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Volumn 2015, Issue , 2015, Pages

The flavonoid apigenin ameliorates cisplatin-induced nephrotoxicity through reduction of p53 activation and promotion of PI3K/Akt pathway in human renal proximal tubular epithelial cells

Author keywords

[No Author keywords available]

Indexed keywords

APIGENIN; CASPASE 3; CISPLATIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P53;

EID: 84930622709     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2015/186436     Document Type: Article
Times cited : (66)

References (40)
  • 1
    • 34547100275 scopus 로고    scopus 로고
    • The resurgence of platinum-based cancer chemotherapy
    • L. Kelland, "The resurgence of platinum-based cancer chemotherapy," Nature Reviews Cancer, vol. 7, no. 8, pp. 573-584, 2007.
    • (2007) Nature Reviews Cancer , vol.7 , Issue.8 , pp. 573-584
    • Kelland, L.1
  • 2
    • 61549087775 scopus 로고    scopus 로고
    • Cisplatin: A review of toxicities and therapeutic applications
    • K. Barabas, R. Milner, D. Lurie, and C. Adin, "Cisplatin: a review of toxicities and therapeutic applications," Veterinary and Comparative Oncology, vol. 6, no. 1, pp. 1-18, 2008.
    • (2008) Veterinary and Comparative Oncology , vol.6 , Issue.1 , pp. 1-18
    • Barabas, K.1    Milner, R.2    Lurie, D.3    Adin, C.4
  • 3
    • 4043092178 scopus 로고    scopus 로고
    • Cisplatin nephrotoxicity: Molecular mechanisms
    • M. H. Hanigan and P. Devarajan, "Cisplatin nephrotoxicity: molecular mechanisms," Cancer Terapy, vol. 1, pp. 47-61, 2003.
    • (2003) Cancer Terapy , vol.1 , pp. 47-61
    • Hanigan, M.H.1    Devarajan, P.2
  • 5
    • 34548485284 scopus 로고    scopus 로고
    • Mechanisms of cisplatin ototoxicity and progress in otoprotection
    • L. P. Rybak, "Mechanisms of cisplatin ototoxicity and progress in otoprotection," Current Opinion in Otolaryngology & Head and Neck Surgery, vol. 15, no. 5, pp. 364-369, 2007.
    • (2007) Current Opinion in Otolaryngology & Head and Neck Surgery , vol.15 , Issue.5 , pp. 364-369
    • Rybak, L.P.1
  • 6
    • 0027078370 scopus 로고
    • Mechanisms by which cancer chemotherapeu-tic drugs induce emesis
    • L. X. Cubeddu, "Mechanisms by which cancer chemotherapeu-tic drugs induce emesis," Seminars in Oncology, vol. 19, no. 6, pp. 2-13, 1992.
    • (1992) Seminars in Oncology , vol.19 , Issue.6 , pp. 2-13
    • Cubeddu, L.X.1
  • 7
    • 0035150608 scopus 로고    scopus 로고
    • Anticancer drug-induced kidney disorders: Incidence, prevention and management
    • P. E. Kintzel, "Anticancer drug-induced kidney disorders: incidence, prevention and management," Drug Safety, vol. 24, no. 1, pp. 19-38, 2001.
    • (2001) Drug Safety , vol.24 , Issue.1 , pp. 19-38
    • Kintzel, P.E.1
  • 8
    • 42149187768 scopus 로고    scopus 로고
    • Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies
    • N. Pabla and Z. Dong, "Cisplatin nephrotoxicity: mechanisms and renoprotective strategies," Kidney International, vol. 73, no. 9, pp. 994-1007, 2008.
    • (2008) Kidney International , vol.73 , Issue.9 , pp. 994-1007
    • Pabla, N.1    Dong, Z.2
  • 9
    • 33947390474 scopus 로고    scopus 로고
    • Efects of hydroxyl radical scavenging on cisplatin-induced p53 activation, tubular cell apoptosis and nephrotoxicity
    • M. Jiang, Q. Wei, N. Pabla et al., "Efects of hydroxyl radical scavenging on cisplatin-induced p53 activation, tubular cell apoptosis and nephrotoxicity," Biochemical Pharmacology, vol. 73, no. 9, pp. 1499-1510, 2007
    • (2007) Biochemical Pharmacology , vol.73 , Issue.9 , pp. 1499-1510
    • Jiang, M.1    Wei, Q.2    Pabla, N.3
  • 10
    • 84902190729 scopus 로고    scopus 로고
    • Role of reactive oxygen species in p53 activation during cisplatin-induced apoptosis of rat mesangial cells
    • S. M. Ju, H. O. Pae, W. S. Kim, D. G. Kang, H. S. Lee, and B. H. Jeon, "Role of reactive oxygen species in p53 activation during cisplatin-induced apoptosis of rat mesangial cells," European Review for Medical and Pharmacological Sciences, vol. 18, no. 8, pp. 1135-1141, 2014.
    • (2014) European Review for Medical and Pharmacological Sciences , vol.18 , Issue.8 , pp. 1135-1141
    • Ju, S.M.1    Pae, H.O.2    Kim, W.S.3    Kang, D.G.4    Lee, H.S.5    Jeon, B.H.6
  • 12
    • 0142166328 scopus 로고    scopus 로고
    • Cancer chemoprevention with dietary phytochemi-cals
    • Y.-J. Surh, "Cancer chemoprevention with dietary phytochemi-cals," Nature Reviews Cancer, vol. 3, no. 10, pp. 768-780, 2003.
    • (2003) Nature Reviews Cancer , vol.3 , Issue.10 , pp. 768-780
    • Surh, Y.-J.1
  • 13
    • 79551665812 scopus 로고    scopus 로고
    • Preparation of novel apigenin-enriched, liposomal and non-liposomal, antiinfammatory topical formulations as substitutes for corticosteroid therapy
    • I. Arsic, V. Tadic, D. Vlaovic et al., "Preparation of novel apigenin-enriched, liposomal and non-liposomal, antiinfammatory topical formulations as substitutes for corticosteroid therapy," Phytotherapy Research, vol. 25, no. 2, pp. 228-233, 2011.
    • (2011) Phytotherapy Research , vol.25 , Issue.2 , pp. 228-233
    • Arsic, I.1    Tadic, V.2    Vlaovic, D.3
  • 14
    • 2442701285 scopus 로고    scopus 로고
    • Protective role of Apigenin on the status of lipid peroxidation and antioxidant defense against hepato-carcinogenesis in Wistar albino rats
    • J. P. V. Singh, K. Selvendiran, S. Mumtaz Banu, R. Padmavathi, and D. Sakthisekaran, "Protective role of Apigenin on the status of lipid peroxidation and antioxidant defense against hepato-carcinogenesis in Wistar albino rats," Phytomedicine, vol. 11, no. 4, pp. 309-314, 2004.
    • (2004) Phytomedicine , vol.11 , Issue.4 , pp. 309-314
    • Singh, J.P.V.1    Selvendiran, K.2    Mumtaz Banu, S.3    Padmavathi, R.4    Sakthisekaran, D.5
  • 15
    • 38349177105 scopus 로고    scopus 로고
    • Apigenin inhibits the production of NO and PGE2 in microglia and inhibits neuronal cell death in a middle cerebral artery occlusion-induced focal ischemia mice model
    • S. K. Ha, P. Lee, J. A. Park et al., "Apigenin inhibits the production of NO and PGE2 in microglia and inhibits neuronal cell death in a middle cerebral artery occlusion-induced focal ischemia mice model," Neurochemistry International, vol. 52, no. 4-5, pp. 878-886, 2008.
    • (2008) Neurochemistry International , vol.52 , Issue.4-5 , pp. 878-886
    • Ha, S.K.1    Lee, P.2    Park, J.A.3
  • 16
    • 0036489186 scopus 로고    scopus 로고
    • Flavonoids increase the intracellular glutathione level by transactivation of the gamma-glutamylcysteine synthetase catalytical subunit promoter
    • M. C. W. Myhrstad, H. Carlsen, O. Nordström, R. Blomhof, and J. Ø. Moskaug, "Flavonoids increase the intracellular glutathione level by transactivation of the gamma-glutamylcysteine synthetase catalytical subunit promoter," Free Radical Biology and Medicine, vol. 32, no. 5, pp. 386-393, 2002.
    • (2002) Free Radical Biology and Medicine , vol.32 , Issue.5 , pp. 386-393
    • Myhrstad, M.C.W.1    Carlsen, H.2    Nordström, O.3    Blomhof, R.4    Moskaug J.Ø5
  • 17
    • 0025176844 scopus 로고
    • Inhibitory efect of apigenin, a plant favonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice
    • H. Wei, L. Tye, E. Bresnick, and D. F. Birt, "Inhibitory efect of apigenin, a plant favonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice," Cancer Research, vol. 50, no. 3, pp. 499-502, 1990.
    • (1990) Cancer Research , vol.50 , Issue.3 , pp. 499-502
    • Wei, H.1    Tye, L.2    Bresnick, E.3    Birt, D.F.4
  • 18
    • 56049126878 scopus 로고    scopus 로고
    • Plant favonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: An in vitro and in vivo study
    • P. Kaur, S. Shukla, and S. Gupta, "Plant favonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study," Carcinogenesis, vol. 29, no. 11, pp. 2210-2217, 2008.
    • (2008) Carcinogenesis , vol.29 , Issue.11 , pp. 2210-2217
    • Kaur, P.1    Shukla, S.2    Gupta, S.3
  • 19
    • 61749103821 scopus 로고    scopus 로고
    • Apigenin causes G2/M arrest associated with the modulation of p21 lp and Cdc2 and activates p53-dependent apoptosis pathway in human breast cancer SK-BR-3 cells
    • E. J. Choi and G.-H. Kim, "Apigenin causes G2/M arrest associated with the modulation of p21 lp and Cdc2 and activates p53-dependent apoptosis pathway in human breast cancer SK-BR-3 cells," The Journal of Nutritional Biochemistry, vol. 20, no. 4, pp. 285-290, 2009.
    • (2009) The Journal of Nutritional Biochemistry , vol.20 , Issue.4 , pp. 285-290
    • Choi, E.J.1    Kim, G.-H.2
  • 20
    • 33750612111 scopus 로고    scopus 로고
    • Mechanism of apoptosis with the involvement of calpain and caspase cascades in human malignant neuroblastoma SH-SY5Y cells exposed to favonoids
    • A. Das, N. L. Banik, and S. K. Ray, "Mechanism of apoptosis with the involvement of calpain and caspase cascades in human malignant neuroblastoma SH-SY5Y cells exposed to favonoids," International Journal of Cancer, vol. 119, no. 11, pp. 2575-2585, 2006.
    • (2006) International Journal of Cancer , vol.119 , Issue.11 , pp. 2575-2585
    • Das, A.1    Banik, N.L.2    Ray, S.K.3
  • 21
    • 0035812747 scopus 로고    scopus 로고
    • Selective growth-inhibitory cell-cycle deregulatory and apoptotic response of apigenin in normal versus human prostate carcinoma cells
    • S. Gupta, F. Afaq, and H. Mukhtar, "Selective growth-inhibitory cell-cycle deregulatory and apoptotic response of apigenin in normal versus human prostate carcinoma cells," Biochemical and Biophysical Research Communications, vol. 287, no. 4, pp. 914-920, 2001.
    • (2001) Biochemical and Biophysical Research Communications , vol.287 , Issue.4 , pp. 914-920
    • Gupta, S.1    Afaq, F.2    Mukhtar, H.3
  • 22
    • 84860797409 scopus 로고    scopus 로고
    • Apigenin induces apoptosis via tumor necrosis factor receptor-and Bcl-2-mediated pathway and enhances susceptibility of head and neck squamous cell carcinoma to 5-fuorouracil and cisplatin
    • L.-P. Chan, T.-H. Chou, H.-Y Ding et al., "Apigenin induces apoptosis via tumor necrosis factor receptor-and Bcl-2-mediated pathway and enhances susceptibility of head and neck squamous cell carcinoma to 5-fuorouracil and cisplatin," Biochimica et Biophysica Acta-General Subjects, vol. 1820, no. 7, pp. 1081-1091, 2012.
    • (2012) Biochimica et Biophysica Acta-General Subjects , vol.1820 , Issue.7 , pp. 1081-1091
    • Chan, L.-P.1    Chou, T.-H.2    Ding, H.-Y.3
  • 23
    • 84906274043 scopus 로고    scopus 로고
    • Apigenin suppresses GLUT-1 and p-AKT expression to enhance the chemosensitivity to cisplatin of laryngeal carcinoma Hep-2 cells: An in vitro study
    • Y. Y. Xu, T. T. Wu, S. H. Zhou et al., "Apigenin suppresses GLUT-1 and p-AKT expression to enhance the chemosensitivity to cisplatin of laryngeal carcinoma Hep-2 cells: an in vitro study," International Journal of Clinical and Experimental Pathology, vol. 7, no. 7, pp. 3938-3947, 2014.
    • (2014) International Journal of Clinical and Experimental Pathology , vol.7 , Issue.7 , pp. 3938-3947
    • Xu, Y.Y.1    Wu, T.T.2    Zhou, S.H.3
  • 25
    • 0036020543 scopus 로고    scopus 로고
    • Modulating poly (ADP-ribose) poly-merase activity: Potential for the prevention and therapy of pathogenic situations involving DNA damage and oxidative stress
    • P. Decker and S. Muller, "Modulating poly (ADP-ribose) poly-merase activity: potential for the prevention and therapy of pathogenic situations involving DNA damage and oxidative stress," Current Pharmaceutical Biotechnology, vol. 3, no. 3, pp. 275-283, 2002.
    • (2002) Current Pharmaceutical Biotechnology , vol.3 , Issue.3 , pp. 275-283
    • Decker, P.1    Muller, S.2
  • 26
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three akts
    • S. R. Datta, A. Brunet, and M. E. Greenberg, "Cellular survival: a play in three akts," Genes & Development, vol. 13, no. 22, pp. 2905-2927, 1999.
    • (1999) Genes & Development , vol.13 , Issue.22 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 28
    • 0142227019 scopus 로고    scopus 로고
    • Targeting the PI3K-Akt pathway in human cancer: Rationale and promise
    • J. Luo, B. D. Manning, and L. C. Cantley, "Targeting the PI3K-Akt pathway in human cancer: rationale and promise," Cancer Cell, vol. 4, no. 4, pp. 257-262, 2003.
    • (2003) Cancer Cell , vol.4 , Issue.4 , pp. 257-262
    • Luo, J.1    Manning, B.D.2    Cantley, L.C.3
  • 29
    • 0037077230 scopus 로고    scopus 로고
    • Akt enhances Mdm2-mediated ubiquitination and degradation of p53
    • Y. Ogawara, S. Kishishita, T. Obata et al., "Akt enhances Mdm2-mediated ubiquitination and degradation of p53," The Journal of Biological Chemistry, vol. 277, no. 24, pp. 21843-21850, 2002.
    • (2002) The Journal of Biological Chemistry , vol.277 , Issue.24 , pp. 21843-21850
    • Ogawara, Y.1    Kishishita, S.2    Obata, T.3
  • 30
    • 84899988383 scopus 로고    scopus 로고
    • Terapeutic potential of apigenin, a plant favonoid, for imatinib-sensitive and resistant chronic myeloid leukemia cells
    • S. Solmaz, A. Adan Gokbulut, B. Cincin et al., "Terapeutic potential of apigenin, a plant favonoid, for imatinib-sensitive and resistant chronic myeloid leukemia cells," Nutrition and Cancer, vol. 66, no. 4, pp. 599-612, 2014.
    • (2014) Nutrition and Cancer , vol.66 , Issue.4 , pp. 599-612
    • Solmaz, S.1    Adan Gokbulut, A.2    Cincin, B.3
  • 31
    • 84885073826 scopus 로고    scopus 로고
    • Apigenin impairs oral squamous cell carcinoma growth in vitro inducing cell cycle arrest and apoptosis
    • D. Maggioni, W. Garavello, R. Rigolio, L. Pignataro, R. Gaini, and G. Nicolini, "Apigenin impairs oral squamous cell carcinoma growth in vitro inducing cell cycle arrest and apoptosis," International Journal of Oncology, vol. 43, no. 5, pp. 1675-1682, 2013.
    • (2013) International Journal of Oncology , vol.43 , Issue.5 , pp. 1675-1682
    • Maggioni, D.1    Garavello, W.2    Rigolio, R.3    Pignataro, L.4    Gaini, R.5    Nicolini, G.6
  • 32
    • 84869205521 scopus 로고    scopus 로고
    • Apigenin induces DNA damage through the PKCα-dependent activation of ATM and H2AX causing down-regulation of genes involved in cell cycle control and DNA repair
    • D. Arango, A. Parihar, F. A. Villamena et al., "Apigenin induces DNA damage through the PKCα-dependent activation of ATM and H2AX causing down-regulation of genes involved in cell cycle control and DNA repair," Biochemical Pharmacology, vol. 84, no. 12, pp. 1571-1580, 2012.
    • (2012) Biochemical Pharmacology , vol.84 , Issue.12 , pp. 1571-1580
    • Arango, D.1    Parihar, A.2    Villamena, F.A.3
  • 33
    • 79960752022 scopus 로고    scopus 로고
    • Apigenin induces apop-tosis in human lung cancer H460 cells through caspase-and mitochondria-dependent pathways
    • H.-F. Lu, Y.-J. Chie, M.-S. Yang et al., "Apigenin induces apop-tosis in human lung cancer H460 cells through caspase-and mitochondria-dependent pathways," Human & Experimental Toxicology, vol. 30, no. 8, pp. 1053-1061, 2011.
    • (2011) Human & Experimental Toxicology , vol.30 , Issue.8 , pp. 1053-1061
    • Lu, H.-F.1    Chie, Y.-J.2    Yang, M.-S.3
  • 34
    • 84876852762 scopus 로고    scopus 로고
    • Diverse mechanisms of AKT pathway activation in human malignancy
    • M. Cheung and J. R. Testa, "Diverse mechanisms of AKT pathway activation in human malignancy," Current Cancer Drug Targets, vol. 13, no. 3, pp. 234-244, 2013.
    • (2013) Current Cancer Drug Targets , vol.13 , Issue.3 , pp. 234-244
    • Cheung, M.1    Testa, J.R.2
  • 35
    • 0031583962 scopus 로고    scopus 로고
    • Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
    • R. Honda, H. Tanaka, and H. Yasuda, "Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53," FEBS Letters, vol. 420, no. 1, pp. 25-27, 1997.
    • (1997) FEBS Letters , vol.420 , Issue.1 , pp. 25-27
    • Honda, R.1    Tanaka, H.2    Yasuda, H.3
  • 36
    • 0034735904 scopus 로고    scopus 로고
    • MDM2-dependent ubi-quitination of nuclear and cytoplasmic P53
    • Z. K. Yu, R. K. Geyer, and C. G. Maki, "MDM2-dependent ubi-quitination of nuclear and cytoplasmic P53," Oncogene, vol. 19, no. 51, pp. 5892-5897, 2000.
    • (2000) Oncogene , vol.19 , Issue.51 , pp. 5892-5897
    • Yu, Z.K.1    Geyer, R.K.2    Maki, C.G.3
  • 37
    • 0242610903 scopus 로고    scopus 로고
    • P53 is a determinant of X-linked inhibitor of apoptosis protein/Akt-mediated chemoresistance in human ovarian cancer cells
    • M. Fraser, B. M. Leung, X. Yan, H. C. Dan, J. Q. Cheng, and B. K. Tsang, "p53 is a determinant of X-linked inhibitor of apoptosis protein/Akt-mediated chemoresistance in human ovarian cancer cells," Cancer Research, vol. 63, no. 21, pp. 7081-7088, 2003.
    • (2003) Cancer Research , vol.63 , Issue.21 , pp. 7081-7088
    • Fraser, M.1    Leung, B.M.2    Yan, X.3    Dan, H.C.4    Cheng, J.Q.5    Tsang, B.K.6
  • 38
    • 73849152723 scopus 로고    scopus 로고
    • Akt promotes chemoresistance in human ovarian cancer cells by modulating cisplatin-induced, p53-dependent ubiquitination of FLICE-like inhibitory protein
    • M. R. Abedini, E. J. Muller, R. Bergeron, D. A. Gray, and B. K. Tsang, "Akt promotes chemoresistance in human ovarian cancer cells by modulating cisplatin-induced, p53-dependent ubiquitination of FLICE-like inhibitory protein," Oncogene, vol. 29, no. 1, pp. 11-25, 2010.
    • (2010) Oncogene , vol.29 , Issue.1 , pp. 11-25
    • Abedini, M.R.1    Muller, E.J.2    Bergeron, R.3    Gray, D.A.4    Tsang, B.K.5
  • 39
    • 35148848549 scopus 로고    scopus 로고
    • Dual inhibition of PI3K/Akt signaling and the DNA damage checkpoint in p53-defcient cells with strong survival signaling: Implications for cancer therapy
    • A. Skladanowski, P. Bozko, M. Sabisz, and A. K. Larsen, "Dual inhibition of PI3K/Akt signaling and the DNA damage checkpoint in p53-defcient cells with strong survival signaling: implications for cancer therapy," Cell Cycle, vol. 6, no. 18, pp. 2268-2275, 2007.
    • (2007) Cell Cycle , vol.6 , Issue.18 , pp. 2268-2275
    • Skladanowski, A.1    Bozko, P.2    Sabisz, M.3    Larsen, A.K.4
  • 40
    • 79957815223 scopus 로고    scopus 로고
    • Knockdown of Akt sensitizes osteosarcoma cells to apoptosis induced by cis-platin treatment
    • G. Zhang, M. Li, X. Zhu, Y. Bai, and C. Yang, "Knockdown of Akt sensitizes osteosarcoma cells to apoptosis induced by cis-platin treatment," International Journal of Molecular Sciences, vol. 12, no. 5, pp. 2994-3005, 2011.
    • (2011) International Journal of Molecular Sciences , vol.12 , Issue.5 , pp. 2994-3005
    • Zhang, G.1    Li, M.2    Zhu, X.3    Bai, Y.4    Yang, C.5


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