Emodin mitigates diesel exhaust particles-induced increase in airway resistance, inflammation and oxidative stress in mice

Respiratory Physiology and Neurobiology

Volumn 215, Issue , 2015, Pages 51-57

  Nemmar, Abderrahim ^a   Al Salam, Suhail ^a   Yuvaraju, Priya ^a   Beegam, Sumaya ^a   Ali, Badreldin H ^b  

^a UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

^b SULTAN QABOOS UNIVERSITY   (Oman)

Author keywords

Airway resistance; Diesel exhaust particles; Emodin; Inflammation; Oxidative stress

Indexed keywords

EMODIN; GLUTATHIONE; METHACHOLINE; REACTIVE OXYGEN METABOLITE; CYTOKINE; METHACHOLINE CHLORIDE; MUSCARINIC AGENT; PARTICULATE MATTER; PROTEIN KINASE INHIBITOR;

AIRWAY RESISTANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL COMPOSITION; CONTROLLED STUDY; EXHAUST GAS; HISTOLOGY; HISTOPATHOLOGY; LIPID PEROXIDATION; LUNG LAVAGE; LUNG PARENCHYMA; MEASUREMENT; MOUSE; NONHUMAN; OSCILLATION; OXIDATIVE STRESS; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION; ANIMAL; BAGG ALBINO MOUSE; CHEMICALLY INDUCED; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; LUNG; LUNG DISEASES; METABOLISM; PARTICULATE MATTER; PATHOLOGY; PNEUMONIA; TIME; TOXICITY;

AIRWAY RESISTANCE; ANIMALS; CYTOKINES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EMODIN; GLUTATHIONE; LIPID PEROXIDATION; LUNG; LUNG DISEASES; METHACHOLINE CHLORIDE; MICE; MICE, INBRED BALB C; MUSCARINIC AGONISTS; OXIDATIVE STRESS; PARTICULATE MATTER; PNEUMONIA; PROTEIN KINASE INHIBITORS; REACTIVE OXYGEN SPECIES; TIME FACTORS;

EID: 84930613274     PISSN: 15699048     EISSN: 18781519     Source Type: Journal    
DOI: 10.1016/j.resp.2015.05.006     Document Type: Article

References (36)

1. Ali B.H., Al-Salam S., Al Husseini I.S., Al-Lawati I., Waly M., Yasin J., Fahim M., Nemmar A. Abrogation of cisplatin-induced nephrotoxicity by emodin in rats. Fundam. Clin. Pharmacol. 2013, 27(2):192-200.
2. Brunekreef B., Holgate S.T. Air pollution and health. Lancet 2002, 360(9341):1233-1242.
3. Cakmak S., Dales R., Leech J., Liu L. The influence of air pollution on cardiovascular and pulmonary function and exercise capacity: Canadian Health Measures Survey (CHMS). Environ. Res. 2011, 111(8):1309-1312.
4. Chang Y.C., Lai T.Y., Yu C.S., Chen H.Y., Yang J.S., Chueh F.S., Lu C.C., Chiang J.H., Huang W.W., Ma C.Y., Chung J.G. Emodin induces apoptotic death in murine myelomonocytic leukemia WEHI-3 cells in vitro and enhances phagocytosis in leukemia mice in vivo. Evid. Based Complement. Alternat. Med. 2011, 2011:523596.
5. Chu X., Wei M., Yang X., Cao Q., Xie X., Guan M., Wang D., Deng X. Effects of an anthraquinone derivative from Rheum officinale Baill, emodin, on airway responses in a murine model of asthma. Food Chem. Toxicol. 2012, 50(7):2368-2375.
6. Driscoll K.E., Costa D.L., Hatch G., Henderson R., Oberdorster G., Salem H., Schlesinger R.B. Intratracheal instillation as an exposure technique for the evaluation of respiratory tract toxicity: uses and limitations. Toxicol. Sci. 2000, 55(1):24-35.
7. Faustini A., Stafoggia M., Cappai G., Forastiere F. Short-term effects of air pollution in a cohort of patients with chronic obstructive pulmonary disease. Epidemiology 2012, 23(6):861-879.
8. Hardy R.D., Coalson J.J., Peters J., Chaparro A., Techasaensiri C., Cantwell A.M., Kannan T.R., Baseman J.B., Dube P.H. Analysis of pulmonary inflammation and function in the mouse and baboon after exposure to Mycoplasma pneumoniae CARDS toxin. PLoS ONE 2009, 4(10):e7562.
9. Inoue K., Takano H., Shiga A., Fujita Y., Makino H., Yanagisawa R., Kato Y., Yoshikawa T. Effects of volatile constituents of rosemary extract on lung inflammation induced by diesel exhaust particles. Basic Clin. Pharmacol. Toxicol. 2006, 99(1):52-57.
10. Kido T., Tamagawa E., Bai N., Suda K., Yang H.H., Li Y., Chiang G., Yatera K., Mukae H., Sin D.D., van Eeden S.F. Particulate matter induces IL-6 translocation from the lung to the systemic circulation. Am. J. Respir. Cell Mol. Biol. 2011, 44(2):197-204.
11. Li D., Zhang N., Cao Y., Zhang W., Su G., Sun Y., Liu Z., Li F., Liang D., Liu B., Guo M., Fu Y., Zhang X., Yang Z. Emodin ameliorates lipopolysaccharide-induced mastitis in mice by inhibiting activation of NF-kappaB and MAPKs signal pathways. Eur. J. Pharmacol. 2013, 705(1-3):79-85.
12. Meng G., Liu Y., Lou C., Yang H. Emodin suppresses lipopolysaccharide-induced pro-inflammatory responses and NF-kappaB activation by disrupting lipid rafts in CD14-negative endothelial cells. Br. J. Pharmacol. 2010, 161(7):1628-1644.
13. Mutlu G.M., Green D., Bellmeyer A., Baker C.M., Burgess Z., Rajamannan N., Christman J.W., Foiles N., Kamp D.W., Ghio A.J., Chandel N.S., Dean D.A., Sznajder J.I., Budinger G.R. Ambient particulate matter accelerates coagulation via an IL-6-dependent pathway. J. Clin. Invest. 2007, 117(10):2952-2961.
14. Nemmar A., Al Maskari S., Ali B.H., Al Amri I.S. Cardiovascular and lung inflammatory effects induced by systemically administered diesel exhaust particles in rats. Am. J. Physiol. Lung Cell. Mol. Physiol. 2007, 292(3):L664-L670.
15. Nemmar A., Al Salam S., Dhanasekaran S., Sudhadevi M., Ali B.H. Pulmonary exposure to diesel exhaust particles promotes cerebral microvessel thrombosis: protective effect of a cysteine prodrug l-2-oxothiazolidine-4-carboxylic acid. Toxicology 2009, 263(2-3):84-92.
16. Nemmar A., Al-Salam S., Subramaniyan D., Yasin J., Yuvaraju P., Beegam S., Ali B.H. Influence of experimental type 1 diabetes on the pulmonary effects of diesel exhaust particles in mice. Toxicol. Lett. 2013, 217(2):170-176.
17. Nemmar A., Al-Salam S., Zia S., Marzouqi F., Al-Dhaheri A., Subramaniyan D., Dhanasekaran S., Yasin J., Ali B.H., Kazzam E.E. Contrasting actions of diesel exhaust particles on the pulmonary and cardiovascular systems and the effects of thymoquinone. Br. J. Pharmacol. 2011, 164(7):1871-1882.
18. Nemmar A., Dhanasekaran S., Yasin J., Ba-Omar H., Fahim M.A., Kazzam E.E., Ali B.H. Evaluation of the direct systemic and cardiopulmonary effects of diesel particles in spontaneously hypertensive rats. Toxicology 2009, 262(1):50-56.
19. Nemmar A., Holme J.A., Rosas I., Schwarze P.E., Alfaro-Moreno E. Recent advances in particulate matter and nanoparticle toxicology: a review of the in vivo and in vitro studies. Biomed. Res. Int. 2013, 279371.
20. Nemmar A., Raza H., Subramaniyan D., John A., Elwasila M., Ali B.H., Adeghate E. Evaluation of the pulmonary effects of short-term nose-only cigarette smoke exposure in mice. Exp. Biol. Med. (Maywood) 2012, 237(12):1449-1456.
21. Nemmar A., Raza H., Yuvaraju P., Beegam S., John A., Yasin J., Hameed R.S., Adeghate E., Ali B.H. Nose-only water-pipe smoking effects on airway resistance, inflammation and oxidative stress in mice. J. Appl. Physiol. 2013, 115(9):1316-1323.
22. Nemmar A., Subramaniyan D., Ali B.H. Protective effect of curcumin on pulmonary and cardiovascular effects induced by repeated exposure to diesel exhaust particles in mice. PLOS ONE 2012, 7(6):e39554.
23. Nemmar A., Subramaniyan D., Zia S., Yasin J., Ali B.H. Airway resistance, inflammation and oxidative stress following exposure to diesel exhaust particle in angiotensin II-induced hypertension in mice. Toxicology 2012, 292(2-3):162-168.
24. Nemmar A., Yuvaraju P., Beegam S., John A., Raza H., Ali B.H. Cardiovascular effects of nose-only water-pipe smoking exposure in mice. Am. J. Physiol. Heart Circ. Physiol. 2013, 305(5):H740-H746.
25. Nemmar A., Zia S., Subramaniyan D., Fahim M.A., Ali B.H. Exacerbation of thrombotic events by diesel exhaust particle in mouse model of hypertension. Toxicology 2011, 285(1-2):39-45.
26. Peters A., Wichmann H.E., Tuch T., Heinrich J., Heyder J. Respiratory effects are associated with the number of ultrafine particles. Am. J. Respir. Crit. Care Med. 1997, 155(4):1376-1383.
27. Rice M.B., Ljungman P.L., Wilker E.H., Gold D.R., Schwartz J.D., Koutrakis P., Washko G.R., O'Connor G.T., Mittleman M.A. Short-term exposure to air pollution and lung function in the Framingham Heart Study. Am. J. Respir. Crit. Care Med. 2013, 188(11):1351-1357.
28. Salvi S., Blomberg A., Rudell B., Kelly F., Sandstrom T., Holgate S.T., Frew A. Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers. Am. J. Respir. Crit. Care Med. 1999, 159(3):702-709.
29. Sunil V.R., Patel K.J., Mainelis G., Turpin B.J., Ridgely S., Laumbach R.J., Kipen H.M., Nazarenko Y., Veleeparambil M., Gow A.J., Laskin J.D., Laskin D.L. Pulmonary effects of inhaled diesel exhaust in aged mice. Toxicol. Appl. Pharmacol. 2009, 241(3):283-293.
30. Tamagawa E., Bai N., Morimoto K., Gray C., Mui T., Yatera K., Zhang X., Xing L., Li Y., Laher I., Sin D.D., Man S.F., van Eeden S.F. Particulate matter exposure induces persistent lung inflammation and endothelial dysfunction. Am. J. Physiol. Lung Cell. Mol. Physiol. 2008, 295(1):L79-L85.
31. van der Vaart, Postma D.S., Timens W., Ten Hacken N.H. Acute effects of cigarette smoke on inflammation and oxidative stress: a review. Thorax 2004, 59(8):713-721.
32. Vermylen J., Nemmar A., Nemery B., Hoylaerts M.F. Ambient air pollution and acute myocardial infarction. J. Thromb. Haemost. 2005, 3(9):1955-1961.
33. Waly M.I., Ali B.H., Al-Lawati I., Nemmar A. Protective effects of emodin against cisplatin-induced oxidative stress in cultured human kidney (HEK 293) cells. J. Appl. Toxicol. 2013, 33(7):626-630.
34. Xia X.M., Wang F.Y., Wang Z.K., Wan H.J., Xu W.A., Lu H. Emodin enhances alveolar epithelial barrier function in rats with experimental acute pancreatitis. World J. Gastroenterol. 2010, 16(24):2994-3001.
35. Xiao M., Zhu T., Zhang W., Wang T., Shen Y.C., Wan Q.F., Wen F.Q. Emodin ameliorates LPS-induced acute lung injury, involving the inactivation of NF-kappaB in mice. Int. J. Mol. Sci. 2014, 15(11):19355-19368.
36. Yao H., Rahman I. Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease. Toxicol. Appl. Pharmacol. 2011, 254(2):72-85.