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Volumn 290, Issue 23, 2015, Pages 14618-14625

Assembly pathway and characterization of the RAG1/2-DNA paired and signal-end complexes

Author keywords

[No Author keywords available]

Indexed keywords

BINS; CELL MEMBRANES; CRYSTAL ATOMIC STRUCTURE; MAMMALS; METAL IONS; METALS; NUCLEIC ACIDS; T-CELLS;

EID: 84930631577     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.641787     Document Type: Article
Times cited : (13)

References (34)
  • 1
    • 0018627375 scopus 로고
    • Sequences at the somatic recombination sites of immunoglobulin light-chain genes
    • Sakano, H., Hüppi, K., Heinrich, G., and Tonegawa, S. (1979) Sequences at the somatic recombination sites of immunoglobulin light-chain genes. Nature 280, 288-294
    • (1979) Nature , vol.280 , pp. 288-294
    • Sakano, H.1    Hüppi, K.2    Heinrich, G.3    Tonegawa, S.4
  • 2
    • 0028048275 scopus 로고
    • The mechanism of V(D)J joining: Lessons from molecular, immunological, and comparative analyses
    • Lewis, S. M. (1994) The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses. Adv. Immunol. 56, 27-150
    • (1994) Adv. Immunol. , vol.56 , pp. 27-150
    • Lewis, S.M.1
  • 3
    • 0019214271 scopus 로고
    • Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes
    • Sakano, H., Maki, R., Kurosawa, Y., Roeder, W., and Tonegawa, S. (1980) Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes. Nature 286, 676-683
    • (1980) Nature , vol.286 , pp. 676-683
    • Sakano, H.1    Maki, R.2    Kurosawa, Y.3    Roeder, W.4    Tonegawa, S.5
  • 4
    • 0028805853 scopus 로고
    • Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps
    • McBlane, J. F., van Gent, D. C., Ramsden, D. A., Romeo, C., Cuomo, C. A., Gellert, M., and Oettinger, M. A. (1995) Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps. Cell 83, 387-395
    • (1995) Cell , vol.83 , pp. 387-395
    • McBlane, J.F.1    Van Gent, D.C.2    Ramsden, D.A.3    Romeo, C.4    Cuomo, C.A.5    Gellert, M.6    Oettinger, M.A.7
  • 5
    • 0025301095 scopus 로고
    • RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
    • Oettinger, M.A., Schatz, D. G., Gorka, C., and Baltimore, D. (1990) RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248, 1517-1523
    • (1990) Science , vol.248 , pp. 1517-1523
    • Oettinger, M.A.1    Schatz, D.G.2    Gorka, C.3    Baltimore, D.4
  • 6
    • 0024846088 scopus 로고
    • The V(D)J recombination activating gene, RAG-1
    • Schatz, D. G., and Oettinger., M. A., and Baltimore, D. (1989) The V(D)J recombination activating gene, RAG-1. Cell 59, 1035-1048
    • (1989) Cell , vol.59 , pp. 1035-1048
    • Schatz, D.G.1    Oettinger, M.A.2    Baltimore, D.3
  • 7
    • 0028307661 scopus 로고
    • Analysis of regions of RAG-2 important for V(D)J recombination
    • Cuomo, C. A., and Oettinger, M. A. (1994) Analysis of regions of RAG-2 important for V(D)J recombination. Nucleic Acids Res. 22, 1810-1814
    • (1994) Nucleic Acids Res. , vol.22 , pp. 1810-1814
    • Cuomo, C.A.1    Oettinger, M.A.2
  • 8
    • 0028237683 scopus 로고
    • Definition of a core region of RAG-2 that is functional in V(D)J recombination
    • Sadofsky, M. J., and Hesse., J. E., and Gellert, M. (1994) Definition of a core region of RAG-2 that is functional in V(D)J recombination. Nucleic Acids Res. 22, 1805-1809
    • (1994) Nucleic Acids Res. , vol.22 , pp. 1805-1809
    • Sadofsky, M.J.1    Hesse, J.E.2    Gellert, M.3
  • 9
    • 0027770854 scopus 로고
    • Expression and V(D)J recombination activity of mutated RAG-1 proteins
    • Sadofsky, M. J., and Hesse., J. E., McBlane, J. F., and Gellert, M. (1993) Expression and V(D)J recombination activity of mutated RAG-1 proteins. Nucleic Acids Res. 21, 5644-5650
    • (1993) Nucleic Acids Res. , vol.21 , pp. 5644-5650
    • Sadofsky, M.J.1    Hesse, J.E.2    McBlane, J.F.3    Gellert, M.4
  • 10
    • 0027197151 scopus 로고
    • Dispensable sequence motifs in the RAG-1 and RAG-2 genes for plasmid V(D)J recombination
    • Silver, D. P., Spanopoulou, E., Mulligan, R. C., and Baltimore, D. (1993) Dispensable sequence motifs in the RAG-1 and RAG-2 genes for plasmid V(D)J recombination. Proc. Natl. Acad. Sci. U.S.A. 90, 6100-6104
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 6100-6104
    • Silver, D.P.1    Spanopoulou, E.2    Mulligan, R.C.3    Baltimore, D.4
  • 11
    • 0000675571 scopus 로고    scopus 로고
    • Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase
    • Kim, D. R., Dai, Y., Mundy, C. L., Yang, W., and Oettinger, M. A. (1999) Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase. Genes Dev. 13, 3070-3080
    • (1999) Genes Dev. , vol.13 , pp. 3070-3080
    • Kim, D.R.1    Dai, Y.2    Mundy, C.L.3    Yang, W.4    Oettinger, M.A.5
  • 12
    • 0033380368 scopus 로고    scopus 로고
    • Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acidsin RAG1 critical for both cleavage steps of V(D)J recombination
    • Landree, M. A., and Wibbenmeyer., J. A., and Roth, D. B. (1999) Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acidsin RAG1 critical for both cleavage steps of V(D)J recombination. Genes Dev. 13, 3059-3069
    • (1999) Genes Dev. , vol.13 , pp. 3059-3069
    • Landree, M.A.1    Wibbenmeyer, J.A.2    Roth, D.B.3
  • 13
    • 0033954892 scopus 로고    scopus 로고
    • Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex
    • Fugmann, S. D., and Villey., I. J., Ptaszek, L. M., and Schatz, D. G. (2000) Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex. Mol. Cell 5, 97-107
    • (2000) Mol. Cell , vol.5 , pp. 97-107
    • Fugmann, S.D.1    Villey, I.J.2    Ptaszek, L.M.3    Schatz, D.G.4
  • 14
    • 0030994385 scopus 로고    scopus 로고
    • Stimulation of V(D)J cleavage by high mobility group proteins
    • van Gent, D. C., Hiom, K., Paull, T. T., and Gellert, M. (1997) Stimulation of V(D)J cleavage by high mobility group proteins. EMBO J. 16, 2665-2670
    • (1997) EMBO J. , vol.16 , pp. 2665-2670
    • Van Gent, D.C.1    Hiom, K.2    Paull, T.T.3    Gellert, M.4
  • 15
    • 84867386682 scopus 로고    scopus 로고
    • Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks
    • Boboila, C., and Alt., F. W., and Schwer, B. (2012) Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks. Adv. Immunol. 116, 1-49
    • (2012) Adv. Immunol. , vol.116 , pp. 1-49
    • Boboila, C.1    Alt, F.W.2    Schwer, B.3
  • 16
    • 84888626405 scopus 로고    scopus 로고
    • Modernizing the nonhomologous end-joining repertoire: Alternative and classical NHEJ share the stage
    • Deriano, L., and Roth, D. B. (2013) Modernizing the nonhomologous end-joining repertoire: alternative and classical NHEJ share the stage. Annu. Rev. Genet. 47, 433-455
    • (2013) Annu. Rev. Genet. , vol.47 , pp. 433-455
    • Deriano, L.1    Roth, D.B.2
  • 17
    • 0030887862 scopus 로고    scopus 로고
    • RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination
    • Agrawal, A., and Schatz, D. G. (1997) RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination. Cell 89, 43-53
    • (1997) Cell , vol.89 , pp. 43-53
    • Agrawal, A.1    Schatz, D.G.2
  • 18
    • 0035818603 scopus 로고    scopus 로고
    • Intermediates in V(D)J recombination: A stable RAG1/2 complex sequesters cleaved RSS ends
    • Jones, J. M., and Gellert, M. (2001) Intermediates in V(D)J recombination: a stable RAG1/2 complex sequesters cleaved RSS ends. Proc. Natl. Acad. Sci. U.S.A. 98, 12926-12931
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 12926-12931
    • Jones, J.M.1    Gellert, M.2
  • 19
    • 0024691453 scopus 로고
    • V(D)J recombination: A functional definition of the joining signals
    • Hesse, J. E., and Lieber., M. R., Mizuuchi, K., and Gellert, M. (1989) V(D)J recombination: a functional definition of the joining signals. Genes Dev. 3, 1053-1061
    • (1989) Genes Dev. , vol.3 , pp. 1053-1061
    • Hesse, J.E.1    Lieber, M.R.2    Mizuuchi, K.3    Gellert, M.4
  • 20
    • 0030964130 scopus 로고    scopus 로고
    • A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage
    • Hiom, K., and Gellert, M. (1997) A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage. Cell 88, 65-72
    • (1997) Cell , vol.88 , pp. 65-72
    • Hiom, K.1    Gellert, M.2
  • 21
    • 0035997348 scopus 로고    scopus 로고
    • V(D)J recombination: RAG proteins, repair factors, and regulation
    • Gellert, M. (2002) V(D)J recombination: RAG proteins, repair factors, and regulation. Annu. Rev. Biochem. 71, 101-132
    • (2002) Annu. Rev. Biochem. , vol.71 , pp. 101-132
    • Gellert, M.1
  • 22
    • 30044450912 scopus 로고    scopus 로고
    • Single-strand recombination signal sequence nicks in vivo: Evidence for a capture model of synapsis
    • Curry, J. D., and Geier., J. K., and Schlissel, M. S. (2005) Single-strand recombination signal sequence nicks in vivo: evidence for a capture model of synapsis. Nat. Immunol. 6, 1272-1279
    • (2005) Nat. Immunol. , vol.6 , pp. 1272-1279
    • Curry, J.D.1    Geier, J.K.2    Schlissel, M.S.3
  • 23
    • 0036682598 scopus 로고    scopus 로고
    • Ordered assembly of the V(D)J synaptic complex ensures accurate recombination
    • Jones, J.M., and Gellert, M. (2002) Ordered assembly of the V(D)J synaptic complex ensures accurate recombination. EMBO J. 21, 4162-4171
    • (2002) EMBO J. , vol.21 , pp. 4162-4171
    • Jones, J.M.1    Gellert, M.2
  • 24
    • 0033638506 scopus 로고    scopus 로고
    • Histone acetylation and hSWI/SNF remodeling act in concert to stimulate V(D)J cleavage of nucleosomal DNA
    • Kwon, J., and Morshead., K. B., Guyon, J. R., Kingston, R. E., and Oettinger, M. A. (2000) Histone acetylation and hSWI/SNF remodeling act in concert to stimulate V(D)J cleavage of nucleosomal DNA. Mol. Cell 6, 1037-1048
    • (2000) Mol. Cell , vol.6 , pp. 1037-1048
    • Kwon, J.1    Morshead, K.B.2    Guyon, J.R.3    Kingston, R.E.4    Oettinger, M.A.5
  • 25
    • 3242892354 scopus 로고    scopus 로고
    • The bounty of RAGs: Recombination signal complexes and reaction outcomes
    • Swanson, P. C. (2004) The bounty of RAGs: recombination signal complexes and reaction outcomes. Immunol. Rev. 200, 90-114
    • (2004) Immunol. Rev. , vol.200 , pp. 90-114
    • Swanson, P.C.1
  • 26
    • 0031826699 scopus 로고    scopus 로고
    • Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences
    • Akamatsu, Y., and Oettinger, M. A. (1998) Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences. Mol. Cell. Biol. 18, 4670-4678
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 4670-4678
    • Akamatsu, Y.1    Oettinger, M.A.2
  • 28
    • 0030707531 scopus 로고    scopus 로고
    • RAG-1 and RAG-2-dependent assembly of functional complexes with V(D)J recombination substrates in solution
    • Li, W., Swanson, P., and Desiderio, S. (1997) RAG-1 and RAG-2-dependent assembly of functional complexes with V(D)J recombination substrates in solution. Mol. Cell. Biol. 17, 6932-6939
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 6932-6939
    • Li, W.1    Swanson, P.2    Desiderio, S.3
  • 31
    • 33745912405 scopus 로고    scopus 로고
    • A time- and cost-efficient system for high-level protein production in Mammalian cells
    • Aricescu, A. R., Lu, W., and Jones, E. Y. (2006) A time- and cost-efficient system for high-level protein production in mammalian cells. Acta Crystallogr. D Biol. Crystallogr. 62, 1243-1250
    • (2006) Acta Crystallogr. D Biol. Crystallogr. , vol.62 , pp. 1243-1250
    • Aricescu, A.R.1    Lu, W.2    Jones, E.Y.3
  • 32
    • 0036839614 scopus 로고    scopus 로고
    • A RAG-1/RAG-2 tetramer supports 12/23-regulated synapsis, cleavage, and transposition of V(D)J recombination signals
    • Swanson, P. C. (2002) A RAG-1/RAG-2 tetramer supports 12/23-regulated synapsis, cleavage, and transposition of V(D)J recombination signals. Mol. Cell. Biol. 22, 7790-7801
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 7790-7801
    • Swanson, P.C.1
  • 34
    • 84924052353 scopus 로고    scopus 로고
    • Crystal structure of the V(D)J recombinase RAG1-RAG2
    • Kim, M.-S., Lapkouski, M., Yang, W., and Gellert, M. (2015) Crystal structure of the V(D)J recombinase RAG1-RAG2. Nature 518, 507-511
    • (2015) Nature , vol.518 , pp. 507-511
    • Kim, M.-S.1    Lapkouski, M.2    Yang, W.3    Gellert, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.