Hypolipidemic effect of dietary pea proteins: Impact on genes regulating hepatic lipid metabolism

Molecular Nutrition and Food Research

Volumn 54, Issue SUPPL. 1, 2010, Pages

  Rigamonti, Elena ^a   Parolini, Cinzia ^a   Marchesi, Marta ^a   Diani, Erika ^a   Brambilla, Stefano ^a   Sirtori, Cesare R ^a   Chiesa, Giulia ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Cholesterol; Hepatic gene expression; Pea proteins; Rats; Triglycerides

Indexed keywords

ANTILIPEMIC AGENT; CASEIN; CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; PRIMER DNA; RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRIACYLGLYCEROL; VEGETABLE PROTEIN;

ANIMAL; ARTICLE; BLOOD; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; LIVER; MALE; PEA; PHYSIOLOGY; POLYMERASE CHAIN REACTION; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; ANTILIPEMIC AGENTS; CASEINS; CHOLESTEROL; CHOLESTEROL, LDL; DNA PRIMERS; GENE EXPRESSION REGULATION; HYDROXYMETHYLGLUTARYL COA REDUCTASES; LIPIDS; LIVER; MALE; PEAS; PLANT PROTEINS; POLYMERASE CHAIN REACTION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, LDL; RNA; RNA, MESSENGER; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRIGLYCERIDES;

PISUM SATIVUM; RATTUS;

EID: 77952349385     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.200900251     Document Type: Article

References (43)

1. Sirtori, C. R., Lovati, M. R., Manzoni, C., Monetti, M. et al., title typecontributorSoy and cholesterol reduction: clinical experience/title. J. Nutr. 1995, 125, 598S-605S.
2. Iritani, N., Hosomi, H., Fukuda, H., Tada, K., Ikeda, H., Soybean protein suppresses hepatic lipogenic enzyme gene expression in Wistar fatty rats. J. Nutr. 1996, 126, 380-388.
3. Tovar, A. R., Murguia, F., Cruz, C., Hernandez-Pando, R. et al., A soy protein diet alters hepatic lipid metabolism gene expression and reduces serum lipids and renal fibrogenic cytokines in rats with chronic nephrotic syndrome. J. Nutr. 2002, 132, 2562-2569.
4. Ascencio, C., Torres, N., Isoard-Acosta, F., Gomez-Perez, F. J. et al., Soy protein affects serum insulin and hepatic SREBP-1 mRNA and reduces fatty liver in rats. J. Nutr. 2004, 134,522-529.
5. Shukla, A., Brandsch, C., Bettzieche, A., Hirche, F. et al., Isoflavone-poor soy protein alters the lipid metabolism of rats by SREBP-mediated down-regulation of hepatic genes. J. Nutr. Biochem. 2007, 18, 313-321.
6. Sirtori, C. R., Lovati, M. R., Manzoni, C., Castiglioni, S. et al., Proteins of white lupin seed, a naturally isoflavone-poor legume, reduce cholesterolemia in rats and increase LDL receptor activity in HepG2 cells. J. Nutr. 2004, 134, 18-23.
7. Spielmann, J., Shukla, A., Brandsch, C., Hirche, F. et al., Dietary lupin protein lowers triglyceride concentrations in liver and plasma in rats by reducing hepatic gene expres- sion of sterol regulatory element-binding protein-1c. Ann. Nutr. Metab. 2007, 51, 387-392.
8. Gueguen, J., Cerletti, P., in: Hudson B. J. F. (Ed.), New and developing sources of food proteins. Proteins of some legume seeds: soybean, pea, fababean and lupin, Chapman and Hall, London 1994, pp. 145-193.
9. Schneider, A. V., Overview of the market and consumption of pulses in Europe. Br. J. Nutr. 2002, 88, 243S-250S.
10. Davidsson, L., Dimitriou, T., Walczyk, T., Hurrell, R. F., Iron absorption from experimental infant formulas based on pea (Pisum sativum)-protein isolate: the effect of phytic acid and ascorbic acid. Br. J. Nutr. 2001, 85, 59-63.
11. Diepvens, K., Haberer, D., Westerterp-Plantenga, M., Different proteins and biopeptides differently affect satiety and anorexigenic/orexigenic hormones in healthy humans. Int. J. Obes. 2008, 32, 510-518.
12. Jacques, H., Deshaies, Y., Savoie, L., Relationship between dietary proteins, their in vitro digestion products, and serum cholesterol in rats. Atherosclerosis 1986, 61, 89-98.
13. Lasekan, J. B., Gueth, L., Khan, S., Influence of dietary golden pea proteins versus casein on plasma and hepatic lipids in rats. Nutr. Res. 1995, 15, 71-84.
14. Spielmann, J., Stangl, G. I., Eder, K., Dietary pea protein stimulates bile acid excretion and lowers hepatic cholesterol concentration in rats. J. Anim. Physiol. Anim. Nutr. 2008,92,683-693.
15. Nath, N., Wiener, R., Harper, A. E., Elvehjem, C. A., Diet and cholesteremia. I Development of a diet for the study of nutritional factors affecting cholesteremia in the rat. J. Nutr. 1959,67,289-307.
16. Deuel, H. J., Jr., Alfin-Slater, R. B., Wells, A. F., Kryder, G. D., Aftergood, L., The effect of fat level of the diet on general nutrition. XIV Further studies of the effect of hydrogenated coconut oil on essential fatty acid deficiency in the rat. J. Nutr. 1955, 55, 337-346.
17. Schultz, J. R., Gong, E. L., McCall, M. R., Nichols, A. V. et al., Expression of human apolipoprotein A-II and its effect on high density lipoproteins in transgenic mice. J. Biol. Chem. 1992,267,21630-21636.
18. Chiesa, G., Parolini, C., Canavesi, M., Colombo, N. et al., Human apolipoproteins A-I and A-II in cell cholesterol efflux: studies with transgenic mice. Arterioscler. Thromb. Vasc. Biol. 1998, 18, 1417-1423.
19. Parolini, C., Chiesa, G., Zhu, Y., Forte, T. et al., Targeted replacement of mouse apolipoprotein A-I with human ApoA-I or the mutant ApoA-Imilano. Evidence of APOA-IM impaired hepatic secretion. J. Biol. Chem. 2003, 278, 4740-4746.
20. Parolini, C., Chiesa, G., Gong, E., Caligari, S. et al., Apolipoprotein A-I and the molecular variant apoA-I(Milano): evaluation of the antiatherogenic effects in knock-in mouse model. Atherosclerosis 2005, 183, 222-229.
21. Kingman, S. M., Walker, A. F., Low, A. G., Sambrook, I. E. et al., Comparative effects of four legume species on plasma lipids and faecal steroid excretion in hypercholes- terolaemic pigs. Br. J. Nutr. 1993, 69, 409-421.
22. Dabai, F. D., Walker, A. F., Sambrook, I. E., Welch, V. A. et al., Comparative effects on blood lipids and faecal steroids of five legume species incorporated into a semi-puri- fied, hypercholesterolaemic rat diet. Br. J. Nutr. 1996, 75, 557-571.
23. Wang, Y. H., McIntosh, G. H., Extrusion and boiling improve rat body weight gain and plasma cholesterol lowering ability of peas and chickpeas. J. Nutr. 1996, 126, 3054-3062.
24. Alonso, R., Grant, G., Marzo, F., Thermal treatment improves nutritional quality of pea seeds (Pisum sativum L.) without reducing their hypocholesterolemic properties. Nutr. Res. 2001, 21, 1067-1077.
25. Martins, J. M., Riottot, M., de Abreu, M. C., Lanca, M. J. et al., Dietary raw peas (Pisum sativum L.) reduce plasma total and LDL cholesterol and hepatic esterified cholesterol in intact and ileorectal anastomosed pigs fed cholesterol- rich diets. J. Nutr. 2004, 134, 3305-3312.
26. Dubois, C., Cara, L., Armand, M., Borel, P. et al., Effects of pea and soybean fibre on postprandial lipaemia and lipo- proteins in healthy adults. Eur. J. Clin. Nutr. 1993, 47, 508-520.
27. Sandstrom, B., Hansen, L. T., Sorensen, A., Pea fiber lowers fasting and postprandial blood triglyceride concentrations in humans. J. Nutr. 1994, 124, 2386-2396.
28. Sirtori, C. R., Lovati, M. R., Soy proteins and cardiovascular disease. Curr. Atheroscler. Rep. 2001, 3, 47-53.
29. Fukui, K., Tachibana, N., Wanezaki, S., Tsuzaki, S. et al., Isoflavone-free soy protein prepared by column chromatography reduces plasma cholesterol in rats. J. Agric. Food. Chem. 2002, 50, 5717-5721.
30. Gianazza, E., Eberini, I., Arnoldi, A., Wait, R., Sirtori, C. R., A proteomic investigation of isolated soy proteins with variable effects in experimental and clinical studies. J. Nutr. 2003,133,9-14.
31. Mazur, W. M., Wahala, K., Rasku, S., Adlercreutz, H., Isoflavonoids and lignans in legumes: nutritional and health aspects in humans. Nutr. Biochem. 1998, 9, 193-200.
32. Blachier, F., Lancha, A. H., Jr., Boutry, C., Tome, D., Alimentary proteins, amino acids and cholesterolemia. Amino Acids 2009, DOI: 10.1007/s00726-009-0239-6.
33. Carroll, K. K., Kurowska, E. M., Soy consumption and cholesterol reduction: review of animal and human studies. J. Nutr. 1995, 125, 594S-597S.
34. Hirche, F., Schroder, A., Knoth, B., Stangl, G. I., Eder, K., Effect of dietary methionine on plasma and liver cholesterol concentrations in rats and expression of hepatic genes involved in cholesterol metabolism. Br. J. Nutr. 2006, 95, 879-888.
35. Vahouny, G. V., Adamson, I., Chalcarz, W., Satchithanandam, S. et al., Effects of casein and soy protein on hepatic and serum lipids and lipoprotein lipid distributions in the rat. Atherosclerosis 1985, 56, 127-137.
36. Spielmann, J., Noatsch, A., Brandsch, C., Stangl, G. I., Eder, K., Effects of various dietary arginine and lysine concentrations on plasma and liver cholesterol concentrations in rats. Ann. Nutr. Metab. 2008, 53, 223-233.
37. Lovati, M. R., Manzoni, C., Gianazza, E., Arnoldi, A. et al., Soy protein peptides regulate cholesterol homeostasis in Hep G2 cells. J. Nutr. 2000, 130, 2543-2549.
38. Cho, S. J., Juillerat, M. A., Lee, C. H., Cholesterol lowering mechanism of soybean protein hydrolysate. J. Agric. Food. Chem. 2007, 55, 10599-10604.
39. Wait, R., Gianazza, E., Brambilla, D., Eberini, I. et al., Analysis of Lupinus albus storage proteins by two-dimensional electrophoresis and mass spectrometry. J. Agric. Food. Chem. 2005, 53, 4599-4606.
40. Goldstein, J. L., Brown, M. S., The LDL receptor. Arterioscler. Thromb. Vasc. Biol. 2009, 29, 431-438.
41. Horton, J. D., Goldstein, J. L., Brown, M. S., SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest. 2002, 109, 1125-1131.
42. Sheng, Z., Otani, H., Brown, M. S., Goldstein, J. L., Inde- pendent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver. Proc. Natl. Acad. Sci. USA 1995,92,935-938.
43. Ferré, P., Foufelle, F., SREBP-1c transcription factor and lipid homeostasis: clinical perspective. Horm. Res. 2007, 68, 72-82.