Acute toxicity screening of novel AChE inhibitors using neuronal networks on microelectrode arrays

NeuroToxicology

Volumn 22, Issue 1, 2001, Pages 3-12

  Keefer, Edward W ^a   Norton, Scott J ^a   Boyle, Nicholas A J ^b   Talesa, Vincenzo ^c   Gross, Guenter W ^a  

^a UNIVERSITY OF NORTH TEXAS   (United States)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

^c UNIVERSITY OF PERUGIA   (Italy)

Author keywords

AChE; Alzheimer; Bio sensors; Drug screening; Extracellular multichannel recording; Substrate integrated electrode arrays

Indexed keywords

CARBONIC ACID; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; NEUROTRANSMITTER; PHYSOSTIGMINE;

ARTICLE; CHOLINESTERASE INHIBITION; CONCENTRATION RESPONSE; DRUG CYTOTOXICITY; DRUG SCREENING; FRONTAL CORTEX; MICROELECTRODE; NERVE CELL NETWORK; NEUROTOXICITY; PRIORITY JOURNAL;

ANIMALS; CHOLINERGIC AGONISTS; CHOLINERGIC ANTAGONISTS; CHOLINESTERASE INHIBITORS; CULTURE MEDIA; DRUG EVALUATION, PRECLINICAL; MICE; MICE, INBRED ICR; MICROELECTRODES; NEURAL NETWORKS (COMPUTER); NEURONS; PHYSOSTIGMINE; PREFRONTAL CORTEX; SYNAPTIC TRANSMISSION;

MURINAE;

EID: 0035099941     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-813X(00)00014-0     Document Type: Article

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