Chronically Ultraviolet-exposed Human Skin Shows a Higher Mutation Frequency of Mitochondrial DNa as Compared to Unexposed Skin and the Hematopoietic System

Photochemistry and Photobiology

Volumn 66, Issue 2, 1997, Pages 271-275

  Berneburg, Mark ^a   Gattermann, Norbert ^a   Stege, Helger ^a   Grewe, Markus ^a   Vogelsang, Kathrin ^a   Ruzicka, Thomas ^a   Krutmann, Jean ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA;

ADULT; AGED; ARTICLE; CUTANEOUS PARAMETERS; HEMATOPOIETIC STEM CELL; HUMAN; MIDDLE AGED; MUTAGENESIS; POLYMERASE CHAIN REACTION; RADIATION EXPOSURE; SKIN; ULTRAVIOLET RADIATION;

ADULT; AGED; AGED, 80 AND OVER; DNA, MITOCHONDRIAL; HEMATOPOIETIC STEM CELLS; HUMANS; MIDDLE AGED; MUTAGENESIS; POLYMERASE CHAIN REACTION; SKIN; SKIN AGING; ULTRAVIOLET RAYS;

EID: 0031196736     PISSN: 00318655     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1751-1097.1997.tb08654.x     Document Type: Article

References (30)

1. Wallace, D. C. (1992) Diseases of the mitochondrial DNA. Annu. Rev. Biochem. 61, 1175-1212.
2. Wallace, D. C. (1993) Mitochondrial diseases: genotype versus phenotype. Trends Genet 9, 128-133.
3. Poulton, J. (1992) Mitochondrial DNA and genetic disease. BioEssays 14, 763-768.
4. Shapira, A. H. V. (1993) Mitochondrial disorders. Curr. Opin. Genet. Dev. 3, 457-465.
5. Di Mauro, S. and D. C. Wallace (1993) Mitochondrial DNA in Human Pathology. Raven Press, New York.
6. Shoffner, J. M., M. T. Lott, A. S. Voljavec, S. A. Soueidan, D. A. Costigan and D. C. Wallace (1989) Spontaneous Kearns-Sayre/chronic external ophthalmoplegia plus syndrome associated with a mitochondrial DNA deletion: a slip-replication model and metabolic therapy. Proc. Natl. Acad. Sci. 86, 7952-7956.
7. Mita, S., C. T. Rizzuto, S. Moraes, S. Shanske, E. Arnaudo, G. M. Fabrizi, Y. Koga, S. Di Mauro and E. A. Schon (1990) Recombination via flanking direct repeats is a major cause of large scale deletions of human mitochondrial DNA. Nucleic Acids Res. 18, 561-567.
8. Corral-Debrinski, M., J. M. Shoffner, M. T. Lott and D. C. Wallace (1992) Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease. Mutat. Res. 275, 169-180.
9. Ikebe, S., M. Tanaka, K. Ohno, W. Sato, K. Hattori, T. Kondo, Y. Mizuno and T. Ozawa (1990) Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence. Biochem. Biophys. Res. Commun. 170, 1044-1048.
10. Cortopassi, G. A. and N. Arnheim (1990) Detection of a specific mitochondrial DNA mutation in tissues of older humans. Nucleic Acids Res. 18, 6927-6933.
11. Linnane, A. W., A. Baumer, R. J. Maxwell, H. Preston, C. Zhang and S. Marzuki (1990) Mitochondrial gene mutation: the ageing process and degenerative diseases. Biochem. Int. 22, 1067-1076.
12. Richter, C. (1995) Oxidative damage to mitochondrial DNA and its relationship to ageing. Int. J. Biochem. Cell Biol. 27, 647-653.
13. Wallace, D. C. (1992) Mitochondrial genetics: a paradigm for ageing and degenerative diseases? Science 256, 628-632.
14. Cortopassi, G. A., D. Shibata, N. W. Soong and N. Arnheim (1992) A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc. Natl. Acad. Sci. USA 89, 7370-7374.
15. Yang, J. H., H. C. Lee and Y. H. Wei (1995) Photoageing-associated mitochondrial DNA length mutations in human skin. Arch. Dermatol. Res. 287, 641-648.
16. Bourgeron, T., D. Chretien, A. Rötig, A. Munnich and P. Rustin (1993) Fate and expression of the deleted mitochondrial DNA differ between human heteroplasmic skin fibroblasts and Epstein-Barr virus-transformed lymphocyte cultures. J. Biol. Chem. 268, 19369-19376.
17. Moraes, C. T., E. A. Schon, S. Di Mauro and A. F. Miranda (1989) Heteroplasmy of mitochondrial genomes in clonal cultures from patients with Kearns-Sayre syndrome. Biochem. Biophys. Res. Commun. 160, 765-771.
18. Gattermann, N., M. Berneburg, J. Heinisch, C. Aul and W. Schneider (1995) Detection of the ageing-associated 5-kb common deletion of mitochondrial DNA in blood and bone marrow of hematologically normal adults. Absence of the deletion in clonal bone marrow disorders. Leukemia 9, 1704-1710.
19. Anderson, S. (1981) Sequence and organization of the human mitochondrial genome. Nature 290, 457-465.
20. Henninger, H. P., R. Hoffmann, M. Grewe, A. Schulze-Specking and K. Decker (1993) Purification and quantitative analysis of nucleic acids by anion-exchange-high-performance liquid chromatography. Biol. Chem. Hoppe-Seyler 374, 625-629.
21. Wallace, D. C., T. M, Lott, A. Torroni, M. D. Brown and J. M. Shoffner (1993) Report of the committee on human mitochondrial DNA. Hum. Gene Mapping 2, 813-845.
22. Grewe, M., K. Gyufko, E. Schöpf and J. Krutmann (1994) Lesional expression of interferon-γ in atopic eczema. Lancet 343, 25-26.
23. Grewe, M., K. Gyufko and J. Krutmann (1995) Interleukin-10 production by cultured human keratinocytes: regulation by ultraviolet B and ultraviolet A1 radiation. J. Invest. Dermatol. 104, 3-7.
24. Holt, I. J., A. E. Harding and J. A. Morgan-Hughes (1988) Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies. Nature 331, 717-719.
25. Wallace, D. C., X. Zheng, M. T. Lott, J. M. Shoffner, J. A. Hodge, R. I. Kelley, C. M. Epstein and L. C. Hopkins (1988) Familial mitochondrial encephalomyopathy (MERFF): genetic, pathophysiological, and biochemical characterization of a mitochondrial DNA disease. Cell 55, 601-610.
26. Miquel, J. (1991) An integrated theory of aging as a result of mitochondrial DNA mutation in differentiated cells. Arch. Gerontol. Geriatr. 12, 99-117.
27. Clayton, D. A., J. N. Doda and E. C. Friedberg (1974) The absence of a pyrimidine dimer repair mechanism in mammalian mitochondria. Proc. Natl. Acad. Sci. USA 71, 2777-2781.
28. Driggers, W. J., S. P. Le Doux and G. L. Wilson (1993) Repair of oxidative damage within the mitochondrial DNA in RINr 38 cells. J. Biol. Chem. 268, 22042-22045.
29. Yakes, M. F. and B. Van Houten (1997) Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc. Natl. Acad. Sci. USA 94, 514-519.
30. Giacomoni, P. U. and P. D'Alessio (1996) Open questions in photobiology IV. Photoageing of the skin. J. Photochem. Phorobiol. 33, 267-272.