Expression and functional significance of nicotinamide n-methyl transferase in skeletal muscles of patients with chronic obstructive pulmonary disease

American Journal of Respiratory and Critical Care Medicine

Volumn 181, Issue 8, 2010, Pages 797-805

  Ho, Cheol Kim ^a   Mofarrahi, Mahroo ^b   Vassilakopoulos, Theodoros ^c   Maltais, Francois ^d   Sigala, Ioanna ^c   Debigare, Richard ^d   Bellenis, Ioannis ^c   Hussain, Sabah N A ^b  

^a Gyeongsang National University School of Medicine   (South Korea)

^b ROYAL VICTORIA HOSPITAL   (Canada)

^c UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^d LAVAL UNIVERSITY   (Canada)

Author keywords

Chronic obstructive pulmonary disease; Diaphragm; Nicotinamide; Oxidative stress; Skeletal muscles

Indexed keywords

CYTOKINE; HYDROGEN PEROXIDE; INTERLEUKIN 6; NICOTINAMIDE METHYLTRANSFERASE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; DIAPHRAGM MUSCLE; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MUSCLE ATROPHY; MYOBLAST; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; QUADRICEPS FEMORIS MUSCLE; SKELETAL MUSCLE; AGED; ANIMAL; BIOPSY; CELL CULTURE; CELL MOTION; DIAPHRAGM; ENZYMOLOGY; GENE EXPRESSION; HOSPITALIZATION; IMMUNOBLOTTING; METABOLISM; MOUSE; MUSCLE DEVELOPMENT;

AGED; ANIMALS; BIOPSY; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; CYTOKINES; DIAPHRAGM; FEMALE; GENE EXPRESSION; HUMANS; IMMUNOBLOTTING; MALE; MICE; MUSCLE DEVELOPMENT; MUSCLE, SKELETAL; NICOTINAMIDE N-METHYLTRANSFERASE; OXIDATIVE STRESS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; QUADRICEPS MUSCLE; SEVERITY OF ILLNESS INDEX;

EID: 77953049766     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.200906-0936OC     Document Type: Article

References (46)

1. Debigare R, Maltais F, Cote CH, Michaud A, Caron MA, Mofarrahi M, LeBlanc P, Hussain SN. Profiling of mRNA expression in quadriceps of patients with COPD and muscle wasting. COPD 2008;5:75-84.
2. Alston TA, Abeles RH. Substrate specificity of nicotinamide methyltransferase isolated from porcine liver. Arch Biochem Biophys 1988;260:601-608.
3. Aksoy S, Brandriff BF, Ward A, Little PF, Weinshilboum RM. Human nicotinamide N-methyltransferase gene: molecular cloning, structural characterization and chromosomal localization. Genomics 1995;29:555-561.
4. Riederer M, Erwa W, Zimmermann R, Frank S, Zechner R. Adipose tissue as a source of nicotinamide N-methyltransferase and homocysteine. Atherosclerosis 2008;204:412-417.
5. Levine S, Kaiser L, Leferovich J, Tikunov B. Cellular adaptations in the diaphragm in chronic obstructive pulmonary disease. N Engl J Med 1997;337:1799-1806. (Pubitemid 28006784)
6. Chen YW, Zhao P, Borup R, Hoffman EP. Expression profiling in the muscular dystrophies: identification of novel aspects of molecular pathophysiology. J Cell Biol 2000;151:1321-1336.
7. Campanaro S, Romualdi C, Fanin M, Celegato B, Pacchioni B, Trevisan S, Laveder P, De PC, Pegoraro E, Hayashi YK, et al. Gene expression profiling in dysferlinopathies using a dedicated muscle microarray. Hum Mol Genet 2002;11:3283-3298. (Pubitemid 36054657)
8. Tezak Z, Hoffman EP, Lutz JL, Fedczyna TO, Stephan D, Bremer EG, Krasnoselska-Riz I, Kumar A, Pachman LM. Gene expression profiling in DQA1*05011 children with untreated dermatomyositis: a novel model of pathogenesis. J Immunol 2002;168:4154-4163.
9. Levine S, Nguyen T, Kaiser LR, Rubinstein NA, Maislin G, Gregory C, Rome LC, Dudley GA, Sieck GC, Shrager JB. Human diaphragm remodeling associated with chronic obstructive pulmonary disease: clinical implications. Am J Respir Crit Care Med 2003;168:706-713.
10. Tomida M, Ohtake H, Yokota T, Kobayashi Y, Kurosumi M. Stat3 upregulates expression of nicotinamide N-methyltransferase in human cancer cells. J Cancer Res Clin Oncol 2008;134:551-559.
11. Dong H, Toyoda N, Yoneyama H, Kurachi M, Kasahara T, Kobayashi Y, Inadera H, Hashimoto S, Matsushima K. Gene expression profile analysis of the mouse liver during bacteria-induced fulminant hepatitis by a cDNA microarray system. Biochem Biophys Res Commun 2002;298:675-686.
12. Nabokikh A, Ilhan A, Bilban M, Gartner W, Vila G, Niederle B, Nielsen JH, Wagner O, Base W, Luger A, et al. Reduced TGF-β1 expression and its target genes in human insulinomas. Exp Clin Endocrinol Diabetes 2007;115:674-682.
13. Dostalek M, Hardy KD, Milne GL, Morrow JD, Chen C, Gonzalez FJ, Gu J, Ding X, Johnson DA, Johnson JA, et al. Development of oxidative stress by cytochrome P450 induction in rodents is selective for barbiturates and related to loss of pyridine nucleotide-dependent protective systems. J Biol Chem 2008;283:17147-17157.
14. Kim HC, Mofarrahi M, Hussain SN. Skeletal muscle dysfunction in patients with chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 2008;3:637-658.
15. Clark JB, Ferris GM, Pinder S. Inhibition of nuclear NAD nucleosidase and poly ADP-ribose polymerase activity from rat liver by nicotinamide and 5′-methyl nicotinamide. Biochim Biophys Acta 1971;238:82-85.
16. Biedron R, Ciszek M, Tokarczyk M, Bobek M, Kurnyta M, Slominska EM, Smolenski RT, Marcinkiewicz J. 1-Methylnicotinamide and nicotinamide: two related anti-inflammatory agents that differentially affect the functions of activated macrophages. Arch Immunol Ther Exp (Warsz) 2008;56:127-134.
17. Wu Y, Siadaty MS, Berens ME, Hampton GM, Theodorescu D. Overlapping gene expression profiles of cell migration and tumor invasion in human bladder cancer identify metallothionein 1E and nicotinamide N-methyltransferase as novel regulators of cell migration. Oncogene 2008;27:6679-6689.
18. Hoshino J, Kuhne U, Kroger H. Methylation of nicotinamide in rat liver cytosol and its correlation with hepatocellular proliferation. Biochim Biophys Acta 1982;719:518-526. (Pubitemid 13191714)
19. Kim HC, Mofarrahi M, Maltais F, Vassilakopoulos T, Sigala I, Voutetakis K, Bellenis I, Hussain SN. Expression and functional significance of nicotinamide N-methyltransferase (NNMT) in quadriceps and diaphragm of patients with COPD [abstract]. Am J Respir Crit Care Med 2008;177:A274.
20. Fabbri LM, Hurd SS. Global strategy for the diagnosis, management and prevention of COPD: 2003 update. Eur Respir J 2003;22:1-2.
21. Bergström J. Percutaneous needle biopsy of skeletal muscle in physiological and clinical research. Scand J Clin Lab Invest 1975;35:609-616.
22. Mofarrahi M, Nouh T, Qureshi S, Guillot L, Mayaki D, Hussain SNA. Regulation of angiopoietin expression by bactrial lipopolysaccharide. Am J Physiol Lung Cell Mol Physiol 2008;294:L955-L963.
23. Mofarrahi M, Brandes RP, Gorlach A, Hanze J, Terada LS, Quinn MT, Mayaki D, Petrof B, Hutchinson DS. Regulation of proliferation of skeletal muscle precursor cells by NADPH oxidase. Antioxid Redox Signal 2008;10:559-574.
24. Abdel-Malak NA, Srikant CB, Kristof AS, Magder SA, Di Battista JA, Hussain SNA. Angiopoietin-1 promotes endothelial proliferation and migration through AP-1 dependent autocrine production of interleukin-8. Blood 2008;111:4145-4154.
25. Barreiro E, Gea J, Di Falco M, Kriazhev L, James S, Hussain SN. Protein carbonyl formation in the diaphragm. Am J Respir Cell Mol Biol 2005;32:9-17.
26. Lochmuller H, Johns T, Shoubridge EA. Expression of the E6 and E7 genes of human papillomavirus (HPV16) extends the life span of human myoblasts. Exp Cell Res 1999;248:186-193.
27. Levine S, Gregory C, Nguyen T, Shrager J, Kaiser L, Rubinstein N, Dudley G. Bioenergetic adaptation of individual human diaphragmatic myofibers to severe COPD. J Appl Physiol 2002;92:1205-1213.
28. Orozco-Levi M, Gea J, Lloreta JL, Felez M, Minguella J, Serrano S, Broquetas JM. Subcellular adaptation of the human diaphragm in chronic obstructive pulmonary disease. Eur Respir J 1999;13:371-378.
29. Montes de OM, Torres SH, De SJ, Mata A, Hernandez N, Talamo C. Skeletal muscle inflammation and nitric oxide in patients with COPD. Eur Respir J 2005;26:390-397.
30. Schols AM, Buurman WA, Staal van den Brekel AJ, Dentener MA, Wouters EF. Evidence for a relation between metabolic derangements and increased levels of inflammatory mediators in a subgroup of patients with chronic obstructive pulmonary disease. Thorax 1996; 51:819-824.
31. Gan WQ, Man SF, Senthilselvan A, Sin DD. Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis. Thorax 2004;59:574-580. (Pubitemid 38901515)
32. Vernooy JH, Kucukaycan M, Jacobs JA, Chavannes NH, Buurman WA, Dentener MA, Wouters EF. Local and systemic inflammation in patients with chronic obstructive pulmonary disease: soluble tumor necrosis factor receptors are increased in sputum. Am J Respir Crit Care Med 2002;166:1218-1224.
33. Carbo N, Busquets S, van Royen M, Alvarez B, Lopez-Soriano FJ, Argiles JM. TNF-alpha is involved in activating DNA fragmentation in skeletal muscle. Br J Cancer 2002;86:1012-1016.
34. Warren GL, Hulderman T, Jensen N, McKinstry M, Mishra M, Luster MI, Simeonova PP. Physiological role of tumor necrosis factor alpha in traumatic muscle injury. FASEB J 2002;16:1630-1632.
35. Xu J, Capezzone M, Xu X, Hershman JM. Activation of nicotinamide N-methyltransferase gene promoter by hepatocyte nuclear factor-1beta in human papillary thyroid cancer cells. Mol Endocrinol 2005; 19:527-539.
36. Leu JI, Crissey MA, Leu JP, Ciliberto G, Taub R. Interleukin-6-induced STAT3 and AP-1 amplify hepatocyte nuclear factor 1-mediated transactivation of hepatic genes, an adaptive response to liver injury. Mol Cell Biol 2001;21:414-424.
37. Roessler M, Rollinger W, Palme S, Hagmann ML, Berndt P, Engel AM, Schneidinger B, Pfeffer M, Andres H, Karl J, et al. Identification of nicotinamide N-methyltransferase as a novel serum tumor marker for colorectal cancer. Clin Cancer Res 2005;11:6550-6557.
38. Yao M, Tabuchi H, Nagashima Y, Baba M, Nakaigawa N, Ishiguro H, Hamada K, Inayama Y, Kishida T, Hattori K, et al. Gene expression analysis of renal carcinoma: adipose differentiation-related protein as a potential diagnostic and prognostic biomarker for clear-cell renal carcinoma. J Pathol 2005;205:377-387.
39. Sartini D, Santarelli A, Rossi V, Goteri G, Rubini C, Ciavarella D, Lo ML, Emanuelli M. Nicotinamide N-methyltransferase upregulation inversely correlates with lymph node metastasis in oral squamous cell carcinoma. Mol Med 2007;13:415-421.
40. Hawke TJ, Garry DJ. Myogenic satellite cells: physiology to molecular biology. J Appl Physiol 2001;91:534-551.
41. Martinez-Llorens J, Casadevall C, Lloreta J, Orozco-Levi M, Barreiro E, Broquetas J, Gea J. (Activation of satellite cells in the intercostal muscles of patients with chronic obstructive pulmonary disease). Arch Bronconeumol 2008;44:239-244.
42. Engelen MP, Schols AM, Does JD, Deutz NE, Wouters EF. Altered glutamate metabolism is associated with reduced muscle glutathione levels in patients with emphysema. Am J Respir Crit Care Med 2000; 161:98-103.
43. Barreiro E, Gea J, Corominas JM, Hussain SNA. Nitric oxide synthases and protein oxidation in the quadriceps femoris of patients with chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 2003;29:771-778. (Pubitemid 38045945)
44. Allaire J, Maltais F, LeBlanc P, Simard PM, Whittom F, Doyon JF, Simard C, Jobin J. Lipofuscin accumulation in the vastus lateralis muscle in patients with chronic obstructive pulmonary disease. Muscle Nerve 2002;25:383-389.
45. Couillard A, Maltais F, Saey D, Debigare R, Michaud A, Koechlin C, LeBlanc P, Prefaut C. Exercise-induced quadriceps oxidative stress and peripheral muscle dysfunction in COPD patients. Am J Respir Crit Care Med 2003;167:1664-1669.
46. Barreiro E, de la Puente B, Minguella J, Corominas JM, Serrano S, Hussain SN, Gea J. Oxidative stress and respiratory muscle dysfunction in severe chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2005;171:1116-1124.