR, Raz N, et al. Mechanisms of age-related cognitive change and targets for intervention: epigenetics. J Gerontol A Biol Sci Med Sci. 2012 Jun; 67:741-6.
    • (2012) J Gerontol A Biol Sci Med Sci. , vol.67 , pp. 741-746
    • Kosik, K.S.1    Rapp, P.R.2    Raz, N.3
  • 95
    • 67349190247 scopus 로고    scopus 로고
    • Linking DNA methylation and histone modification: patterns and paradigms
    • May
    • Cedar H, Bergman Y. Linking DNA methylation and histone modification: patterns and paradigms. Nat Rev Genet. 2009 May;10:295-304.
    • (2009) Nat Rev Genet , vol.10 , pp. 295-304
    • Cedar, H.1    Bergman, Y.2
  • 96
    • 34249279527 scopus 로고    scopus 로고
    • Stability and flexibility of epigenetic gene regulation in mammalian development
    • May 24
    • Reik W. Stability and flexibility of epigenetic gene regulation in mammalian development. Nature. 2007 May 24;447:425-32.
    • (2007) Nature , vol.447 , pp. 425-432
    • Reik, W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.