Tissue methionine cycle activity and homocysteine metabolism in female rats: Impact of dietary methionine and folate plus choline

American Journal of Physiology - Endocrinology and Metabolism

Volumn 296, Issue 4, 2009, Pages

  Wilson, Fiona A ^a,d   Van Den Borne, Joost J G C ^b   Calder, A Graham ^a   O'Kennedy, Niamh ^c   Holtrop, Grietje ^c   Rees, William D ^a   Lobley, Gerald E ^a  

^a ROWETT RESEARCH INSTITUTE   (United Kingdom)

^b WAGENINGEN UNIVERSITY   (Netherlands)

^c UNIVERSITY OF ABERDEEN   (United Kingdom)

^d PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Homocysteine methylation; Isotopomer analysis; Metabolic models; Stable isotopes

Indexed keywords

CHOLINE; FOLIC ACID; HOMOCYSTEINE; METHIONINE; METHYL GROUP; METHYLTRANSFERASE;

AMINO ACID ANALYSIS; AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; AMINO ACID SYNTHESIS; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIET; FEMALE; HEART; HUMAN; HYPERHOMOCYSTEINEMIA; HYPERTENSION; IN VIVO STUDY; LIVER; NONHUMAN; PANCREAS; PRIORITY JOURNAL; RAT; TISSUE METABOLISM; VITAMIN DEFICIENCY; ANIMAL; BIOLOGICAL MODEL; BODY COMPOSITION; DRUG EFFECT; METABOLISM; PROTEIN INTAKE; TISSUE DISTRIBUTION;

ANIMALS; BODY COMPOSITION; CHOLINE; DIET; DIETARY PROTEINS; FEMALE; FOLIC ACID; HOMOCYSTEINE; METHIONINE; MODELS, BIOLOGICAL; RATS; TISSUE DISTRIBUTION;

EID: 65649133063     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.90670.2008     Document Type: Article

References (42)

1. Abu-Lebdeh HS, Barazzoni R, Meek SE, Bigelow ML, Persson XM, Nair KS. Effects of insulin deprivation and treatment on homocysteine metabolism in people with type 1 diabetes. J Clin Endocrinol Metab 91: 3344-3348, 2006. (Pubitemid 44402102)
2. Arnesen E, Refsum H, Bonaa KH, Ueland PM, Forde OH, Nordrehaug JE. Serum total homocysteine and coronary heart disease. Int J Epidemiol 24: 704-709, 1995.
3. Balaghi M, Wagner C. Methyl group metabolism in the pancreas of folate-deficient rats. J Nutr 122: 1391-1396, 1992.
4. Balaghi M, Wagner C. Folate deficiency inhibits pancreatic amylase secretion in rats. Am J Clin Nutr 61: 90-96, 1995.
5. Bostom A, Brosnan JT, Hall B, Nadeau MR, Selhub J. Net uptake of plasma homocysteine by the rat kidney in vivo. Atherosclerosis 116: 59-62, 1995.
6. Boushey CJ, Beresford SA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. J Am Med Assoc 274: 1049-1057, 1995.
7. Brosnan JT, Brosnan ME. The sulfur-containing amino acids: an overview. J Nutr 136: 1636S-1640S, 2006.
8. Calder AG, Garden KE, Anderson SE, Lobley GE. Quantitation of blood and plasma amino acids using isotope dilution electron impact gas chromatography/mass spectrometry with U-(13)C amino acids as internal standards. Rapid Commum Mass Spectrom 13: 2080-2083, 1999.
9. Candito M, Rivet R, Herbeth B, Boisson C, Rudigoz RC, Luton D, Journel H, Oury JF, Roux F, Saura R, Vernhet I, Gaucherand P, Muller F, Guidicelli B, Heckenroth H, Poulain P, Blayau M, Francannet C, Roszyk L, Brustie C, Staccini P, Gerard P, Fillion-Emery N, Gueant-Rodriguez RM, Van Obberghen E, Gueant JL. Nutritional and genetic determinants of vitamin B and homocysteine metabolisms in neural tube defects: a multicenter case-control study. Am J Med Genet A 146A: 1128-1133, 2008.
10. Cook JW, Taylor LM, Orloff SL, Landry GJ, Moneta GL, Porter JM. Homocysteine and arterial disease. Experimental mechanisms. Vascul Pharmacol 38: 293-300, 2002.
11. Emmert JL, Webel DM, Biehl RR, Griffiths MA, Garrow LS, Garrow TA, Baker DH. Hepatic and renal betaine-homocysteine methyltransferase activity in pigs as affected by dietary intakes of sulfur amino acids, choline, and betaine. J Anim Sci 76: 606-610, 1998.
12. Finkelstein JD, Kyle W, Harris BJ. Methionine metabolism in mammals. Regulation of homocysteine methyltransferases in rat tissue. Arch Biochem Biophys 146: 84-92, 1971.
13. Hoogeveen EK, Kostense PJ, Jakobs C, Rauwerda JA, Dekker JM, Nijpels G, Bouter LM, Heine RJ, Stehouwer CD. Hyperhomocysteinaemia is not associated with isolated crural arterial occlusive disease: the Hoorn Study. J Intern Med 247: 442-448, 2000. (Pubitemid 30253162)
14. House JD, Brosnan ME, Brosnan JT. Characterization of homocysteine metabolism in the rat kidney. Biochem J 328: 287-292, 1997.
15. House JD, Brosnan ME, Brosnan JT. Renal uptake and excretion of homocysteine in rats with acute hyperhomocysteinemia. Kidney Int 54: 1601-1607, 1998.
16. Jacques PF, Selhub J, Bostom AG, Wilson PW, Rosenberg IH. The effect of folic acid fortification on plasma folate and total homocysteine concentrations. N Engl J Med 340: 1449-1454, 1999. (Pubitemid 29220543)
17. Lobley GE, Connell A, Revell D. The importance of transmethylation reactions to methionine metabolism in sheep: effects of supplementation with creatine and choline. Br J Nutr 75: 47-56, 1996. (Pubitemid 26059365)
18. Lobley GE, Shen X, Le G, Bremner DM, Milne E, Graham CA, Anderson SE, Dennison N. Oxidation of essential amino acids by the ovine gastrointestinal tract. Br J Nutr 89: 617-630, 2003. (Pubitemid 36592089)
19. MacCoss MJ, Fukagawa NK, Matthews DE. Measurement of intracellular sulfur amino acid metabolism in humans. Am J Physiol Endocrinol Metab 280: E947-E955, 2001.
20. Maloney CA, Hay SM, Rees WD. Folate deficiency during pregnancy impacts on methyl metabolism without affecting global DNA methylation in the rat fetus. Br J Nutr 97: 1090-1098, 2007.
21. Mato JM, Corrales FJ, Lu SC, Avila MA. S-adenosylmethionine: a control switch that regulates liver function. FASEB J 16: 15-26, 2002.
22. Matthews DE, Schwarz HP, Yang RD, Motil KJ, Young VR, Bier DM. Relationship of plasma leucine and alpha-ketoisocaproate during a L-[1-13C]leucine infusion in man: a method for measuring human intracellular leucine tracer enrichment. Metabolism 31: 1105-1112, 1982.
23. McNeil CJ, Hay SM, Rucklidge GJ, Reid M, Duncan G, Maloney CA, Rees WD. Disruption of lipid metabolism in the liver of the pregnant rat fed folate-deficient and methyl donor-deficient diets. Br J Nutr 99: 262-271, 2008.
24. Mercier S, Breuille D, Buffiere C, Gimonet J, Papet I, Mirand PP, Obled C. Methionine kinetics are altered in the elderly both in the basal state and after vaccination. Am J Clin Nutr 83: 291-298, 2006.
25. Mudd SH, Brosnan JT, Brosnan ME, Jacobs RL, Stabler SP, Allen RH, Vance DE, Wagner C. Methyl balance and transmethylation fluxes in humans. Am J Clin Nutr 85: 19-25, 2007.
26. Noga AA, Stead LM, Zhao Y, Brosnan ME, Brosnan JT, Vance DE. Plasma homocysteine is regulated by phospholipid methylation. J Biol Chem 278: 5952-5955, 2003.
27. Reed MC, Nijhout HF, Neuhouser ML, Gregory JF, III, Shane B, James SJ, Boynton A, Ulrich CM. A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism. J Nutr 136: 2653-2661, 2006. (Pubitemid 44521628)
28. Rees WD, Hay SM, Buchan V, Antipatis C, Palmer RM. The effects of maternal protein restriction on the growth of the rat fetus and its amino acid supply. Br J Nutr 81: 243-250, 1999. (Pubitemid 29182190)
29. Rees WD, Hay SM, Cruickshank M, Reusens B, Remacle C, Antipatis C, Grant G. Maternal protein intake in the pregnant rat programs the insulin axis and body composition in the offspring. Metabolism 55: 642-649, 2006.
30. Reeves PG, Nielsen FH, Fahey GC Jr. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123: 1939-1951, 1993.
31. Rowling MJ, McMullen MH, Chipman DC, Schalinske KL. Hepatic glycine N-methyltransferase is up-regulated by excess dietary methionine in rats. J Nutr 132: 2545-2550, 2002.
32. Shinohara Y, Hasegawa H, Ogawa K, Tagoku K, Hashimoto T. Distinct effects of folate and choline deficiency on plasma kinetics of methionine and homocysteine in rats. Metabolism 55: 899-906, 2006. (Pubitemid 43902892)
33. Shiraiwa T, Tadokoro K, Ishikawa J, Tanaka H, Masaki T, Kurokawa H. Synthesis of four stereoisomers of 1,4-thiazane-3-carboxylic acid 1-oxide via the asymmetric transformation (combined isomerization-preferential crystallization) of 1,4-thiazane-3-carboxylic acid. Biosci Biotechnol Biochem 64: 341-347, 2000.
34. Stead LM, Au KP, Jacobs RL, Brosnan ME, Brosnan JT. Methylation demand and homocysteine metabolism: effects of dietary provision of creatine and guanidinoacetate. Am J Physiol Endocrinol Metab 281: E1095-E1100, 2001.
35. Stead LM, Brosnan ME, Brosnan JT. Characterization of homocysteine metabolism in the rat liver. Biochem J 350: 685-692, 2000.
36. 3]methionine kinetics in humans: methionine conservation and cystine sparing. Am J Physiol Endocrinol Metab 258: E790-E798, 1990.
37. Tessari P, Coracina A, Kiwanuka E, Vedovato M, Vettore M, Valerio A, Zaramella M, Garibotto G. Effects of insulin on methionine and homocysteine kinetics in type 2 diabetes with nephropathy. Diabetes 54: 2968-2976, 2005. (Pubitemid 41401094)
38. Tessari P, Kiwanuka E, Coracina A, Zaramella M, Vettore M, Valerio A, Garibotto G. Insulin in methionine and homocysteine kinetics in healthy humans: plasma vs. intracellular models. Am J Physiol Endocrinol Metab 288: E1270-E1276, 2005. (Pubitemid 40726817)
39. Van den Veyver I. Genetic effects of methylation diets. Annu Rev Nutr 22: 255-282, 2002. (Pubitemid 35221462)
40. Wijekoon EP, Hall B, Ratnam S, Brosnan ME, Zeisel SH, Brosnan JT. Homocysteine metabolism in ZDF (type 2) diabetic rats. Diabetes 54: 3245-3251, 2005. (Pubitemid 43334381)
41. Xue GP, Snoswell AM. Comparative studies on the methionine synthesis in sheep and rat tissues. Comp Biochem Physiol B 80: 489-494, 1985.
42. Yu YM, Burke JF, Young VR. A kinetic study of L-2H3-methyl-1-13C- methionine in patients with severe burn injury. J Trauma 35: 1-7, 1993.