Synthesis and glycosidase inhibitory activity of novel (2-phenyl-4H- benzopyrimedo[2,1-b]-thiazol-4-yliden)acetonitrile derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 23, 2012, Pages 7011-7014

  Patil, Vijay S ^a,b   Nandre, Kamalakar P ^b   Ghosh, Sougata ^c   Rao, Vaidya Jayathirtha ^b   Chopade, Balu A ^c   Bhosale, Sheshanath V ^d   Bhosale, Sidhanath V ^a,b  

^a NORTH MAHARASHTRA UNIVERSITY   (India)

^b INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^c UNIVERSITY OF PUNE   (India)

^d RMIT UNIVERSITY   (Australia)

Author keywords

2 Aminobenzothiazoles; Glycosidase inhibitors; Murine intestinal glycosidase; Porcine pancreatic amylase

Indexed keywords

(2 PHENYL 4H BENZOPYRIMEDO[2,1 B]THIAZOL 4 YLIDEN)ACETONITRILE DERIVATIVE; [2 (2 NAPHTHYL) 4H BENZO[D]PYRIMIDO[2,1B][1,3]THIAZOL 4YLIDEN]ACETONITRILE; [2 (2 PHENYL) 4H BENZO[D]PYRIMIDO[2,1 B][1,3]THIAZOL 4 YLIDEN]ACETONITRILE; [2 (4 BROMOPHENYL) 4H BENZO[D]PYRIMIDO[2,1 B][1,3]THIAZOL 4 YLIDEN]ACETONITRILE; [2 (4 BROMOROPHENYL) 8 METHOXY 4H BENZO[D]PYRIMIDO[2,1 B][1,3]THIAZOL 4 YLIDEN]ACETONITRILE; [2 (4 CHLOROPHENYL) 4H BENZO[D]PYRIMIDO[2,1B][1,3]THIAZOL 4 YLIDEN]ACETONITRILE; [2 (4 CHLOROPHENYL) 8 METHOXY 4H BENZO[D]PYRIMIDO[2,1 B][1,3]THIAZOL 4 YLIDEN]ACETONITRILE; [2 (4 FLUOROPHENYL) 4H BENZO[D]PYRIMIDO[2,1 B][1,3]THIAZOL 4 YLIDEN]ACETONITRILE; [2 (4 FLUROPHENYL) 8 METHOXY 4H BENZO[D]PYRIMIDO[2,1 B][1,3]THIAZOL 4 YLIDEN]ACETONITRILE; [2 (4 METHYLPHENYL) 4H BENZO[D]PYRIMIDO[2,1 B][1,3]THIAZOL 4 YLIDEN]ACETONITRILE; [8 ETHOXY 2 PHENYL 4H BENZO[D]PYRIMIDO[2,1 B][1,3]THIAZOL 4 YLIDEN]ACETONITRILE; [8 METHOXY 2 (2 NAPHTHYL) 4H BENZO[D]PYRIMIDO[2,1 B][1,3]THIAZOL 4 YLIDEN]ACETONITRILE; [8 METHOXY 2 (4 METHYLPHENYL) 4H BENZO[D]PYRIMIDO[2,1 B][1,3]THIAZOL 4 YLIDEN]ACETONITRILE; [8 METHOXY 2 PHENYL 4H BENZO[D]PYRIMIDO[2,1 B][1,3]THIAZOL 4 YLIDEN]ACETONITRILE; ACETONITRILE DERIVATIVE; ALPHA GLUCOSIDASE; AMYLASE; GLYCOSIDASE INHIBITOR; NITRILE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME INHIBITION; MALE; MOUSE; NONHUMAN; SYNTHESIS;

ACETONITRILES; ALPHA-GLUCOSIDASES; AMYLASES; ANIMALS; ENZYME ACTIVATION; ENZYME INHIBITORS; HYPOGLYCEMIC AGENTS; INTESTINES; LIVER; MICE; PANCREAS; PROTEIN BINDING; SWINE;

MURINAE; SUS;

EID: 84869089541     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.10.025     Document Type: Article

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