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Volumn 77, Issue 2, 2010, Pages 218-227

A comparison of the roles of peroxisome proliferator-activated receptor and retinoic acid receptor on CYP26 regulation

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; CYTOCHROME P450; CYTOCHROME P450 26A1; CYTOCHROME P450 26B1; ISOENZYME; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PIOGLITAZONE; RETINOIC ACID; RETINOIC ACID RECEPTOR; RETINOIC ACID RECEPTOR ALPHA; RETINOIC ACID RECEPTOR BETA; RETINOIC ACID RECEPTOR GAMMA; ROSIGLITAZONE; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

EID: 74549158430     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.109.059071     Document Type: Article
Times cited : (40)

References (46)
  • 1
    • 0035862977 scopus 로고    scopus 로고
    • Abu-Abed S, Dollé P, Metzger D, Beckett B, Chambon P, and PetkovichM (2001) The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures. Genes Dev 15:226-240.
    • Abu-Abed S, Dollé P, Metzger D, Beckett B, Chambon P, and PetkovichM (2001) The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures. Genes Dev 15:226-240.
  • 2
    • 0035659816 scopus 로고    scopus 로고
    • Differential expression of the retinoic acid-metabolizing enzymes CYP26A1 and CYP26B1 during murine organogenesis
    • Abu-Abed S, MacLean G, Fraulob V, Chambon P, Petkovich M, and Dollé P (2002) Differential expression of the retinoic acid-metabolizing enzymes CYP26A1 and CYP26B1 during murine organogenesis. Mech Dev 110:173-177.
    • (2002) Mech Dev , vol.110 , pp. 173-177
    • Abu-Abed, S.1    MacLean, G.2    Fraulob, V.3    Chambon, P.4    Petkovich, M.5    Dollé, P.6
  • 3
    • 0031916848 scopus 로고    scopus 로고
    • Mouse P450RAI (CYP26) expression and retinoic acidinducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor gamma and retinoid X receptor alpha
    • Abu-Abed SS, Beckett BR, Chiba H, Chithalen JV, Jones G, Metzger D, Chambon P, and Petkovich M (1998) Mouse P450RAI (CYP26) expression and retinoic acidinducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor gamma and retinoid X receptor alpha. J Biol Chem 273:2409-2415.
    • (1998) J Biol Chem , vol.273 , pp. 2409-2415
    • Abu-Abed, S.S.1    Beckett, B.R.2    Chiba, H.3    Chithalen, J.V.4    Jones, G.5    Metzger, D.6    Chambon, P.7    Petkovich, M.8
  • 5
    • 33745387612 scopus 로고    scopus 로고
    • Overview of retinoid metabolism and function
    • Blomhoff R and Blomhoff HK (2006) Overview of retinoid metabolism and function. J Neurobiol 66:606-630.
    • (2006) J Neurobiol , vol.66 , pp. 606-630
    • Blomhoff, R.1    Blomhoff, H.K.2
  • 6
    • 0036029643 scopus 로고    scopus 로고
    • The role of vitamin A in mammalian reproduction and embryonic development
    • Clagett-Dame M and DeLuca HF (2002) The role of vitamin A in mammalian reproduction and embryonic development. Annu Rev Nutr 22:347-381.
    • (2002) Annu Rev Nutr , vol.22 , pp. 347-381
    • Clagett-Dame, M.1    DeLuca, H.F.2
  • 7
    • 0024404265 scopus 로고
    • Differential expression and ligand regulation of the retinoic acid receptor alpha and beta genes
    • de The H, Marchio A, Tiollais P, and Dejean A (1989) Differential expression and ligand regulation of the retinoic acid receptor alpha and beta genes. EMBO J 8:429-433.
    • (1989) EMBO J , vol.8 , pp. 429-433
    • de The, H.1    Marchio, A.2    Tiollais, P.3    Dejean, A.4
  • 9
    • 51549116267 scopus 로고    scopus 로고
    • Retinoic acid synthesis and signaling during early organogenesis
    • Duester G (2008) Retinoic acid synthesis and signaling during early organogenesis. Cell 134:921-931.
    • (2008) Cell , vol.134 , pp. 921-931
    • Duester, G.1
  • 10
    • 33751573877 scopus 로고    scopus 로고
    • ADME transcriptome in Hispanic versus White donor livers: Evidence of a globally enhanced NR1I3 (CAR, constitutive androstane receptor) gene signature in Hispanics
    • Finkelstein D, Lamba V, Assem M, Rengelshausen J, Yasuda K, Strom S, and Schuetz E (2006) ADME transcriptome in Hispanic versus White donor livers: evidence of a globally enhanced NR1I3 (CAR, constitutive androstane receptor) gene signature in Hispanics. Xenobiotica 36:989-1012.
    • (2006) Xenobiotica , vol.36 , pp. 989-1012
    • Finkelstein, D.1    Lamba, V.2    Assem, M.3    Rengelshausen, J.4    Yasuda, K.5    Strom, S.6    Schuetz, E.7
  • 11
    • 33846023037 scopus 로고    scopus 로고
    • Regulation of expression of the retinoic acid metabolizing enzyme CYP26A1 in uteri of ovariectomized mice after treatment with ovarian steroid hormones
    • Fritzsche B, Vermot J, Neumann U, Schmidt A, Schweigert FJ, Dollé P, and Rühl R (2007) Regulation of expression of the retinoic acid metabolizing enzyme CYP26A1 in uteri of ovariectomized mice after treatment with ovarian steroid hormones. Mol Reprod Dev 74:258-264.
    • (2007) Mol Reprod Dev , vol.74 , pp. 258-264
    • Fritzsche, B.1    Vermot, J.2    Neumann, U.3    Schmidt, A.4    Schweigert, F.J.5    Dollé, P.6    Rühl, R.7
  • 13
    • 33846545127 scopus 로고    scopus 로고
    • Cyp26 enzymes generate the retinoic acid response pattern necessary for hindbrain development
    • Hernandez RE, Putzke AP, Myers JP, Margaretha L, and Moens CB (2007) Cyp26 enzymes generate the retinoic acid response pattern necessary for hindbrain development. Development 134:177-187.
    • (2007) Development , vol.134 , pp. 177-187
    • Hernandez, R.E.1    Putzke, A.P.2    Myers, J.P.3    Margaretha, L.4    Moens, C.B.5
  • 14
    • 19344361824 scopus 로고    scopus 로고
    • Regulation of CYP26A1 expression by selective RAR and RXR agonists in human NB4 promyelocytic leukemia cells
    • Idres N, Marill J, and Chabot GG (2005) Regulation of CYP26A1 expression by selective RAR and RXR agonists in human NB4 promyelocytic leukemia cells. Biochem Pharmacol 69:1595-1601.
    • (2005) Biochem Pharmacol , vol.69 , pp. 1595-1601
    • Idres, N.1    Marill, J.2    Chabot, G.G.3
  • 15
    • 0038418393 scopus 로고    scopus 로고
    • Regulation of retinoic acid receptor beta expression by peroxisome proliferator-activated receptor gamma ligands in cancer cells
    • James SY, Lin F, Kolluri SK, Dawson MI, and Zhang XK (2003) Regulation of retinoic acid receptor beta expression by peroxisome proliferator-activated receptor gamma ligands in cancer cells. Cancer Res 63:3531-3538.
    • (2003) Cancer Res , vol.63 , pp. 3531-3538
    • James, S.Y.1    Lin, F.2    Kolluri, S.K.3    Dawson, M.I.4    Zhang, X.K.5
  • 17
    • 0035029849 scopus 로고    scopus 로고
    • Effects of receptor-selective retinoids on CYP26 gene expression and metabolism of all-trans-retinoic acid in intestinal cells
    • Lampen A, Meyer S, and Nau H (2001a) Effects of receptor-selective retinoids on CYP26 gene expression and metabolism of all-trans-retinoic acid in intestinal cells. Drug Metab Dispos 29:742-747.
    • (2001) Drug Metab Dispos , vol.29 , pp. 742-747
    • Lampen, A.1    Meyer, S.2    Nau, H.3
  • 18
    • 0035980221 scopus 로고    scopus 로고
    • Phytanic acid and docosahexaenoic acid increase the metabolism of all-trans-retinoic acid and CYP26 gene expression in intestinal cells
    • Lampen A, Meyer S, and Nau H (2001b) Phytanic acid and docosahexaenoic acid increase the metabolism of all-trans-retinoic acid and CYP26 gene expression in intestinal cells. Biochim Biophys Acta 1521:97-106.
    • (2001) Biochim Biophys Acta , vol.1521 , pp. 97-106
    • Lampen, A.1    Meyer, S.2    Nau, H.3
  • 19
    • 10044267434 scopus 로고    scopus 로고
    • Activation of retinoic acid receptor-dependent transcription by organochlorine pesticides
    • Lemaire G, Balaguer P, Michel S, and Rahmani R (2005) Activation of retinoic acid receptor-dependent transcription by organochlorine pesticides. Toxicol Appl Pharmacol 202:38-49.
    • (2005) Toxicol Appl Pharmacol , vol.202 , pp. 38-49
    • Lemaire, G.1    Balaguer, P.2    Michel, S.3    Rahmani, R.4
  • 20
    • 0033743405 scopus 로고    scopus 로고
    • Cytochrome P450RAI(CYP26) promoter: A distinct composite retinoic acid response element underlies the complex regulation of retinoic acid metabolism
    • Loudig O, Babichuk C, White J, Abu-Abed S, Mueller C, and Petkovich M (2000) Cytochrome P450RAI(CYP26) promoter: a distinct composite retinoic acid response element underlies the complex regulation of retinoic acid metabolism. Mol Endocrinol 14:1483-1497.
    • (2000) Mol Endocrinol , vol.14 , pp. 1483-1497
    • Loudig, O.1    Babichuk, C.2    White, J.3    Abu-Abed, S.4    Mueller, C.5    Petkovich, M.6
  • 21
    • 28044448712 scopus 로고    scopus 로고
    • Transcriptional co-operativity between distant retinoic acid response elements in regulation of Cyp26A1 inducibility
    • Loudig O, Maclean GA, Dore NL, Luu L, and Petkovich M (2005) Transcriptional co-operativity between distant retinoic acid response elements in regulation of Cyp26A1 inducibility. Biochem J 392:241-248.
    • (2005) Biochem J , vol.392 , pp. 241-248
    • Loudig, O.1    Maclean, G.A.2    Dore, N.L.3    Luu, L.4    Petkovich, M.5
  • 24
    • 0034886924 scopus 로고    scopus 로고
    • Cloning of a novel retinoic-acid metabolizing cytochrome P450, Cyp26B1, and comparative expression analysis with Cyp26A1 during early murine development
    • MacLean G, Abu-Abed S, Dollé P, Tahayato A, Chambon P, and Petkovich M (2001) Cloning of a novel retinoic-acid metabolizing cytochrome P450, Cyp26B1, and comparative expression analysis with Cyp26A1 during early murine development. Mech Dev 107:195-201.
    • (2001) Mech Dev , vol.107 , pp. 195-201
    • MacLean, G.1    Abu-Abed, S.2    Dollé, P.3    Tahayato, A.4    Chambon, P.5    Petkovich, M.6
  • 25
    • 0028950218 scopus 로고
    • Separation of transactivation and AP1 antagonism functions of retinoic acid receptor alpha
    • Nagpal S, Athanikar J, and Chandraratna RA (1995) Separation of transactivation and AP1 antagonism functions of retinoic acid receptor alpha. J Biol Chem 270:923-927.
    • (1995) J Biol Chem , vol.270 , pp. 923-927
    • Nagpal, S.1    Athanikar, J.2    Chandraratna, R.A.3
  • 26
    • 0032831815 scopus 로고    scopus 로고
    • Interactions of retinoid binding proteins and enzymes in retinoid metabolism
    • Napoli JL (1999) Interactions of retinoid binding proteins and enzymes in retinoid metabolism. Biochim Biophys Acta 1440:139-162.
    • (1999) Biochim Biophys Acta , vol.1440 , pp. 139-162
    • Napoli, J.L.1
  • 27
    • 26944460025 scopus 로고    scopus 로고
    • Regulation of a highly specific retinoic acid-4-hydroxylase (CYP26A1) enzyme and all-trans-retinoic acid metabolism in human intestinal, liver, endothelial, and acute promyelocytic leukemia cells
    • Ozpolat B, Mehta K, and Lopez-Berestein G (2005) Regulation of a highly specific retinoic acid-4-hydroxylase (CYP26A1) enzyme and all-trans-retinoic acid metabolism in human intestinal, liver, endothelial, and acute promyelocytic leukemia cells. Leuk Lymphoma 46:1497-1506.
    • (2005) Leuk Lymphoma , vol.46 , pp. 1497-1506
    • Ozpolat, B.1    Mehta, K.2    Lopez-Berestein, G.3
  • 28
    • 0036240012 scopus 로고    scopus 로고
    • all-trans-Retinoic acid-induced expression and regulation of retinoic acid 4-hydroxylase (CYP26) in human promyelocytic leukemia
    • Ozpolat B, Mehta K, Tari AM, and Lopez-Berestein G (2002) all-trans-Retinoic acid-induced expression and regulation of retinoic acid 4-hydroxylase (CYP26) in human promyelocytic leukemia. Am J Hematol 70:39-47.
    • (2002) Am J Hematol , vol.70 , pp. 39-47
    • Ozpolat, B.1    Mehta, K.2    Tari, A.M.3    Lopez-Berestein, G.4
  • 29
    • 33644767914 scopus 로고    scopus 로고
    • RAR-mediated epigenetic control of the cytochrome P450 Cyp26a1 in embryocarcinoma cells
    • Pozzi S, Rossetti S, Bistulfi G, and Sacchi N (2006) RAR-mediated epigenetic control of the cytochrome P450 Cyp26a1 in embryocarcinoma cells. Oncogene 25:1400-1407.
    • (2006) Oncogene , vol.25 , pp. 1400-1407
    • Pozzi, S.1    Rossetti, S.2    Bistulfi, G.3    Sacchi, N.4
  • 30
    • 0030810985 scopus 로고    scopus 로고
    • CYP26, a novel mammalian cytochrome P450, is induced by retinoic acid and defines a new family
    • Ray WJ, Bain G, Yao M, and Gottlieb DI (1997) CYP26, a novel mammalian cytochrome P450, is induced by retinoic acid and defines a new family. J Biol Chem 272:18702-18708.
    • (1997) J Biol Chem , vol.272 , pp. 18702-18708
    • Ray, W.J.1    Bain, G.2    Yao, M.3    Gottlieb, D.I.4
  • 31
    • 3042562178 scopus 로고    scopus 로고
    • Generating gradients of retinoic acid in the chick embryo: Cyp26C1 expression and a comparative analysis of the Cyp26 enzymes
    • Reijntjes S, Gale E, and Maden M (2004) Generating gradients of retinoic acid in the chick embryo: Cyp26C1 expression and a comparative analysis of the Cyp26 enzymes. Dev Dyn 230:509-517.
    • (2004) Dev Dyn , vol.230 , pp. 509-517
    • Reijntjes, S.1    Gale, E.2    Maden, M.3
  • 32
    • 0037229271 scopus 로고    scopus 로고
    • Retinoid production and catabolism: Role of diet in regulating retinol esterification and retinoic Acid oxidation
    • Ross AC (2003) Retinoid production and catabolism: role of diet in regulating retinol esterification and retinoic Acid oxidation. J Nutr 133:291S-296S.
    • (2003) J Nutr , vol.133
    • Ross, A.C.1
  • 33
    • 0035862976 scopus 로고    scopus 로고
    • The retinoic acid-inactivating enzyme CYP26 is essential for establishing an uneven distribution of retinoic acid along the anterio-posterior axis within the mouse embryo
    • Sakai Y, Meno C, Fujii H, Nishino J, Shiratori H, Saijoh Y, Rossant J, and Hamada H (2001) The retinoic acid-inactivating enzyme CYP26 is essential for establishing an uneven distribution of retinoic acid along the anterio-posterior axis within the mouse embryo. Genes Dev 15:213-225.
    • (2001) Genes Dev , vol.15 , pp. 213-225
    • Sakai, Y.1    Meno, C.2    Fujii, H.3    Nishino, J.4    Shiratori, H.5    Saijoh, Y.6    Rossant, J.7    Hamada, H.8
  • 34
    • 34249087361 scopus 로고    scopus 로고
    • Opposing effects of retinoic acid on cell growth result from alternate activation of two different nuclear receptors
    • Schug TT, Berry DC, Shaw NS, Travis SN, and Noy N (2007) Opposing effects of retinoic acid on cell growth result from alternate activation of two different nuclear receptors. Cell 129:723-733.
    • (2007) Cell , vol.129 , pp. 723-733
    • Schug, T.T.1    Berry, D.C.2    Shaw, N.S.3    Travis, S.N.4    Noy, N.5
  • 35
    • 0142149220 scopus 로고    scopus 로고
    • Retinoic acid is a high affinity selective ligand for the peroxisome proliferator-activated receptor beta/delta
    • Shaw N, Elholm M, and Noy N (2003) Retinoic acid is a high affinity selective ligand for the peroxisome proliferator-activated receptor beta/delta. J Biol Chem 278: 41589-41592.
    • (2003) J Biol Chem , vol.278 , pp. 41589-41592
    • Shaw, N.1    Elholm, M.2    Noy, N.3
  • 36
    • 33747880635 scopus 로고    scopus 로고
    • Up-regulation of CYP26A1 in adenomatous polyposis colideficient vertebrates via a WNT-dependent mechanism: Implications for intestinal cell differentiation and colon tumor development
    • Shelton DN, Sandoval IT, Eisinger A, Chidester S, Ratnayake A, Ireland CM, and Jones DA (2006) Up-regulation of CYP26A1 in adenomatous polyposis colideficient vertebrates via a WNT-dependent mechanism: implications for intestinal cell differentiation and colon tumor development. Cancer Res 66:7571-7577.
    • (2006) Cancer Res , vol.66 , pp. 7571-7577
    • Shelton, D.N.1    Sandoval, I.T.2    Eisinger, A.3    Chidester, S.4    Ratnayake, A.5    Ireland, C.M.6    Jones, D.A.7
  • 37
    • 0347683479 scopus 로고    scopus 로고
    • A novel human cytochrome P450, CYP26C1, involved in metabolism of 9-cis and all-trans isomers of retinoic acid
    • Taimi M, Helvig C, Wisniewski J, Ramshaw H, White J, Amad M, Korczak B, and Petkovich M (2004) A novel human cytochrome P450, CYP26C1, involved in metabolism of 9-cis and all-trans isomers of retinoic acid. J Biol Chem 279:77-85.
    • (2004) J Biol Chem , vol.279 , pp. 77-85
    • Taimi, M.1    Helvig, C.2    Wisniewski, J.3    Ramshaw, H.4    White, J.5    Amad, M.6    Korczak, B.7    Petkovich, M.8
  • 38
    • 33846858891 scopus 로고    scopus 로고
    • CYP26A1 and CYP26C1 cooperatively regulate anterior-posterior patterning of the developing brain and the production of migratory cranial neural crest cells in the mouse
    • Uehara M, Yashiro K, Mamiya S, Nishino J, Chambon P, Dolle P, and Sakai Y (2007) CYP26A1 and CYP26C1 cooperatively regulate anterior-posterior patterning of the developing brain and the production of migratory cranial neural crest cells in the mouse. Dev Biol 302:399-411.
    • (2007) Dev Biol , vol.302 , pp. 399-411
    • Uehara, M.1    Yashiro, K.2    Mamiya, S.3    Nishino, J.4    Chambon, P.5    Dolle, P.6    Sakai, Y.7
  • 39
    • 0037095625 scopus 로고    scopus 로고
    • Cloning of rat cytochrome P450RAI (CYP26) cDNA and regulation of its gene expression by all-trans-retinoic acid in vivo
    • Wang Y, Zolfaghari R, and Ross AC (2002) Cloning of rat cytochrome P450RAI (CYP26) cDNA and regulation of its gene expression by all-trans-retinoic acid in vivo. Arch Biochem Biophys 401:235-243.
    • (2002) Arch Biochem Biophys , vol.401 , pp. 235-243
    • Wang, Y.1    Zolfaghari, R.2    Ross, A.C.3
  • 40
    • 0030746211 scopus 로고    scopus 로고
    • cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450
    • White JA, Beckett-Jones B, Guo YD, Dilworth FJ, Bonasoro J, Jones G, and Petkovich M (1997) cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450. J Biol Chem272:18538-18541.
    • (1997) J Biol Chem , vol.272 , pp. 18538-18541
    • White, J.A.1    Beckett-Jones, B.2    Guo, Y.D.3    Dilworth, F.J.4    Bonasoro, J.5    Jones, G.6    Petkovich, M.7
  • 41
    • 0034612252 scopus 로고    scopus 로고
    • Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism
    • White JA, Ramshaw H, Taimi M, StangleW, Zhang A, Everingham S, Creighton S, Tam SP, Jones G, and Petkovich M (2000) Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism. Proc Natl Acad Sci U S A 97:6403-6408.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 6403-6408
    • White, J.A.1    Ramshaw, H.2    Taimi, M.3    Stangle, W.4    Zhang, A.5    Everingham, S.6    Creighton, S.7    Tam, S.P.8    Jones, G.9    Petkovich, M.10
  • 42
    • 46749092864 scopus 로고    scopus 로고
    • Expression of RALDHs (ALDH1As) and CYP26s in human tissues and during the neural differentiation of P19 embryonal carcinoma stem cell
    • Xi J and Yang Z (2008) Expression of RALDHs (ALDH1As) and CYP26s in human tissues and during the neural differentiation of P19 embryonal carcinoma stem cell. Gene Expr Patterns 8:438-442.
    • (2008) Gene Expr Patterns , vol.8 , pp. 438-442
    • Xi, J.1    Yang, Z.2
  • 43
    • 0033815009 scopus 로고    scopus 로고
    • Regulation of CYP26 (cytochrome P450RAI) mRNA expression and retinoic acid metabolism by retinoids and dietary vitamin A in liver of mice and rats
    • Yamamoto Y, Zolfaghari R, and Ross AC (2000) Regulation of CYP26 (cytochrome P450RAI) mRNA expression and retinoic acid metabolism by retinoids and dietary vitamin A in liver of mice and rats. Faseb J 14:2119-2127.
    • (2000) Faseb J , vol.14 , pp. 2119-2127
    • Yamamoto, Y.1    Zolfaghari, R.2    Ross, A.C.3
  • 44
    • 1642287727 scopus 로고    scopus 로고
    • Regulation of retinoic acid distribution is required for proximodistal patterning and outgrowth of the developing mouse limb
    • Yashiro K, Zhao X, Uehara M, Yamashita K, NishijimaM, Nishino J, Saijoh Y, Sakai Y, and Hamada H (2004) Regulation of retinoic acid distribution is required for proximodistal patterning and outgrowth of the developing mouse limb. Dev Cell 6:411-422.
    • (2004) Dev Cell , vol.6 , pp. 411-422
    • Yashiro, K.1    Zhao, X.2    Uehara, M.3    Yamashita, K.4    Nishijima, M.5    Nishino, J.6    Saijoh, Y.7    Sakai, Y.8    Hamada, H.9
  • 45
    • 0024381154 scopus 로고
    • Cloning of murine alpha and beta retinoic acid receptors and a novel receptor gamma predominantly expressed in skin
    • Zelent A, Krust A, Petkovich M, Kastner P, and Chambon P (1989) Cloning of murine alpha and beta retinoic acid receptors and a novel receptor gamma predominantly expressed in skin. Nature 339:714-717.
    • (1989) Nature , vol.339 , pp. 714-717
    • Zelent, A.1    Krust, A.2    Petkovich, M.3    Kastner, P.4    Chambon, P.5
  • 46


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