High glucose enhances responsiveness of human airways smooth muscle via the Rho/ROCK pathway

American Journal of Respiratory Cell and Molecular Biology

Volumn 47, Issue 4, 2012, Pages 509-516

  Cazzola, Mario ^a,b   Calzetta, Luigino ^b   Rogliani, Paola ^a   Lauro, Davide ^a   Novelli, Lucia ^a   Page, Clive P ^c   Kanabar, Varsha ^c   Matera, Maria Gabriella ^d  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b IRCCS SAN RAFFAELE PISANA   (Italy)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

Airway hyperresponsiveness; Cultured airway smooth muscle cells; Human isolated airways; Hyperglycemia; Rho ROCK pathway

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ACETYLCHOLINE; BRADYKININ; CALCIUM; GLUCOSE; HISTAMINE; MANNITOL; RHO FACTOR; RHO KINASE INHIBITOR;

ADULT; AIRWAY SMOOTH MUSCLE CELL; ARTICLE; BRONCHUS; BRONCHUS HYPERREACTIVITY; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL ISOLATION; CELL STIMULATION; CONTROLLED STUDY; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; INCUBATION TIME; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; PROTEIN PHOSPHORYLATION; SMOOTH MUSCLE; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE FIBER;

ACETYLCHOLINE; AMIDES; BRADYKININ; BRONCHI; CALCIUM SIGNALING; CELLS, CULTURED; ENZYME ACTIVATION; FEMALE; GLUCOSE; HISTAMINE; HUMANS; HYPERGLYCEMIA; IMIDAZOLES; MALE; MANNITOL; MIDDLE AGED; MUSCLE CONTRACTION; MUSCLE, SMOOTH; MYOSIN-LIGHT-CHAIN PHOSPHATASE; OSMOLAR CONCENTRATION; OXADIAZOLES; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PYRIDINES; RHO GTP-BINDING PROTEINS; RHO-ASSOCIATED KINASES;

EID: 84867024495     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2011-0449OC     Document Type: Article

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