메뉴 건너뛰기




Volumn 53, Issue 4, 2016, Pages 2489-2497

Angiotensin-(1-7) is Reduced and Inversely Correlates with Tau Hyperphosphorylation in Animal Models of Alzheimer’s Disease

Author keywords

Alzheimer s disease; Angiotensin (1 7); Hyperphosphorylation; P301S mice; SAMP8; Tau

Indexed keywords

ANGIOTENSIN[1-7]; TAU PROTEIN; ANGIOTENSIN I; ANGIOTENSIN I (1-7); PEPTIDE FRAGMENT;

EID: 84930536005     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-015-9260-9     Document Type: Article
Times cited : (68)

References (44)
  • 1
    • 84888062913 scopus 로고    scopus 로고
    • Epidemiology and etiology of Alzheimer’s disease: from genetic to non-genetic factors
    • COI: 1:CAS:528:DC%2BC3sXhsFKktLzE, PID: 23919770
    • Jiang T, Yu JT, Tian Y, Tan L (2013) Epidemiology and etiology of Alzheimer’s disease: from genetic to non-genetic factors. Curr Alzheimer Res 10(8):852–867
    • (2013) Curr Alzheimer Res , vol.10 , Issue.8 , pp. 852-867
    • Jiang, T.1    Yu, J.T.2    Tian, Y.3    Tan, L.4
  • 2
    • 84865576332 scopus 로고    scopus 로고
    • Novel disease-modifying therapies for Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC38Xht1GhurbN, PID: 22669013
    • Jiang T, Yu JT, Tan L (2012) Novel disease-modifying therapies for Alzheimer’s disease. J Alzheimers Dis 31(3):475–492. doi:10.3233/JAD-2012-120640
    • (2012) J Alzheimers Dis , vol.31 , Issue.3 , pp. 475-492
    • Jiang, T.1    Yu, J.T.2    Tan, L.3
  • 3
    • 79960675107 scopus 로고    scopus 로고
    • Brain renin-angiotensin—a new look at an old system
    • COI: 1:CAS:528:DC%2BC3MXhtVOjs7rO, PID: 21777652
    • Wright JW, Harding JW (2011) Brain renin-angiotensin—a new look at an old system. Prog Neurobiol 95(1):49–67. doi:10.1016/j.pneurobio.2011.07.001
    • (2011) Prog Neurobiol , vol.95 , Issue.1 , pp. 49-67
    • Wright, J.W.1    Harding, J.W.2
  • 4
    • 84873060951 scopus 로고    scopus 로고
    • The brain renin-angiotensin system: a diversity of functions and implications for CNS diseases
    • COI: 1:CAS:528:DC%2BC3sXhsVOit78%3D
    • Wright JW, Harding JW (2013) The brain renin-angiotensin system: a diversity of functions and implications for CNS diseases. Pflugers Arch-Eur J Physiol 465(1):133–151. doi:10.1007/s00424-012-1102-2
    • (2013) Pflugers Arch-Eur J Physiol , vol.465 , Issue.1 , pp. 133-151
    • Wright, J.W.1    Harding, J.W.2
  • 5
    • 77952546615 scopus 로고    scopus 로고
    • The brain RAS and Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3cXlsFShs7k%3D, PID: 19782074
    • Wright JW, Harding JW (2010) The brain RAS and Alzheimer’s disease. Exp Neurol 223(2):326–333. doi:10.1016/j.expneurol.2009.09.012
    • (2010) Exp Neurol , vol.223 , Issue.2 , pp. 326-333
    • Wright, J.W.1    Harding, J.W.2
  • 6
    • 84905369537 scopus 로고    scopus 로고
    • A role for the brain RAS in Alzheimer’s and Parkinson’s diseases
    • Wright JW, Kawas LH, Harding JW (2013) A role for the brain RAS in Alzheimer’s and Parkinson’s diseases. Front Endocrinol 4:158. doi:10.3389/fendo.2013.00158
    • (2013) Front Endocrinol , vol.4 , pp. 158
    • Wright, J.W.1    Kawas, L.H.2    Harding, J.W.3
  • 7
    • 67649665617 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme levels and activity in Alzheimer’s disease: differences in brain and CSF ACE and association with ACE1 genotypes
    • COI: 1:CAS:528:DC%2BD1MXhtFejs7nO, PID: 19956428
    • Miners S, Ashby E, Baig S, Harrison R, Tayler H, Speedy E, Prince JA, Love S et al (2009) Angiotensin-converting enzyme levels and activity in Alzheimer’s disease: differences in brain and CSF ACE and association with ACE1 genotypes. Am J Transl Res 1(2):163–177
    • (2009) Am J Transl Res , vol.1 , Issue.2 , pp. 163-177
    • Miners, S.1    Ashby, E.2    Baig, S.3    Harrison, R.4    Tayler, H.5    Speedy, E.6    Prince, J.A.7    Love, S.8
  • 8
    • 40149093247 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme (ACE) levels and activity in Alzheimer’s disease, and relationship of perivascular ACE-1 to cerebral amyloid angiopathy
    • COI: 1:STN:280:DC%2BD1c7ks1Ohsw%3D%3D, PID: 17973905
    • Miners JS, Ashby E, Van Helmond Z, Chalmers KA, Palmer LE, Love S, Kehoe PG (2008) Angiotensin-converting enzyme (ACE) levels and activity in Alzheimer’s disease, and relationship of perivascular ACE-1 to cerebral amyloid angiopathy. Neuropathol Appl Neurobiol 34(2):181–193. doi:10.1111/j.1365-2990.2007.00885.x
    • (2008) Neuropathol Appl Neurobiol , vol.34 , Issue.2 , pp. 181-193
    • Miners, J.S.1    Ashby, E.2    Van Helmond, Z.3    Chalmers, K.A.4    Palmer, L.E.5    Love, S.6    Kehoe, P.G.7
  • 9
    • 79551541587 scopus 로고    scopus 로고
    • Central angiotensin II stimulation promotes beta amyloid production in Sprague Dawley rats
    • COI: 1:CAS:528:DC%2BC3MXhvVKksrk%3D, PID: 21297982
    • Zhu D, Shi J, Zhang Y, Wang B, Liu W, Chen Z, Tong Q (2011) Central angiotensin II stimulation promotes beta amyloid production in Sprague Dawley rats. PLoS ONE 6(1):e16037. doi:10.1371/journal.pone.0016037
    • (2011) PLoS ONE , vol.6 , Issue.1 , pp. e16037
    • Zhu, D.1    Shi, J.2    Zhang, Y.3    Wang, B.4    Liu, W.5    Chen, Z.6    Tong, Q.7
  • 10
    • 84867575084 scopus 로고    scopus 로고
    • Central angiotensin II-induced Alzheimer-like tau phosphorylation in normal rat brains
    • COI: 1:CAS:528:DC%2BC38Xhtl2ksbzF, PID: 22982863
    • Tian M, Zhu D, Xie W, Shi J (2012) Central angiotensin II-induced Alzheimer-like tau phosphorylation in normal rat brains. FEBS Lett 586(20):3737–3745. doi:10.1016/j.febslet.2012.09.004
    • (2012) FEBS Lett , vol.586 , Issue.20 , pp. 3737-3745
    • Tian, M.1    Zhu, D.2    Xie, W.3    Shi, J.4
  • 11
    • 80052647359 scopus 로고    scopus 로고
    • Perindopril, a centrally active angiotensin-converting enzyme inhibitor, prevents cognitive impairment in mouse models of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3MXhtFOht73P
    • Dong YF, Kataoka K, Tokutomi Y, Nako H, Nakamura T, Toyama K, Sueta D, Koibuchi N et al (2011) Perindopril, a centrally active angiotensin-converting enzyme inhibitor, prevents cognitive impairment in mouse models of Alzheimer’s disease. FASEB J Off Publ Fed Am Soc Exp Biol 25(9):2911–2920. doi:10.1096/fj.11-182873
    • (2011) FASEB J Off Publ Fed Am Soc Exp Biol , vol.25 , Issue.9 , pp. 2911-2920
    • Dong, Y.F.1    Kataoka, K.2    Tokutomi, Y.3    Nako, H.4    Nakamura, T.5    Toyama, K.6    Sueta, D.7    Koibuchi, N.8
  • 12
    • 84901047652 scopus 로고    scopus 로고
    • Angiotensin II type 1 receptor blocker losartan prevents and rescues cerebrovascular, neuropathological and cognitive deficits in an Alzheimer’s disease model
    • Ongali B, Nicolakakis N, Tong XK, Aboulkassim T, Papadopoulos P, Rosa-Neto P, Lecrux C, Imboden H et al (2014) Angiotensin II type 1 receptor blocker losartan prevents and rescues cerebrovascular, neuropathological and cognitive deficits in an Alzheimer’s disease model. Neurobiol Dis 68C:126–136. doi:10.1016/j.nbd.2014.04.018
    • (2014) Neurobiol Dis , vol.68C , pp. 126-136
    • Ongali, B.1    Nicolakakis, N.2    Tong, X.K.3    Aboulkassim, T.4    Papadopoulos, P.5    Rosa-Neto, P.6    Lecrux, C.7    Imboden, H.8
  • 13
    • 74949131237 scopus 로고    scopus 로고
    • Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: prospective cohort analysis
    • PID: 20068258
    • Li NC, Lee A, Whitmer RA, Kivipelto M, Lawler E, Kazis LE, Wolozin B (2010) Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: prospective cohort analysis. BMJ 340:b5465. doi:10.1136/bmj.b5465
    • (2010) BMJ , vol.340 , pp. b5465
    • Li, N.C.1    Lee, A.2    Whitmer, R.A.3    Kivipelto, M.4    Lawler, E.5    Kazis, L.E.6    Wolozin, B.7
  • 14
    • 84883803181 scopus 로고    scopus 로고
    • Angiotensin converting enzyme inhibitors and the reduced risk of Alzheimer’s disease in the absence of apolipoprotein E4 allele
    • COI: 1:CAS:528:DC%2BC3sXhsVehtrbM, PID: 23948883
    • Qiu WQ, Mwamburi M, Besser LM, Zhu H, Li H, Wallack M, Phillips L, Qiao L et al (2013) Angiotensin converting enzyme inhibitors and the reduced risk of Alzheimer’s disease in the absence of apolipoprotein E4 allele. J Alzheimers Dis 37(2):421–428. doi:10.3233/JAD-130716
    • (2013) J Alzheimers Dis , vol.37 , Issue.2 , pp. 421-428
    • Qiu, W.Q.1    Mwamburi, M.2    Besser, L.M.3    Zhu, H.4    Li, H.5    Wallack, M.6    Phillips, L.7    Qiao, L.8
  • 15
    • 84884628143 scopus 로고    scopus 로고
    • Antihypertensive drugs decrease risk of Alzheimer disease: Ginkgo Evaluation of Memory Study
    • COI: 1:CAS:528:DC%2BC3sXhsVSgsbrI, PID: 23911756
    • Yasar S, Xia J, Yao W, Furberg CD, Xue QL, Mercado CI, Fitzpatrick AL, Fried LP et al (2013) Antihypertensive drugs decrease risk of Alzheimer disease: Ginkgo Evaluation of Memory Study. Neurology 81(10):896–903. doi:10.1212/WNL.0b013e3182a35228
    • (2013) Neurology , vol.81 , Issue.10 , pp. 896-903
    • Yasar, S.1    Xia, J.2    Yao, W.3    Furberg, C.D.4    Xue, Q.L.5    Mercado, C.I.6    Fitzpatrick, A.L.7    Fried, L.P.8
  • 16
    • 79954555219 scopus 로고    scopus 로고
    • ACE2/ANG-(1-7)/Mas pathway in the brain: the axis of good
    • COI: 1:CAS:528:DC%2BC3MXlt1Okt7o%3D, PID: 21178125
    • Xu P, Sriramula S, Lazartigues E (2011) ACE2/ANG-(1-7)/Mas pathway in the brain: the axis of good. Am J Physiol Regul Integr Comp Physiol 300(4):R804–R817. doi:10.1152/ajpregu.00222.2010
    • (2011) Am J Physiol Regul Integr Comp Physiol , vol.300 , Issue.4 , pp. R804-R817
    • Xu, P.1    Sriramula, S.2    Lazartigues, E.3
  • 17
    • 84876743592 scopus 로고    scopus 로고
    • ACE2-Ang-(1-7)-Mas axis in brain: a potential target for prevention and treatment of ischemic stroke
    • COI: 1:CAS:528:DC%2BC3sXms1Oquro%3D, PID: 23997755
    • Jiang T, Gao L, Lu J, Zhang YD (2013) ACE2-Ang-(1-7)-Mas axis in brain: a potential target for prevention and treatment of ischemic stroke. Curr Neuropharmacol 11(2):209–217. doi:10.2174/1570159X11311020007
    • (2013) Curr Neuropharmacol , vol.11 , Issue.2 , pp. 209-217
    • Jiang, T.1    Gao, L.2    Lu, J.3    Zhang, Y.D.4
  • 18
    • 20444423644 scopus 로고    scopus 로고
    • Angiotensin-(1-7) enhances LTP in the hippocampus through the G-protein-coupled receptor Mas
    • COI: 1:CAS:528:DC%2BD2MXltFejtL0%3D, PID: 15950155
    • Hellner K, Walther T, Schubert M, Albrecht D (2005) Angiotensin-(1-7) enhances LTP in the hippocampus through the G-protein-coupled receptor Mas. Mol Cell Neurosci 29(3):427–435. doi:10.1016/j.mcn.2005.03.012
    • (2005) Mol Cell Neurosci , vol.29 , Issue.3 , pp. 427-435
    • Hellner, K.1    Walther, T.2    Schubert, M.3    Albrecht, D.4
  • 19
  • 20
    • 84870903418 scopus 로고    scopus 로고
    • Angiotensin-(1-7) modulates renin-angiotensin system associated with reducing oxidative stress and attenuating neuronal apoptosis in the brain of hypertensive rats
    • COI: 1:CAS:528:DC%2BC38XhvVCku7fF
    • Jiang T, Gao L, Shi J, Lu J, Wang Y, Zhang Y (2013) Angiotensin-(1-7) modulates renin-angiotensin system associated with reducing oxidative stress and attenuating neuronal apoptosis in the brain of hypertensive rats. Pharmacol Res Off J Ital Pharmacol Soc 67(1):84–93. doi:10.1016/j.phrs.2012.10.014
    • (2013) Pharmacol Res Off J Ital Pharmacol Soc , vol.67 , Issue.1 , pp. 84-93
    • Jiang, T.1    Gao, L.2    Shi, J.3    Lu, J.4    Wang, Y.5    Zhang, Y.6
  • 21
    • 84876103234 scopus 로고    scopus 로고
    • Angiotensin-(1-7) inhibits autophagy in the brain of spontaneously hypertensive rats
    • COI: 1:CAS:528:DC%2BC3sXls1Cgsbk%3D
    • Jiang T, Gao L, Zhu XC, Yu JT, Shi JQ, Tan MS, Lu J, Tan L et al (2013) Angiotensin-(1-7) inhibits autophagy in the brain of spontaneously hypertensive rats. Pharmacol Res Off J Ital Pharmacol Soc 71:61–68. doi:10.1016/j.phrs.2013.03.001
    • (2013) Pharmacol Res Off J Ital Pharmacol Soc , vol.71 , pp. 61-68
    • Jiang, T.1    Gao, L.2    Zhu, X.C.3    Yu, J.T.4    Shi, J.Q.5    Tan, M.S.6    Lu, J.7    Tan, L.8
  • 22
    • 84903936250 scopus 로고    scopus 로고
    • Angiotensin-(1-7) improves cognitive function in rats with chronic cerebral hypoperfusion
    • Xie W, Zhu D, Ji L, Tian M, Xu C, Shi J (2014) Angiotensin-(1-7) improves cognitive function in rats with chronic cerebral hypoperfusion. Brain Res. doi:10.1016/j.brainres.2014.05.019
    • (2014) Brain Res
    • Xie, W.1    Zhu, D.2    Ji, L.3    Tian, M.4    Xu, C.5    Shi, J.6
  • 23
    • 84896822801 scopus 로고    scopus 로고
    • Age-related alterations in the metabolic profile in the hippocampus of the senescence-accelerated mouse prone 8: a spontaneous Alzheimer’s disease mouse model
    • COI: 1:CAS:528:DC%2BC2cXisVagsL4%3D, PID: 24284365
    • Wang H, Lian K, Han B, Wang Y, Kuo SH, Geng Y, Qiang J, Sun M et al (2014) Age-related alterations in the metabolic profile in the hippocampus of the senescence-accelerated mouse prone 8: a spontaneous Alzheimer’s disease mouse model. J Alzheimers Dis 39(4):841–848. doi:10.3233/JAD-131463
    • (2014) J Alzheimers Dis , vol.39 , Issue.4 , pp. 841-848
    • Wang, H.1    Lian, K.2    Han, B.3    Wang, Y.4    Kuo, S.H.5    Geng, Y.6    Qiang, J.7    Sun, M.8
  • 24
    • 84895831104 scopus 로고    scopus 로고
    • Nodes and biological processes identified on the basis of network analysis in the brain of the senescence accelerated mice as an Alzheimer’s disease animal model
    • PID: 24194717
    • Cheng XR, Cui XL, Zheng Y, Zhang GR, Li P, Huang H, Zhao YY, Bo XC et al (2013) Nodes and biological processes identified on the basis of network analysis in the brain of the senescence accelerated mice as an Alzheimer’s disease animal model. Front Aging Neurosci 5:65. doi:10.3389/fnagi.2013.00065
    • (2013) Front Aging Neurosci , vol.5 , pp. 65
    • Cheng, X.R.1    Cui, X.L.2    Zheng, Y.3    Zhang, G.R.4    Li, P.5    Huang, H.6    Zhao, Y.Y.7    Bo, X.C.8
  • 25
    • 84858157217 scopus 로고    scopus 로고
    • The senescence accelerated mouse (SAMP8) as a model for oxidative stress and Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC38Xjs1GktLo%3D, PID: 22142563
    • Morley JE, Armbrecht HJ, Farr SA, Kumar VB (2012) The senescence accelerated mouse (SAMP8) as a model for oxidative stress and Alzheimer’s disease. Biochim Biophys Acta 1822(5):650–656. doi:10.1016/j.bbadis.2011.11.015
    • (2012) Biochim Biophys Acta , vol.1822 , Issue.5 , pp. 650-656
    • Morley, J.E.1    Armbrecht, H.J.2    Farr, S.A.3    Kumar, V.B.4
  • 26
    • 27644465539 scopus 로고    scopus 로고
    • Hyperphosphorylation of microtubule-associated protein tau in senescence-accelerated mouse (SAM)
    • COI: 1:CAS:528:DC%2BD2MXht1Sks7zN, PID: 16171847
    • Canudas AM, Gutierrez-Cuesta J, Rodriguez MI, Acuna-Castroviejo D, Sureda FX, Camins A, Pallas M (2005) Hyperphosphorylation of microtubule-associated protein tau in senescence-accelerated mouse (SAM). Mech Ageing Dev 126(12):1300–1304. doi:10.1016/j.mad.2005.07.008
    • (2005) Mech Ageing Dev , vol.126 , Issue.12 , pp. 1300-1304
    • Canudas, A.M.1    Gutierrez-Cuesta, J.2    Rodriguez, M.I.3    Acuna-Castroviejo, D.4    Sureda, F.X.5    Camins, A.6    Pallas, M.7
  • 27
    • 84877109118 scopus 로고    scopus 로고
    • Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice
    • COI: 1:CAS:528:DC%2BC3sXnslGjurk%3D, PID: 23667480
    • Ozcelik S, Fraser G, Castets P, Schaeffer V, Skachokova Z, Breu K, Clavaguera F, Sinnreich M et al (2013) Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice. PLoS ONE 8(5):e62459. doi:10.1371/journal.pone.0062459
    • (2013) PLoS ONE , vol.8 , Issue.5 , pp. e62459
    • Ozcelik, S.1    Fraser, G.2    Castets, P.3    Schaeffer, V.4    Skachokova, Z.5    Breu, K.6    Clavaguera, F.7    Sinnreich, M.8
  • 28
    • 77954331629 scopus 로고    scopus 로고
    • Guidelines for reporting experiments involving animals: the ARRIVE guidelines
    • COI: 1:CAS:528:DC%2BC3MXhsFSqtLg%3D, PID: 20649560
    • McGrath JC, Drummond GB, McLachlan EM, Kilkenny C, Wainwright CL (2010) Guidelines for reporting experiments involving animals: the ARRIVE guidelines. Br J Pharmacol 160(7):1573–1576. doi:10.1111/j.1476-5381.2010.00873.x
    • (2010) Br J Pharmacol , vol.160 , Issue.7 , pp. 1573-1576
    • McGrath, J.C.1    Drummond, G.B.2    McLachlan, E.M.3    Kilkenny, C.4    Wainwright, C.L.5
  • 29
    • 77954326944 scopus 로고    scopus 로고
    • Animal research: reporting in vivo experiments: the ARRIVE guidelines
    • COI: 1:CAS:528:DC%2BC3MXhsFSqtLk%3D, PID: 20649561
    • Kilkenny C, Browne W, Cuthill IC, Emerson M, Altman DG (2010) Animal research: reporting in vivo experiments: the ARRIVE guidelines. Br J Pharmacol 160(7):1577–1579. doi:10.1111/j.1476-5381.2010.00872.x
    • (2010) Br J Pharmacol , vol.160 , Issue.7 , pp. 1577-1579
    • Kilkenny, C.1    Browne, W.2    Cuthill, I.C.3    Emerson, M.4    Altman, D.G.5
  • 30
    • 79951978361 scopus 로고    scopus 로고
    • Improving planning, design, reporting and scientific quality of animal experiments by using the Gold Standard Publication Checklist, in addition to the ARRIVE guidelines
    • COI: 1:CAS:528:DC%2BC3MXivF2lt7g%3D, PID: 21091655
    • Hooijmans CR, de Vries R, Leenaars M, Curfs J, Ritskes-Hoitinga M (2011) Improving planning, design, reporting and scientific quality of animal experiments by using the Gold Standard Publication Checklist, in addition to the ARRIVE guidelines. Br J Pharmacol 162(6):1259–1260. doi:10.1111/j.1476-5381.2010.01128.x
    • (2011) Br J Pharmacol , vol.162 , Issue.6 , pp. 1259-1260
    • Hooijmans, C.R.1    de Vries, R.2    Leenaars, M.3    Curfs, J.4    Ritskes-Hoitinga, M.5
  • 31
    • 84904253583 scopus 로고    scopus 로고
    • Conversion of Abeta43 to Abeta40 by the successive action of angiotensin-converting enzyme 2 and angiotensin-converting enzyme
    • Liu S, Liu J, Miura Y, Tanabe C, Maeda T, Terayama Y, Turner AJ, Zou K et al (2014) Conversion of Abeta43 to Abeta40 by the successive action of angiotensin-converting enzyme 2 and angiotensin-converting enzyme. J Neurosci Res. doi:10.1002/jnr.23404
    • (2014) J Neurosci Res
    • Liu, S.1    Liu, J.2    Miura, Y.3    Tanabe, C.4    Maeda, T.5    Terayama, Y.6    Turner, A.J.7    Zou, K.8
  • 32
    • 85027919143 scopus 로고    scopus 로고
    • Angiotensin-(1-7) induces cerebral ischaemic tolerance by promoting brain angiogenesis in a Mas/eNOS-dependent pathway
    • COI: 1:CAS:528:DC%2BC2cXhsVektr3E, PID: 24824997
    • Jiang T, Yu JT, Zhu XC, Zhang QQ, Tan MS, Cao L, Wang HF, Lu J et al (2014) Angiotensin-(1-7) induces cerebral ischaemic tolerance by promoting brain angiogenesis in a Mas/eNOS-dependent pathway. Br J Pharmacol 171(18):4222–4232. doi:10.1111/bph.12770
    • (2014) Br J Pharmacol , vol.171 , Issue.18 , pp. 4222-4232
    • Jiang, T.1    Yu, J.T.2    Zhu, X.C.3    Zhang, Q.Q.4    Tan, M.S.5    Cao, L.6    Wang, H.F.7    Lu, J.8
  • 33
    • 84896338549 scopus 로고    scopus 로고
    • Temsirolimus promotes autophagic clearance of amyloid-beta and provides protective effects in cellular and animal models of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC2cXltl2iurw%3D
    • Jiang T, Yu JT, Zhu XC, Tan MS, Wang HF, Cao L, Zhang QQ, Shi JQ et al (2014) Temsirolimus promotes autophagic clearance of amyloid-beta and provides protective effects in cellular and animal models of Alzheimer’s disease. Pharmacol Res Off J Ital Pharmacol Soc 81:54–63. doi:10.1016/j.phrs.2014.02.008
    • (2014) Pharmacol Res Off J Ital Pharmacol Soc , vol.81 , pp. 54-63
    • Jiang, T.1    Yu, J.T.2    Zhu, X.C.3    Tan, M.S.4    Wang, H.F.5    Cao, L.6    Zhang, Q.Q.7    Shi, J.Q.8
  • 34
    • 84903362065 scopus 로고    scopus 로고
    • Triggering receptor expressed on myeloid cells 2 knockdown exacerbates aging-related neuroinflammation and cognitive deficiency in senescence-accelerated mouse prone 8 mice
    • COI: 1:CAS:528:DC%2BC3sXitVWisrbO, PID: 24368090
    • Jiang T, Yu JT, Zhu XC, Tan MS, Gu LZ, Zhang YD, Tan L (2014) Triggering receptor expressed on myeloid cells 2 knockdown exacerbates aging-related neuroinflammation and cognitive deficiency in senescence-accelerated mouse prone 8 mice. Neurobiol Aging 35(6):1243–1251. doi:10.1016/j.neurobiolaging.2013.11.026
    • (2014) Neurobiol Aging , vol.35 , Issue.6 , pp. 1243-1251
    • Jiang, T.1    Yu, J.T.2    Zhu, X.C.3    Tan, M.S.4    Gu, L.Z.5    Zhang, Y.D.6    Tan, L.7
  • 35
    • 84896334276 scopus 로고    scopus 로고
    • Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy
    • COI: 1:CAS:528:DC%2BC2cXpsVKrtro%3D, PID: 24611741
    • Jiang T, Yu JT, Zhu XC, Wang HF, Tan MS, Cao L, Zhang QQ, Gao L et al (2014) Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy. Br J Pharmacol 171(13):3146–3157. doi:10.1111/bph.12655
    • (2014) Br J Pharmacol , vol.171 , Issue.13 , pp. 3146-3157
    • Jiang, T.1    Yu, J.T.2    Zhu, X.C.3    Wang, H.F.4    Tan, M.S.5    Cao, L.6    Zhang, Q.Q.7    Gao, L.8
  • 36
    • 84938270248 scopus 로고    scopus 로고
    • Ischemic preconditioning provides neuroprotection by induction of AMP-activated protein kinase-dependent autophagy in a rat model of ischemic stroke
    • Jiang T, Yu JT, Zhu XC, Zhang QQ, Tan MS, Cao L, Wang HF, Shi JQ et al (2014) Ischemic preconditioning provides neuroprotection by induction of AMP-activated protein kinase-dependent autophagy in a rat model of ischemic stroke. Mol Neurobiol. doi:10.1007/s12035-014-8725-6
    • (2014) Mol Neurobiol
    • Jiang, T.1    Yu, J.T.2    Zhu, X.C.3    Zhang, Q.Q.4    Tan, M.S.5    Cao, L.6    Wang, H.F.7    Shi, J.Q.8
  • 37
    • 84946491536 scopus 로고    scopus 로고
    • Pharmacologic blockade of 12/15-lipoxygenase ameliorates memory deficits, Abeta and tau neuropathology in the triple-transgenic mice
    • PID: 25560760
    • Chu J, Li JG, Giannopoulos PF, Blass BE, Childers W, Abou-Gharbia M, Pratico D (2015) Pharmacologic blockade of 12/15-lipoxygenase ameliorates memory deficits, Abeta and tau neuropathology in the triple-transgenic mice. Mol Psychiatry. doi:10.1038/mp.2014.170
    • (2015) Mol Psychiatry
    • Chu, J.1    Li, J.G.2    Giannopoulos, P.F.3    Blass, B.E.4    Childers, W.5    Abou-Gharbia, M.6    Pratico, D.7
  • 38
    • 84902181067 scopus 로고    scopus 로고
    • Aging-associated reductions in lipolytic and mitochondrial proteins in mouse adipose tissue are not rescued by metformin treatment
    • Mennes E, Dungan CM, Frendo-Cumbo S, Williamson DL, Wright DC (2013) Aging-associated reductions in lipolytic and mitochondrial proteins in mouse adipose tissue are not rescued by metformin treatment. J Gerontol A: Biol Med Sci. doi:10.1093/gerona/glt156
    • (2013) J Gerontol A: Biol Med Sci
    • Mennes, E.1    Dungan, C.M.2    Frendo-Cumbo, S.3    Williamson, D.L.4    Wright, D.C.5
  • 39
    • 84863214208 scopus 로고    scopus 로고
    • Angiotensin-(1-7) inhibits allergic inflammation, via the MAS1 receptor, through suppression of ERK1/2- and NF-kappaB-dependent pathways
    • COI: 1:CAS:528:DC%2BC38XhtVOrsr7L, PID: 22339213
    • El-Hashim AZ, Renno WM, Raghupathy R, Abduo HT, Akhtar S, Benter IF (2012) Angiotensin-(1-7) inhibits allergic inflammation, via the MAS1 receptor, through suppression of ERK1/2- and NF-kappaB-dependent pathways. Br J Pharmacol 166(6):1964–1976. doi:10.1111/j.1476-5381.2012.01905.x
    • (2012) Br J Pharmacol , vol.166 , Issue.6 , pp. 1964-1976
    • El-Hashim, A.Z.1    Renno, W.M.2    Raghupathy, R.3    Abduo, H.T.4    Akhtar, S.5    Benter, I.F.6
  • 40
    • 85027932464 scopus 로고    scopus 로고
    • Angiotensin-(1-7) via the mas receptor alleviates the diabetes-induced decrease in GFAP and GAP-43 immunoreactivity with concomitant reduction in the COX-2 in hippocampal formation: an immunohistochemical study
    • COI: 1:CAS:528:DC%2BC38XhslKgtLzO, PID: 22711212
    • Renno WM, Al-Banaw AG, George P, Abu-Ghefreh AA, Akhtar S, Benter IF (2012) Angiotensin-(1-7) via the mas receptor alleviates the diabetes-induced decrease in GFAP and GAP-43 immunoreactivity with concomitant reduction in the COX-2 in hippocampal formation: an immunohistochemical study. Cell Mol Neurobiol 32(8):1323–1336. doi:10.1007/s10571-012-9858-7
    • (2012) Cell Mol Neurobiol , vol.32 , Issue.8 , pp. 1323-1336
    • Renno, W.M.1    Al-Banaw, A.G.2    George, P.3    Abu-Ghefreh, A.A.4    Akhtar, S.5    Benter, I.F.6
  • 41
    • 38749144389 scopus 로고    scopus 로고
    • Analysis of tau phosphorylation and truncation in a mouse model of human tauopathy
    • COI: 1:CAS:528:DC%2BD1cXhslOmtbc%3D, PID: 18079436
    • Delobel P, Lavenir I, Fraser G, Ingram E, Holzer M, Ghetti B, Spillantini MG, Crowther RA et al (2008) Analysis of tau phosphorylation and truncation in a mouse model of human tauopathy. Am J Pathol 172(1):123–131. doi:10.2353/ajpath.2008.070627
    • (2008) Am J Pathol , vol.172 , Issue.1 , pp. 123-131
    • Delobel, P.1    Lavenir, I.2    Fraser, G.3    Ingram, E.4    Holzer, M.5    Ghetti, B.6    Spillantini, M.G.7    Crowther, R.A.8
  • 42
    • 84868667825 scopus 로고    scopus 로고
    • Suppressing inflammation by inhibiting the NF-kappaB pathway contributes to the neuroprotective effect of angiotensin-(1-7) in rats with permanent cerebral ischaemia
    • COI: 1:CAS:528:DC%2BC38XhslCmu7bM, PID: 22817481
    • Jiang T, Gao L, Guo J, Lu J, Wang Y, Zhang Y (2012) Suppressing inflammation by inhibiting the NF-kappaB pathway contributes to the neuroprotective effect of angiotensin-(1-7) in rats with permanent cerebral ischaemia. Br J Pharmacol 167(7):1520–1532. doi:10.1111/j.1476-5381.2012.02105.x
    • (2012) Br J Pharmacol , vol.167 , Issue.7 , pp. 1520-1532
    • Jiang, T.1    Gao, L.2    Guo, J.3    Lu, J.4    Wang, Y.5    Zhang, Y.6
  • 43
    • 84886948916 scopus 로고    scopus 로고
    • The expression of angiotensin-converting enzyme 2-angiotensin-(1-7)-Mas receptor axis are upregulated after acute cerebral ischemic stroke in rats
    • COI: 1:CAS:528:DC%2BC3sXhsFCitrzN, PID: 24090950
    • Lu J, Jiang T, Wu L, Gao L, Wang Y, Zhou F, Zhang S, Zhang Y (2013) The expression of angiotensin-converting enzyme 2-angiotensin-(1-7)-Mas receptor axis are upregulated after acute cerebral ischemic stroke in rats. Neuropeptides 47(5):289–295. doi:10.1016/j.npep.2013.09.002
    • (2013) Neuropeptides , vol.47 , Issue.5 , pp. 289-295
    • Lu, J.1    Jiang, T.2    Wu, L.3    Gao, L.4    Wang, Y.5    Zhou, F.6    Zhang, S.7    Zhang, Y.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.