A protein extract from chicken reduces plasma homocysteine in rats

Nutrients

Volumn 7, Issue 6, 2015, Pages 4498-4511

  Lysne, Vegard ^a,b   Bjørndal, Bodil ^a   Vik, Rita ^a   Nordrehaug, Jan Erik ^a   Skorve, Jon ^a   Nygård, Ottar ^a,b   Berge, Rolf K ^a,b  

^a UNIVERSITY OF BERGEN   (Norway)

^b HAUKELAND UNIVERSITY HOSPITAL   (Norway)

Author keywords

Chicken protein; Homocysteine; One carbon metabolism; Peroxisome proliferator activated receptor; Wistar rats

Indexed keywords

5 METHYLTETRAHYDROFOLATE HOMOCYSTEINE METHYLTRANSFERASE; BETAINE; BETAINE HOMOCYSTEINE METHYLTRANSFERASE; CASEIN; CHICKEN PROTEIN; COBALAMIN; CREATININE; CYSTATHIONINE; CYSTATHIONINE GAMMA LYASE; CYSTEINE; DIMETHYLGLYCINE; FLAVINE MONONUCLEOTIDE; FOLIC ACID; GLYCINE; GLYCINE HYDROXYMETHYLTRANSFERASE; HOMOCYSTEINE; MESSENGER RNA; METHIONINE; METHIONINE SYNTHASE; METHYLMALONIC ACID; PROTEIN; PYRIDOXAL; PYRIDOXAL 5 PHOSPHATE; PYRIDOXIC ACID; RIBOFLAVIN; SARCOSINE; SERINE; UNCLASSIFIED DRUG; CHOLINE; CYANOCOBALAMIN; PROTEIN INTAKE; PYRIDOXINE;

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; LIQUID CHROMATOGRAPHY; MALE; MASS FRAGMENTOGRAPHY; NONHUMAN; RAT; REAL TIME POLYMERASE CHAIN REACTION; TANDEM MASS SPECTROMETRY; ADMINISTRATION AND DOSAGE; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; CHICKEN; DRUG EFFECTS; GENETICS; LIVER; MEAT; METABOLISM; PROTEIN INTAKE; WISTAR RAT;

RATTUS; RATTUS NORVEGICUS;

5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE S-METHYLTRANSFERASE; ANIMALS; BETAINE; BETAINE-HOMOCYSTEINE S-METHYLTRANSFERASE; CASEINS; CHICKENS; CHOLINE; CYSTATHIONINE GAMMA-LYASE; CYSTEINE; DIETARY PROTEINS; FOLIC ACID; GLYCINE; HOMOCYSTEINE; LIVER; MALE; MEAT; METHIONINE; RATS; RATS, WISTAR; RIBOFLAVIN; RNA, MESSENGER; SARCOSINE; SERINE; VITAMIN B 12; VITAMIN B 6;

EID: 84930959460     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu7064498     Document Type: Article

References (37)

1. Gudbrandsen, O.A.; Wergedahl, H.; Liaset, B.; Espe, M.; Berge, R.K. Dietary proteins with high isoflavone content or low methionine-glycine and lysine-arginine ratios are hypocholesterolaemic and lower the plasma homocysteine level in male zucker fa/fa rats. Br. J. Nutr.2005, 94, 321–330
2. Liaset, B.; Hao, Q.; Jorgensen, H.; Hallenborg, P.; Du, Z.Y.; Ma, T.; Marschall, H.U.; Kruhoffer, M.; Li, R.; Li, Q.; et al. Nutritional regulation of bile acid metabolism is associated with improved pathological characteristics of the metabolic syndrome. J. Biol. Chem.2011, 286, 28382–28395
3. Wergedahl, H.; Liaset, B.; Gudbrandsen, O.A.; Lied, E.; Espe, M.; Muna, Z.; Mork, S.; Berge, R.K. Fish protein hydrolysate reduces plasma total cholesterol, increases the proportion of hdl cholesterol, and lowers acyl-coa:Cholesterol acyltransferase activity in liver of zucker rats. J. Nutr.2004, 134, 1320–1327
4. Shukla, A.; Bettzieche, A.; Hirche, F.; Brandsch, C.; Stangl, G.I.; Eder, K. Dietary fish protein alters blood lipid concentrations and hepatic genes involved in cholesterol homeostasis in the rat model. Br. J. Nutr.2006, 96, 674–682
5. Rigamonti, E.; Parolini, C.; Marchesi, M.; Diani, E.; Brambilla, S.; Sirtori, C.R.; Chiesa, G. Hypolipidemic effect of dietary pea proteins: Impact on genes regulating hepatic lipid metabolism. Mol. Nutr. Food Res.2010, 54, S24–S30
6. Hosomi, R.; Fukunaga, K.; Arai, H.; Nishiyama, T.; Yoshida, M. Effects of dietary fish protein on serum and liver lipid concentrations in rats and the expression of hepatic genes involved in lipid metabolism. J. Agric. Food Chem.2009, 57, 9256–9262
7. Hosomi, R.; Fukunaga, K.; Arai, H.; Kanda, S.; Nishiyama, T.; Yoshida, M. Fish protein decreases serum cholesterol in rats by inhibition of cholesterol and bile acid absorption. J. Food Sci.2011, 76, H116–H121
8. Kritchevsky, D.; Tepper, S.A.; Czarnecki, S.K.; Klurfeld, D.M. Atherogenicity of animal and vegetable protein. Influence of the lysine to arginine ratio. Atherosclerosis 1982, 41, 429–431
9. Morita, T.; Oh-hashi, A.; Takei, K.; Ikai, M.; Kasaoka, S.; Kiriyama, S. Cholesterol-lowering effects of soybean, potato and rice proteins depend on their low methionine contents in rats fed a cholesterol-free purified diet. J. Nutr.1997, 127, 470–477
10. Sugiyama, K.; Ohkawa, S.; Muramatsu, K. Relationship between amino acid composition of diet and plasma cholesterol level in growing rats fed a high cholesterol diet. J. Nutr. Sci. Vitaminol.1986, 32, 413–423.
11. Vik, R.; Bjorndal, B.; Bohov, P.; Brattelid, T.; Svardal, A.; Nygard, O.K.; Nordrehaug, J.E.; Skorve, J.; Berge, R.K. Hypolipidemic effect of dietary water-soluble protein extract from chicken: Impact on genes regulating hepatic lipid and bile acid metabolism. Eur. J. Nutr.2014, 54, 193–204
12. Selhub, J. Homocysteine metabolism. Annu. Rev. Nutr.1999, 19, 217–246
13. Refsum, H.; Ueland, P.M.; Nygard, O.; Vollset, S.E. Homocysteine and cardiovascular disease. Annu. Rev. Med.1998, 49, 31–62
14. Clarke, R.; Halsey, J.; Lewington, S.; Lonn, E.; Armitage, J.; Manson, J.E.; Bonaa, K.H.; Spence, J.D.; Nygard, O.; Jamison, R.; et al. Effects of lowering homocysteine levels with b vitamins on cardiovascular disease, cancer, and cause-specific mortality: Meta-analysis of 8 randomized trials involving 37,485 individuals. Arch. Intern. Med.2010, 170, 1622–1631
15. Zeisel, S.H.; Corbin, K.D. Choline. In Present Knowledge in Nutrition, 10th ed.; Erdman, J.W., Macdonald, I.A., Zeisel, S.H., Eds.; International Life Sciences Institute: Washington, DC, USA, 2012; pp. 405–418
16. Porter, D.H.; Cook, R.J.; Wagner, C. Enzymatic properties of dimethylglycine dehydrogenase and sarcosine dehydrogenase from rat liver. Arch. Biochem. Biophys.1985, 243, 396–407
17. Ogawa, H.; Gomi, T.; Takusagawa, F.; Fujioka, M. Structure, function and physiological role of glycine N-methyltransferase. Int. J. Biochem. Cell Biol.1998, 30, 13–26
18. Luka, Z.; Mudd, S.H.; Wagner, C. Glycine N-methyltransferase and regulation of S-adenosylmethionine levels. J. Biol. Chem. 2009, 284, 22507–22511
19. Schirch, V.; Szebenyi, D.M. Serine hydroxymethyltransferase revisited. Curr. Opin. Chem. Biol.2005, 9, 482–487
20. Ueland, P.M.; Midttun, O.; Windelberg, A.; Svardal, A.; Skalevik, R.; Hustad, S. Quantitative profiling of folate and one-carbon metabolism in large-scale epidemiological studies by mass spectrometry. Clin. Chem. Lab. Med.: CCLM/FESCC2007, 45, 1737–1745
21. Midttun, O.; Kvalheim, G.; Ueland, P.M. High-throughput, low-volume, multianalyte quantification of plasma metabolites related to one-carbon metabolism using hplc-ms/ms. Anal. Bioanal. Chem.2013, 405, 2009–2017
22. Midttun, O.; Hustad, S.; Ueland, P.M. Quantitative profiling of biomarkers related to b-vitamin status, tryptophan metabolism and inflammation in human plasma by liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass spectrom.: RCM2009, 23, 1371–1379
23. Kelleher, B.P.; Broin, S.D. Microbiological assay for vitamin B12 performed in 96-well microtitre plates. J. Clin. Pathol.1991, 44, 592–595
24. Molloy, A.M.; Scott, J.M. Microbiological assay for serum, plasma, and red cell folate using cryopreserved, microtiter plate method. Methods Enzymol. 1997, 281, 43–53
25. Andersen, C.L.; Jensen, J.L.; Orntoft, T.F. Normalization of real-time quantitative reverse transcription-pcr data: A model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Cancer Res. 2004, 64, 5245–5250
26. Mudd, S.H.; Poole, J.R. Labile methyl balances for normal humans on various dietary regimens. Metabolism1975, 24, 721–735
27. Wilson, F.A.; van den Borne, J.J.; Calder, A.G.; O'Kennedy, N.; Holtrop, G.; Rees, W.D.; Lobley, G.E. Tissue methionine cycle activity and homocysteine metabolism in female rats: Impact of dietary methionine and folate plus choline. Am. J. Physiol. Endocrinol. Metab.2009, 296, E702–E713
28. Finkelstein, J.D.; Harris, B.J.; Martin, J.J.; Kyle, W.E. Regulation of hepatic betaine-homocysteine methyltransferase by dietary methionine. Biochem. Biophys. Res. Commun.1982, 108, 344–348
29. Clarke, R.; Armitage, J. Vitamin supplements and cardiovascular risk: Review of the randomized trials of homocysteine-lowering vitamin supplements. Semin Thromb Hemost 2000, 26, 341–348
30. Van Oort, F.V.; Melse-Boonstra, A.; Brouwer, I.A.; Clarke, R.; West, C.E.; Katan, M.B.; Verhoef, P. Folic acid and reduction of plasma homocysteine concentrations in older adults: A dose-response study. Am. J. Clin Nutr 2003, 77, 1318–1323
31. Nieman, K.M.; Hartz, C.S.; Szegedi, S.S.; Garrow, T.A.; Sparks, J.D.; Schalinske, K.L. Folate status modulates the induction of hepatic glycine n-methyltransferase and homocysteine metabolism in diabetic rats. Am. J. Physiol. Endocrinol. Metab.2006, 291, E1235–E1242
32. Davis, S.R.; Quinlivan, E.P.; Shelnutt, K.P.; Ghandour, H.; Capdevila, A.; Coats, B.S.; Wagner, C.; Shane, B.; Selhub, J.; Bailey, L.B.; et al. Homocysteine synthesis is elevated but total remethylation is unchanged by the methylenetetrahydrofolate reductase 677c->t polymorphism and by dietary folate restriction in young women. J. Nutr.2005, 135, 1045–1050
33. Kutzbach, C.; Stokstad, E.L. Mammalian methylenetetrahydrofolate reductase. Partial purification, properties, and inhibition by s-adenosylmethionine. Biochim. Biophys. Acta1971, 250, 459–477
34. Leclerc, D.; Wilson, A.; Dumas, R.; Gafuik, C.; Song, D.; Watkins, D.; Heng, H.H.; Rommens, J.M.; Scherer, S.W.; Rosenblatt, D.S.; et al. Cloning and mapping of a cdna for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria. Proc. Natl. Acad. Sci. USA1998, 95, 3059–3064
35. Finkelstein, J.D.; Martin, J.J. Methionine metabolism in mammals. Distribution of homocysteine between competing pathways. J. Biol. Chem.1984, 259, 9508–9513
36. Wang, W.; Wu, Z.; Dai, Z.; Yang, Y.; Wang, J.; Wu, G. Glycine metabolism in animals and humans: Implications for nutrition and health. J. Amino Acids 2013, 45, 463–477
37. Kikuchi, G.; Motokawa, Y.; Yoshida, T.; Hiraga, K. Glycine cleavage system: Reaction mechanism, physiological significance, and hyperglycinemia. Proc. Jpn. Acad. Ser. B Phys. Biol. Sci.2008, 84, 246–263.