The expression of angiotensin-converting enzyme 2-angiotensin-(1-7)-Mas receptor axis are upregulated after acute cerebral ischemic stroke in rats

Neuropeptides

Volumn 47, Issue 5, 2013, Pages 289-295

  Lu, Jie ^b   Jiang, Teng ^a   Wu, Liang ^a   Gao, Li ^b   Wang, Yao ^b   Zhou, Feng ^a   Zhang, Shugang ^b   Zhang, Yingdong ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Angiotensin (1 7); Angiotensin converting enzyme 2 (ACE2); Ischemic cerebrovascular diseases; Mas; Renin Angiotensin system

Indexed keywords

ANGIOTENSIN CONVERTING ENZYME 2; ANGIOTENSIN[1-7]; MESSENGER RNA; RECEPTOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; ENZYME IMMUNOASSAY; MALE; NERVE CELL LESION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; WESTERN BLOTTING;

RATTUS;

ANGIOTENSIN-(1-7); ANGIOTENSIN-CONVERTING ENZYME 2 (ACE2); ISCHEMIC CEREBROVASCULAR DISEASES; MAS; RENIN-ANGIOTENSIN SYSTEM;

ACUTE DISEASE; ANGIOTENSIN I; ANIMALS; BRAIN ISCHEMIA; CEREBRAL CORTEX; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; PEPTIDE FRAGMENTS; PEPTIDYL-DIPEPTIDASE A; PROTO-ONCOGENE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; STROKE; UP-REGULATION;

EID: 84886948916     PISSN: 01434179     EISSN: 15322785     Source Type: Journal    
DOI: 10.1016/j.npep.2013.09.002     Document Type: Article

References (44)

1. Arnold A.C., Gallagher P.E., Diz D.I. Brain renin-angiotensin system in the nexus of hypertension and aging. Hypertens. Res. 2012, 36:5-13.
2. Bos D., van der Rijk M.J., Geeraedts T.E., Hofman A., Krestin G.P., Witteman J.C., van der Lugt A., Ikram M.A., Vernooij M.W. Intracranial carotid artery atherosclerosis: prevalence and risk factors in the general population. Stroke 2012, 43:1878-1884.
3. Cerrato B.D., Frasch A.P., Nakagawa P., Longo-Carbajosa N., Peña C., Höcht C., Gironacci M.M. Angiotensin-(1-7) upregulates central nitric oxide synthase in spontaneously hypertensive rats. Brain Res. 2012, 1453:1-7.
4. 1 and Mas receptors to modulate central blood pressure control in the nucleus tractus solitarii. Br. J. Pharmacol. 2012, 166:2024-2035.
5. Danielyan K.E., Oganesyn H.M., Nahapetyan K.M., Kevorkian G.A., Vladimir D., Galoyan A.A., Grigorian G.S. Stroke burden in adults in Armenia. Int. J. Stroke 2012, 7:248-249.
6. Dantas A.P., Sandberg K. Regulation of ACE2 and ANG-(1-7) in the aorta: new insights into the renin-angiotensin system in the control of vascular function. Am. J. Physiol. Heart Circ. Physiol. 2005, 289:H980-981.
7. Dendorfer A., Dominiak P., Schunkert H. ACE inhibitors and angiotensin II receptor antagonists. Handb. Exp. Pharmacol. 2005, 170:407-442.
8. El-Hashim A.Z., Renno W.M., Raghupathy R., Abduo H.T., Akhtar S., Benter I.F. Angiotensin-(1-7) inhibits allergic inflammation, via the MAS1 receptor, through suppression of ERK1/2- and NF-κB-dependent pathways. Br. J. Pharmacol. 2012, 166:1964-1976.
9. Ferrario C.M., Chappell M.C., Tallant E.A., Brosnihan K.B., Diz D.I. Counterregulatory actions of angiotensin-(1-7). Hypertension 1997, 30:535-541.
10. Ferrario C.M., Varagic J. The ANG-(1-7)/ACE2/Mas axis in the regulation of nephron function. Am. J. Physiol. Renal Physiol. 2010, 298:F1297-1305.
11. Ferreira A.J., Santos R.A., Almeida A.P. Angiotensin-(1-7): cardioprotective effect in myocardial ischemia/reperfusion. Hypertension 2001, 38:665-668.
12. Ferreira A.J., Santos R.A. Cardiovascular actions of angiotensin-(1-7). Braz. J. Med. Biol. Res. 2005, 38:499-507.
13. Ferreira A.J., Jacoby B.A., Araújo C.A., Macedo F.A., Silva G.A., Almeida A.P., Caliari M.V., Santos R.A. The nonpeptide angiotensin-(1-7) receptor Mas agonist AVE-0991 attenuates heart failure induced by myocardial infarction. Am. J. Physiol. Heart Circ. Physiol. 2007, 292:H1113-1119.
14. Ferreira A.J., Bader M., Santos R.A. Therapeutic targeting of the angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas cascade in the renin-angiotensin system: a patent review. Expert Opin. Ther. Pat. 2012, 22:567-574.
15. Fraga-Silva R.A., Da Silva D.G., Montecucco F., Mach F., Stergiopulos N., da Silva R.F., Santos R.A. The angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas receptor axis: a potential target for treating thrombotic diseases. Thromb. Haemost. 2012, 108:1089-1096.
16. Freund M., Walther T., von Bohlen und Halbach O. Immunohistochemical localization of the angiotensin-(1-7) receptor Mas in the murine forebrain. Cell Tissue Res. 2012, 348:29-35.
17. Iwai M., Nakaoka H., Senba I., Kanno H., Moritani T., Horiuchi M. Possible involvement of angiotensin-converting enzyme 2 and Mas activation in inhibitory effects of angiotensin II Type 1 receptor blockade on vascular remodeling. Hypertension 2012, 60:137-144.
18. Iyer S.N., Chappell M.C., Averill D.B., Diz D.I., Ferrario C.M. Vasodepressor actions of angiotensin-(1-7) unmasked during combined treatment with lisinopril and losartan. Hypertension 1998, 31:699-705.
19. Jiang T., Gao L., Shi J., Lu J., Wang Y., Zhang Y. Angiotensin-(1-7) modulates renin-angiotensin system associated with reducing oxidative stress and attenuating neuronal apoptosis in the brain of hypertensive rats. Pharmacol. Res. 2012, 67:84-93.
20. Jiang T., Gao L., Guo J., Lu J., Wang Y., Zhang Y. Suppressing inflammation by inhibiting the NF-κB pathway contributes to the neuroprotective effect of angiotensin-(1-7) in rats with permanent cerebral ischaemia. Br. J. Pharmacol. 2012, 67:1520-1532.
21. Li P., Zhang F., Zhou Y.B., Cui B.P., Han Y. Superoxide anions modulate the effects of angiotensin-(1-7) in the rostral ventrolateral medulla on cardiac sympathetic afferent reflex and sympathetic activity in rats. Neuroscience 2012, 223:388-398.
22. Lu J., Zhang Y., Shi J. Effects of intracerebroventricular infusion of angiotensin-(1-7) on bradykinin formation and the kinin receptor expression after focal cerebral ischemia-reperfusion in rats. Brain Res. 2008, 1219:127-135.
23. Mecca A.P., Regenhardt R.W., O'Connor T.E., Joseph J.P., Raizada M.K., Katovich M.J., Sumners C. Cerebroprotection by angiotensin-(1-7) in endothelin-1-induced ischaemic stroke. Exp. Physiol. 2011, 96:1084-1096.
24. Nautiyal M., Shaltout H.A., de Lima D.C., do Nascimento K., Chappell M.C., Diz D.I. Central angiotensin-(1-7) improves vagal function independent of blood pressure in hypertensive (mRen2)27 rats. Hypertension 2012, 60:1257-1265.
25. Nguyen Dinh Cat A., Touyz R.M. A new look at the renin-angiotensin system - focusing on the vascular system. Peptides 2011, 32:2141-2150.
26. Olindo S., Cabre P., Deschamps R., Chatot-Henry C., René-Corail P., Fournerie P., Saint-Vil M., May F., Smadja D. Acute stroke in the very elderly: epidemiological features, stroke subtypes, management, and outcome in Martinique, French West Indies. Stroke 2003, 34:1593-1597.
27. Ovbiagele B., Diener H.C., Yusuf S., Martin R.H., Cotton D., Vinisko R., Donnan G.A., Bath P.M. PROFESS investigators (2011) level of systolic blood pressure within the normal range and risk of recurrent stroke. JAMA 2011, 306:2137-2144.
28. Pate Bilman V., Mares-Guia L., Nadu A.P., Bader M., Campagnole-Santos M.J., Santos R.A., Santos S.H. Decreased hepatic gluconeogenesis in transgenic rats with increased circulating angiotensin-(1-7). Peptides 2012, 37:247-251.
29. Patel V.B., Bodiga S., Fan D., Das S.K., Wang Z., Wang W., Basu R., Zhong J., Kassiri Z., Oudit G.Y. Cardioprotective effects mediated by angiotensin II type 1 receptor blockade and enhancing angiotensin 1-7 in experimental heart failure in angiotensin-converting enzyme 2-null mice. Hypertension 2012, 59(6):1195-1203.
30. Raffai G., Durand M.J., Lombard J.H. Acute and chronic angiotensin-(1-7) restores vasodilation and reduces oxidative stress in mesenteric arteries of salt-fed rats. Am. J. Physiol. Heart Circ. Physiol. 2011, 301:H1341-1352.
31. Roks A.J., Van Geel P.P., Pinto Y.M., Buikema H., Henning R.H., De Zeeuw D., Van Gilst W.H. Angiotensin-(1-7) is a modulator of the human renin-angiotensin system. Hypertension 1999, 34:296-301.
32. Santos R.A., Ferreira A.J., Verano-Braga T., Bader M. Angiotensin-converting enzyme 2, angiotensin-(1-7) and Mas: new players of the renin angiotensin system. J. Endocrinol. 2012, 216:R1-R17.
33. Shahid M. The angiotensin-converting enzyme 2-angiotensin-(1-7) axis: the other side of the renin-angiotensin system. Exp. Physiol. 2011, 96:987-988.
34. Silva R.A., Chu Y., Miller J.D., Mitchell I.J., Penninger J.M., Faraci F.M., Heistad D.D. Impact of ACE2 deficiency and oxidative stress on cerebrovascular function with aging. Stroke 2012, 43:3358-3363.
35. Sriramula S., Cardinale J.P., Lazartigues E., Francis J. ACE2 overexpression in the paraventricular nucleus attenuates angiotensin II-induced hypertension. Cardiovasc. Res. 2011, 92:401-408.
36. Tan P.S., Killinger S., Horiuchi J., Dampney R.A. Baroreceptor reflex modulation by circulating angiotensin II is mediated by AT1 receptors in the nucleus tractus solitarius. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2007, 293:R2267-R2278.
37. Trask A.J., Ferrario C.M. Angiotensin-(1-7): pharmacology and new perspectives in cardiovascular treatments. Cardiovasc. Drug Rev. 2007, 25:162-174.
38. Verdecchia P., Gentile G., Angeli F., Reboldi G. Beyond blood pressure: evidence for cardiovascular, cerebrovascular, and renal protective effects of renin-angiotensin system blockers. Ther. Adv. Cardiovasc. Dis. 2012, 6:81-91.
39. Wang Y., Wang J., Liu R., Qi H., Wen Y., Sun F., Yin C. Severe acute pancreatitis is associated with upregulation of the ACE2-angiotensin-(1-7)-Mas axis and promotes increased circulating angiotensin-(1-7). Pancreatology 2012, 12:451-457.
40. Xiao L., Gao L., Lazartigues E., Zucker I.H. Brain-selective overexpression of angiotensin-converting enzyme 2 attenuates sympathetic nerve activity and enhances baroreflex function in chronic heart failure. Hypertension 2011, 58:1057-1065.
41. Yamazato M., Yamazato Y., Sun C., Diez-Freire C., Raizada M.K. Overexpression of angiotensin-converting enzyme 2 in the rostral ventrolateral medulla causes long-term decrease in blood pressure in the spontaneously hypertensive rats. Hypertension 2007, 49(4):926-931.
42. Ye M., Wysocki J., Gonzalez-Pacheco F.R., Salem M., Evora K., Garcia-Halpin L., Poglitsch M., Schuster M., Batlle D. Murine recombinant angiotensin-converting enzyme 2: effect on angiotensin II-dependent hypertension and distinctive angiotensin-converting enzyme 2 inhibitor characteristics on rodent and human angiotensin-converting enzyme 2. Hypertension 2012, 60:730-740.
43. Zhang Y., Lu J., Shi J., Lin X., Dong J., Zhang S., Liu Y., Tong Q. Central administration of angiotensin-(1-7) stimulates nitric oxide release and upregulates the endothelial nitric oxide synthase expression following focal cerebral ischemia/reperfusion in rats. Neuropeptides 2008, 42:593-600.
44. Zheng H., Liu X., Patel K.P. Angiotensin-converting enzyme 2 overexpression improves central nitric oxide-mediated sympathetic outflow in chronic heart failure. Am. J. Physiol. Heart Circ. Physiol. 2011, 301:H2402-H2412.