메뉴 건너뛰기




Volumn 1, Issue 1, 2013, Pages 32-49

From Phage lambda to human cancer: endogenous molecular-cellular network hypothesis

Author keywords

Adaptive Landscape; Genetic Switch; Intrinsic State; Phage Lambda; Regulatory Machinery

Indexed keywords


EID: 84931037043     PISSN: 20954689     EISSN: 20954697     Source Type: Journal    
DOI: 10.1007/s40484-013-0007-1     Document Type: Review
Times cited : (23)

References (111)
  • 2
    • 79952010844 scopus 로고    scopus 로고
    • A note from history: landmarks in history of cancer, part 1
    • PID: 20960499
    • Hajdu, S. I. (2011) A note from history: landmarks in history of cancer, part 1. Cancer, 117, 1097–1102.
    • (2011) Cancer , vol.117 , pp. 1097-1102
    • Hajdu, S.I.1
  • 3
    • 38749098685 scopus 로고    scopus 로고
    • Cancer as robust intrinsic state of endogenous molecular-cellular network shaped by evolution
    • PID: 17766049, COI: 1:CAS:528:DC%2BD1cXhslartLc%3D
    • Ao, P., Galas, D., Hood, L. and Zhu, X. (2008) Cancer as robust intrinsic state of endogenous molecular-cellular network shaped by evolution. Med. Hypotheses, 70, 678–684.
    • (2008) Med. Hypotheses , vol.70 , pp. 678-684
    • Ao, P.1    Galas, D.2    Hood, L.3    Zhu, X.4
  • 4
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • PID: 21376230, COI: 1:CAS:528:DC%2BC3MXjsFeqtrk%3D
    • Hanahan, D. and Weinberg, R. A. (2011) Hallmarks of cancer: the next generation. Cell, 144, 646–674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 5
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • PID: 959840, COI: 1:STN:280:DyaE283ntFWmsw%3D%3D
    • Nowell, P. C. (1976) The clonal evolution of tumor cell populations. Science, 194, 23–28.
    • (1976) Science , vol.194 , pp. 23-28
    • Nowell, P.C.1
  • 6
    • 84856013431 scopus 로고    scopus 로고
    • Clonal evolution in cancer
    • PID: 22258609, COI: 1:CAS:528:DC%2BC38Xps1CrtA%3D%3D
    • Greaves, M. and Maley, C. C. (2012) Clonal evolution in cancer. Nature, 481, 306–313.
    • (2012) Nature , vol.481 , pp. 306-313
    • Greaves, M.1    Maley, C.C.2
  • 7
    • 84863229772 scopus 로고    scopus 로고
    • Single-cell exome sequencing and monoclonal evolution of a JAK2-negative myeloproliferative neoplasm
    • PID: 22385957, COI: 1:CAS:528:DC%2BC38XjtlSltr0%3D
    • Hou, Y., Song, L., Zhu, P., Zhang, B., Tao, Y., Xu, X., Li, F., Wu, K., Liang, J., Shao, D., et al. (2012) Single-cell exome sequencing and monoclonal evolution of a JAK2-negative myeloproliferative neoplasm. Cell, 148, 873–885.
    • (2012) Cell , vol.148 , pp. 873-885
    • Hou, Y.1    Song, L.2    Zhu, P.3    Zhang, B.4    Tao, Y.5    Xu, X.6    Li, F.7    Wu, K.8    Liang, J.9    Shao, D.10
  • 8
    • 0020520516 scopus 로고
    • Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
    • PID: 6308472, COI: 1:CAS:528:DyaL3sXltlCks7c%3D
    • Land, H., Parada, L. F. and Weinberg, R. A. (1983) Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature, 304, 596–602.
    • (1983) Nature , vol.304 , pp. 596-602
    • Land, H.1    Parada, L.F.2    Weinberg, R.A.3
  • 9
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • PID: 7736585, COI: 1:CAS:528:DyaK2MXlsFSrs7k%3D
    • Weinberg, R. A. (1995) The retinoblastoma protein and cell cycle control. Cell, 81, 323–330.
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 10
    • 0024708518 scopus 로고
    • The distribution of secondary growths in cancer of the breast. 1889
    • PID: 2673568, COI: 1:STN:280:DyaL1Mzns1OmsA%3D%3D
    • Paget, S. (1989) The distribution of secondary growths in cancer of the breast. 1889. Cancer Metastasis Rev., 8, 98–101.
    • (1989) Cancer Metastasis Rev. , vol.8 , pp. 98-101
    • Paget, S.1
  • 11
    • 47849101658 scopus 로고    scopus 로고
    • The “seed and soil” hypothesis revisited
    • PID: 18672217
    • Fidler, I. J. and Poste, G. (2008) The “seed and soil” hypothesis revisited. Lancet Oncol., 9, 808.
    • (2008) Lancet Oncol. , vol.9 , pp. 808
    • Fidler, I.J.1    Poste, G.2
  • 12
  • 13
    • 0019996706 scopus 로고
    • Amplification and adaptation in regulatory and sensory systems
    • PID: 7089556, COI: 1:CAS:528:DyaL38XkvVOisLs%3D
    • Koshland, D. E. Jr, Goldbeter, A. and Stock, J. B. (1982) Amplification and adaptation in regulatory and sensory systems. Science, 217, 220–225.
    • (1982) Science , vol.217 , pp. 220-225
    • Koshland, D.E.1    Goldbeter, A.2    Stock, J.B.3
  • 14
    • 59849117990 scopus 로고    scopus 로고
    • Global view of bionetwork dynamics: adaptive landscape
    • PID: 19232305
    • Ao, P. (2009) Global view of bionetwork dynamics: adaptive landscape. J. Genet. Genomics, 36, 63–73.
    • (2009) J. Genet. Genomics , vol.36 , pp. 63-73
    • Ao, P.1
  • 15
    • 1842687878 scopus 로고    scopus 로고
    • The yeast cellcycle network is robustly designed
    • PID: 15037758, COI: 1:CAS:528:DC%2BD2cXjsFCjur4%3D
    • Li, F., Long, T., Lu, Y., Ouyang, Q. and Tang, C. (2004) The yeast cellcycle network is robustly designed. Proc. Natl. Acad. Sci. USA, 101, 4781–4786.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 4781-4786
    • Li, F.1    Long, T.2    Lu, Y.3    Ouyang, Q.4    Tang, C.5
  • 16
    • 11144321198 scopus 로고    scopus 로고
    • Robustness, stability and efficiency of phage lambda genetic switch: dynamical structure analysis
    • PID: 15617166, COI: 1:CAS:528:DC%2BD2MXpsFWgt7k%3D
    • Zhu, X. M., Yin, L., Hood, L. and Ao, P. (2004) Robustness, stability and efficiency of phage lambda genetic switch: dynamical structure analysis. J. Bioinform. Comput. Biol., 2, 785–817.
    • (2004) J. Bioinform. Comput. Biol. , vol.2 , pp. 785-817
    • Zhu, X.M.1    Yin, L.2    Hood, L.3    Ao, P.4
  • 17
    • 59849113447 scopus 로고    scopus 로고
    • Efficiency, robustness, and stochasticity of gene regulatory networks in systems biology: λ switch as a working example
    • Choi S, (ed)
    • Zhu, X., Yin, L., Hood, L., Galas, D. and Ao, P. (2007) Efficiency, robustness, and stochasticity of gene regulatory networks in systems biology: λ switch as a working example. In Choi, S. (ed.), Introduction to Systems Biology. Humana Press, 336–371.
    • (2007) Introduction to Systems Biology , pp. 336-371
    • Zhu, X.1    Yin, L.2    Hood, L.3    Galas, D.4    Ao, P.5
  • 19
    • 0023233801 scopus 로고
    • Multiple-drug resistance in human cancer
    • PID: 3553950, COI: 1:STN:280:DyaL2s3gtFOqsQ%3D%3D
    • Pastan, I. and Gottesman, M. (1987) Multiple-drug resistance in human cancer. N. Engl. J. Med., 316, 1388–1393.
    • (1987) N. Engl. J. Med. , vol.316 , pp. 1388-1393
    • Pastan, I.1    Gottesman, M.2
  • 20
    • 0015380016 scopus 로고
    • Tumor dormancy in vivo by prevention of neovascularization
    • PID: 5043412
    • Gimbrone, M. A. Jr, Leapman, S. B., Cotran, R. S. and Folkman, J. (1972) Tumor dormancy in vivo by prevention of neovascularization. J. Exp. Med., 136, 261–276.
    • (1972) J. Exp. Med. , vol.136 , pp. 261-276
    • Gimbrone, M.A.1    Leapman, S.B.2    Cotran, R.S.3    Folkman, J.4
  • 21
    • 0033518234 scopus 로고    scopus 로고
    • From molecular to modular cell biology
    • PID: 10591225, COI: 1:CAS:528:DyaK1MXnslKms70%3D
    • Hartwell, L. H., Hopfield, J. J., Leibler, S. and Murray, A. W. (1999) From molecular to modular cell biology. Nature, 402, C47–C52.
    • (1999) Nature , vol.402 , pp. C47-C52
    • Hartwell, L.H.1    Hopfield, J.J.2    Leibler, S.3    Murray, A.W.4
  • 22
    • 0035501062 scopus 로고    scopus 로고
    • TGF-β signaling in cancer-a double-edged sword
    • PID: 11684442, COI: 1:CAS:528:DC%2BD3MXnvFGrsb8%3D
    • Akhurst, R. J. and Derynck, R. (2001) TGF-β signaling in cancer-a double-edged sword. Trends Cell Biol., 11, S44–S51.
    • (2001) Trends Cell Biol. , vol.11 , pp. S44-S51
    • Akhurst, R.J.1    Derynck, R.2
  • 23
    • 84856994812 scopus 로고    scopus 로고
    • Conflicting roles of molecules in hepatocarcinogenesis: paradigm or paradox
    • PID: 22340589, COI: 1:CAS:528:DC%2BC38Xit1yqu78%3D
    • Feng, G.-S. (2012) Conflicting roles of molecules in hepatocarcinogenesis: paradigm or paradox. Cancer Cell, 21, 150–154.
    • (2012) Cancer Cell , vol.21 , pp. 150-154
    • Feng, G.-S.1
  • 24
    • 0016662402 scopus 로고    scopus 로고
    • Control circuits for determination and transdetermination: interpreting positional information in a binary epigenetic code
    • Porter R, Rivers J, (eds)
    • Kauffman, S. (2008) Control circuits for determination and transdetermination: interpreting positional information in a binary epigenetic code. In Porter, R. and Rivers J. (eds.), Ciba Foundation Symposium 29 — Cell Patterning. John Wiley & Sons, Ltd., 201–221.
    • (2008) Ciba Foundation Symposium 29 — Cell Patterning , pp. 201-221
    • Kauffman, S.1
  • 25
    • 77953397764 scopus 로고    scopus 로고
    • Systems medicine: the future of medical genomics and healthcare
    • PID: 19348689, COI: 1:CAS:528:DC%2BD1MXhtFGnur7F
    • Auffray, C., Chen, Z. and Hood, L. (2009) Systems medicine: the future of medical genomics and healthcare. Genome Med., 1, 2.
    • (2009) Genome Med. , vol.1 , pp. 2
    • Auffray, C.1    Chen, Z.2    Hood, L.3
  • 27
    • 84865429505 scopus 로고    scopus 로고
    • A personal view on systems medicine and the emergence of proactive P4 medicine: predictive, preventive, personalized and participatory
    • COI: 1:CAS:528:DC%2BC38Xht1KrsrvN
    • Hood, L. and Flores, M. (2012) A personal view on systems medicine and the emergence of proactive P4 medicine: predictive, preventive, personalized and participatory. New Biotechnol., 29, 613–624.
    • (2012) New Biotechnol. , vol.29 , pp. 613-624
    • Hood, L.1    Flores, M.2
  • 29
    • 77956838760 scopus 로고    scopus 로고
    • Towards predictive stochastic dynamical modeling of cancer genesis and progression
    • PID: 20640781, COI: 1:STN:280:DC%2BC3claktA%3D%3D
    • Ao, P., Galas, D., Hood, L., Yin, L. and Zhu, X. M. (2010) Towards predictive stochastic dynamical modeling of cancer genesis and progression. Interdiscip. Sci., 2, 140–144.
    • (2010) Interdiscip. Sci. , vol.2 , pp. 140-144
    • Ao, P.1    Galas, D.2    Hood, L.3    Yin, L.4    Zhu, X.M.5
  • 30
    • 0034614334 scopus 로고    scopus 로고
    • A long twentieth century of the cell cycle and beyond
    • PID: 10647932, COI: 1:CAS:528:DC%2BD3cXks1Ckug%3D%3D
    • Nurse, P. (2000) A long twentieth century of the cell cycle and beyond. Cell, 100, 71–78.
    • (2000) Cell , vol.100 , pp. 71-78
    • Nurse, P.1
  • 31
    • 0035814424 scopus 로고    scopus 로고
    • Beyond the Nobel Prize: cell cycle research offers new view of cancer
    • PID: 11734586, COI: 1:STN:280:DC%2BD3MnovVGhtw%3D%3D
    • Garber, K. (2001) Beyond the Nobel Prize: cell cycle research offers new view of cancer. J. Natl. Cancer Inst., 93, 1766–1768.
    • (2001) J. Natl. Cancer Inst. , vol.93 , pp. 1766-1768
    • Garber, K.1
  • 32
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • PID: 18035408, COI: 1:CAS:528:DC%2BD2sXhsVCntbbK
    • Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K. and Yamanaka, S. (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell, 131, 861–872.
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5    Tomoda, K.6    Yamanaka, S.7
  • 33
    • 79960637387 scopus 로고    scopus 로고
    • Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors
    • PID: 21562492, COI: 1:CAS:528:DC%2BC3MXmsFyqsro%3D
    • Huang, P., He, Z., Ji, S., Sun, H., Xiang, D., Liu, C., Hu, Y., Wang, X. and Hui, L. (2011) Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors. Nature, 475, 386–389.
    • (2011) Nature , vol.475 , pp. 386-389
    • Huang, P.1    He, Z.2    Ji, S.3    Sun, H.4    Xiang, D.5    Liu, C.6    Hu, Y.7    Wang, X.8    Hui, L.9
  • 34
    • 50849121703 scopus 로고    scopus 로고
    • Temporal organization of the cell cycle
    • PID: 18786381, COI: 1:CAS:528:DC%2BD1cXhtVyku77I
    • Tyson, J. J. and Novak, B. (2008) Temporal organization of the cell cycle. Curr. Biol., 18, R759–R768.
    • (2008) Curr. Biol. , vol.18 , pp. R759-R768
    • Tyson, J.J.1    Novak, B.2
  • 35
    • 79952635820 scopus 로고    scopus 로고
    • Measuring and modeling apoptosis in single cells
    • PID: 21414484, COI: 1:CAS:528:DC%2BC3MXjsFCrtr8%3D
    • Spencer, S. L. and Sorger, P. K. (2011) Measuring and modeling apoptosis in single cells. Cell, 144, 926–939.
    • (2011) Cell , vol.144 , pp. 926-939
    • Spencer, S.L.1    Sorger, P.K.2
  • 36
    • 0018817388 scopus 로고
    • R3: their roles in mediating the effects of repressor and cro
    • PID: 6447795, COI: 1:CAS:528:DyaL3cXlsVKjtLc%3D
    • R3: their roles in mediating the effects of repressor and cro. J. Mol. Biol., 139, 163–194.
    • (1980) J. Mol. Biol. , vol.139 , pp. 163-194
    • Meyer, B.J.1    Maurer, R.2    Ptashne, M.3
  • 37
    • 0032549745 scopus 로고    scopus 로고
    • Genomic cisregulatory logic: experimental and computational analysis of a sea urchin gene
    • PID: 9506933, COI: 1:CAS:528:DyaK1cXhvFKnsLY%3D
    • Yuh, C. H., Bolouri, H. and Davidson, E. H. (1998) Genomic cisregulatory logic: experimental and computational analysis of a sea urchin gene. Science, 279, 1896–1902.
    • (1998) Science , vol.279 , pp. 1896-1902
    • Yuh, C.H.1    Bolouri, H.2    Davidson, E.H.3
  • 38
    • 80051634563 scopus 로고    scopus 로고
    • Systems biology and cancer: promises and perils
    • PID: 21419159
    • Baker, S. G. and Kramer, B. S. (2011) Systems biology and cancer: promises and perils. Prog. Biophys. Mol. Biol., 106, 410–413.
    • (2011) Prog. Biophys. Mol. Biol. , vol.106 , pp. 410-413
    • Baker, S.G.1    Kramer, B.S.2
  • 41
    • 60749102185 scopus 로고    scopus 로고
    • Attractors and democratic dynamics
    • PID: 19229023, COI: 1:CAS:528:DC%2BD1MXisVCjt74%3D
    • Bar-Yam, Y., Harmon, D. and de Bivort, B. (2009) Attractors and democratic dynamics. Science, 323, 1016–1017.
    • (2009) Science , vol.323 , pp. 1016-1017
    • Bar-Yam, Y.1    Harmon, D.2    de Bivort, B.3
  • 42
    • 20344364613 scopus 로고    scopus 로고
    • Laws in Darwinian evolutionary theory
    • Ao, P. (2005) Laws in Darwinian evolutionary theory. Phys. Life Rev., 2, 117–156.
    • (2005) Phys. Life Rev. , vol.2 , pp. 117-156
    • Ao, P.1
  • 43
    • 47749139256 scopus 로고    scopus 로고
    • Cancer as an overhealing wound: an old hypothesis revisited
    • PID: 18628784, COI: 1:CAS:528:DC%2BD1cXosl2rsbc%3D
    • Schäfer, M. and Werner, S. (2008) Cancer as an overhealing wound: an old hypothesis revisited. Nat. Rev. Mol. Cell Biol., 9, 628–638.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 628-638
    • Schäfer, M.1    Werner, S.2
  • 44
    • 0033590207 scopus 로고    scopus 로고
    • The role of cyclooxygenases in inflammation, cancer, and development
    • PID: 10630643, COI: 1:CAS:528:DC%2BD3cXks1KlsA%3D%3D
    • Williams, C. S., Mann, M. and DuBois, R. N. (1999) The role of cyclooxygenases in inflammation, cancer, and development. Oncogene, 18, 7908–7916.
    • (1999) Oncogene , vol.18 , pp. 7908-7916
    • Williams, C.S.1    Mann, M.2    DuBois, R.N.3
  • 48
    • 0022429106 scopus 로고
    • The OR control system of bacteriophage lambda: a physical-chemical model for gene regulation
    • PID: 3157005, COI: 1:CAS:528:DyaL2MXhs1Wgsrk%3D
    • Shea, M. A. and Ackers, G. K. (1985) The OR control system of bacteriophage lambda: a physical-chemical model for gene regulation. J. Mol. Biol., 181, 211–230.
    • (1985) J. Mol. Biol. , vol.181 , pp. 211-230
    • Shea, M.A.1    Ackers, G.K.2
  • 50
    • 0020392141 scopus 로고
    • The shifting balance theory and macroevolution
    • PID: 6760797, COI: 1:STN:280:DyaL3s7isFChtg%3D%3D
    • Wright, S. (1982) The shifting balance theory and macroevolution. Annu. Rev. Genet., 16, 1–19.
    • (1982) Annu. Rev. Genet. , vol.16 , pp. 1-19
    • Wright, S.1
  • 51
    • 79957710315 scopus 로고    scopus 로고
    • Quantifying the Waddington landscape and biological paths for development and differentiation
    • PID: 21536909, COI: 1:CAS:528:DC%2BC3MXmsF2jsbg%3D
    • Wang, J., Zhang, K., Xu, L. and Wang, E. (2011) Quantifying the Waddington landscape and biological paths for development and differentiation. Proc. Natl. Acad. Sci. USA, 108, 8257–8262.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 8257-8262
    • Wang, J.1    Zhang, K.2    Xu, L.3    Wang, E.4
  • 52
    • 78649871073 scopus 로고    scopus 로고
    • Probability landscape of heritable and robust epigenetic state of lysogeny in phage lambda
    • PID: 20937911, COI: 1:CAS:528:DC%2BC3cXhtl2mtbvP
    • Cao, Y., Lu, H. M. and Liang, J. (2010) Probability landscape of heritable and robust epigenetic state of lysogeny in phage lambda. Proc. Natl. Acad. Sci. USA, 107, 18445–18450.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 18445-18450
    • Cao, Y.1    Lu, H.M.2    Liang, J.3
  • 53
    • 0028947257 scopus 로고
    • Funnels, pathways, and the energy landscape of protein folding: a synthesis
    • COI: 1:CAS:528:DyaK2MXks12qtrk%3D
    • Bryngelson, J. D., Onuchic, J. N., Socci, N. D. and Wolynes, P. G. (1995) Funnels, pathways, and the energy landscape of protein folding: a synthesis. Proteins: Struct. Func. Bioinfo., 21, 167–195.
    • (1995) Proteins: Struct. Func. Bioinfo. , vol.21 , pp. 167-195.
    • Bryngelson, J.D.1    Onuchic, J.N.2    Socci, N.D.3    Wolynes, P.G.4
  • 54
    • 34247106650 scopus 로고    scopus 로고
    • On the existence of potential landscape in the evolution of complex systems
    • Ao, P., Kwon, C. and Qian, H. (2007) On the existence of potential landscape in the evolution of complex systems. Complexity, 12, 19–27.
    • (2007) Complexity , vol.12 , pp. 19-27
    • Ao, P.1    Kwon, C.2    Qian, H.3
  • 55
    • 84864415377 scopus 로고    scopus 로고
    • Beyond Itô versus Stratonovich
    • Yuan, R. S. and Ao, P. (2012) Beyond Itô versus Stratonovich. J. Stat. Mech., 2012, P07010.
    • (2012) J. Stat. Mech. , vol.2012 , pp. P07010
    • Yuan, R.S.1    Ao, P.2
  • 57
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: epidemiology and molecular carcinogenesis
    • PID: 17570226, COI: 1:CAS:528:DC%2BD2sXnvFOgsrw%3D
    • El-Serag, H. B. and Rudolph, K. L. (2007) Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology, 132, 2557–2576.
    • (2007) Gastroenterology , vol.132 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 61
    • 0001276586 scopus 로고
    • Experimental pathology of the liver: I. Restoration of the liver of the while rat following surgical removal
    • Higgins, G. M. (1931) Experimental pathology of the liver: I. Restoration of the liver of the while rat following surgical removal. Arch. Pathol. (Chic), 12, 186–202.
    • (1931) Arch. Pathol. (Chic) , vol.12 , pp. 186-202
    • Higgins, G.M.1
  • 62
    • 84961054225 scopus 로고
    • A morphologic study of deoxyribonucleic acid synthesis and cell proliferation in regenerating rat liver; autoradiography with thymidine-H3
    • PID: 13902009, COI: 1:CAS:528:DyaF38Xks1GnurY%3D
    • Grisham, J. W. (1962) A morphologic study of deoxyribonucleic acid synthesis and cell proliferation in regenerating rat liver; autoradiography with thymidine-H3. Cancer Res., 22, 842–849.
    • (1962) Cancer Res. , vol.22 , pp. 842-849
    • Grisham, J.W.1
  • 63
    • 0034740215 scopus 로고    scopus 로고
    • C/EBPα arrests cell proliferation through direct inhibition of Cdk2 and Cdk4
    • PID: 11684017, COI: 1:CAS:528:DC%2BD3MXotlagurk%3D
    • Wang, H., Iakova, P., Wilde, M., Welm, A., Goode, T., Roesler, W. J. and Timchenko, N. A. (2001) C/EBPα arrests cell proliferation through direct inhibition of Cdk2 and Cdk4. Mol. Cell, 8, 817–828.
    • (2001) Mol. Cell , vol.8 , pp. 817-828
    • Wang, H.1    Iakova, P.2    Wilde, M.3    Welm, A.4    Goode, T.5    Roesler, W.J.6    Timchenko, N.A.7
  • 64
    • 0037663743 scopus 로고    scopus 로고
    • Regulation and role of p21 and p27 cyclin-dependent kinase inhibitors during hepatocyte differentiation and growth
    • PID: 12646420, COI: 1:CAS:528:DC%2BD3sXls1Wms7g%3D
    • Ilyin, G. P., Glaise, D., Gilot, D., Baffet, G. and Guguen-Guillouzo, C. (2003) Regulation and role of p21 and p27 cyclin-dependent kinase inhibitors during hepatocyte differentiation and growth. Am. J. Physiol. Gastrointest. Liver Physiol., 285, G115–G127.
    • (2003) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.285 , pp. G115-G127
    • Ilyin, G.P.1    Glaise, D.2    Gilot, D.3    Baffet, G.4    Guguen-Guillouzo, C.5
  • 66
    • 62849093368 scopus 로고    scopus 로고
    • Death receptor signal transducers: nodes of coordination in immune signaling networks
    • PID: 19295631, COI: 1:CAS:528:DC%2BD1MXjtlymsLw%3D
    • Wilson, N. S., Dixit, V. and Ashkenazi, A. (2009) Death receptor signal transducers: nodes of coordination in immune signaling networks. Nat. Immunol., 10, 348–355.
    • (2009) Nat. Immunol. , vol.10 , pp. 348-355
    • Wilson, N.S.1    Dixit, V.2    Ashkenazi, A.3
  • 67
    • 3442886811 scopus 로고    scopus 로고
    • The pathophysiology of mitochondrial cell death
    • PID: 15286356, COI: 1:CAS:528:DC%2BD2cXmtFWqsrc%3D
    • Green, D. R. and Kroemer, G. (2004) The pathophysiology of mitochondrial cell death. Science, 305, 626–629.
    • (2004) Science , vol.305 , pp. 626-629
    • Green, D.R.1    Kroemer, G.2
  • 68
    • 0032575688 scopus 로고    scopus 로고
    • The Bcl-2 protein family: arbiters of cell survival
    • PID: 9735050, COI: 1:CAS:528:DyaK1cXlvVegsb8%3D
    • Adams, J. M. and Cory, S. (1998) The Bcl-2 protein family: arbiters of cell survival. Science, 281, 1322–1326.
    • (1998) Science , vol.281 , pp. 1322-1326
    • Adams, J.M.1    Cory, S.2
  • 72
    • 0034616945 scopus 로고    scopus 로고
    • Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
    • PID: 10929711, COI: 1:CAS:528:DC%2BD3cXkvFCrsbc%3D
    • Du, C., Fang, M., Li, Y., Li, L. and Wang, X. (2000) Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell, 102, 33–42.
    • (2000) Cell , vol.102 , pp. 33-42
    • Du, C.1    Fang, M.2    Li, Y.3    Li, L.4    Wang, X.5
  • 73
    • 63849268421 scopus 로고    scopus 로고
    • Caspase-8: a key role in the pathogenesis of diabetic embryopathy
    • PID: 19194987, COI: 1:CAS:528:DC%2BD1MXjt1Wksro%3D
    • Zhao, Z., Yang, P., Eckert, R. L. and Reece, E. A. (2009) Caspase-8: a key role in the pathogenesis of diabetic embryopathy. Birth Defects Res. B Dev. Reprod. Toxicol., 86, 72–77.
    • (2009) Birth Defects Res. B Dev. Reprod. Toxicol. , vol.86 , pp. 72-77
    • Zhao, Z.1    Yang, P.2    Eckert, R.L.3    Reece, E.A.4
  • 74
    • 0028129732 scopus 로고
    • Hepatocyte and immune system: acute phase reaction as a contribution to early defence mechanisms
    • PID: 7525420, COI: 1:CAS:528:DyaK2cXmslyht70%3D
    • Trautwein, C., Böker, K. and Manns, M. P. (1994) Hepatocyte and immune system: acute phase reaction as a contribution to early defence mechanisms. Gut, 35, 1163–1166.
    • (1994) Gut , vol.35 , pp. 1163-1166
    • Trautwein, C.1    Böker, K.2    Manns, M.P.3
  • 75
    • 0034127757 scopus 로고    scopus 로고
    • Cytokine regulation of liver injury and repair
    • PID: 10807515, COI: 1:CAS:528:DC%2BD3cXjtVygsrc%3D
    • Diehl, A. M. (2000) Cytokine regulation of liver injury and repair. Immunol. Rev., 174, 160–171.
    • (2000) Immunol. Rev. , vol.174 , pp. 160-171
    • Diehl, A.M.1
  • 76
    • 80052014052 scopus 로고    scopus 로고
    • Inflammation meets cancer, with NF-κB as the matchmaker
    • PID: 21772280, COI: 1:CAS:528:DC%2BC3MXptV2isrk%3D
    • Ben-Neriah, Y. and Karin, M. (2011) Inflammation meets cancer, with NF-κB as the matchmaker. Nat. Immunol., 12, 715–723.
    • (2011) Nat. Immunol. , vol.12 , pp. 715-723
    • Ben-Neriah, Y.1    Karin, M.2
  • 77
    • 33645799492 scopus 로고    scopus 로고
    • Mechanisms of Liver Injury. I. TNF-α-induced liver injury: role of IKK, JNK, and ROS pathways
    • PID: 16537970, COI: 1:CAS:528:DC%2BD28Xks1Sls7Y%3D
    • Schwabe, R. F. and Brenner, D. A. (2006) Mechanisms of Liver Injury. I. TNF-α-induced liver injury: role of IKK, JNK, and ROS pathways. Am. J. Physiol. Gastrointest. Liver Physiol., 290, G583–G589.
    • (2006) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.290 , pp. G583-G589
    • Schwabe, R.F.1    Brenner, D.A.2
  • 78
    • 48649109203 scopus 로고    scopus 로고
    • Hepatocyte necrosis induced by oxidative stress and IL-1α release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis
    • PID: 18691550, COI: 1:CAS:528:DC%2BD1cXhtVSrtrjJ
    • Sakurai, T., He, G., Matsuzawa, A., Yu, G.-Y., Maeda, S., Hardiman, G. and Karin, M. (2008) Hepatocyte necrosis induced by oxidative stress and IL-1α release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis. Cancer Cell, 14, 156–165.
    • (2008) Cancer Cell , vol.14 , pp. 156-165
    • Sakurai, T.1    He, G.2    Matsuzawa, A.3    Yu, G.-Y.4    Maeda, S.5    Hardiman, G.6    Karin, M.7
  • 79
    • 58649100056 scopus 로고    scopus 로고
    • Inflammation and cancer: IL-6 and STAT3 complete the link
    • PID: 19185839, COI: 1:CAS:528:DC%2BD1MXltFSmtL4%3D
    • Bromberg, J. and Wang, T. C. (2009) Inflammation and cancer: IL-6 and STAT3 complete the link. Cancer Cell, 15, 79–80.
    • (2009) Cancer Cell , vol.15 , pp. 79-80
    • Bromberg, J.1    Wang, T.C.2
  • 80
    • 0037222997 scopus 로고    scopus 로고
    • Modulation of liver injury by interleukin-10
    • PID: 12812143, COI: 1:STN:280:DC%2BD3s3osFWqtg%3D%3D
    • Louis, H., Le Moine, O., Goldman, M. and Devière, J. (2003) Modulation of liver injury by interleukin-10. Acta Gastroenterol. Belg., 66, 7–14.
    • (2003) Acta Gastroenterol. Belg. , vol.66 , pp. 7-14
    • Louis, H.1    Le Moine, O.2    Goldman, M.3    Devière, J.4
  • 81
    • 79251517382 scopus 로고    scopus 로고
    • Regulation of cancer cell metabolism
    • PID: 21258394, COI: 1:CAS:528:DC%2BC3MXps1ahuw%3D%3D
    • Cairns, R. A., Harris, I. S. and Mak, T. W. (2011) Regulation of cancer cell metabolism. Nat. Rev. Cancer, 11, 85–95.
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 85-95
    • Cairns, R.A.1    Harris, I.S.2    Mak, T.W.3
  • 82
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: the metabolic requirements of cell proliferation
    • PID: 19460998, COI: 1:CAS:528:DC%2BD1MXmtVKlsbg%3D
    • Vander Heiden, M. G., Cantley, L. C. and Thompson, C. B. (2009) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science, 324, 1029–1033.
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 83
    • 76049100577 scopus 로고    scopus 로고
    • HIF-1: upstream and downstream of cancer metabolism
    • PID: 19942427, COI: 1:CAS:528:DC%2BC3cXhslWktr0%3D
    • Semenza, G. (2010) HIF-1: upstream and downstream of cancer metabolism. Curr. Opin. Genet. Dev., 20, 51–56.
    • (2010) Curr. Opin. Genet. Dev. , vol.20 , pp. 51-56
    • Semenza, G.1
  • 84
    • 66149180568 scopus 로고    scopus 로고
    • An Akt/hypoxia-inducible factor-1α/plateletderived growth factor-BB autocrine loop mediates hypoxia-induced chemoresistance in liver cancer cells and tumorigenic hepatic progenitor cells
    • PID: 19447872, COI: 1:CAS:528:DC%2BD1MXmtVKlsr8%3D
    • Lau, C. K., Yang, Z. F., Ho, D.W., Ng, M. N., Yeoh, G. C., Poon, R. T. and Fan, S. T. (2009) An Akt/hypoxia-inducible factor-1α/plateletderived growth factor-BB autocrine loop mediates hypoxia-induced chemoresistance in liver cancer cells and tumorigenic hepatic progenitor cells. Clin. Cancer Res., 15, 3462–3471.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 3462-3471
    • Lau, C.K.1    Yang, Z.F.2    Ho, D.W.3    Ng, M.N.4    Yeoh, G.C.5    Poon, R.T.6    Fan, S.T.7
  • 85
    • 34249689753 scopus 로고    scopus 로고
    • Molecular regulation of angiogenesis and lymphangiogenesis
    • PID: 17522591, COI: 1:CAS:528:DC%2BD2sXlsFOhsb4%3D
    • Adams, R. H. and Alitalo, K. (2007) Molecular regulation of angiogenesis and lymphangiogenesis. Nat. Rev. Mol. Cell Biol., 8, 464–478.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 464-478
    • Adams, R.H.1    Alitalo, K.2
  • 87
    • 0031685620 scopus 로고    scopus 로고
    • TGF-β signal transduction
    • PID: 9759503
    • Massagué, J. (1998) TGF-β signal transduction. Annu. Rev. Biochem., 67, 753–791.
    • (1998) Annu. Rev. Biochem. , vol.67 , pp. 753-791
    • Massagué, J.1
  • 88
    • 0345736990 scopus 로고    scopus 로고
    • Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of β-catenin, and enhanced tumor cell invasion
    • PID: 14706341, COI: 1:CAS:528:DC%2BD2cXitFOjtw%3D%3D
    • Lu, Z., Ghosh, S., Wang, Z. and Hunter, T. (2003) Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of β-catenin, and enhanced tumor cell invasion. Cancer Cell, 4, 499–515.
    • (2003) Cancer Cell , vol.4 , pp. 499-515
    • Lu, Z.1    Ghosh, S.2    Wang, Z.3    Hunter, T.4
  • 90
    • 0033636789 scopus 로고    scopus 로고
    • Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors
    • PID: 11030331, COI: 1:CAS:528:DC%2BD3cXntVyhs70%3D
    • Lu, T. T., Makishima, M., Repa, J. J., Schoonjans, K., Kerr, T. A., Auwerx, J. and Mangelsdorf, D. J. (2000) Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. Mol. Cell, 6, 507–515.
    • (2000) Mol. Cell , vol.6 , pp. 507-515
    • Lu, T.T.1    Makishima, M.2    Repa, J.J.3    Schoonjans, K.4    Kerr, T.A.5    Auwerx, J.6    Mangelsdorf, D.J.7
  • 91
    • 69949088230 scopus 로고    scopus 로고
    • Stochastic dynamics and nonequilibrium thermodynamics of a bistable chemical system: the Schlögl model revisited
    • PID: 19095615, COI: 1:CAS:528:DC%2BD1MXht1Wqu77L
    • Vellela, M. and Qian, H. (2009) Stochastic dynamics and nonequilibrium thermodynamics of a bistable chemical system: the Schlögl model revisited. J. R. Soc. Interface, 6, 925–940.
    • (2009) J. R. Soc. Interface , vol.6 , pp. 925-940
    • Vellela, M.1    Qian, H.2
  • 92
    • 80051634248 scopus 로고    scopus 로고
    • Mathematical descriptions of biochemical networks: stability, stochasticity, evolution
    • PID: 21419158
    • Rosenfeld, S. (2011) Mathematical descriptions of biochemical networks: stability, stochasticity, evolution. Prog. Biophys. Mol. Biol., 106, 400–409.
    • (2011) Prog. Biophys. Mol. Biol. , vol.106 , pp. 400-409
    • Rosenfeld, S.1
  • 93
    • 84866329024 scopus 로고    scopus 로고
    • General theory of genotype to phenotype mapping: derivation of epigenetic landscapes from N-node complex gene regulatory networks
    • PID: 23005679, COI: 1:CAS:528:DC%2BC38XhsFWktbzF
    • Villarreal, C., Padilla-Longoria, P., and Alvarez-Buylla, E. R. (2012) General theory of genotype to phenotype mapping: derivation of epigenetic landscapes from N-node complex gene regulatory networks. Phys. Rev. Lett., 109, 118102.
    • (2012) Phys. Rev. Lett. , vol.109 , pp. 118102
    • Villarreal, C.1    Padilla-Longoria, P.2    Alvarez-Buylla, E.R.3
  • 94
    • 0035910064 scopus 로고    scopus 로고
    • Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver
    • PID: 11752456, COI: 1:CAS:528:DC%2BD38XpsVSr
    • Xu, X. R., Huang, J., Xu, Z. G., Qian, B. Z., Zhu, Z. D., Yan, Q., Cai, T., Zhang, X., Xiao, H. S., Qu, J., et al. (2001) Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. Proc. Natl. Acad. Sci. USA, 98, 15089–15094.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 15089-15094
    • Xu, X.R.1    Huang, J.2    Xu, Z.G.3    Qian, B.Z.4    Zhu, Z.D.5    Yan, Q.6    Cai, T.7    Zhang, X.8    Xiao, H.S.9    Qu, J.10
  • 95
    • 49249122615 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling contributes to activation of normal and tumorigenic liver progenitor cells
    • PID: 18519688, COI: 1:CAS:528:DC%2BD1cXmsFKmur8%3D
    • Yang, W., Yan, H. X., Chen, L., Liu, Q., He, Y. Q., Yu, L. X., Zhang, S. H., Huang, D. D., Tang, L., Kong, X. N., et al. (2008) Wnt/β-catenin signaling contributes to activation of normal and tumorigenic liver progenitor cells. Cancer Res., 68, 4287–4295.
    • (2008) Cancer Res. , vol.68 , pp. 4287-4295
    • Yang, W.1    Yan, H.X.2    Chen, L.3    Liu, Q.4    He, Y.Q.5    Yu, L.X.6    Zhang, S.H.7    Huang, D.D.8    Tang, L.9    Kong, X.N.10
  • 96
    • 27644470686 scopus 로고    scopus 로고
    • Ninety plus thirty years of nonlinear dynamics: less is more and more is different
    • Holmes, P. (2005) Ninety plus thirty years of nonlinear dynamics: less is more and more is different. Int. J. Bifurcat. Chaos, 15, 2703–2716.
    • (2005) Int. J. Bifurcat. Chaos , vol.15 , pp. 2703-2716
    • Holmes, P.1
  • 97
    • 84893164085 scopus 로고    scopus 로고
    • Darwinian dynamics implies developmental ascendency
    • Ao, P. (2007) Darwinian dynamics implies developmental ascendency. Biol. Theory, 2, 113–115.
    • (2007) Biol. Theory , vol.2 , pp. 113-115
    • Ao, P.1
  • 98
    • 34047241883 scopus 로고    scopus 로고
    • Orders of magnitude change in phenotype rate caused by mutation
    • PID: 17429143, COI: 1:CAS:528:DC%2BD2sXjs12kurw%3D
    • Ao, P. (2007) Orders of magnitude change in phenotype rate caused by mutation. Cell. Oncol., 29, 67–69.
    • (2007) Cell. Oncol. , vol.29 , pp. 67-69
    • Ao, P.1
  • 99
    • 37149032224 scopus 로고    scopus 로고
    • Generic enzymatic rate equation under living conditions
    • COI: 1:CAS:528:DC%2BD2sXhsVaisr3I
    • Lee, L., Yin, L., Zhu, X. and Ao, P. (2007) Generic enzymatic rate equation under living conditions. J. Biol. Syst., 15, 495–514.
    • (2007) J. Biol. Syst. , vol.15 , pp. 495-514
    • Lee, L.1    Yin, L.2    Zhu, X.3    Ao, P.4
  • 100
    • 47149095277 scopus 로고    scopus 로고
    • Towards kinetic modeling of global metabolic networks: methylobacterium extorquens AM1 growth as validation
    • COI: 1:CAS:528:DC%2BD1cXhsFWntL7K
    • Ao, P., Lee, L. W., Lidstrom, M. E., Yin, L. and Zhu, X. (2008) Towards kinetic modeling of global metabolic networks: methylobacterium extorquens AM1 growth as validation. Chin. J. Biotechnol., 24, 980–994.
    • (2008) Chin. J. Biotechnol. , vol.24 , pp. 980-994
    • Ao, P.1    Lee, L.W.2    Lidstrom, M.E.3    Yin, L.4    Zhu, X.5
  • 101
    • 84867120393 scopus 로고    scopus 로고
    • A glimpse of enzymology within the idea of systems
    • PID: 23015132
    • Liu, C., Fan, D., Shi, Y. and Zhou, Q. (2012) A glimpse of enzymology within the idea of systems. Sci. China Life Sci., 55, 826–833.
    • (2012) Sci. China Life Sci. , vol.55 , pp. 826-833
    • Liu, C.1    Fan, D.2    Shi, Y.3    Zhou, Q.4
  • 102
    • 79960728672 scopus 로고    scopus 로고
    • On the intrinsic inevitability of cancer: from foetal to fatal attraction
    • PID: 21640825
    • Huang, S. (2011) On the intrinsic inevitability of cancer: from foetal to fatal attraction. Semin. Cancer Biol., 21, 183–199.
    • (2011) Semin. Cancer Biol. , vol.21 , pp. 183-199
    • Huang, S.1
  • 103
    • 84868578989 scopus 로고    scopus 로고
    • Quasipotential landscape in complex multi-stable systems
    • PID: 22933187
    • Zhou, J. X., Aliyu, M. D., Aurell, E. and Huang, S. (2012) Quasipotential landscape in complex multi-stable systems. J. R. Soc. Interface, 9, 3539–3553.
    • (2012) J. R. Soc. Interface , vol.9 , pp. 3539-3553
    • Zhou, J.X.1    Aliyu, M.D.2    Aurell, E.3    Huang, S.4
  • 104
    • 78650171589 scopus 로고    scopus 로고
    • Towards a unifying theory of late stochastic effects of ionizing radiation
    • PID: 21078408, COI: 1:CAS:528:DC%2BC3cXhsF2isLfE
    • Baverstock, K. and Karotki, A. V. (2011) Towards a unifying theory of late stochastic effects of ionizing radiation. Mutat. Res., 718, 1–9.
    • (2011) Mutat. Res. , vol.718 , pp. 1-9
    • Baverstock, K.1    Karotki, A.V.2
  • 105
    • 79951873316 scopus 로고    scopus 로고
    • Cancer tumors as Metazoa 1.0: apping genes of ancient ancestors
    • PID: 21301065, COI: 1:STN:280:DC%2BC3M3jt1Kitw%3D%3D
    • Davies, P. C. W. and Lineweaver, C. H. (2011) Cancer tumors as Metazoa 1.0: apping genes of ancient ancestors. Phys. Biol., 8, 015001.
    • (2011) Phys. Biol. , vol.8 , pp. 015001
    • Davies, P.C.W.1    Lineweaver, C.H.2
  • 106
    • 80053061834 scopus 로고    scopus 로고
    • Cancer: beyond speciation
    • PID: 21925308, COI: 1:CAS:528:DC%2BC38XhvV2ns7fF
    • Vincent, M. D. (2011) Cancer: beyond speciation. Adv. Cancer Res., 112, 283–350.
    • (2011) Adv. Cancer Res. , vol.112 , pp. 283-350
    • Vincent, M.D.1
  • 108
    • 80051967505 scopus 로고    scopus 로고
    • Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
    • PID: 21854987, COI: 1:CAS:528:DC%2BC3MXhtVKjsbrM
    • Gupta, P. B., Fillmore, C. M., Jiang, G., Shapira, S. D., Tao, K., Kuperwasser, C. and Lander, E. S. (2011) Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. Cell, 146, 633–644.
    • (2011) Cell , vol.146 , pp. 633-644
    • Gupta, P.B.1    Fillmore, C.M.2    Jiang, G.3    Shapira, S.D.4    Tao, K.5    Kuperwasser, C.6    Lander, E.S.7
  • 109
    • 80053006367 scopus 로고    scopus 로고
    • Decoding the genome beyond sequencing: the new phase of genomic research
    • PID: 21640814, COI: 1:CAS:528:DC%2BC3MXht1ClsbfM
    • Heng, H. H. Q., Liu, G., Stevens, J. B., Bremer, S. W., Ye, K. J., Abdallah, B. Y., Horne, S. D. and Ye, C. J. (2011) Decoding the genome beyond sequencing: the new phase of genomic research. Genomics, 98, 242–252.
    • (2011) Genomics , vol.98 , pp. 242-252
    • Heng, H.H.Q.1    Liu, G.2    Stevens, J.B.3    Bremer, S.W.4    Ye, K.J.5    Abdallah, B.Y.6    Horne, S.D.7    Ye, C.J.8
  • 111
    • 67650095196 scopus 로고    scopus 로고
    • Elite and stochastic models for induced pluripotent stem cell generation
    • PID: 19571877, COI: 1:CAS:528:DC%2BD1MXotVSgu7c%3D
    • Yamanaka, S. (2009) Elite and stochastic models for induced pluripotent stem cell generation. Nature, 460, 49–52.
    • (2009) Nature , vol.460 , pp. 49-52
    • Yamanaka, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.