Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 5, 2015, Pages 1577-1582

  Ketscher, Lars ^a   Hannß, Ronny ^b,c   Moralese, David J ^d   Basters, Anja ^a   Guerra, Susana ^e   Goldmann, Tobias ^a   Hausmann, Annika ^a   Prinz, Marco ^a   Naumann, Ronald ^f   Pekosz, Andrew ^g   Utermöhlen, Olaf ^h   Lenschow, Deborah J ^d   Knobeloch, Klaus Peter ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c FREIE UNIVERSITÄT BERLIN   (Germany)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^f MAX PLANCK INSTITUTE OF MOLECULAR CELL BIOLOGY AND GENETICS   (Germany)

^g JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^h UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Interferonubiquitin; ISG15; Isopeptidaseinfluenza; UBP43

Indexed keywords

BETA INTERFERON; ISG15 PROTEIN; PROTEIN; PROTEINASE; STAT1 PROTEIN; UNCLASSIFIED DRUG; USP18 ISOPEPTIDASE; ANTIVIRUS AGENT; CYTOKINE; G1P2 PROTEIN, MOUSE; UBIQUITIN; UBIQUITIN THIOLESTERASE; USP18 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CATALYSIS; ENZYME ACTIVITY; INFLUENZA B; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; VACCINIA; VACCINIA VIRUS; VIRUS RESISTANCE; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; ANTIVIRAL RESISTANCE; C57BL MOUSE; CELL CULTURE; DRUG EFFECTS; INFLUENZA B VIRUS; METABOLISM; TRANSGENIC MOUSE;

ANIMALIA; INFLUENZA B VIRUS; MUS; VACCINIA VIRUS;

ANIMALS; ANTIVIRAL AGENTS; CELLS, CULTURED; CYTOKINES; DRUG RESISTANCE, VIRAL; INFLUENZA B VIRUS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; UBIQUITIN THIOLESTERASE; UBIQUITINS;

EID: 84922326351     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1412881112     Document Type: Article

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