Decrease of intracellular pH as possible mechanism of embryotoxicity of glycol ether alkoxyacetic acid metabolites

Toxicology and Applied Pharmacology

Volumn 245, Issue 2, 2010, Pages 236-243

  Louisse, Jochem ^a,b   Bai, Yanqing ^a   Verwei, Miriam ^a,b   van de Sandt, Johannes J M ^a,b   Blaauboer, Bas J ^c   Rietjens, Ivonne M C M ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b TNO   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

BALB c 3T3 cells; Embryonic stem cells; Embryotoxicity; Glycol ethers; Intracellular pH; Mechanism

Indexed keywords

ACETAZOLAMIDE; ACETIC ACID DERIVATIVE; ALKOXYACETIC ACID GLYCOL ETHER DERIVATIVE; AMILORIDE; BUTOXYACETIC ACID; ETHOXYACETIC ACID; FLUOROURACIL; METHOXYACETIC ACID; PHENOXYACETIC ACID; RETINOIC ACID; UNCLASSIFIED DRUG; VALPROIC ACID;

ACIDIFICATION; ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CELL DIFFERENTIATION; CELL PH; CELL STRAIN 3T3; CONTROLLED STUDY; EMBRYONIC STEM CELL; EMBRYOTOXICITY; METABOLITE; MOUSE; NONHUMAN; PH MEASUREMENT;

ACETAZOLAMIDE; ACETIC ACIDS; ANIMALS; BALB 3T3 CELLS; CELL DIFFERENTIATION; EMBRYO, MAMMALIAN; EMBRYONIC STEM CELLS; ETHYLENE GLYCOLS; GLYCOLATES; HYDROGEN-ION CONCENTRATION; INTRACELLULAR FLUID; MICE; TERATOGENS; VALPROIC ACID;

EID: 77952891094     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.03.005     Document Type: Article

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