Drug-loaded nano/microbubbles for combining ultrasonography and targeted chemotherapy

Ultrasonics

Volumn 48, Issue 4, 2008, Pages 260-270

  Gao, Zhonggao ^a,b   Kennedy, Anne M ^a,b   Christensen, Douglas A ^a,b   Rapoport, Natalya Y ^a,b  

^a Department of Electrical and Computer Engineering   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Cavitation; Coalescence; Collapse; Contrast enhanced ultrasonography; Nanobubbles; Targeted chemotherapy

Indexed keywords

ACOUSTIC WAVES; BIOTECHNOLOGY; BLOCK COPOLYMERS; BUBBLES (IN FLUIDS); CHEMICALS; CHEMOTHERAPY; DRUG DELIVERY; DRUG DOSAGE; POLYMERS; STABILIZERS (AGENTS); TUMORS; ULTRASONIC APPLICATIONS; ULTRASONIC TRANSMISSION; ULTRASONICS; ULTRASONOGRAPHY;

(PL) PROPERTIES; BIODEGRADABLE BLOCK COPOLYMERS; BREAST CANCER TUMORS; BUBBLE SIZES; COLLAPSE (DRYING); DRUG UPTAKE; ECHOGENIC; ELSEVIER (CO); INTRAVENOUS INJECTIONS; LONG LASTING; MICRO-BUBBLES; MICRO-VASCULATURE; MULTI-FUNCTIONAL NANOPARTICLES; NANO BUBBLE; NANO-DROPLETS; NEW CLASS; PERFLUOROCARBON (PFC); PHASE STATES; PHYSIOLOGICAL TEMPERATURES; POLYMERIC DRUG CARRIERS; ROOM-TEMPERATURE (RT); TARGETED CHEMOTHERAPY; TUMOR CELLS; TUMOR TISSUES; TUMOR VOLUMES; ULTRASOUND (US) IMAGES; ULTRASOUND CONTRAST; VOLUME RATIOS;

ULTRASONIC IMAGING;

DOXORUBICIN; NANOPARTICLE; POLYMER;

ANIMAL; ARTICLE; DRUG DELIVERY SYSTEM; EXPERIMENTAL NEOPLASM; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; INSTRUMENTATION; METHODOLOGY; MICROBUBBLE; MOUSE; NUDE MOUSE; TRANSDUCER; ULTRASOUND THERAPY;

ANIMALS; DOXORUBICIN; DRUG DELIVERY SYSTEMS; FLOW CYTOMETRY; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, NUDE; MICROBUBBLES; MICROSCOPY, FLUORESCENCE; NANOPARTICLES; POLYMERS; TRANSDUCERS; ULTRASONIC THERAPY;

EID: 48149101117     PISSN: 0041624X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ultras.2007.11.002     Document Type: Article

References (31)

1. terHaar G., and Coussios C. Int. J. Hypertherm. 23 2 (2007) 85-87
2. Wilson S.R., Burnes P.N., Muradali D., Wilson J.A., and Lai X. Radiology 215 (2000) 153-161
3. Kedar R.P., Cosgrove D., McCready V.R., Bamber J.C., and Carter E.R. Radiology 198 (1996) 679-686
4. Halpern E.J., Rosenberg M., and Gomella L.G. Radiology 219 (2002) 219-225
5. Bauer A., Becher H., Borges A., Cosgrove D., Leen E., Schlief R., and Tiemann K. Acad. Radiol. 9 (2002) 46-51
6. Lathia J.D., Leodore L., and Wheatley M.A. Ultrasonics 42 (2004) 763-768
7. El-Sherif D.M., and Wheatley M.A. J. Biomed. Mater. Res. 66 (2003) 347-355
8. El-Sherif D.M., Lathia J.D., Le N.T., and Wheatley M.A. J. Biomed. Mater. Res. 68 (2004) 71-78
9. Basude R., and Wheatley M.A. Ultrasonics 39 (2001) 437-444
10. Takalkar A.M., Klibanov A.L., Rychak J.J., Lindner J.R., and Ley K. J. Control. Release 96 (2004) 473-482
11. Rychak J.J., Li B., Acton S.T., Leppanen A., Cummings R.D., Ley K., and Klibanov A.L. Mol. Pharmacol. 3 (2006) 516-524
12. Lankford M., Behm C.Z., Yeh J., Klibanov A.L., Robinson P., and Lindner J.R. Invest. Radiol. 41 (2006) 721-728
13. Rychak J.J., Lindner J.R., Ley K., and Klibanov A.L. J. Control. Release 3 (2006) 288-299
14. Weller G.E., Wong M.K., Modzelewski R.A., Lu E., Klibanov A.L., Wagner W.R., and Villanueva F.S. Cancer Res. 65 (2005) 533-539
15. Klibanov A.L. Bioconjugate Chem. 16 (2005) 9-17
16. J.J. Rychak, A.L. Klibanov, K.F. Ley, J.A. Hossack, Ultrasound Med. Biol. (2007) (Epub ahead of print).
17. Bloch S.H., Dayton P.A., and Ferrara K.W. IEEE Eng. Med. Biol. Mag. 23 (2004) 18-29
18. Dayton P.A., and Ferrara K.W. J. Magn. Reson. Imaging 16 (2002) 362-377
19. Bloch S.H., Short R.E., Ferrara K.W., and Wisner E.R. Ultrasound Med. Biol. 31 (2005) 439-444
20. Zhao S., Borden M., Bloch S.H., Kruse D., Ferrara K.W., and Dayton P.A. Mol. Imaging 3 (2004) 135-148
21. Ungar E.C., Porter T., Culp W., Labell R., Matsunaga T., and Zutshi R. Adv. Drug Deliv. Rev. 56 (2004) 1291-1314
22. Lum A.F.H., Borden M.A., Dayton P.A., Kruse D.E., Simon S.I., and Ferrara K.W. J. Control. Release 111 (2006) 128-134
23. Shortencarier M.J., Dayton P.A., Bloch S.H., Schumann P.A., Matsunaga T.O., and Ferrara K.W. IEEE Trans. Ultrason. Ferroelectr. Freq. Control 51 (2004) 822-831
24. N. Rapoport, Z. Gao, WO 2006/127953 A2 (2006) (priority data 60/683,829 23/05/2005).
25. Rapoport N., Kennedy A., and Gao Z. J. Natl. Cancer Inst. 99 (2007) 1-12
26. Rapoport N., Marin A., and Christensen D. Drug Deliv. Syst. Sci. 2 (2002) 37-46
27. Kripfgans O., Fabiilli M., Carson P., and Fowlkes J. J. Acoust. Soc. Am. 116 (2004) 272-281
28. Kripfgans O., Fowlkes J., Miller D., Eldevik O., and Carson P. Ultrasound Med. Biol. 26 (2000) 1177-1189
29. Hobbs S.K., Monsky W.L., Yuan F., Roberts G., Griffith L., Torchilin V.P., and Jain R. Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. PNAS 95 (1998) 4507-4612
30. Campbell R.B. Tumor physiology and delivery of nanopharmaceuticals. Anti-Cancer Agents Med. Chem. 6 (2006) 503-512
31. Kamaev P., and Rapoport N. Effect of anticancer drug on cell sensitivity to ultrasound in vitro and in vivo. Am. J. Phys. 829 (2006) 543-545