A formal perturbation equation between genotype and phenotype determines the Evolutionary Action of protein-coding variations on fitness

Genome Research

Volumn 24, Issue 12, 2014, Pages 2050-2058

  Katsonis, Panagiotis ^a   Lichtarge, Olivier ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; PROTEIN;

ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; CORRELATIONAL STUDY; GENE MUTATION; GENETIC CODE; GENETIC CONSERVATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE PHENOTYPE CORRELATION; GEOMETRY; HOMOZYGOTE; HUMAN; IN VITRO STUDY; MOLECULAR EVOLUTION; MORBIDITY; MUTATIONAL ANALYSIS; PHYLOGENETIC TREE; PHYLOGENY; POINT MUTATION; POPULATION GENETICS; PROTEIN FUNCTION; SEQUENCE ANALYSIS; ALGORITHM; BIOLOGICAL MODEL; GENETIC ASSOCIATION; GENOTYPE; MUTATION; OPEN READING FRAME; PHENOTYPE; RECEIVER OPERATING CHARACTERISTIC; REPRODUCTIVE FITNESS;

ALGORITHMS; EVOLUTION, MOLECULAR; GENETIC ASSOCIATION STUDIES; GENETIC FITNESS; GENETIC VARIATION; GENETICS, POPULATION; GENOTYPE; HUMANS; MODELS, GENETIC; MORBIDITY; MUTATION; OPEN READING FRAMES; PHENOTYPE; POLYMORPHISM, GENETIC; ROC CURVE;

EID: 84913588353     PISSN: 10889051     EISSN: 15495469     Source Type: Journal    
DOI: 10.1101/gr.176214.114     Document Type: Article

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