Apparent loss-of-function mutant GPCRs revealed as constitutively desensitized receptors

Biochemistry

Volumn 41, Issue 40, 2002, Pages 11981-11989

  Wilbanks, Alyson M ^a   Laporte, Stéphane A ^a   Bohn, Laura M ^a   Barak, Larry S ^a   Caron, Marc G ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SEQUENCES;

AMINO ACIDS; BIOLOGICAL MEMBRANES; CHROMOSOMES;

PROTEINS;

ALPHA 1B ADRENERGIC RECEPTOR; ANGIOTENSIN 1 RECEPTOR; ARGININE; ASPARTIC ACID; BETA ARRESTIN; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; TYROSINE; VASOPRESSIN RECEPTOR;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; ENDOCYTOSIS; ENDOSOME; GENETIC CONSERVATION; HORMONE RESISTANCE; HUMAN; HUMAN CELL; MUTANT; PHENOTYPE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; RECEPTOR DOWN REGULATION; WILD TYPE;

AMINO ACID MOTIFS; ANIMALS; ARGININE; ARRESTIN; CELL LINE; DYNAMINS; GREEN FLUORESCENT PROTEINS; GTP-BINDING PROTEINS; HUMANS; LUMINESCENT PROTEINS; MUTATION; PROTEIN-SERINE-THREONINE KINASES; RATS; RECEPTORS, CELL SURFACE; RECEPTORS, VASOPRESSIN; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037044297     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi020275m     Document Type: Article

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