Polymerase incorporation of a 2′-deoxynucleoside-5′-triphosphate bearing a 4-hydroxy-2-mercaptobenzimidazole nucleobase analogue

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 15, 2015, Pages 2888-2891

  Morihiro, Kunihiko ^a,b   Hoshino, Hidekazu ^b   Hasegawa, Osamu ^b   Kasahara, Yuuya ^a,b   Nakajima, Kohsuke ^c   Kuwahara, Masayasu ^c   Tsunoda, Shin Ichi ^a   Obika, Satoshi ^a,b  

^a NATIONAL INSTITUTE OF BIOMEDICAL INNOVATION   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c GUNMA UNIVERSITY   (Japan)

Author keywords

5 Triphosphates; DNA polymerases; Glycosidic conformation; Nucleobase modification; Primer extension

Indexed keywords

4 HYDROXY 2 MERCAPTOBENZIMIDAZOLE DERIVATIVE; BENZIMIDAZOLE DERIVATIVE; DNA POLYMERASE; NUCLEIC ACID BASE; NUCLEOTIDE; OLIGONUCLEOTIDE; UNCLASSIFIED DRUG; 2-MERCAPTOBENZIMIDAZOLE; ADENINE; DNA DIRECTED DNA POLYMERASE; POLYPHOSPHATE; PRIMER DNA; TRIPHOSPHORIC ACID;

ARTICLE; BIOTECHNOLOGY; DNA TEMPLATE; DRUG SCREENING; DRUG SYNTHESIS; ION EXCHANGE CHROMATOGRAPHY; POLYMERIZATION; BASE PAIRING; CHEMISTRY; METABOLISM; NUCLEOTIDE SEQUENCE;

ADENINE; BASE PAIRING; BASE SEQUENCE; BENZIMIDAZOLES; DNA PRIMERS; DNA-DIRECTED DNA POLYMERASE; NUCLEOTIDES; OLIGONUCLEOTIDES; POLYMERIZATION; POLYPHOSPHATES;

EID: 84930927179     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.05.075     Document Type: Article

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