Simultaneous determination of nicotinic acid and its four metabolites in rat plasma using high performance liquid chromatography with tandem mass spectrometric detection (LC/MS/MS)

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 11-12, 2010, Pages 895-902

  Szafarz, Malgorzata ^a   Lomnicka, Magdalena ^a   Sternak, Magdalena ^a   Chlopicki, Stefan ^a   Szymura Oleksiak, Joanna ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

LC MS MS; Metabolites; N methylnicotinamide; Nicotinic acid; Plasma; Rat

Indexed keywords

1-METHYL-2-PYRIDONE-5-CARBOXAMIDE; AFTER-TREATMENT; AGILENT; ANALYTES; ANALYTICAL COLUMNS; APPLIED BIOSYSTEMS; AUTOSAMPLERS; CARBOXAMIDES; CONCENTRATION OF; DEPROTEINIZATION; DRY RESIDUE; FREEZE/THAW CYCLES; GRADIENT ELUTION; HARVARD; HYPERTRIGLYCERIDEMIA; INFUSION PUMP; INTERNAL STANDARDS; ION PRODUCTION; LC/MS/MS; LIQUID CHROMATOGRAPHY ELECTROSPRAY; LONG-TERM STORAGE STABILITY; MATRIX EFFECTS; MOBILE PHASE; MONITORING MODE; N-METHYLNICOTINAMIDE; NICOTINIC ACID; PROTONATED MOLECULAR IONS; PYRIDONES; RAT PLASMA; SIMULTANEOUS DETERMINATIONS; STABILITY STUDY; STANDARD SOLUTIONS; TANDEM MASS SPECTROMETRIC DETECTION; TRIPLE-QUADRUPOLE MASS SPECTROMETER;

ACETONITRILE; AMIDES; BIOLOGICAL SYSTEMS; BIOMOLECULES; CENTRIFUGATION; CHROMATOGRAPHY; COMPOSITE MICROMECHANICS; FORMIC ACID; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IONIZATION; LIQUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; METABOLISM; METABOLITES; ORGANIC ACIDS; PARTICLE DETECTORS; PLASMA (HUMAN); PLASMAS; SYSTEM STABILITY;

ELECTROSPRAY IONIZATION;

1 METHYL 4(1H) OXO 5 PYRIDINECARBOXAMIDE; 1 METHYL 6 OXONICOTINAMIDE; 1 METHYLNICOTINAMIDE; 6 CHLORONICOTINAMIDE; ACETONITRILE; DRUG METABOLITE; FORMIC ACID; FRUCTOSE; NICOTINAMIDE; NICOTINAMIDE DERIVATIVE; NICOTINIC ACID; UNCLASSIFIED DRUG; WATER;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CENTRIFUGATION; CONTROLLED STUDY; DRUG DETERMINATION; DRUG STABILITY; DRUG STORAGE; ELECTROSPRAY; ELUTION; EVAPORATION; FREEZE THAWING; GLUCOSE INTAKE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPERTRIGLYCERIDEMIA; INFUSION PUMP; ION MONITORING; MASS SPECTROMETER; NONHUMAN; PLASMA; PRIORITY JOURNAL; RAT; SUPERNATANT; TANDEM MASS SPECTROMETRY; VALIDATION STUDY;

ANIMALS; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYPERTRIGLYCERIDEMIA; NIACIN; RATS; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

NICA; RATTUS;

EID: 77949486998     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.02.009     Document Type: Article

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