Elucidation of G-protein and β-arrestin functional selectivity at the dopamine D2 receptor

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 22, 2015, Pages 7097-7102

  Peterson, Sean M ^a   Pack, Thomas F ^a   Wilkins, Angela D ^b   Urs, Nikhil M ^a   Urban, Daniel J ^a   Bass, Caroline E ^c   Lichtarge, Olivier ^b   Caron, Marc G ^a  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY AT BUFFALO   (United States)

Author keywords

Dopamine; Functional selectivity; G protein; GPCR; arrestin

Indexed keywords

BETA ARRESTIN; DOPAMINE 2 RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; RETINA S ANTIGEN;

ANIMAL EXPERIMENT; ARTICLE; CENTRAL NERVOUS SYSTEM FUNCTION; CORPUS STRIATUM; DOWNSTREAM PROCESSING; LOCOMOTION; MATHEMATICAL ANALYSIS; MOUSE; MUTAGENESIS; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CRYSTALLOGRAPHY; CYTOLOGY; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; PHYSIOLOGY; PROTEIN CONFORMATION; REGRESSION ANALYSIS;

MUS;

ANIMALS; ARRESTINS; CORPUS STRIATUM; CRYSTALLOGRAPHY; GTP-BINDING PROTEINS; HEK293 CELLS; HUMANS; MAP KINASE SIGNALING SYSTEM; MICE; MODELS, MOLECULAR; MUTAGENESIS; NEURONS; PROTEIN CONFORMATION; RECEPTORS, DOPAMINE D2; REGRESSION ANALYSIS;

EID: 84930965993     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1502742112     Document Type: Article

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