Generation of high-affinity DNA aptamers using an expanded genetic alphabet

Nature Biotechnology

Volumn 31, Issue 5, 2013, Pages 453-457

  Kimoto, Michiko ^a,b   Yamashige, Rie ^a   Matsunaga, Ken Ichiro ^a   Yokoyama, Shigeyuki ^a   Hirao, Ichiro ^a,b  

^a RIKEN   (Japan)

^b TagCyx Biotechnologies   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING AFFINITIES; DNA MOLECULES; FUNCTIONAL NUCLEIC ACIDS; NATURAL BASIS; RANDOM SEQUENCE; STRUCTURAL DIVERSITY; TARGET PROTEINS; VASCULAR ENDOTHELIAL CELL GROWTHS;

BINDING ENERGY; NUCLEOTIDES; PROTEINS;

DNA;

ADENINE; APTAMER; CYTOSINE; DNA APTAMER; DNA FRAGMENT; GAMMA INTERFERON; GUANINE; IMIDAZO[4,5 B]PYRIDINE DERIVATIVE; PYRROLE DERIVATIVE; SINGLE STRANDED DNA; THYMINE; UNCLASSIFIED DRUG; VASCULOTROPIN 165;

ARTICLE; BINDING AFFINITY; DNA LIBRARY; GENETIC VARIABILITY; HYDROPHOBICITY; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN SECONDARY STRUCTURE; SURFACE PLASMON RESONANCE;

APTAMERS, NUCLEOTIDE; BINDING SITES; GENE LIBRARY;

EID: 84877338254     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.2556     Document Type: Article

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