Doxorubicin and paclitaxel loaded microbubbles for ultrasound triggered drug delivery

International Journal of Pharmaceutics

Volumn 414, Issue 1-2, 2011, Pages 161-170

  Cochran, Michael C ^a   Eisenbrey, John ^a   Ouma, Richard O ^a   Soulen, Michael ^b   Wheatley, Margaret A ^a  

^a DREXEL UNIVERSITY   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Microbubble; Nanoparticle; Paclitaxel; Targeted drug delivery; Ultrasound contrast agent

Indexed keywords

DOXORUBICIN; NANOPARTICLE; PACLITAXEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ENCAPSULATION; HUMAN; HUMAN CELL; HYDROPHILICITY; HYDROPHOBICITY; IN VITRO STUDY; MICROBUBBLE; NONHUMAN; PARTICLE SIZE; POROSITY; PRIORITY JOURNAL; RABBIT; SUSTAINED DRUG RELEASE; ULTRASOUND;

ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BREAST NEOPLASMS; CELL SURVIVAL; CONTRAST MEDIA; DOXORUBICIN; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; EXTRAVASATION OF DIAGNOSTIC AND THERAPEUTIC MATERIALS; FEMALE; HUMANS; MICROBUBBLES; NANOPARTICLES; PACLITAXEL; POLYMERS; TUMOR CELLS, CULTURED; ULTRASONICS;

EID: 79959760764     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.05.030     Document Type: Article

References (51)

1. S.H. Bloch, M. Wan, P.M. Dayton, and K.W. Ferrara Optical observations of lipid and polymer-shelled ultrasound microbubble contrast agents Appl. Phys. Lett. 84 2004 631 633
2. A.K. Conlin, and A.D. Seidman Taxanes in breast cancer: an update Curr. Oncol. Rep. 9 2007 22 30 (Pubitemid 46075630)
3. H.F. Dvorak, L.F. Brown, M. Detmar, and A.M. Dvorak Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis Am. J. Pathol. 146 1995 1029 1039
4. J.R. Eisenbrey, P. Huang, J. Hsu, and M.A. Wheatley Ultrasound triggered cell death in vitro with DOXorubicin loaded poly lactic-acid contrast agents Ultrasonics 49 2009 628 633
5. J.R. Eisenbrey, O.M. Burstein, R. Kambhampati, F. Forsberg, J.B. Liu, and M.A. Wheatley Development and optimization of a doxorubicin loaded poly(lactic acid) contrast agent for ultrasound directed drug delivery J. Control. Release 143 2010 38 44
6. J.R. Eisenbrey, M.C. Soulen, and M.A. Wheatley Delivery of encapsulated doxorubicin by ultrasound-mediated size reduction of drug-loaded polymer contrast agents IEEE Trans. Biomed. Eng. 57 2010 24 28
7. D.M. El-Sherif, J.D. Lathia, N.T. Le, and M.A. Wheatley Ultrasound degradation of novel polymer contrast agents J. Biomed. Mater. Res. Part A 68 2004 71 78 (Pubitemid 38030186)
8. D.M. El-Sherif, and M.A. Wheatley Development of a novel method for synthesis of a polymeric ultrasound contrast agent J. Biomed. Mater. Res. Part A 66 2003 347 355 (Pubitemid 37517235)
9. J. Fang, H. Nakamura, and H. Maeda The EPR effect: unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect Adv. Drug Deliv. Rev. 63 2011 136 151
10. K. Ferrara, R. Pollard, and M. Borden Ultrasound microbubble contrast agents: fundamentals and application to gene and drug delivery Annu. Rev. Biomed. Eng. 9 2007 415 447 (Pubitemid 350246663)
11. K.W. Ferrara Driving delivery vehicles with ultrasound Adv. Drug Deliv. Rev. 60 2008 1097 1102
12. K.W. Ferrara, M.A. Borden, and H. Zhang Lipid-shelled vehicles: engineering for ultrasound molecular imaging and drug delivery Acc. Chem. Res. 42 2009 881 892
13. Y. Gan, M.G. Wientjes, J. Lu, and J.L. Au Cytostatic and apoptotic effects of paclitaxel in human breast tumors Cancer Chemother. Pharmacol. 42 1998 177 182 (Pubitemid 28329193)
14. G. Gaucher, R.H. Marchessault, and J.C. Leroux Polyester-based micelles and nanoparticles for the parenteral delivery of taxanes J. Control. Release 143 2010 2 12
15. H. Gelderblom, J. Verweij, K. Nooter, and A. Sparreboom Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation Eur. J. Cancer 37 2001 1590 1598 (Pubitemid 32778603)
16. J.M. Gorce, M. Arditi, and M. Schneider Influence of bubble size distribution on the echogenicity of ultrasound contrast agents: a study of SonoVue Invest. Radiol. 35 2000 661 671
17. M.R. Green, G.M. Manikhas, S. Orlov, B. Afanasyev, A.M. Makhson, P. Bhar, and M.J. Hawkins Abraxane, a novel Cremophor-free, albumin-bound particle form of paclitaxel for the treatment of advanced non-small-cell lung cancer Ann. Oncol. 17 2006 1263 1268 (Pubitemid 44288216)
18. T. Hamaguchi, Y. Matsumura, M. Suzuki, K. Shimizu, R. Goda, I. Nakamura, I. Nakatomi, M. Yokoyama, K. Kataoka, and T. Kakizoe NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumour activity and reduce the neurotoxicity of paclitaxel Br. J. Cancer 92 2005 1240 1246 (Pubitemid 40604398)
19. S.K. Hobbs, W.L. Monsky, F. Yuan, W.G. Roberts, L. Griffith, V.P. Torchilin, and R.K. Jain Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment Proc. Natl. Acad. Sci. U. S. A. 95 1998 4607 4612 (Pubitemid 28207960)
20. N.K. Ibrahim, N. Desai, S. Legha, P. Soon-Shiong, R.L. Theriault, E. Rivera, B. Esmaeli, S.E. Ring, A. Bedikian, G.N. Hortobagyi, and J.A. Ellerhorst Phase I and pharmacokinetic study of ABI-007, a Cremophor-free, protein-stabilized, nanoparticle formulation of paclitaxel Clin. Cancer Res. 8 2002 1038 1044 (Pubitemid 34517637)
21. M. Ishitobi, E. Shin, and N. Kikkawa Metastatic breast cancer with resistance to both anthracycline and docetaxel successfully treated with weekly paclitaxel Int. J. Clin. Oncol. 6 2001 55 58 (Pubitemid 32230365)
22. A. Jemal, R. Siegel, E. Ward, Y. Hao, J. Xu, T. Murray, and M.J. Thun Cancer statistics, 2008 CA Cancer J. Clin. 58 2008 71 96 (Pubitemid 351521864)
23. B.K. Kang, S.K. Chon, S.H. Kim, S.Y. Jeong, M.S. Kim, S.H. Cho, H.B. Lee, and G. Khang Controlled release of paclitaxel from microemulsion containing PLGA and evaluation of anti-tumor activity in vitro and in vivo Int. J. Pharm. 286 2004 147 156 (Pubitemid 39410482)
24. A.L. Klibanov, T.I. Shevchenko, B.I. Raju, R. Seip, and C.T. Chin Ultrasound-triggered release of materials entrapped in microbubble-liposome constructs: a tool for targeted drug delivery J. Control. Release 148 2010 13 17
25. G. Kong, R.D. Braun, and M.W. Dewhirst Hyperthermia enables tumor-specific nanoparticle delivery: effect of particle size Cancer Res. 60 2000 4440 4445 (Pubitemid 32103623)
26. J. Kost, K. Leong, and R. Langer Ultrasound-enhanced polymer degradation and release of incorporated substances Proc. Natl. Acad. Sci. U. S. A. 86 1989 7663 7666
27. W.M. Kuijpers, P.D. Iedema, M.F. Kemmere, and T.J. Keurentjes The mechanism of cavitation-induced polymer scission; experimental and computational verification Polymer 45 2004 6461 6467 (Pubitemid 39172108)
28. I. Lentacker, B. Geers, J. Demeester, S.C. De Smedt, and N.N. Sanders Design and evaluation of doxorubicin-containing microbubbles for ultrasound triggered doxorubicin delivery: cytotoxicicty and mechanisms involved Mol. Ther. 18 2010 101 108
29. C. Li, and S. Wallace Polymer-drug conjugates: recent development in clinical oncology Adv. Drug Deliv. Rev. 60 2008 886 898
30. R.T. Liggins, W.L. Hunter, and H.M. Burt Solid-state characterization of paclitaxel J. Pharm. Sci. 86 1997 1458 1463 (Pubitemid 28018330)
31. A.F. Lum, M.A. Borden, P.A. Dayton, D.E. Kruse, S.I. Simon, and K.W. Ferrara Ultrasound radiation force enables targeted deposition of model drug carriers loaded on microbubbles J. Control. Release 111 2006 128 134 (Pubitemid 43290001)
32. H. Maeda, J. Wu, T. Sawa, Y. Matsumura, and K. Hori Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review J. Control. Release 65 2000 271 284 (Pubitemid 30122932)
33. B.D. Meijering, L.J. Juffermans, A. van Wamel, R.H. Henning, I.S. Zuhorn, M. Emmer, A.M. Versteilen, W.J. Paulus, W.H. van Gilst, K. Kooiman, N. de Jong, R.J. Musters, L.E. Deelman, and O. Kamp Ultrasound and microbubble-targeted delivery of macromolecules is regulated by induction of endocytosis and pore formation Circ. Res. 104 2009 679 687
34. E. Miele, G.P. Spinelli, F. Tomao, and S. Tomao Albumin-bound formulation of paclitaxel (Abraxane ABI-007) in the treatment of breast cancer Int. J. Nanomed. 4 2009 99 105
35. N.J. Millenbaugh, Y. Gan, and J.L. Au Cytostatic and apoptotic effects of paclitaxel in human ovarian tumors Pharm. Res. 15 1998 122 127 (Pubitemid 28080878)
36. L. Mu, and S.S. Feng A novel controlled release formulation for the anticancer drug paclitaxel (Taxol): PLGA nanoparticles containing vitamin E TPGS J. Control. Release 86 2003 33 48 (Pubitemid 35469120)
37. Y. Patil, T. Sadhukha, L. Ma, and J. Panyam Nanoparticle-mediated simultaneous and targeted delivery of paclitaxel and tariquidar overcomes tumor drug resistance J. Control. Release 136 2009 21 29
38. J. Panyam, and V. Labhasetwar Biodegradable nanoparticles for drug and gene delivery to cells and tissue Adv. Drug Deliv. Rev. 55 2003 329 347 (Pubitemid 36297053)
39. R.J. Price, D.M. Skyba, S. Kaul, and T.C. Skalak Delivery of colloidal particles and red blood cells to tissue through microvessel ruptures created by targeted microbubble destruction with ultrasound Circulation 98 1998 1264 1267 (Pubitemid 28443388)
40. M.D. Rosenblum, and R.R. Shivers 'Rings' of F-actin form around the nucleus in cultured human MCF7 adenocarcinoma cells upon exposure to both taxol and taxotere Comp. Biochem. Physiol. C Toxicol. Pharmacol. 125 2000 121 131 (Pubitemid 30204591)
41. E.K. Rowinsky, and R.C. Donehower Paclitaxel (taxol) N. Engl. J. Med. 332 1995 1004 1014
42. S.S. Shah, Y. Cha, and C.G. Pitt Poly(glycolic acid-co-dl-lactic acid): diffusion or degradation controlled drug delivery? J. Control. Release 18 1992 261 270
43. A.K. Singla, A. Garg, and D. Aggarwal Paclitaxel and its formulations Int. J. Pharm. 235 2002 179 192 (Pubitemid 34185449)
44. M.S. Tartis, J. McCallan, A.F. Lum, R. LaBell, S.M. Stieger, T.O. Matsunaga, and K.W. Ferrara Therapeutic effects of paclitaxel-containing ultrasound contrast agents Ultrasound Med. Biol. 32 2006 1771 1780 (Pubitemid 44716573)
45. J.T. Thigpen, J.A. Blessing, H. Ball, S.J. Hummel, and R.J. Barrett Phase II trial of paclitaxel in patients with progressive ovarian carcinoma after platinum-based chemotherapy: a Gynecologic Oncology Group study J. Clin. Oncol. 12 1994 1748 1753 (Pubitemid 24349373)
46. A. van Wamel, A. Bouakaz, M. Versluis, and N. de Jong Micromanipulation of endothelial cells: ultrasound-microbubble-cell interaction Ultrasound Med. Biol. 30 2004 1255 1258 (Pubitemid 39531632)
47. A. van Wamel, K. Kooiman, M. Harteveld, M. Emmer, F.J. ten Cate, M. Versluis, and N. de Jong Vibrating microbubbles poking individual cells: drug transfer into cells via sonoporation J. Control. Release 112 2006 149 155
48. R.B. Weiss, R.C. Donehower, P.H. Wiernik, T. Ohnuma, R.J. Gralla, D.L. Trump, J.R. Baker Jr.; D.A. Van Echo, D.D. Von Hoff, and B. Leyland-Jones Hypersensitivity reactions from taxol J. Clin. Oncol. 8 1990 1263 1268 (Pubitemid 20195638)
49. J. Xie, and C.H. Wang Self-assembled biodegradable nanoparticles developed by direct dialysis for the delivery of paclitaxel Pharm. Res. 22 2005 2079 2090 (Pubitemid 41821587)
50. T.K. Yeung, C. Germond, X. Chen, and Z. Wang The mode of action of taxol: apoptosis at low concentration and necrosis at high concentration Biochem. Biophys. Res. Commun. 263 1999 398 404 (Pubitemid 29467208)
51. Z. Zhang, S.H. Lee, C.W. Gan, and S.S. Feng In vitro and in vivo investigation on PLA-TPGS nanoparticles for controlled and sustained small molecule chemotherapy Pharm. Res. 25 2008 1925 1935