Diosgenin from Dioscorea bulbifera: Novel hit for treatment of type II diabetes mellitus with inhibitory activity against α-amylase and α-glucosidase

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Ghosh, Sougata ^a   More, Piyush ^a   Derle, Abhishek ^a   Patil, Ajay B ^a   Markad, Pramod ^a   Asok, Adersh ^b   Kumbhar, Navanath ^a   Shaikh, Mahemud L ^c   Ramanamurthy, Boppana ^c   Shinde, Vaishali S ^a   Dhavale, Dilip D ^a   Chopade, Balu A ^a  

^a UNIVERSITY OF PUNE   (India)

^b INDIAN INSTITUTE OF TECHNOLOGY BOMBAY   (India)

^c NATIONAL CENTRE FOR CELL SCIENCE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ACARBOSE; ALPHA GLUCOSIDASE; AMYLASE; ANTIDIABETIC AGENT; CARBOXYL GROUP; DIOSCOREA BULBIFERA EXTRACT; DIOSGENIN; PLANT EXTRACT; UNCLASSIFIED DRUG; ENZYME INHIBITOR; PROTEIN BINDING;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CIRCULAR DICHROISM; CONTROLLED STUDY; DIOSCOREA BULBIFERA; DRUG BINDING; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGEN BOND; INFRARED SPECTROSCOPY; MALE; MOLECULAR DOCKING; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PLANT BULB; PROTON NUCLEAR MAGNETIC RESONANCE; TIME OF FLIGHT MASS SPECTROMETRY; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; ENZYMOLOGY; INTESTINE; ISOLATION AND PURIFICATION; KINETICS; METABOLISM; PATHOLOGY; PIG; SPECTROFLUOROMETRY; YAM;

DIOSCOREA BULBIFERA;

ALPHA-AMYLASES; ALPHA-GLUCOSIDASES; ANIMALS; CATALYTIC DOMAIN; CIRCULAR DICHROISM; DIABETES MELLITUS, EXPERIMENTAL; DIOSCOREA; DIOSGENIN; ENZYME INHIBITORS; INTESTINES; KINETICS; MICE; MOLECULAR DOCKING SIMULATION; PLANT EXTRACTS; PROTEIN BINDING; SPECTROMETRY, FLUORESCENCE; SUS SCROFA;

EID: 84930647697     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0106039     Document Type: Article

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