C-H activation generates period-shortening molecules that target cryptochrome in the mammalian circadian clock

Angewandte Chemie - International Edition

Volumn 54, Issue 24, 2015, Pages 7193-7197

  Oshima, Tsuyoshi ^a   Yamanaka, Iori ^a   Kumar, Anupriya ^a   Yamaguchi, Junichiro ^a   Nishiwaki Ohkawa, Taeko ^a   Muto, Kei ^a   Kawamura, Rika ^a   Hirota, Tsuyoshi ^a,b   Yagita, Kazuhiro ^c   Irle, Stephan ^a   Kay, Steve A ^a,d   Yoshimura, Takashi ^a,e   Itami, Kenichiro ^a,b  

^a NAGOYA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^e NATIONAL INSTITUTE FOR BASIC BIOLOGY   (Japan)

Author keywords

circadian clock; cryptochrome; C H activation; small molecule modulators; structure activity relationships

Indexed keywords

CHEMICAL ACTIVATION; CLOCKS; CUTTING TOOLS; FUNCTIONAL ANALYSIS; MAMMALS; MOLECULES;

C-H ACTIVATION; CIRCADIAN CLOCK; CRYPTOCHROMES; CUTTING EDGES; REGULATORY MECHANISM; SMALL MOLECULES; STRUCTURE ACTIVITY RELATIONSHIPS;

ACTIVATION ANALYSIS;

CARBAZOLE DERIVATIVE; CARBON; CRYPTOCHROME; HYDROGEN; KL001; SULFONAMIDE; TRANSCRIPTION FACTOR ARNTL;

BINDING SITE; CELL LINE; CHEMISTRY; CIRCADIAN RHYTHM; DRUG EFFECTS; GENETICS; HEK293 CELL LINE; HUMAN; LUMINESCENCE; METABOLISM; MOLECULAR DOCKING; PROTEIN TERTIARY STRUCTURE; REPORTER GENE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ARNTL TRANSCRIPTION FACTORS; BINDING SITES; CARBAZOLES; CARBON; CELL LINE; CIRCADIAN RHYTHM; CRYPTOCHROMES; GENES, REPORTER; HEK293 CELLS; HUMANS; HYDROGEN; LUMINESCENT MEASUREMENTS; MOLECULAR DOCKING SIMULATION; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 84930626086     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201502942     Document Type: Article

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