-
1
-
-
84893769397
-
Dose-finding study for tiotropium and olodaterol when administered in combination via the Respimat® inhaler in patients with COPD
-
R. Aalbers, M.R. Maleki-Yazdi, A. Hamilton, S. Waitere-Wijker, A. Pivovarova, O. Schmidt, and L. Bjermer Dose-finding study for tiotropium and olodaterol when administered in combination via the Respimat® inhaler in patients with COPD Eur. Respir. J. 40 2012 525 526s
-
(2012)
Eur. Respir. J.
, vol.40
, pp. 525-526s
-
-
Aalbers, R.1
Maleki-Yazdi, M.R.2
Hamilton, A.3
Waitere-Wijker, S.4
Pivovarova, A.5
Schmidt, O.6
Bjermer, L.7
-
2
-
-
84880229392
-
Dual bronchodilation with QVA149 versus single bronchodilator therapy: The SHINE study
-
E.D. Bateman, G.T. Ferguson, N. Barnes, N. Gallagher, Y. Green, M. Henley, and D. Banerji Dual bronchodilation with QVA149 versus single bronchodilator therapy: the SHINE study Eur. Respir. J. 42 2013 1484 1494
-
(2013)
Eur. Respir. J.
, vol.42
, pp. 1484-1494
-
-
Bateman, E.D.1
Ferguson, G.T.2
Barnes, N.3
Gallagher, N.4
Green, Y.5
Henley, M.6
Banerji, D.7
-
3
-
-
25444440319
-
Signaling and regulation of G protein-coupled receptors in airway smooth muscle
-
C.K. Billington, and R.B. Penn Signaling and regulation of G protein-coupled receptors in airway smooth muscle Respir. Res. 4 2003 2
-
(2003)
Respir. Res.
, vol.4
, pp. 2
-
-
Billington, C.K.1
Penn, R.B.2
-
4
-
-
84926500092
-
Tiotropium and olodaterol fixed-dose combination versus mono-components in COPD (GOLD 2-4)
-
R. Buhl, F. Maltais, R. Abrahams, L. Bjermer, E. Derom, G. Ferguson, M. Flezar, J. Hebert, L. McGarvey, E. Pizzichini, J. Reid, A. Veale, L. Gronke, A. Hamilton, L. Korducki, K. Tetzlaff, S. Waitere-Wijker, H. Watz, and E. Bateman Tiotropium and olodaterol fixed-dose combination versus mono-components in COPD (GOLD 2-4) Eur. Respir. J. 2015
-
(2015)
Eur. Respir. J.
-
-
Buhl, R.1
Maltais, F.2
Abrahams, R.3
Bjermer, L.4
Derom, E.5
Ferguson, G.6
Flezar, M.7
Hebert, J.8
McGarvey, L.9
Pizzichini, E.10
Reid, J.11
Veale, A.12
Gronke, L.13
Hamilton, A.14
Korducki, L.15
Tetzlaff, K.16
Waitere-Wijker, S.17
Watz, H.18
Bateman, E.19
-
5
-
-
84882399041
-
Effect of the mixed phosphodiesterase 3/4 inhibitor RPL554 on human isolated bronchial smooth muscle tone
-
L. Calzetta, C.P. Page, D. Spina, M. Cazzola, P. Rogliani, F. Facciolo, and M.G. Matera Effect of the mixed phosphodiesterase 3/4 inhibitor RPL554 on human isolated bronchial smooth muscle tone J. Pharmacol. Exp. Ther. 346 2013 414 423
-
(2013)
J. Pharmacol. Exp. Ther.
, vol.346
, pp. 414-423
-
-
Calzetta, L.1
Page, C.P.2
Spina, D.3
Cazzola, M.4
Rogliani, P.5
Facciolo, F.6
Matera, M.G.7
-
6
-
-
84856404019
-
Pharmacological characterization of adenosine receptors on isolated human bronchi
-
L. Calzetta, D. Spina, M. Cazzola, C.P. Page, F. Facciolo, E.A. Rendina, and M.G. Matera Pharmacological characterization of adenosine receptors on isolated human bronchi Am. J. Respir. Cell Mol. Biol. 45 2011 1222 1231
-
(2011)
Am. J. Respir. Cell Mol. Biol.
, vol.45
, pp. 1222-1231
-
-
Calzetta, L.1
Spina, D.2
Cazzola, M.3
Page, C.P.4
Facciolo, F.5
Rendina, E.A.6
Matera, M.G.7
-
7
-
-
80053625994
-
Protein prenylation contributes to the effects of LPS on EFS-induced responses in human isolated bronchi
-
M. Cazzola, L. Calzetta, C.P. Page, B. Rinaldi, A. Capuano, and M.G. Matera Protein prenylation contributes to the effects of LPS on EFS-induced responses in human isolated bronchi Am. J. Respir. Cell Mol. Biol. 45 2011 704 710
-
(2011)
Am. J. Respir. Cell Mol. Biol.
, vol.45
, pp. 704-710
-
-
Cazzola, M.1
Calzetta, L.2
Page, C.P.3
Rinaldi, B.4
Capuano, A.5
Matera, M.G.6
-
8
-
-
84919360274
-
Pharmacological characterization of the interaction between aclidinium bromide and formoterol fumarate on human isolated bronchi
-
M. Cazzola, L. Calzetta, C.P. Page, P. Rogliani, F. Facciolo, A. Gavalda, and M.G. Matera Pharmacological characterization of the interaction between aclidinium bromide and formoterol fumarate on human isolated bronchi Eur. J. Pharmacol. 745 2014 135 143
-
(2014)
Eur. J. Pharmacol.
, vol.745
, pp. 135-143
-
-
Cazzola, M.1
Calzetta, L.2
Page, C.P.3
Rogliani, P.4
Facciolo, F.5
Gavalda, A.6
Matera, M.G.7
-
9
-
-
84867024495
-
High glucose enhances responsiveness of human airways smooth muscle via the Rho/ROCK pathway
-
M. Cazzola, L. Calzetta, P. Rogliani, D. Lauro, L. Novelli, C.P. Page, V. Kanabar, and M.G. Matera High glucose enhances responsiveness of human airways smooth muscle via the Rho/ROCK pathway Am. J. Respir. Cell Mol. Biol. 47 2012 509 516
-
(2012)
Am. J. Respir. Cell Mol. Biol.
, vol.47
, pp. 509-516
-
-
Cazzola, M.1
Calzetta, L.2
Rogliani, P.3
Lauro, D.4
Novelli, L.5
Page, C.P.6
Kanabar, V.7
Matera, M.G.8
-
10
-
-
84928945280
-
TranslAtional study searching for synergy between glycopyrronium and Indacaterol
-
M. Cazzola, L. Calzetta, A. Segreti, F. Facciolo, P. Rogliani, and M.G. Matera Translational Study Searching for Synergy between Glycopyrronium and Indacaterol Chronic Obstr. Pulm. Dis. 12 2015 175 181
-
(2015)
Chronic Obstr. Pulm. Dis.
, vol.12
, pp. 175-181
-
-
Cazzola, M.1
Calzetta, L.2
Segreti, A.3
Facciolo, F.4
Rogliani, P.5
Matera, M.G.6
-
11
-
-
52949146750
-
Novel long-acting bronchodilators for COPD and asthma
-
M. Cazzola, and M.G. Matera Novel long-acting bronchodilators for COPD and asthma Br. J. Pharmacol. 155 2008 291 299
-
(2008)
Br. J. Pharmacol.
, vol.155
, pp. 291-299
-
-
Cazzola, M.1
Matera, M.G.2
-
12
-
-
84893722023
-
Bronchodilators: Current and future
-
M. Cazzola, and M.G. Matera Bronchodilators: current and future Clin. Chest Med. 35 2014 191 201
-
(2014)
Clin. Chest Med.
, vol.35
, pp. 191-201
-
-
Cazzola, M.1
Matera, M.G.2
-
13
-
-
77953232163
-
The scientific rationale for combining long-acting beta2-agonists and muscarinic antagonists in COPD
-
M. Cazzola, and M. Molimard The scientific rationale for combining long-acting beta2-agonists and muscarinic antagonists in COPD Pulm. Pharmacol. Ther. 23 2010 257 267
-
(2010)
Pulm. Pharmacol. Ther.
, vol.23
, pp. 257-267
-
-
Cazzola, M.1
Molimard, M.2
-
14
-
-
84885231930
-
New developments in the combination treatment of COPD: Focus on umeclidinium/vilanterol
-
M. Cazzola, A. Segreti, and M.G. Matera New developments in the combination treatment of COPD: focus on umeclidinium/vilanterol Drug Des. Dev. Ther. 7 2013 1201 1208
-
(2013)
Drug Des. Dev. Ther.
, vol.7
, pp. 1201-1208
-
-
Cazzola, M.1
Segreti, A.2
Matera, M.G.3
-
15
-
-
33748794547
-
Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies
-
T.C. Chou Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies Pharmacol. Rev. 58 2006 621 681
-
(2006)
Pharmacol. Rev.
, vol.58
, pp. 621-681
-
-
Chou, T.C.1
-
16
-
-
33748774989
-
-
ComboSyn, Paramus, NJ
-
Chou, T.C., Martin, N., 2005. CompuSyn for Drug Combinations: PC Software and User's Guide: a Computer Program for Quantitation of Synergism and Antagonism in Drug Combinations, and the Determination of IC50 and ED50 and LD50 Values. ComboSyn, Paramus, NJ.
-
(2005)
CompuSyn for Drug Combinations: PC Software and User's Guide: A Computer Program for Quantitation of Synergism and Antagonism in Drug Combinations, and the Determination of IC50 and ED50 and LD50 Values
-
-
Chou, T.C.1
Martin, N.2
-
17
-
-
70350462573
-
Characterization of aclidinium bromide, a novel inhaled muscarinic antagonist, with long duration of action and a favorable pharmacological profile
-
A. Gavalda, M. Miralpeix, I. Ramos, R. Otal, C. Carreno, M. Vinals, T. Domenech, C. Carcasona, B. Reyes, D. Vilella, J. Gras, J. Cortijo, E. Morcillo, J. Llenas, H. Ryder, and J. Beleta Characterization of aclidinium bromide, a novel inhaled muscarinic antagonist, with long duration of action and a favorable pharmacological profile J. Pharmacol. Exp. Ther. 331 2009 740 751
-
(2009)
J. Pharmacol. Exp. Ther.
, vol.331
, pp. 740-751
-
-
Gavalda, A.1
Miralpeix, M.2
Ramos, I.3
Otal, R.4
Carreno, C.5
Vinals, M.6
Domenech, T.7
Carcasona, C.8
Reyes, B.9
Vilella, D.10
Gras, J.11
Cortijo, J.12
Morcillo, E.13
Llenas, J.14
Ryder, H.15
Beleta, J.16
-
19
-
-
34247177620
-
A mathematical approach to study combined effects of toxicants in vitro: Evaluation of the Bliss Independence criterion and the Loewe additivity model
-
M. Goldoni, and C. Johansson A mathematical approach to study combined effects of toxicants in vitro: evaluation of the Bliss Independence criterion and the Loewe additivity model Toxicol. In Vitro 21 2007 759 769
-
(2007)
Toxicol. in Vitro
, vol.21
, pp. 759-769
-
-
Goldoni, M.1
Johansson, C.2
-
20
-
-
84859201195
-
Quantum mechanics can reduce the complexity of classical models
-
M. Gu, K. Wiesner, E. Rieper, and V. Vedral Quantum mechanics can reduce the complexity of classical models Nat. Commun. 3 2012 762
-
(2012)
Nat. Commun.
, vol.3
, pp. 762
-
-
Gu, M.1
Wiesner, K.2
Rieper, E.3
Vedral, V.4
-
21
-
-
84866758536
-
Tiotropium in asthma poorly controlled with standard combination therapy
-
H.A. Kerstjens, M. Engel, R. Dahl, P. Paggiaro, E. Beck, M. Vandewalker, R. Sigmund, W. Seibold, P. Moroni-Zentgraf, and E.D. Bateman Tiotropium in asthma poorly controlled with standard combination therapy N. Engl. J. Med. 367 2012 1198 1207
-
(2012)
N. Engl. J. Med.
, vol.367
, pp. 1198-1207
-
-
Kerstjens, H.A.1
Engel, M.2
Dahl, R.3
Paggiaro, P.4
Beck, E.5
Vandewalker, M.6
Sigmund, R.7
Seibold, W.8
Moroni-Zentgraf, P.9
Bateman, E.D.10
-
22
-
-
84906049219
-
Long-acting inhaled therapy (beta-agonists, anticholinergics and steroids) for COPD: A network meta-analysis
-
K.M. Kew, S. Dias, and C.J. Cates Long-acting inhaled therapy (beta-agonists, anticholinergics and steroids) for COPD: a network meta-analysis Cochrane Database Syst. Rev. 2014 3
-
(2014)
Cochrane Database Syst. Rev.
, pp. 3
-
-
Kew, K.M.1
Dias, S.2
Cates, C.J.3
-
23
-
-
71249112362
-
Relaxant effect of brain natriuretic peptide in nonsensitized and passively sensitized isolated human bronchi
-
M.G. Matera, L. Calzetta, V. Parascandolo, G. Curradi, P. Rogliani, and M. Cazzola Relaxant effect of brain natriuretic peptide in nonsensitized and passively sensitized isolated human bronchi Pulm. Pharmacol. Ther. 22 2009 478 482
-
(2009)
Pulm. Pharmacol. Ther.
, vol.22
, pp. 478-482
-
-
Matera, M.G.1
Calzetta, L.2
Parascandolo, V.3
Curradi, G.4
Rogliani, P.5
Cazzola, M.6
-
24
-
-
79960926521
-
Epithelium integrity is crucial for the relaxant activity of brain natriuretic peptide in human isolated bronchi
-
M.G. Matera, L. Calzetta, D. Passeri, F. Facciolo, E.A. Rendina, C. Page, M. Cazzola, and A. Orlandi Epithelium integrity is crucial for the relaxant activity of brain natriuretic peptide in human isolated bronchi Br. J. Pharmacol. 163 2011 1740 1754
-
(2011)
Br. J. Pharmacol.
, vol.163
, pp. 1740-1754
-
-
Matera, M.G.1
Calzetta, L.2
Passeri, D.3
Facciolo, F.4
Rendina, E.A.5
Page, C.6
Cazzola, M.7
Orlandi, A.8
-
25
-
-
26244458211
-
Immune sensitization of equine bronchus: Glutathione, IL-1beta expression and tissue responsiveness
-
M.G. Matera, L. Calzetta, A. Peli, A. Scagliarini, C. Matera, and M. Cazzola Immune sensitization of equine bronchus: glutathione, IL-1beta expression and tissue responsiveness Respir. Res. 6 2005 104
-
(2005)
Respir. Res.
, vol.6
, pp. 104
-
-
Matera, M.G.1
Calzetta, L.2
Peli, A.3
Scagliarini, A.4
Matera, C.5
Cazzola, M.6
-
26
-
-
79951945911
-
Evaluation of the effects of the R- and S-enantiomers of salbutamol on equine isolated bronchi
-
M.G. Matera, L. Calzetta, P. Rogliani, F. Bardaro, C.P. Page, and M. Cazzola Evaluation of the effects of the R- and S-enantiomers of salbutamol on equine isolated bronchi Pulm. Pharmacol. Ther. 24 2011 221 226
-
(2011)
Pulm. Pharmacol. Ther.
, vol.24
, pp. 221-226
-
-
Matera, M.G.1
Calzetta, L.2
Rogliani, P.3
Bardaro, F.4
Page, C.P.5
Cazzola, M.6
-
27
-
-
47049130107
-
Effects of neuraminidase on equine isolated bronchi
-
M.G. Matera, L. Calzetta, A. Sanduzzi, C.P. Page, and M. Cazzola Effects of neuraminidase on equine isolated bronchi Pulm. Pharmacol. Ther. 21 2008 624 629
-
(2008)
Pulm. Pharmacol. Ther.
, vol.21
, pp. 624-629
-
-
Matera, M.G.1
Calzetta, L.2
Sanduzzi, A.3
Page, C.P.4
Cazzola, M.5
-
29
-
-
84916928423
-
Umeclidinium bromide+vilanterol for the treatment of chronic obstructive pulmonary disease
-
M.G. Matera, P. Rogliani, B. Rinaldi, and M. Cazzola Umeclidinium bromide+vilanterol for the treatment of chronic obstructive pulmonary disease Expert Rev. Clin. Pharmacol. 8 2015 35 41
-
(2015)
Expert Rev. Clin. Pharmacol.
, vol.8
, pp. 35-41
-
-
Matera, M.G.1
Rogliani, P.2
Rinaldi, B.3
Cazzola, M.4
-
30
-
-
84873170983
-
Muscarinic receptors on airway mesenchymal cells: Novel findings for an ancient target
-
H. Meurs, B.G. Dekkers, H. Maarsingh, A.J. Halayko, J. Zaagsma, and R. Gosens Muscarinic receptors on airway mesenchymal cells: novel findings for an ancient target Pulm. Pharmacol. Ther. 26 2013 145 155
-
(2013)
Pulm. Pharmacol. Ther.
, vol.26
, pp. 145-155
-
-
Meurs, H.1
Dekkers, B.G.2
Maarsingh, H.3
Halayko, A.J.4
Zaagsma, J.5
Gosens, R.6
-
31
-
-
33847313718
-
Combination inhaled bronchodilator therapy in the management of chronic obstructive pulmonary disease
-
J. Nichols Combination inhaled bronchodilator therapy in the management of chronic obstructive pulmonary disease Pharmacotherapy 27 2007 447 454
-
(2007)
Pharmacotherapy
, vol.27
, pp. 447-454
-
-
Nichols, J.1
-
32
-
-
84917708632
-
Treatment of chronic obstructive pulmonary disease by dual bronchodilation with coformulation of indacaterol/glycopyrronium
-
G. Pelaia, R. Maselli, and M.G. Matera Treatment of Chronic Obstructive Pulmonary Disease by Dual Bronchodilation with Coformulation of Indacaterol/Glycopyrronium Pharmacology 94 2014 249 258
-
(2014)
Pharmacology
, vol.94
, pp. 249-258
-
-
Pelaia, G.1
Maselli, R.2
Matera, M.G.3
-
33
-
-
84904535558
-
Efficacy and safety of a fixed-dose combination of indacaterol and Glycopyrronium for the treatment of COPD: A systematic review
-
G.J. Rodrigo, and V. Plaza Efficacy and safety of a fixed-dose combination of indacaterol and Glycopyrronium for the treatment of COPD: a systematic review Chest 146 2014 309 317
-
(2014)
Chest
, vol.146
, pp. 309-317
-
-
Rodrigo, G.J.1
Plaza, V.2
-
34
-
-
84875951169
-
The influence of propofol, remifentanil and lidocaine on the tone of human bronchial smooth muscle
-
P. Rogliani, L. Calzetta, E.A. Rendina, D. Massullo, M. Dauri, B. Rinaldi, A. Capuano, and M.G. Matera The influence of propofol, remifentanil and lidocaine on the tone of human bronchial smooth muscle Pulm. Pharmacol. Ther. 26 2013 325 331
-
(2013)
Pulm. Pharmacol. Ther.
, vol.26
, pp. 325-331
-
-
Rogliani, P.1
Calzetta, L.2
Rendina, E.A.3
Massullo, D.4
Dauri, M.5
Rinaldi, B.6
Capuano, A.7
Matera, M.G.8
-
35
-
-
84866528977
-
P137 Efficacy and safety of once-daily aclidinium bromide 200 μg in combination with formoterol in patients with COPD
-
P. ͆liwiński, D.W. Perng, A. Chuchalin, and P.W. Jones P137 Efficacy and safety of once-daily aclidinium bromide 200 μg in combination with formoterol in patients with COPD Thorax 65 2010 A136-A136
-
(2010)
Thorax
, vol.65
, pp. A136-A136
-
-
͆liwiński, P.1
Perng, D.W.2
Chuchalin, A.3
Jones, P.W.4
-
36
-
-
84867602726
-
The Influence of receptor kinetics on the onset and duration of action and the therapeutic index of NVA237 and tiotropium
-
D.A. Sykes, M.R. Dowling, J. Leighton-Davies, T.C. Kent, L. Fawcett, E. Renard, A. Trifilieff, and S.J. Charlton The Influence of receptor kinetics on the onset and duration of action and the therapeutic index of NVA237 and tiotropium. J. Pharmacol. Exp. Ther. 343 2012 520 528
-
(2012)
J. Pharmacol. Exp. Ther.
, vol.343
, pp. 520-528
-
-
Sykes, D.A.1
Dowling, M.R.2
Leighton-Davies, J.3
Kent, T.C.4
Fawcett, L.5
Renard, E.6
Trifilieff, A.7
Charlton, S.J.8
-
37
-
-
84862488682
-
Revisiting the isobole and related quantitative methods for assessing drug synergism
-
R.J. Tallarida Revisiting the isobole and related quantitative methods for assessing drug synergism J. Pharmacol. Exp. Ther. 342 2012 2 8
-
(2012)
J. Pharmacol. Exp. Ther.
, vol.342
, pp. 2-8
-
-
Tallarida, R.J.1
-
38
-
-
84877682284
-
Combination bronchodilator therapy in the management of chronic obstructive pulmonary disease
-
D.P. Tashkin, and G.T. Ferguson Combination bronchodilator therapy in the management of chronic obstructive pulmonary disease Respir. Res. 14 2013 49
-
(2013)
Respir. Res.
, vol.14
, pp. 49
-
-
Tashkin, D.P.1
Ferguson, G.T.2
-
39
-
-
85027923918
-
Beyond lung function in COPD management: Effectiveness of LABA/LAMA combination therapy on patient-centred outcomes
-
T. van der Molen, and M. Cazzola Beyond lung function in COPD management: effectiveness of LABA/LAMA combination therapy on patient-centred outcomes Prim. Care Respir. J. 21 2012 101 108
-
(2012)
Prim. Care Respir. J.
, vol.21
, pp. 101-108
-
-
Van Der Molen, T.1
Cazzola, M.2
-
40
-
-
84877131237
-
Analysis of chronic obstructive pulmonary disease exacerbations with the dual bronchodilator QVA149 compared with glycopyrronium and tiotropium (SPARK): A randomised, double-blind, parallel-group study
-
J.A. Wedzicha, M. Decramer, J.H. Ficker, D.E. Niewoehner, T. Sandstrom, A.F. Taylor, P. D'Andrea, C. Arrasate, H. Chen, and D. Banerji Analysis of chronic obstructive pulmonary disease exacerbations with the dual bronchodilator QVA149 compared with glycopyrronium and tiotropium (SPARK): a randomised, double-blind, parallel-group study Lancet Respir. Med. 1 2013 199 209
-
(2013)
Lancet Respir. Med.
, vol.1
, pp. 199-209
-
-
Wedzicha, J.A.1
Decramer, M.2
Ficker, J.H.3
Niewoehner, D.E.4
Sandstrom, T.5
Taylor, A.F.6
D'Andrea, P.7
Arrasate, C.8
Chen, H.9
Banerji, D.10
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