Differential involvement of IL-6 in the early and late phase of 1-methylnicotinamide (MNA) release in Concanavalin A-induced hepatitis

International Immunopharmacology

Volumn 28, Issue 1, 2015, Pages 105-114

  Sternak, Magdalena ^a   Jakubowski, Andrzej ^b   Czarnowska, Elzbieta ^c   Slominska, Ewa M ^d   Smolenski, Ryszard T ^d   Szafarz, Malgorzata ^a,b   Walczak, Maria ^a,b   Sitek, Barbara ^a   Wojcik, Tomasz ^a   Jasztal, Agnieszka ^a   Kaminski, Karol ^e   Chlopicki, Stefan ^a,b  

^a JAGIELLONIAN UNIVERSITY   (Poland)

^b JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^c CHILDREN'S MEMORIAL HEALTH INSTITUTE   (Poland)

^d MEDICAL UNIVERSITY OF GDANSK   (Poland)

^e MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

Author keywords

1 Methylnicotinamide; Concanavalin A; Hepatitis; Interleukin 6

Indexed keywords

1 METHYLNICOTINAMIDE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ALANINE AMINOTRANSFERASE; ALDEHYDE OXIDASE; CONCANAVALIN A; GAMMA INTERFERON; HAPTOGLOBIN; INTERLEUKIN 6; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE METHYLTRANSFERASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; AOX1 PROTEIN, MOUSE; CYTOKINE; N(1)-METHYLNICOTINAMIDE; NICOTINAMIDE; NNMT PROTEIN, MOUSE;

ACUTE PHASE RESPONSE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CELL ENERGY; CONCANAVALIN A-INDUCED HEPATITIS; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVITY; LIVER CELL; LIVER INJURY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; DRUG EFFECTS; ENERGY METABOLISM; GENETICS; HEPATITIS; KNOCKOUT MOUSE; LIVER FUNCTION TEST; LIVER MITOCHONDRION; METABOLISM; PATHOLOGY; TOXIC HEPATITIS;

ACUTE-PHASE REACTION; ALDEHYDE OXIDASE; ANIMALS; CONCANAVALIN A; CYTOKINES; DRUG-INDUCED LIVER INJURY; ENERGY METABOLISM; HEPATITIS; HEPATOCYTES; INTERLEUKIN-6; LIVER FUNCTION TESTS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA, LIVER; NIACINAMIDE; NICOTINAMIDE N-METHYLTRANSFERASE;

EID: 84930938700     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2015.04.053     Document Type: Article

References (40)

1. S. Chlopicki, J. Swies, and a Mogielnicki 1-Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/prostacyclin pathway Br. J. Pharmacol. 152 2007 230 239
2. M. Bartus̈, M. Łomnicka, and R.B. Kostogrys 1-Methylnicotinamide (MNA) prevents endothelial dysfunction in hypertriglyceridemic and diabetic rats Pharmacol. Rep. 60 2008 127 138
3. J. Gebicki, A. Sysa-Jedrzejowska, and J. Adamus 1-Methylnicotinamide: a potent anti-inflammatory agent of vitamin origin Pol. J. Pharmacol. 55 2003 109 112
4. A. Wozniacka, M. Wieczorkowska, J. Gebicki, and A. Sysa-Jedrzejowska Topical application of 1-methylnicotinamide in the treatment of rosacea: a pilot study Clin. Exp. Dermatol. 30 2005 632 635
5. K. Bryniarski, R. Biedron, A. Jakubowski, S. Chlopicki, and J. Marcinkiewicz Anti-inflammatory effect of 1-methylnicotinamide in contact hypersensitivity to oxazolone in mice; involvement of prostacyclin Eur. J. Pharmacol. 578 2008 332 338
6. T. Brzozowski, P.C. Konturek, and S. Chlopicki Therapeutic potential of 1-methylnicotinamide against acute gastric lesions induced by stress : role of endogenous prostacyclin and sensory nerves 326 2008 105 116
7. M. Slomka, E. Zieminska, E. Salinska, and J.W. Lazarewicz Neuroprotective effects of nicotinamide and 1-methylnicotinamide in acute excitotoxicity in vitro 46 2008 Folia neuropathologica/Association of Polish Neuropathologists and Medical Research Centre, Polish Academy of Sciences 69 80
8. M. Slomka, E. Zieminska, and J. Lazarewicz Nicotinamide and 1-methylnicotinamide reduce homocysteine neurotoxicity in primary cultures of rat cerebellar granule cells Acta Neurobiol. Exp. 68 2008 1 9
9. T. Kuchmerovska, I. Shymanskyy, S. Chlopicki, and A. Klimenko 1-Methylnicotinamide (MNA) in prevention of diabetes-associated brain disorders Neurochem. Int. 56 2010 221 228
10. C. Watała, P. Kaźmierczak, and M. Dobaczewski Anti-diabetic effects of 1-methylnicotinamide (MNA) in streptozocin-induced diabetes in rats Pharmacol. Rep. 61 2009 86 98
11. K. Aoyama, K. Matsubara, K. Okada, S. Fukushima, K. Shimizu, S. Yamaguchi, T. Uezono, M. Satomi, N. Hayase, S. Ohta, H. Shiono, and S. Kobayashi N-methylation ability for azaheterocyclic amines is higher in Parkinson's disease: nicotinamide loading test J. Neural Transm. 107 2000 985 995
12. C.L. Cazzullo, and E.S.E. Sacchetti N-methylnicotinamide excretion and affective disorders Psychol. Med. 6 1976 265 270
13. G.B. Barlow, and J.L.W.A. Sutton Metabolism of nicotinic acid in children with burns and scalds Clin. Chim. Acta 75 1977 337 342
14. R. Pumpo, G. Sarnelli, a Spinella, G. Budillon, and R. Cuomo The metabolism of nicotinamide in human liver cirrhosis: a study on N-methylnicotinamide and 2-pyridone-5-carboxamide production Am. J. Gastroenterol. 96 2001 1183 1187
15. Ł. Mateuszuk, T.I. Khomich, and E. Słomińska Activation of nicotinamide N-methyltransferase and increased formation of 1-methylnicotinamide (MNA) in atherosclerosis Pharmacol. Rep. 61 2009 76 85
16. D. Sartini, A. Santarelli, and V. Rossi Nicotinamide N-methyltransferase upregulation inversely correlates with lymph node metastasis in oral squamous cell carcinoma 3 2007 2 8
17. J. Kim, S.J. Hong, and E.K. Lim Expression of nicotinamide N-methyltransferase in hepatocellular carcinoma is associated with poor prognosis J. Exp. Clin. Cancer Res. 28 2009 20
18. B.-H. Lim, B.-I. Cho, and Y.N. Kim Overexpression of nicotinamide N-methyltransferase in gastric cancer tissues and its potential post-translational modification Exp. Mol. Med. 38 2006 455 465
19. M. Kopf, H. Baumann, and G. Freer Impaired immune and acute-phase responses in interleukin-6-deficient mice Nature 368 1994 339 342
20. R.T. Smolenski, D.R. Lachno, and S.J.Y.M. Ledingham Determination of sixteen nucleotides, nucleosides and bases using high-performance liquid chromatography and its application to the study of purine metabolism in hearts for transplantation J. Chromatogr. 527 1990 414 420
21. E.M. Slominska, P. Adamski, M. Lipinski, J. Swierczynski, and R.T. Smolenski Liquid chromatographic/mass spectrometric procedure for measurement of NAD catabolites in human and rat plasma and urine Nucleosides Nucleotides Nucleic Acids 25 2006 1245 1249
22. M. Szafarz, M. Lomnicka, M. Sternak, S. Chlopicki, and J. Szymura-Oleksiak Simultaneous determination of nicotinic acid and its four metabolites in rat plasma using high performance liquid chromatography with tandem mass spectrometric detection (LC/MS/MS) J. Chromatogr. B 878 2010 895 902
23. M. Bourdi, D.P. Eiras, and M.P. Holt Role of IL-6 in an IL-10 and IL-4 double knockout mouse model uniquely susceptible to acetaminophen-induced liver injury † Chem. Res. Toxicol. 20 2007 208 216
24. S. Malchow, W. Thaiss, and N. Jänner Essential role of neutrophil mobilization in concanavalin A-induced hepatitis is based on classic IL-6 signaling but not on IL-6 trans-signaling Biochim. Biophys. Acta 2011 1812 290 301
25. Y. Tagawa, P. Matthys, and H. Heremans Bimodal role of endogenous interleukin-6 in concanavalin A-induced hepatitis in mice J. Leukoc. Biol. 67 2000 90 96
26. B.H. Mizuhara, E.O. Neill, and T. Ogawa T cell activation-associated hepatic injury: mediation by tumor necrosis factors and protection by interleukin 6 J. Exp. Med. 179 1994 1529 1537
27. H. Mizuhara, M. Uno, and N. Seki Critical involvement of interferon gamma in the pathogenesis of T-cell activation-associated hepatitis and regulatory mechanisms of interleukin-6 for the manifestations of hepatitis Hepatology 23 1996 1608 1615
28. R. Cuomo, R. Pumpo, G. Sarnelli, G. Capuano, and G. Budillon Nicotinamide methylation and hepatic energy reserve: a study by liver perfusion in vitro J. Hepatol. 23 1995 465 470
29. J. Hoshino, and U.K.H. Schlüter Nicotinamide methylation and its relation to NAD synthesis in rat liver tissue culture. Biochemical basis for the physiological activities of 1-methylnicotinamide Biochim. Biophys. Acta 801 2 1984 250 258
30. R.B. Parsons, S. Aravindan, and A. Kadampeswaran The expression of nicotinamide N-methyltransferase increases ATP synthesis and protects SH-SY5Y neuroblastoma cells against the toxicity of Complex I inhibitors Biochem. J. 436 2011 145 155
31. R.B. Parsons, M.-L. Smith, A.C. Williams, A.H. Waring, and D.B. Ramsden Expression of nicotinamide n-methyltransferase (E.C. 2.1.1.1) in the Parkinsonian brain J. Neuropathol. Exp. Neurol. 61 2002
32. F.P. D'Andrea, A. Safwat, and M. Kassem Cancer stem cell overexpression of nicotinamide N-methyltransferase enhances cellular radiation resistance Radiother. Oncol. 99 2011 373 378
33. H.C. Kim, M. Mofarrahi, and T. Vassilakopoulos Expression and functional significance of nicotinamide N-methyl transferase in skeletal muscles of patients with chronic obstructive pulmonary disease Am. J. Respir. Crit. Care Med. 181 2010 797 805
34. S. Schmeisser, S. Priebe, and M. Groth Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension Molecular Metabolism 2 2013 92 102
35. M. Sternak, T.I. Khomich, and A. Jakubowski Nicotinamide N-methyltransferase (NNMT) and 1-methylnicotinamide (MNA) in experimental hepatitis induced by concanavalin A in the mouse Pharmacol. Rep. 62 2010 483 493
36. D. Strassheim, S.R. Riddle, D.L. Burke, M.W. Geraci, and R. Kurt Prostacyclin inhibits IFN-gamma-stimulated cytokine expression by reduced recruitment of CBP/p300 to STAT1 in a SOCS-1-independent manner J. Immunol. 183 2009 6981 6988
37. S. Ohta, M. Nakamuta, and M. Fukushima Beraprost sodium, a prostacyclin (PGI2) analogue, ameliorates concanavalin A-induced liver injury in mice Liver Int. 25 2005 1061 1068
38. E. Gediki, I S G, and B. Deniz Iloprost, a prostacyclin (PGI 2) analogue, reduces liver injury in hepatic ischemia - Iloprost, um análogo da prostaciclina (PGI 2), reduz danos da isquemia/reperfusão hepática em ratos 24 2009 226 232
39. A.A. Nanji, and S.S.S. Khwaja Decreased prostacyclin production by liver non-parenchymal cells precedes liver injury in experimental alcoholic liver disease Life Sci. 54 1994 455 461
40. C.-J. Chu, C.-C. Hsiao, and T.-F. Wang Prostacyclin inhibition by indomethacin aggravates hepatic damage and encephalopathy in rats with thioacetamide-induced fulminant hepatic failure World J. Gastroenterol. 11 2005 232 236