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Volumn 7, Issue , 2013, Pages 1201-1208

New developments in the combination treatment of COPD: Focus on umeclidinium/vilanterol

Author keywords

COPD; Dual bronchodilation; Muscarinic antagonist

Indexed keywords

ACLIDINIUM BROMIDE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; FORMOTEROL; GLYCOPYRRONIUM BROMIDE; GLYCOPYRRONIUM PLUS INDACATEROL; MUSCARINIC RECEPTOR BLOCKING AGENT; OLODATEROL PLUS TIOTROPIUM; PLACEBO; TIOTROPIUM BROMIDE; UMECLIDINIUM; UMECLIDINIUM PLUS VILANTEROL; UNCLASSIFIED DRUG; VILANTEROL;

EID: 84885231930     PISSN: 11778881     EISSN: None     Source Type: Journal    
DOI: 10.2147/DDDT.S39449     Document Type: Article
Times cited : (37)

References (41)
  • 1
    • 79961046696 scopus 로고    scopus 로고
    • American College of Physicians; American College of Chest Physicians; American Thoracic Society; European Respiratory Society. Diagnosis and management of stable chronic obstructive pulmonary disease: A clinical practice guideline update from the American College of Physicians, American College of Chest Physicians, American Thoracic Society, and European Respiratory Society
    • Qaseem A, Wilt TJ, Weinberger SE, et al; American College of Physicians; American College of Chest Physicians; American Thoracic Society; European Respiratory Society. Diagnosis and management of stable chronic obstructive pulmonary disease: a clinical practice guideline update from the American College of Physicians, American College of Chest Physicians, American Thoracic Society, and European Respiratory Society. Ann Intern Med. 2011;155:179-191.
    • (2011) Ann Intern Med , vol.155 , pp. 179-191
    • Qaseem, A.1    Wilt, T.J.2    Weinberger, S.E.3
  • 2
    • 84885218729 scopus 로고    scopus 로고
    • Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease. Global Initiative for Chronic Obstructive Lung Disease (GOLD); 2013. Available from, Accessed June 20
    • Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease. Global Initiative for Chronic Obstructive Lung Disease (GOLD); 2013. Available from: http://www.goldcopd.org/guidelines-global-strategy-for-diagnosis-management.html. Accessed June 20, 2013.
    • (2013)
  • 4
    • 84874571203 scopus 로고    scopus 로고
    • Project PriMo: Sharing principles and practices of bronchodilator therapy monitoring in COPD: A consensus initiative for optimizing therapeutic appropriateness among Italian specialists
    • Cazzola M, Brusasco V, Centanni S, et al. Project PriMo: sharing principles and practices of bronchodilator therapy monitoring in COPD: a consensus initiative for optimizing therapeutic appropriateness among Italian specialists. Pulm Pharmacol Ther. 2013;26:218-228.
    • (2013) Pulm Pharmacol Ther , vol.26 , pp. 218-228
    • Cazzola, M.1    Brusasco, V.2    Centanni, S.3
  • 5
    • 70350120604 scopus 로고    scopus 로고
    • Combination of formoterol and tiotropium in the treatment of COPD: Effects on lung function
    • Cazzola M, Tashkin DP. Combination of formoterol and tiotropium in the treatment of COPD: effects on lung function. COPD. 2009;6:404-415.
    • (2009) COPD , vol.6 , pp. 404-415
    • Cazzola, M.1    Tashkin, D.P.2
  • 6
    • 85027923918 scopus 로고    scopus 로고
    • Beyond lung function in COPD management: Effectiveness of LABA/LAMA combination therapy on patient-centred outcomes
    • van der Molen T, Cazzola M. Beyond lung function in COPD management: effectiveness of LABA/LAMA combination therapy on patient-centred outcomes. Prim Care Respir J. 2012;21:101-108.
    • (2012) Prim Care Respir J , vol.21 , pp. 101-108
    • van der Molen, T.1    Cazzola, M.2
  • 7
    • 84877131237 scopus 로고    scopus 로고
    • Analysis of chronic obstructive pulmonary disease exacerbations with the dual bronchodilator QVA149 compared with glycopyrronium and tiotropium (SPARK): A randomised, double-blind, parallel-group study
    • Wedzicha JA, Decramer M, Ficker JH, et al. Analysis of chronic obstructive pulmonary disease exacerbations with the dual bronchodilator QVA149 compared with glycopyrronium and tiotropium (SPARK): a randomised, double-blind, parallel-group study. Lancet Respir Med. 2013;1:199-209.
    • (2013) Lancet Respir Med , vol.1 , pp. 199-209
    • Wedzicha, J.A.1    Decramer, M.2    Ficker, J.H.3
  • 8
    • 27644516884 scopus 로고    scopus 로고
    • Combination therapy for chronic obstructive pulmonary disease: Clinical aspects
    • Donohue JF. Combination therapy for chronic obstructive pulmonary disease: clinical aspects. Proc Am Thorac Soc. 2005;2:272-281.
    • (2005) Proc Am Thorac Soc , vol.2 , pp. 272-281
    • Donohue, J.F.1
  • 9
    • 77953232163 scopus 로고    scopus 로고
    • The scientific rationale for combining long-acting f{hook}À2-agonists and muscarinic antagonists in COPD
    • Cazzola M, Molimard M. The scientific rationale for combining long-acting f{hook}À2-agonists and muscarinic antagonists in COPD. Pulm Pharmacol Ther. 2010;23:257-267.
    • (2010) Pulm Pharmacol Ther , vol.23 , pp. 257-267
    • Cazzola, M.1    Molimard, M.2
  • 10
    • 79953717418 scopus 로고    scopus 로고
    • F{hook}À2-adrenoceptor agonists: Current and future direction
    • Cazzola M, Calzetta L, Matera MG. f{hook}À2-adrenoceptor agonists: current and future direction. Br J Pharmacol. 2011;163:4-17.
    • (2011) Br J Pharmacol , vol.163 , pp. 4-17
    • Cazzola, M.1    Calzetta, L.2    Matera, M.G.3
  • 11
    • 84879121971 scopus 로고    scopus 로고
    • A new perspective on muscarinic receptor antagonism in obstructive airways diseases
    • Meurs H, Oenema TA, Kistemaker LE, Gosens R. A new perspective on muscarinic receptor antagonism in obstructive airways diseases. Curr Opin Pharmacol. 2013;13:316-323.
    • (2013) Curr Opin Pharmacol , vol.13 , pp. 316-323
    • Meurs, H.1    Oenema, T.A.2    Kistemaker, L.E.3    Gosens, R.4
  • 13
    • 84865018122 scopus 로고    scopus 로고
    • F{hook}À2-adrenoceptors and muscarinic receptors mediate opposing effects on endothelin-1 expression in human lung fibroblasts
    • Ahmedat AS, Warnken M, Juergens UR, Paul Pieper M, Racke K. f{hook}À2-adrenoceptors and muscarinic receptors mediate opposing effects on endothelin-1 expression in human lung fibroblasts. Eur J Pharmacol. 2012;691:218-224.
    • (2012) Eur J Pharmacol , vol.691 , pp. 218-224
    • Ahmedat, A.S.1    Warnken, M.2    Juergens, U.R.3    Paul, P.M.4    Racke, K.5
  • 14
    • 84860350181 scopus 로고    scopus 로고
    • F{hook}À2 long-acting and anticholinergic drugs control TGF-f{hook}À1-mediated neutrophilic inflammation in COPD
    • Profita M, Bonanno A, Montalbano AM, et al. f{hook}À2 long-acting and anticholinergic drugs control TGF-f{hook}À1-mediated neutrophilic inflammation in COPD. Biochim Biophys Acta. 2012;1822:1079-1089.
    • (2012) Biochim Biophys Acta , vol.1822 , pp. 1079-1089
    • Profita, M.1    Bonanno, A.2    Montalbano, A.M.3
  • 15
    • 84877682284 scopus 로고    scopus 로고
    • Combination bronchodilator therapy in the management of chronic obstructive pulmonary disease
    • Tashkin DP, Ferguson GT. Combination bronchodilator therapy in the management of chronic obstructive pulmonary disease. Respir Res. 2013;14:49.
    • (2013) Respir Res , vol.14 , pp. 49
    • Tashkin, D.P.1    Ferguson, G.T.2
  • 16
    • 79960958698 scopus 로고    scopus 로고
    • Novel bronchodilators for the treatment of chronic obstructive pulmonary disease
    • Matera MG, Page CP, Cazzola M. Novel bronchodilators for the treatment of chronic obstructive pulmonary disease. Trends Pharmacol Sci. 2011;32:495-506.
    • (2011) Trends Pharmacol Sci , vol.32 , pp. 495-506
    • Matera, M.G.1    Page, C.P.2    Cazzola, M.3
  • 19
    • 84875128903 scopus 로고    scopus 로고
    • Aclidinium bromide/formoterol fumarate fixed-dose combination for the treatment of chronic obstructive pulmonary disease
    • Cazzola M, Rogliani P, Matera MG. Aclidinium bromide/formoterol fumarate fixed-dose combination for the treatment of chronic obstructive pulmonary disease. Expert Opin Pharmacother. 2013;14:775-781.
    • (2013) Expert Opin Pharmacother , vol.14 , pp. 775-781
    • Cazzola, M.1    Rogliani, P.2    Matera, M.G.3
  • 20
    • 84876518288 scopus 로고    scopus 로고
    • Pharmacological characterization of GSK573719 (umeclidinium): A novel, long-acting, inhaled antagonist of the muscarinic cholinergic receptors for treatment of pulmonary diseases
    • Salmon M, Luttmann MA, Foley JJ, et al. Pharmacological characterization of GSK573719 (umeclidinium): a novel, long-acting, inhaled antagonist of the muscarinic cholinergic receptors for treatment of pulmonary diseases. J Pharmacol Exp Ther. 2013;345:260-270.
    • (2013) J Pharmacol Exp Ther , vol.345 , pp. 260-270
    • Salmon, M.1    Luttmann, M.A.2    Foley, J.J.3
  • 21
    • 84873377631 scopus 로고    scopus 로고
    • Initial assessment of single and repeat doses of inhaled umeclidinium in patients with chronic obstructive pulmonary disease: Two randomised studies
    • Tal-Singer R, Cahn A, Mehta R, et al. Initial assessment of single and repeat doses of inhaled umeclidinium in patients with chronic obstructive pulmonary disease: two randomised studies. Eur J Pharmacol. 2013;701:40-48.
    • (2013) Eur J Pharmacol , vol.701 , pp. 40-48
    • Tal-Singer, R.1    Cahn, A.2    Mehta, R.3
  • 22
    • 84879834099 scopus 로고    scopus 로고
    • Safety, tolerability, pharmacokinetics and pharmacodynamics of single and repeat inhaled doses of umeclidinium in healthy subjects: Two randomized studies
    • Cahn A, Tal-Singer R, Pouliquen IJ, et al. Safety, tolerability, pharmacokinetics and pharmacodynamics of single and repeat inhaled doses of umeclidinium in healthy subjects: two randomized studies. Clin Drug Investig. 2013;33:477-488.
    • (2013) Clin Drug Investig , vol.33 , pp. 477-488
    • Cahn, A.1    Tal-Singer, R.2    Pouliquen, I.J.3
  • 23
    • 84871923164 scopus 로고    scopus 로고
    • Bronchodilation of umeclidinium, a new long-acting muscarinic antagonist, in COPD patients
    • Decramer M, Maltais F, Feldman G, et al. Bronchodilation of umeclidinium, a new long-acting muscarinic antagonist, in COPD patients. Respir Physiol Neurobiol. 2013;185:393-399.
    • (2013) Respir Physiol Neurobiol , vol.185 , pp. 393-399
    • Decramer, M.1    Maltais, F.2    Feldman, G.3
  • 24
    • 84861189477 scopus 로고    scopus 로고
    • A randomized, double-blind dose-ranging study of the novel LAMA GSK573719 in patients with COPD
    • Donohue JF, Anzueto A, Brooks J, Mehta R, Kalberg C, Crater G. A randomized, double-blind dose-ranging study of the novel LAMA GSK573719 in patients with COPD. Respir Med. 2012;106: 970-979.
    • (2012) Respir Med , vol.106 , pp. 970-979
    • Donohue, J.F.1    Anzueto, A.2    Brooks, J.3    Mehta, R.4    Kalberg, C.5    Crater, G.6
  • 25
    • 84871697898 scopus 로고    scopus 로고
    • In vitro pharmacological characterization of vilanterol, a novel long-acting f{hook}À2-adrenoceptor agonist with 24-hour duration of action
    • Slack RJ, Barrett VJ, Morrison VS, et al. In vitro pharmacological characterization of vilanterol, a novel long-acting f{hook}À2-adrenoceptor agonist with 24-hour duration of action. J Pharmacol Exp Ther. 2013;344: 218-230.
    • (2013) J Pharmacol Exp Ther , vol.344 , pp. 218-230
    • Slack, R.J.1    Barrett, V.J.2    Morrison, V.S.3
  • 26
    • 84871547267 scopus 로고    scopus 로고
    • Metabolism and disposition of vilanterol, a long-acting f{hook}À2-adrenoceptor agonist for inhalation use in humans
    • Harrell AW, Siederer SK, Bal J, et al. Metabolism and disposition of vilanterol, a long-acting f{hook}À2-adrenoceptor agonist for inhalation use in humans. Drug Metab Dispos. 2013;41:89-100.
    • (2013) Drug Metab Dispos , vol.41 , pp. 89-100
    • Harrell, A.W.1    Siederer, S.K.2    Bal, J.3
  • 27
    • 84874563028 scopus 로고    scopus 로고
    • Vilanterol trifenatate, a novel inhaled long-acting beta2 adrenoceptor agonist, is well tolerated in healthy subjects and demonstrates prolonged bronchodilation in subjects with asthma and COPD
    • Kempsford R, Norris V, Siederer S. Vilanterol trifenatate, a novel inhaled long-acting beta2 adrenoceptor agonist, is well tolerated in healthy subjects and demonstrates prolonged bronchodilation in subjects with asthma and COPD. Pulm Pharmacol Ther. 2013;26: 256-264.
    • (2013) Pulm Pharmacol Ther , vol.26 , pp. 256-264
    • Kempsford, R.1    Norris, V.2    Siederer, S.3
  • 28
    • 84858957208 scopus 로고    scopus 로고
    • The efficacy and safety of the novel long-acting f{hook}À2 agonist vilanterol in patients with COPD: A randomized placebo-controlled trial
    • Hanania NA, Feldman G, Zachgo W, et al. The efficacy and safety of the novel long-acting f{hook}À2 agonist vilanterol in patients with COPD: a randomized placebo-controlled trial. Chest. 2012;142:119-127.
    • (2012) Chest , vol.142 , pp. 119-127
    • Hanania, N.A.1    Feldman, G.2    Zachgo, W.3
  • 29
    • 84871319130 scopus 로고    scopus 로고
    • Safety, tolerability, pharmacodynamics and pharmacokinetics of umeclidinium and vilanterol alone and in combination: A randomized crossover trial
    • Kelleher DL, Mehta RS, Jean-Francois BM, et al. Safety, tolerability, pharmacodynamics and pharmacokinetics of umeclidinium and vilanterol alone and in combination: a randomized crossover trial. PLoS One. 2012;7:e50716.
    • (2012) PLoS One , vol.e50716 , pp. 7
    • Kelleher, D.L.1    Mehta, R.S.2    Jean-Francois, B.M.3
  • 30
    • 84886378516 scopus 로고    scopus 로고
    • A placebo- and moxifloxacin-controlled thorough QT study of umeclidinium monotherapy and umeclidinium/vilanterol combination in healthy subjects
    • Kelleher D, Tombs L, Crater G, Preece A, Brealey N, Mehta R. A placebo- and moxifloxacin-controlled thorough QT study of umeclidinium monotherapy and umeclidinium/vilanterol combination in healthy subjects. Am J Respir Crit Care Med. 2013;187:A1487.
    • (2013) Am J Respir Crit Care Med , vol.187
    • Kelleher, D.1    Tombs, L.2    Crater, G.3    Preece, A.4    Brealey, N.5    Mehta, R.6
  • 31
    • 84870236438 scopus 로고    scopus 로고
    • 28-day safety and tolerability of umeclidinium in combination with vilanterol in COPD: A randomized placebo-controlled trial
    • Feldman G, Walker RR, Brooks J, Mehta R, Crater G. 28-day safety and tolerability of umeclidinium in combination with vilanterol in COPD: a randomized placebo-controlled trial. Pulm Pharmacol Ther. 2012;25:465-471.
    • (2012) Pulm Pharmacol Ther , vol.25 , pp. 465-471
    • Feldman, G.1    Walker, R.R.2    Brooks, J.3    Mehta, R.4    Crater, G.5
  • 33
    • 84886416641 scopus 로고    scopus 로고
    • A 24-week randomized, double-blind, placebo-controlled study of the efficacy and safety of once-daily umeclidinium/vilanterol 125/25 mcg in COPD
    • Celli BR, Crater G, Kilbride S, et al. A 24-week randomized, double-blind, placebo-controlled study of the efficacy and safety of once-daily umeclidinium/vilanterol 125/25 mcg in COPD. Am J Respir Crit Care Med. 2013;187:A2435.
    • (2013) Am J Respir Crit Care Med , vol.187
    • Celli, B.R.1    Crater, G.2    Kilbride, S.3
  • 34
    • 84886395702 scopus 로고    scopus 로고
    • The efficacy and safety of umeclidinium/vilanterol compared with tiotropium or vilanterol over 24 weeks in subjects with COPD
    • Anzueto A, Decramer M, Kaelin T, et al. The efficacy and safety of umeclidinium/vilanterol compared with tiotropium or vilanterol over 24 weeks in subjects with COPD. Am J Respir Crit Care Med. 2013;187:A4268.
    • (2013) Am J Respir Crit Care Med , vol.187
    • Anzueto, A.1    Decramer, M.2    Kaelin, T.3
  • 35
    • 84875959946 scopus 로고    scopus 로고
    • Long-acting muscarinic receptor antagonists for the treatment of respiratory disease
    • Cazzola M, Page C, Matera MG. Long-acting muscarinic receptor antagonists for the treatment of respiratory disease. Pulm Pharmacol Ther. 2013;26:307-317.
    • (2013) Pulm Pharmacol Ther , vol.26 , pp. 307-317
    • Cazzola, M.1    Page, C.2    Matera, M.G.3
  • 36
    • 69249213484 scopus 로고    scopus 로고
    • Agonist efficacy and receptor desensitization: From partial truths to a fuller picture
    • Charlton SJ. Agonist efficacy and receptor desensitization: from partial truths to a fuller picture. Br J Pharmacol. 2009;158:165-168.
    • (2009) Br J Pharmacol , vol.158 , pp. 165-168
    • Charlton, S.J.1
  • 37
    • 0034928922 scopus 로고    scopus 로고
    • In patients with COPD, treatment with a combination of formoterol and ipratropium is more effective than a combination of salbutamol and ipratropium: A 3-week, randomized, double-blind, within-patient, multicenter study
    • D'Urzo AD, De Salvo MC, Ramirez-Rivera A, et al. In patients with COPD, treatment with a combination of formoterol and ipratropium is more effective than a combination of salbutamol and ipratropium: a 3-week, randomized, double-blind, within-patient, multicenter study. Chest. 2001;119:1347-1356.
    • (2001) Chest , vol.119 , pp. 1347-1356
    • D'Urzo, A.D.1    de Salvo, M.C.2    Ramirez-Rivera, A.3
  • 39
    • 79551580131 scopus 로고    scopus 로고
    • Population pharmacodynamic model of the longitudinal FEV1 response to an inhaled long-acting anti-muscarinic in COPD patients
    • Wu K, Looby M, Pillai G, Pinault G, Drollman AF, Pascoe S. Population pharmacodynamic model of the longitudinal FEV1 response to an inhaled long-acting anti-muscarinic in COPD patients. J Pharmacokinet Pharmacodyn. 2011;38:105-119.
    • (2011) J Pharmacokinet Pharmacodyn , vol.38 , pp. 105-119
    • Wu, K.1    Looby, M.2    Pillai, G.3    Pinault, G.4    Drollman, A.F.5    Pascoe, S.6
  • 40
    • 84886432966 scopus 로고    scopus 로고
    • An analysis of the dose response of umeclidinium (GSK573719) administered once or twice daily in patients with COPD
    • Church A, Kalberg C, Shah P, Beerahee M, Donohue J. An analysis of the dose response of umeclidinium (GSK573719) administered once or twice daily in patients with COPD. Chest. 2012;142:672A.
    • (2012) Chest , vol.672 A , pp. 142
    • Church, A.1    Kalberg, C.2    Shah, P.3    Beerahee, M.4    Donohue, J.5
  • 41
    • 84862535597 scopus 로고    scopus 로고
    • Efficacy and optimal dosing interval of the long-acting beta2 agonist, vilanterol, in persistent asthma: A randomised trial
    • Sterling R, Lim J, Frith L, Snowise NG, Jacques L, Haumann B. Efficacy and optimal dosing interval of the long-acting beta2 agonist, vilanterol, in persistent asthma: a randomised trial. Respir Med. 2012;106: 1110-1115.
    • (2012) Respir Med , vol.106 , pp. 1110-1115
    • Sterling, R.1    Lim, J.2    Frith, L.3    Snowise, N.G.4    Jacques, L.5    Haumann, B.6


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