Liquid chromatographic/mass spectrometric procedure for measurement of NAD catabolites in human and rat plasma and urine

Nucleosides, Nucleotides and Nucleic Acids

Volumn 25, Issue 9-11, 2006, Pages 1245-1249

  Slominska, E M ^b   Adamski, P ^b   Lipinski, M ^b   Swierczynski, J ^b   Smolenski, R T ^a  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

^b NONE

Author keywords

Liquid chromatography mass spectrometry; N Methylnicotinamide; Nicotinamide; Poly(ADP ribose) polymerase (PARP)

Indexed keywords

NICOTINAMIDE ADENINE DINUCLEOTIDE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ELECTROSPRAY; ENZYME BLOOD LEVEL; ENZYME METABOLISM; ENZYMURIA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ION TRAP MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; RAT;

ANIMALS; CHROMATOGRAPHY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; HUMANS; MASS SPECTROMETRY; NAD; NIACINAMIDE; POLY(ADP-RIBOSE) POLYMERASES; RATS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TIME FACTORS;

EID: 33750476348     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770600894725     Document Type: Article

References (5)

1. D'Amours, D.; Desnoyers, S.; D'Silva, I.; Poirier, G.G. Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions. Biochem. J. 1999, 342(Pt. 2), 249-268.
2. Stratford, M.R.; Dennis, M.F. High-performance liquid chromatographic determination of nicotinamide and its metabolites in human and murine plasma and urine. J. Chromatogr. 1992, 582, 145-151.
3. Gale, E.A.; Bingley, P.J.; Emmett, C.L.; Collier, T. European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes. Lancet 2004, 363, 925-931.
4. Maiese, K.; Chong, Z.Z. Nicotinamide: necessary nutrient emerges as a novel cytoprotectant for the brain. Trends Pharmacol. Sci. 2003, 24, 228-232.
5. Slominska, E.M.; Smolenski, R.T.; Szolkiewicz, M.; Leaver, N.; Rutkowski, B.; Simmonds, H.A.; Swierczynski, J. Accumulation of plasma N-methyl-2-pyridone-5-carboxamide in patients with chronic renal failure. Mol. Cell Biochem. 2002, 231, 83-88.