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Volumn 62, Issue 3, 2010, Pages 483-493

Nicotinamide n-methyltransferase (nnmt) and 1-methylnicotinamide (mna) in experimental hepatitis induced by concanavalin a in the mouse

Author keywords

1 methylnicotinamide; BALB c mice; Concanavalin A; Hepatits; Nicotinamide N methyltransferase

Indexed keywords

1 METHYL 4(1H) OXO 5 PYRIDINECARBOXAMIDE; 1 METHYL 6 OXONICOTINAMIDE; 1 METHYLNICOTINAMIDE; ALANINE AMINOTRANSFERASE; CONCANAVALIN A; DRUG METABOLITE; GAMMA INTERFERON; NICOTINAMIDE METHYLTRANSFERASE; PROSTACYCLIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; N(1)-METHYLNICOTINAMIDE; NICOTINAMIDE; RECOMBINANT PROTEIN;

EID: 77954841794     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/S1734-1140(10)70304-2     Document Type: Article
Times cited : (44)

References (47)
  • 1
    • 0028225401 scopus 로고
    • Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization
    • Aksoy S, Szumlanski CL, Weinshilboum RM: Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization. J Biol Chem, 1994, 269, 14835-14840.
    • (1994) J Biol Chem , vol.269 , pp. 14835-14840
    • Aksoy, S.1    Szumlanski, C.L.2    Weinshilboum, R.M.3
  • 2
    • 0033791071 scopus 로고    scopus 로고
    • N-methylation ability for azaheterocyclic amines is higher in Parkinson's disease: Nicotinamide loading test
    • Aoyama K, Matsubara K, Okada K, Fukushima S, Shimizu K, Yamaguchi S, Uezono T et al.: N-methylation ability for azaheterocyclic amines is higher in Parkinson's disease: nicotinamide loading test. J Neural Transm, 2000, 107, 985-995.
    • (2000) J Neural Transm , vol.107 , pp. 985-995
    • Aoyama, K.1    Matsubara, K.2    Okada, K.3    Fukushima, S.4    Shimizu, K.5    Yamaguchi, S.6    Uezono, T.7
  • 3
    • 0017336339 scopus 로고
    • Metabolism of nicotinic acid in children with burns and scalds
    • Barlow GB, Sutton JL, Wilkinson AW: Metabolism of nicotinic acid in children with burns and scalds. Clin Chim Acta, 1977, 75, 337-342.
    • (1977) Clin Chim Acta , vol.75 , pp. 337-342
    • Barlow, G.B.1    Sutton, J.L.2    Wilkinson, A.W.3
  • 4
    • 42549117206 scopus 로고    scopus 로고
    • Smoleński RT et al.: 1-Methylnicotinamide (MNA) prevents endothelial dysfunction in hypertriglyceridemic and diabetic rats
    • Bartuś M, Łomnicka M, Kostogrys RB, Kaźmierczak P, Watała C, Słomińska EM, Smoleński RT et al.: 1-Methylnicotinamide (MNA) prevents endothelial dysfunction in hypertriglyceridemic and diabetic rats. Pharmacol Rep, 2008, 60, 127-138.
    • (2008) Pharmacol Rep , vol.60 , pp. 127-138
    • Bartuś, M.1    łomnicka, M.2    Kostogrys, R.B.3    Kaźmierczak, P.4    Watała, C.5    Słomińska, E.M.6
  • 5
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem, 1976, 72, 248-254.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 6
    • 37349020941 scopus 로고    scopus 로고
    • Anti-inflammatory effect of 1-methylnicotinamide in contact hypersensitivity to oxazolone in mice; involvement of prostacyclin
    • Bryniarski K, Biedron R, Jakubowski A, Chlopicki S, Marcinkiewicz J: Anti-inflammatory effect of 1-methylnicotinamide in contact hypersensitivity to oxazolone in mice; involvement of prostacyclin. Eur J Pharmacol, 2008, 578, 332-338.
    • (2008) Eur J PharMacol , vol.578 , pp. 332-338
    • Bryniarski, K.1    Biedron, R.2    Jakubowski, A.3    Chlopicki, S.4    Marcinkiewicz, J.5
  • 7
    • 45749132575 scopus 로고    scopus 로고
    • Therapeutic potential of 1-methylnicotinamide against acute gastric lesions induced by stress: Role of endogenous prostacyclin and sensory nerves
    • Brzozowski T, Konturek PC, Chlopicki S, Sliwowski Z, Pawlik M, Ptak-Belowska A, Kwiecień S et al.: Therapeutic potential of 1-methylnicotinamide against acute gastric lesions induced by stress: role of endogenous prostacyclin and sensory nerves. J Pharmacol Exp Ther, 2008, 326, 105-116.
    • (2008) J Pharmacol Exp Ther , vol.326 , pp. 105-116
    • Brzozowski, T.1    Konturek, P.C.2    Chlopicki, S.3    Sliwowski, Z.4    Pawlik, M.5    Ptak-Belowska, A.6    Kwiecień, S.7
  • 8
    • 34948823247 scopus 로고    scopus 로고
    • Ge{ogonek}bicki J: 1-Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/ prostacyclin pathway
    • Chlopicki S, Swies J, Mogielnicki A, Buczko W, Bartuś M, Łomnicka M, Adamus J, Ge{ogonek}bicki J: 1-Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/ prostacyclin pathway. Br J Pharmacol, 2007, 152, 230-239.
    • (2007) Br J Pharmacol , vol.152 , pp. 230-239
    • Chlopicki, S.1    Swies, J.2    Mogielnicki, A.3    Buczko, W.4    Bartuś, M.5    łomnicka, M.6    Adamus, J.7
  • 9
    • 19944430667 scopus 로고    scopus 로고
    • Prostacyclin inhibition by indomethacin aggravates hepatic damage and encephalopathy in rats with thioacetamide-induced fulminant hepatic failure
    • Chu CJ, Hsiao CC, Wang TF, Chan CY, Lee FY, Chang FY, Chen YC et al.: Prostacyclin inhibition by indomethacin aggravates hepatic damage and encephalopathy in rats with thioacetamide-induced fulminant hepatic failure. World J Gastroenterol, 2005, 11, 232-236.
    • (2005) World J Gastroenterol , vol.11 , pp. 232-236
    • Chu, C.J.1    Hsiao, C.C.2    Wang, T.F.3    Chan, C.Y.4    Lee, F.Y.5    Chang, F.Y.6    Chen, Y.C.7
  • 10
    • 0002705479 scopus 로고    scopus 로고
    • S-adenosylmethionine-dependent methyltrasferases
    • In: Homocysteine in health and disease. Eds., Cambridge University Press, Cambridge
    • Clarke S, Banfield K: S-adenosylmethionine-dependent methyltrasferases. In: Homocysteine in health and disease. Eds. Carmel R. Jacobsen DW, Cambridge University Press, Cambridge, 2001, 63-78.
    • (2001) Carmel R. Jacobsen DW , pp. 63-78
    • Clarke, S.1    Banfield, K.2
  • 12
    • 0029021296 scopus 로고
    • Nicotinamide methylation and hepatic energy reserve: A study by liver perfusion in vitro
    • Cuomo R, Pumpo R, Sarnelli G, Capuano G, Budillon G: Nicotinamide methylation and hepatic energy reserve: a study by liver perfusion in vitro. J Hepatol, 1995, 23, 465-470.
    • (1995) J Hepatol , vol.23 , pp. 465-470
    • Cuomo, R.1    Pumpo, R.2    Sarnelli, G.3    Capuano, G.4    Budillon, G.5
  • 13
    • 0036432873 scopus 로고    scopus 로고
    • Gene expression profile analysis of the mouse liver during bacteria-induced fulminant hepatitis by a cDNA microarray system
    • Dong H, Toyoda N, Yoneyama H, Kurachi M, Kasahara T, Kobayashi Y, Inadera H et al.: Gene expression profile analysis of the mouse liver during bacteria-induced fulminant hepatitis by a cDNA microarray system. Biochem Biophys Res Commun, 2002, 298, 675-686.
    • (2002) Biochem Biophys Res Commun , vol.298 , pp. 675-686
    • Dong, H.1    Toyoda, N.2    Yoneyama, H.3    Kurachi, M.4    Kasahara, T.5    Kobayashi, Y.6    Inadera, H.7
  • 14
    • 47749112410 scopus 로고    scopus 로고
    • Development of oxidative stress by cytochrome P450 induction in rodents is selective for barbiturates and related to loss of pyridine nucleotidedependent protective systems
    • Dostalek M, Hardy KD, Milne GL, Morrow JD, Chen C, Gonzalez FJ, Gu J et al.: Development of oxidative stress by cytochrome P450 induction in rodents is selective for barbiturates and related to loss of pyridine nucleotidedependent protective systems. J Biol Chem, 2008, 283, 17147-17157.
    • (2008) J Biol Chem , vol.283 , pp. 17147-17157
    • Dostalek, M.1    Hardy, K.D.2    Milne, G.L.3    Morrow, J.D.4    Chen, C.5    Gonzalez, F.J.6    Gu, J.7
  • 16
  • 17
    • 0028795171 scopus 로고
    • Concanavalin A-induced T-cell-mediated hepatic injury in mice: The role of tumor necrosis factor
    • Gantner F, Leist M, Lohse AW, Germann PG, Tiegs G: Concanavalin A-induced T-cell-mediated hepatic injury in mice: the role of tumor necrosis factor. Hepatology, 1995,21,1901-98.
    • (1995) Hepatology , vol.21 , pp. 1901-1998
    • Gantner, F.1    Leist, M.2    Lohse, A.W.3    Germann, P.G.4    Tiegs, G.5
  • 18
    • 67649760245 scopus 로고    scopus 로고
    • Iloprost, a prostacyclin (PGI2) analogue, reduces liver injury in hepatic ischemia-reperfusion in rats
    • Gedik E, Girgin S, Obay BD, Ozturk H, Ozturk H, Buyukbayram H: Iloprost, a prostacyclin (PGI2) analogue, reduces liver injury in hepatic ischemia-reperfusion in rats. Acta Cir Bras, 2009, 24, 226-232.
    • (2009) Acta Cir Bras , vol.24 , pp. 226-232
    • Gedik, E.1    Girgin, S.2    Obay, B.D.3    Ozturk, H.4    Ozturk, H.5    Buyukbayram, H.6
  • 19
    • 42549161100 scopus 로고    scopus 로고
    • Prostacyclin among prostanoids
    • Gryglewski RJ: Prostacyclin among prostanoids. Pharmacol Rep, 2008, 60, 3-11.
    • (2008) PharMacol Rep , vol.60 , pp. 3-11
    • Gryglewski, R.J.1
  • 20
    • 0020378624 scopus 로고
    • Enhancement of DNA synthesis and cell proliferation by 1-methylnicotinamide in rat liver cells in culture: Implication for its in vivo role
    • Hoshino J, Kuhne U, Kroger H: Enhancement of DNA synthesis and cell proliferation by 1-methylnicotinamide in rat liver cells in culture: implication for its in vivo role. Biochem Biophys Res Commun, 1982, 105, 1446-1452.
    • (1982) Biochem Biophys Res Commun , vol.105 , pp. 1446-1452
    • Hoshino, J.1    Kuhne, U.2    Kroger, H.3
  • 21
    • 0021192645 scopus 로고
    • Nicotinamide methylation and its relation to NAD synthesis in rat liver tissue culture. Biochemical basis for the physiological activities of 1-methylnicotinamide
    • Hoshino J, Schluter U, Kroger H: Nicotinamide methylation and its relation to NAD synthesis in rat liver tissue culture. Biochemical basis for the physiological activities of 1-methylnicotinamide. Biochim Biophys Acta, 1984, 801,250-258.
    • (1984) Biochim Biophys Acta , vol.801 , pp. 250-258
    • Hoshino, J.1    Schluter, U.2    Kroger, H.3
  • 22
    • 9244246248 scopus 로고    scopus 로고
    • The differential proteome profile of stomach cancer: Identification of the biomarker candidates
    • Jang JS, Cho HY, Lee YJ, Ha WS, Kim HW: The differential proteome profile of stomach cancer: identification of the biomarker candidates. Oncol Res, 2004,14, 491-499.
    • (2004) Oncol Res , vol.14 , pp. 491-499
    • Jang, J.S.1    Cho, H.Y.2    Lee, Y.J.3    Ha, W.S.4    Kim, H.W.5
  • 23
    • 62749170002 scopus 로고    scopus 로고
    • Expression of nicotinamide N-methyltransferase in hepatocellular carcinoma is associated with poor prognosis
    • Kim J, Hong SJ, Lim EK, Yu YS, Kim SW, Roh JH, Do IG et al.: Expression of nicotinamide N-methyltransferase in hepatocellular carcinoma is associated with poor prognosis. J Exp Clin Cancer Res, 2009, 28-20.
    • (2009) J Exp Clin Cancer Res , pp. 28-20
    • Kim, J.1    Hong, S.J.2    Lim, E.K.3    Yu, Y.S.4    Kim, S.W.5    Roh, J.H.6    Do, I.G.7
  • 24
    • 0030017301 scopus 로고    scopus 로고
    • Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A
    • Kusters S, Gantner F, Kunstle G, Tiegs G: Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A. Gastroenterology, 1996, 111, 462-471.
    • (1996) GastroenterolOgy , vol.111 , pp. 462-471
    • Kusters, S.1    Gantner, F.2    Kunstle, G.3    Tiegs, G.4
  • 25
    • 33750742433 scopus 로고    scopus 로고
    • Overexpression of nicotinamide N-methyltransferase in gastric cancer tissues and its potential post-translational modification
    • Lim BH, Cho BI, Kim YN, Kim JW, Park ST, Lee CW: Overexpression of nicotinamide N-methyltransferase in gastric cancer tissues and its potential post-translational modification. Exp Mol Med, 2006, 38, 455-465.
    • (2006) Exp Mol Med , vol.38 , pp. 455-465
    • Lim, B.H.1    Cho, B.I.2    Kim, Y.N.3    Kim, J.W.4    Park, S.T.5    Lee, C.W.6
  • 28
    • 0028115862 scopus 로고
    • Decreased prostacyclin production by liver non-parenchymal cells precedes liver injury in experimental alcoholic liver disease
    • Nanji AA, Khwaja S, Sadrzadeh SM: Decreased prostacyclin production by liver non-parenchymal cells precedes liver injury in experimental alcoholic liver disease. Life Sci, 1994, 54,455-461.
    • (1994) Life Sci , vol.54 , pp. 455-461
    • Nanji, A.A.1    Khwaja, S.2    Sadrzadeh, S.M.3
  • 29
    • 26044471694 scopus 로고    scopus 로고
    • Beraprost sodium, a prostacyclin (PGI) analogue, ameliorates concanavalin A-induced liver injury in mice
    • Ohta S, Nakamuta M, Fukushima M, Kohjima M, Kotoh K, Enjoji M, Nawata H: Beraprost sodium, a prostacyclin (PGI) analogue, ameliorates concanavalin A-induced liver injury in mice. Liver Int, 2005, 25, 1061-1068.
    • (2005) Liver Int , vol.25 , pp. 1061-1068
    • Ohta, S.1    Nakamuta, M.2    Fukushima, M.3    Kohjima, M.4    Kotoh, K.5    Enjoji, M.6    Nawata, H.7
  • 30
    • 0031844546 scopus 로고    scopus 로고
    • Increased hepatic nicotinamide N-methyltransferase activity as a marker of cancer cachexia in mice bearing colon 26 adenocarcinoma
    • Okamura A, Ohmura Y, Islam MM, Tagawa M, Horitsu K, Moriyama Y, Fujimura S: Increased hepatic nicotinamide N-methyltransferase activity as a marker of cancer cachexia in mice bearing colon 26 adenocarcinoma. Jpn J Cancer Res, 1998, 89, 649-656.
    • (1998) Jpn J Cancer Res , vol.89 , pp. 649-656
    • Okamura, A.1    Ohmura, Y.2    Islam, M.M.3    Tagawa, M.4    Horitsu, K.5    Moriyama, Y.6    Fujimura, S.7
  • 31
    • 0035049509 scopus 로고    scopus 로고
    • The metabolism of nicotinamide in human liver cirrhosis: A study on N-methylnicotinamide and 2-pyridone-5carboxamide production
    • Pumpo R, Sarnelli G, Spinella A, Budillon G, Cuomo R: The metabolism of nicotinamide in human liver cirrhosis: a study on N-methylnicotinamide and 2-pyridone-5carboxamide production. Am J Gastroenterol, 2001, 96, 1183-1187.
    • (2001) Am J Gastroenterol , vol.96 , pp. 1183-1187
    • Pumpo, R.1    Sarnelli, G.2    Spinella, A.3    Budillon, G.4    Cuomo, R.5
  • 32
    • 67349224402 scopus 로고    scopus 로고
    • Adipose tissue as a source of nicotinamide N-methyl-transferase and homocysteine
    • Riederer M, Erwa W, Zimmermann R, Frank S, Zechner R: Adipose tissue as a source of nicotinamide N-methyltransferase and homocysteine. Atherosclerosis, 2008, 204, 412-417.
    • (2008) Atherosclerosis , vol.204 , pp. 412-417
    • Riederer, M.1    Erwa, W.2    Zimmermann, R.3    Frank, S.4    Zechner, R.5
  • 33
    • 0025058295 scopus 로고
    • Human liver nicotinamide N-methyltransferase: Ion-pairing radiochemical assay, biochemical properties and individual variation
    • Rini J, Szumlanski C, Guerciolini R, Weinshilboum RM: Human liver nicotinamide N-methyltransferase: ionpairing radiochemical assay, biochemical properties and individual variation. Clin Chim Acta, 1990, 186, 359-374.
    • (1990) Clin Chim Acta , vol.186 , pp. 359-374
    • Rini, J.1    Szumlanski, C.2    Guerciolini, R.3    Weinshilboum, R.M.4
  • 35
    • 0024938665 scopus 로고
    • Fluorometric assay of nicotinamide methyltransferase with a new substrate, 4-methylnicotinamide
    • Sano A, Takimoto N, Takitani S: Fluorometric assay of nicotinamide methyltransferase with a new substrate, 4-methylnicotinamide. Chem Pharm Bull (Tokyo), 1989, 37, 3330-3332.
    • (1989) Chem Pharm Bull (Tokyo) , vol.37 , pp. 3330-3332
    • Sano, A.1    Takimoto, N.2    Takitani, S.3
  • 36
    • 34548471787 scopus 로고    scopus 로고
    • Nicotinamide N-methyltransferase upregulation inversely correlates with lymph node metastasis in oral squamous cell carcinoma
    • Sartini D, Santarelli A, Rossi V, Goteri G, Rubini C, Ciavarella D, Lo Muzio L, Emanuelli M: Nicotinamide N-methyltransferase upregulation inversely correlates with lymph node metastasis in oral squamous cell carcinoma. Mol Med, 2007, 13, 415-421.
    • (2007) Mol Med , vol.13 , pp. 415-421
    • Sartini, D.1    Santarelli, A.2    Rossi, V.3    Goteri, G.4    Rubini, C.5    Ciavarella, D.6    Lo, M.L.7    Emanuelli, M.8
  • 37
    • 0036401433 scopus 로고    scopus 로고
    • Cytokine expression in three mouse models of experimental hepatitis
    • Sass G, Heinlein S, Agli A, Bang R, Schumann J, Tiegs G: Cytokine expression in three mouse models of experimental hepatitis. Cytokine, 2002, 19, 115-120.
    • (2002) Cytokine , vol.19 , pp. 115-120
    • Sass, G.1    Heinlein, S.2    Agli, A.3    Bang, R.4    Schumann, J.5    Tiegs, G.6
  • 38
    • 0021168439 scopus 로고
    • Nicotinamide methylation. Tissue distribution, developmental and neoplastic changes
    • Seifert R, Hoshino J, Kroger H: Nicotinamide methylation. Tissue distribution, developmental and neoplastic changes. Biochim Biophys Acta, 1984, 801, 259-264.
    • (1984) Biochim Biophys Acta , vol.801 , pp. 259-264
    • Seifert, R.1    Hoshino, J.2    Kroger, H.3
  • 39
    • 21044434160 scopus 로고    scopus 로고
    • A genomewide exploration suggests a new candidate gene at chromosome 11q23 as the major determinant of plasma homocysteine levels: Results from the GAIT project
    • Souto JC, Blanco-Vaca F, Soria JM, Buil A, Almasy L, Ordońez-Llanos J, Martín-Campos JM et al.: A genomewide exploration suggests a new candidate gene at chromosome 11q23 as the major determinant of plasma homocysteine levels: results from the GAIT project. Am J Hum Genet, 2005, 76, 925-933.
    • (2005) Am J Hum Genet , vol.76 , pp. 925-933
    • Souto, J.C.1    Blanco-Vaca, F.2    Soria, J.M.3    Buil, A.4    Almasy, L.5    Ordońez-Llanos, J.6    Martín-Campos, J.M.7
  • 40
    • 0015083915 scopus 로고
    • Metabolic origins of the pyridones of N 1-Methylnicotinamide In Man and Rat
    • Stanulovic M, Chaykin S: Metabolic origins of the pyridones of N 1-methylnicotinamide in man and rat. Arch Biochem Biophys, 1971, 145, 35-42.
    • (1971) Arch Biochem Biophys , vol.145 , pp. 35-42
    • Stanulovic, M.1    Chaykin, S.2
  • 42
    • 0026643743 scopus 로고
    • A T cell-dependent experimental liver injury in mice inducible by concanavalin A
    • Tiegs G, Hentschel J, Wendel A: A T cell-dependent experimental liver injury in mice inducible by concanavalin A. J Clin Invest, 1992, 90, 196-203.
    • (1992) J Clin Invest , vol.90 , pp. 196-203
    • Tiegs, G.1    Hentschel, J.2    Wendel, A.3
  • 44
    • 41149141308 scopus 로고    scopus 로고
    • Stat3 up-regulates expression of nicotinamide N-methyltransferase in human cancer cells
    • Tomida M, Ohtake H, Yokota T, Kobayashi Y, Kurosumi M: Stat3 up-regulates expression of nicotinamide N-methyltransferase in human cancer cells. J Cancer Res Clin Oncol, 2008, 134, 551-559.
    • (2008) J Cancer Res Clin Oncol , vol.134 , pp. 551-559
    • Tomida, M.1    Ohtake, H.2    Yokota, T.3    Kobayashi, Y.4    Kurosumi, M.5
  • 46
    • 56149086395 scopus 로고    scopus 로고
    • Overlapping gene expression profiles of cell migration and tumor invasion in human bladder cancer identify metallothionein 1E and nicotinamide N-methyl-transferase as novel regulators of cell migration
    • Wu Y, Siadaty MS, Berens ME, Hampton GM, Theodorescu D: Overlapping gene expression profiles of cell migration and tumor invasion in human bladder cancer identify metallothionein 1E and nicotinamide N-methyl-transferase as novel regulators of cell migration. Oncogene, 2008, 27, 6679-6689.
    • (2008) OncoGene , vol.27 , pp. 6679-6689
    • Wu, Y.1    Siadaty, M.S.2    Berens, M.E.3    Hampton, G.M.4    Theo-dorescu, D.5
  • 47
    • 0030669835 scopus 로고    scopus 로고
    • Mouse liver nicotinamide N-methyltransferase: CDNA cloning, expression, and nucleotide sequence polymorphisms
    • Yan L, Otterness DM, Craddock TL, Weinshilboum RM: Mouse liver nicotinamide N-methyltransferase: cDNA cloning, expression, and nucleotide sequence polymorphisms. Biochem Pharmacol, 1997, 54, 1139-1149.
    • (1997) Biochem Pharmacol , vol.54 , pp. 1139-1149
    • Yan, L.1    Otterness, D.M.2    Craddock, T.L.3    Weinshilboum, R.M.4


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