Quantitative profiling of folate and one-carbon metabolism in large-scale epidemiological studies by mass spectrometry

Clinical Chemistry and Laboratory Medicine

Volumn 45, Issue 12, 2007, Pages 1737-1745

  Ueland, Per Magne ^a   Midttun, Øivind ^a,b   Windelberg, Amrei ^a   Svardal, Asbjørn ^a   Skålevik, Rita ^a   Hustad, Steinar ^a,c  

^a UNIVERSITY OF BERGEN   (Norway)

^b BEVITAL AS   (Norway)

^c HAUKELAND UNIVERSITY HOSPITAL   (Norway)

Author keywords

Choline; Folate; Mass spectrometry; One carbon metabolism; Riboflavin; Vitamin B6

Indexed keywords

1,1,1 TRICHLOROETHANE; ACETIC ACID; AMINO ACID; ARGININE; BETAINE HOMOCYSTEINE METHYLTRANSFERASE; CARBON; CHOLINE; COTININE; CREATINE; CREATININE; CYSTATHIONINE; CYSTEINE; FOLIC ACID; GLYCINE; HOMOCYSTEINE; KYNURENINE; METHIONINE; METHIONINE SULFOXIDE; METHYLMALONIC ACID; N(G),N(G) DIMETHYLARGININE; NEOPTERIN; PYRIDOXAL 5 PHOSPHATE; PYRIDOXIC ACID; PYRIDOXINE; RIBOFLAVIN; SARCOSINE; SERINE; TRYPTOPHAN; UNINDEXED DRUG; VITAMIN;

BIODIVERSITY; CARBON METABOLISM; CONCENTRATION (PARAMETERS); CONFERENCE PAPER; DERIVATIZATION; ENZYME SUBSTRATE; EPIDEMIOLOGICAL DATA; FOLATE METABOLISM; GAS CHROMATOGRAPHY; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITE; PRIORITY JOURNAL; PROTEIN METABOLISM; QUANTITATIVE ANALYSIS; REVERSED PHASE LIQUID CHROMATOGRAPHY; SENSITIVITY ANALYSIS; TANDEM MASS SPECTROMETRY;

CARBON; CHROMATOGRAPHY, LIQUID; EPIDEMIOLOGIC STUDIES; FOLIC ACID; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; TANDEM MASS SPECTROMETRY;

EID: 36849028695     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2007.339     Document Type: Conference Paper

References (56)

1. Gregory JF. Chemical and nutritional aspects of folate research - analytical procedures, methods of folate synthesis, stability, and bioavailability of dietary folates. Adv Food Nutr Res 1990;33:1-101.
2. Stover PJ. Physiology of folate and vitamin B12 in health and disease. Nutr Rev 2004;62:S3-12;discussion:S3.
3. Stead LM, Brosnan JT, Brosnan ME, Vance DE, Jacobs RL. Is it time to reevaluate methyl balance in humans? Am J Clin Nutr 2006;83:5-10.
4. Suh JR, Herbig AK, Stover PJ. New perspectives on folate catabolism. Annu Rev Nutr 2001;21:255-82.
5. Finkelstein JD. Methionine metabolism in mammals. J Nutr Biochem 1990;1:228-37.
6. Ueland PM, Holm PI, Hustad S. Betaine: a key modulator of one-carbon metabolism and homocysteine status. Clin Chem Lab Med 2005;43:1069-75.
7. Zeisel SH. Choline: critical role during fetal development and dietary requirements in adults. Annu Rev Nutr 2006;26:229-50.
8. Wittwer AJ, Wagner C. Identification of the folate-binding proteins of rat liver mitochondria as dimethylglycine dehydrogenase and sarcosine dehydrogenase. Flavoprotein nature and enzymatic properties of the purified proteins. J Biol Chem 1981;256:4109-15.
9. Steenkamp DJ, Husain M. The effect of tetrahydrofolate on the reduction of electron transfer flavoprotein by sarcosine and dimethylglycine dehydrogenases. Biochem J 1982;203:707-15.
10. Wyss M, Kaddurah-Daouk R. Creatine and creatinine metabolism. Physiol Rev 2000;80:1107-213.
11. Refsum H, Smith AD, Ueland PM, Nexo E, Clarke R, McPartlin J, et al. Facts and recommendations about total homocysteine determinations: an expert opinion. Clin Chem 2004;50:3-32.
12. Allen RH, Stabler SP, Savage DG, Lindenbaum J. Diagnosis of cobalamin deficiency. 1. Usefulness of serum methylmalonic acid and total homocysteine concentrations. Am J Hematol 1990;34:90-8.
13. Pahlich S, Zakaryan RP, Gehring H. Protein arginine methylation: cellular functions and methods of analysis. Biochim Biophys Acta 2006;1764:1890-903.
14. Siroen MP, Teerlink T, Nijveldt RJ, Prins HA, Richir MC, van Leeuwen PA. The clinical significance of asymmetric dimethylarginine. Annu Rev Nutr 2006;26:203-28.
15. Stuhlinger MC, Stanger O. Asymmetric dimethyl-L-arginine (ADMA): a possible link between homocyst(e)ine and endothelial dysfunction. Curr Drug Metab 2005;6:3-14.
16. Schroecksnadel K, Frick B, Winkler C, Leblhuber F, Wirleitner B, Fuchs D. Hyperhomocysteinemia and immune activation. Clin Chem Lab Med 2003;41:1438-43.
17. Schrocksnadel K, Wirleitner B, Winkler C, Fuchs D. Monitoring tryptophan metabolism in chronic immune activation. Clin Chim Acta 2006;364:82-90.
18. Frick B, Gruber B, Schroecksnadel K, Leblhuber F, Fuchs D. Homocysteine but not neopterin declines in demented patients on B vitamins. J Neural Transm 2006;113:1815-9.
19. Ueland PM, Vollset SE. Homocysteine and folate in pregnancy. Clin Chem 2004;50:1293-5.
20. Tamura T, Picciano MF. Folate and human reproduction. Am J Clin Nutr 2006;83:993-1016.
21. Carmel R. Anemia and aging: an overview of clinical, diagnostic and biological issues. Blood Rev 2001;15:9-18.
22. Ulrich CM. Nutrigenetics in cancer research - folate metabolism and colorectal cancer. J Nutr 2005;135:2698-702.
23. Powers HJ. Interaction among folate, riboflavin, genotype, and cancer, with reference to colorectal and cervical cancer. J Nutr 2005;135: S2960-6.
24. Clarke R, Collins R, Lewington S, Donald A, Alfthan G, Tuomilehto J. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. J Am Med Assoc 2002;288:2015-22.
25. Stabler SP. Vitamins, homocysteine, and cognition. Am J Clin Nutr 2003;78:359-60.
26. Bottiglieri T. Homocysteine and folate metabolism in depression. Prog Neuropsychopharmacol Biol Psychiatry 2005;29:1103-12.
27. Cashman KD. Homocysteine and osteoporotic fracture risk: a potential role for B vitamins. Nutr Rev 2005;63:29-36.
28. Lentz SR, Rodionov RN, Dayal S. Hyperhomocysteinemia, endothelial dysfunction, and cardiovascular risk: the potential role of ADMA. Atheroscler Suppl 2003;4:61-5.
29. Endemann DH, Schiffrin EL. Endothelial dysfunction. J Am Soc Nephrol 2004;15:1983-92.
30. Bønaa KH, Njølstad I, Ueland PM, Schirmer H, Tverdal A, Steigen T, et al. Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Engl J Med 2006;354:1578-88.
31. Bazzano LA, Reynolds K, Holder KN, He J. Effect of folic acid supplementation on risk of cardiovascular diseases: a meta-analysis of randomized controlled trials. J Am Med Assoc 2006;296:2720-6.
32. Ueland PM, Clarke R. Homocysteine and cardiovascular risk: considering the evidence in the context of study design, folate fortification, and statistical power. Clin Chem 2007;53:807-9.
33. Wang X, Qin X, Demirtas H, Li J, Mao G, Huo Y, et al. Efficacy of folic acid supplementation in stroke prevention: a meta-analysis. Lancet 2007;369:1876-82.
34. Durga J, van Boxtel MP, Schouten EG, Kok FJ, Jolles J, Katan MB, et al. Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. Lancet 2007;369:208-16.
35. Vollset SE, Ueland PM. B vitamins and cognitive function: do we need more and larger trials? Am J Clin Nutr 2005;81:951-2.
36. Eussen SJ, de Groot LC, Joosten LW, Bloo RJ, Clarke R, Ueland PM, et al. Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial. Am J Clin Nutr 2006;84:361-70.
37. Carlsson CM. Lowering homocysteine for stroke prevention. Lancet 2007;369:1841-2.
38. Wald DS, Wald NJ, Morris JK, Law M. Folic acid, homocysteine, and cardiovascular disease: judging causality in the face of inconclusive trial evidence. Br Med J 2006;333:1114-7.
39. Lichtenstein AH, Russell RM. Essential nutrients: food or supplements? Where should the emphasis be? J Am Med Assoc 2005;294:351-8.
40. Hustad S, Midttun Ø, Schneede J, Vollset SE, Grotmol T, Ueland PM. The methylenetetrahydrofolate reductase 677 C→T polymorphism as a modulator of a B-vitamin network with major effects on homocysteine metabolism. Am J Hum Genet 2007;80:846-55.
41. Holm PI, Hustad S, Ueland PM, Vollset SE, Grotmol T, Schneede J. Modulation of the homocysteine-betaine relationship by methylenetetrahydrofolate reductase 677 C→T genotypes and B-vitamin status in a large-scale epidemiological study. J Clin Endocrinol Metab 2007;92:1535-41.
42. Dunn WB, Ellis DI. Metabolomics: current analytical platforms and methodologies. Trends Analyt Chem 2005;24:285-94.
43. Piyathilake CJ, Macaluso M, Hine RJ, Richards EW, Krumdieck CL. Local and systemic effects of cigarette smoking on folate and vitamin B-12. Am J Clin Nutr 1994;60:559-66.
44. Gellekink H, van Oppenraaij-Emmerzaal D, van Rooij A, Struys EA, den Heijer M, Blom HJ. Stable-isotope dilution liquid chromatography-electrospray injection tandem mass spectrometry method for fast, selective measurement of S-adenosylmethionine and S-adenosylhomocysteine in plasma. Clin Chem 2005;51:1487-92.
45. Mastovska K, Lehotay SJ. Practical approaches to fast gas chromatography-mass spectrometry. J Chromatogr A 2003;1000:153-80.
46. Maurer HH. Role of gas chromatography-mass spectrometry with negative ion chemical ionization in clinical and forensic toxicology, doping control, and biomonitoring. Ther Drug Monit 2002;24:247-54.
47. Vogeser M. Liquid chromatography-tandem mass spectrometry - application in the clinical laboratory. Clin Chem Lab Med 2003;41:117-26.
48. Taylor PJ. Matrix effects: the Achilles heel of quantitative high-performance liquid chromatography-electrospray-tandem mass spectrometry. Clin Biochem 2005;38:328-34.
49. Windelberg A, Arseth O, Kvalheim G, Ueland PM. Automated assay for the determination of methylmalonic acid, total homocysteine, and related amino acids in human serum or plasma by means of methylchloroformate derivatization and gas chromatography-mass spectrometry. Clin Chem 2005;51:2103-9.
50. Holm PI, Ueland PM, Kvalheim G, Lien EA. Determination of choline, betaine, and dimethylglycine in plasma by a high-throughput method based on normal-phase chromatography-tandem mass spectrometry. Clin Chem 2003;49:286-94.
51. Midttun Ø, Hustad S, Solheim E, Schneede J, Ueland PM. Multianalyte quantification of vitamin B6 and B2 species in the nanomolar range in human plasma by liquid chromatography-tandem mass spectrometry. Clin Chem 2005;51:1206-16.
52. Kamel AM, Brown PR, Munson B. Effects of mobile-phase additives, solution pH, ionization constant, and analyte concentration on the sensitivities and electrospray ionization mass spectra of nucleoside antiviral agents. Anal Chem 1999;71:5481-92.
53. Passing H, Bablok W. A new biometrical procedure for testing the equality of measurements from two different analytical methods. Application of linear regression procedures for method comparison studies in clinical chemistry, Part I. J Clin Chem Clin Biochem 1983;21:709-20.
54. Ulvik A, Ueland PM, Fredriksen A, Meyer K, Vollset SE, Hoff G, et al. Functional inference of the methylenetetrahydrofolate reductase 677 C→T and 1298A→C polymorphisms from a large-scale epidemiological study. Hum Genet 2007;121:57-64.
55. Midttun Ø, Hustad S, Vollset SE, Schneede J, Ueland PM. Plasma vitamin B6 forms and their relations to transsulfuration metabolites in a large-scale population-based study. Am J Clin Nutr 2007;86:131-8.
56. Fredriksen A, Meyer K, Ueland PM, Vollset SE, Grotmol T, Schneede J. Large-scale population-based metabolic phenotyping of thirteen genetic polymorphisms related to one-carbon metabolism. Hum Mutat 2007;28:856-65.