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Volumn 39, Issue 4, 2014, Pages 841-848

Age-Related alterations in the metabolic profile in the hippocampus of the senescence-accelerated mouse prone 8: A spontaneous Alzheimer's disease mouse model

Author keywords

Aging; Alzheimer's disease; cholesterol; gas chromatography mass spectrometry; hippocampus; metabolic profiles

Indexed keywords

4 AMINOBUTYRIC ACID; 5,8,11,14,17 ICOSAPENTAENOIC ACID; ADENOSINE PHOSPHATE; ALANINE; ASCORBIC ACID; ASPARTIC ACID; CHOLESTEROL; CITRIC ACID; CREATININE; ELAIDIC ACID; FUMARIC ACID; GLUTAMIC ACID; GLYCEROL STEARATE; GLYCEROPHOSPHOLIPID; GLYCINE; INOSITOL; INOSITOL PHOSPHATE; LACTIC ACID; MALIC ACID; N ACETYLASPARTIC ACID; OLEIC ACID; PALMITIC ACID; PHOSPHORIC ACID; PYROGLUTAMIC ACID; SERINE; STEARIC ACID; SUCCINIC ACID; THREONINE; UREA;

EID: 84896822801     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-131463     Document Type: Article
Times cited : (44)

References (38)
  • 1
    • 79959886270 scopus 로고    scopus 로고
    • Amyloid precursor protein processing and Alzheimer's disease
    • O'Brien RJ, Wong PC (2011) Amyloid precursor protein processing and Alzheimer's disease. Annu Rev Neurosci 34, 185-204.
    • (2011) Annu Rev Neurosci , vol.34 , pp. 185-204
    • O'Brien, R.J.1    Wong, P.C.2
  • 3
    • 84877888815 scopus 로고    scopus 로고
    • Identification of altered metabolic pathways in plasma and CSF in mild cognitive impairment and Alzheimer's disease using metabolomics
    • Trushina E, Dutta T, Persson XM, Mielke MM, Petersen RC (2013) Identification of altered metabolic pathways in plasma and CSF in mild cognitive impairment and Alzheimer's disease using metabolomics. PLoS One 8, e63644.
    • (2013) PLoS One , vol.8
    • Trushina, E.1    Dutta, T.2    Persson, X.M.3    Mielke, M.M.4    Petersen, R.C.5
  • 4
    • 84857125516 scopus 로고    scopus 로고
    • The SAMP8 mouse: A model to develop therapeutic interventions for Alzheimer's disease
    • Morley JE, Farr SA, Kumar VB, Armbrecht HJ (2012) The SAMP8 mouse: A model to develop therapeutic interventions for Alzheimer's disease. Curr Pharm Des 18, 1123-1130.
    • (2012) Curr Pharm des , vol.18 , pp. 1123-1130
    • Morley, J.E.1    Farr, S.A.2    Kumar, V.B.3    Armbrecht, H.J.4
  • 5
    • 84858157217 scopus 로고    scopus 로고
    • The senescence accelerated mouse (SAMP8) as a model for oxida-tive stress and Alzheimer's disease
    • Morley JE, Armbrecht HJ, Farr SA, Kumar VB (2012) The senescence accelerated mouse (SAMP8) as a model for oxida-tive stress and Alzheimer's disease. Biochim Biophys Acta 1822, 650-656.
    • (2012) Biochim Biophys Acta , vol.1822 , pp. 650-656
    • Morley, J.E.1    Armbrecht, H.J.2    Farr, S.A.3    Kumar, V.B.4
  • 6
    • 25844496169 scopus 로고    scopus 로고
    • Lipid alterations in the earliest clinically recognizable stage of Alzheimer's disease: Implication of the role of lipids in the pathogenesis of Alzheimer's disease
    • Han X (2005) Lipid alterations in the earliest clinically recognizable stage of Alzheimer's disease: Implication of the role of lipids in the pathogenesis of Alzheimer's disease. Curr Alzheimer Res 2, 65-77.
    • (2005) Curr Alzheimer Res , vol.2 , pp. 65-77
    • Han, X.1
  • 8
    • 84872498729 scopus 로고    scopus 로고
    • Role of cholesterol in APP metabolism and its significance in Alzheimer's disease pathogenesis
    • Maulik M, Westaway D, Jhamandas JH, Kar S (2013) Role of cholesterol in APP metabolism and its significance in Alzheimer's disease pathogenesis. Mol Neurobiol 47, 37-63.
    • (2013) Mol Neurobiol , vol.47 , pp. 37-63
    • Maulik, M.1    Westaway, D.2    Jhamandas, J.H.3    Kar, S.4
  • 9
    • 18244390483 scopus 로고    scopus 로고
    • Mitochondrial abnormalities in Alzheimer brain: Mechanistic implications
    • Bubber P, Haroutunian V, Fisch G, Blass JP, Gibson GE (2005) Mitochondrial abnormalities in Alzheimer brain: Mechanistic implications. Ann Neurol 57, 695-703.
    • (2005) Ann Neurol , vol.57 , pp. 695-703
    • Bubber, P.1    Haroutunian, V.2    Fisch, G.3    Blass, J.P.4    Gibson, G.E.5
  • 10
    • 84864311250 scopus 로고    scopus 로고
    • Estrogen regulation of mito-chondrial bioenergetics: Implications for prevention of Alzheimer's disease
    • Yao J, Brinton RD (2012) Estrogen regulation of mito-chondrial bioenergetics: Implications for prevention of Alzheimer's disease. Adv Pharmacol 64, 327-371.
    • (2012) Adv Pharmacol , vol.64 , pp. 327-371
    • Yao, J.1    Brinton, R.D.2
  • 11
    • 0022966681 scopus 로고
    • A postmortem study of amino acid neurotransmitters in Alzheimer's disease
    • Ellison DW, Beal MF, Mazurek MF, Bird ED, Martin JB (1986) A postmortem study of amino acid neurotransmitters in Alzheimer's disease. Ann Neurol 20, 616-621.
    • (1986) Ann Neurol , vol.20 , pp. 616-621
    • Ellison, D.W.1    Beal, M.F.2    Mazurek, M.F.3    Bird, E.D.4    Martin, J.B.5
  • 12
    • 84867579571 scopus 로고    scopus 로고
    • Altered neurochemical profile in the McGill-R-Thy1-APP rat model of Alzheimer's disease: A longitudinal in vivo 1 H MRS study
    • Nilsen LH, Melo TM, Saether O, Witter MP, Sonnewald U (2012) Altered neurochemical profile in the McGill-R-Thy1-APP rat model of Alzheimer's disease: A longitudinal in vivo 1 H MRS study. J Neurochem 123, 532-541.
    • (2012) J Neurochem , vol.123 , pp. 532-541
    • Nilsen, L.H.1    Melo, T.M.2    Saether, O.3    Witter, M.P.4    Sonnewald, U.5
  • 13
  • 14
    • 0033102614 scopus 로고    scopus 로고
    • Age-related defects in lifespan and learning ability in SAMP8 mice
    • Nomura Y, Okuma Y (1999) Age-related defects in lifespan and learning ability in SAMP8 mice. Neurobiol Aging 20, 111-115.
    • (1999) Neurobiol Aging , vol.20 , pp. 111-115
    • Nomura, Y.1    Okuma, Y.2
  • 15
    • 79956324801 scopus 로고    scopus 로고
    • Age-related autophagy alterations in the brain of senescence accelerated mouse prone 8 (SAMP8) mice
    • Ma Q, Qiang J, Gu P, Wang Y, Geng Y, Wang M (2011) Age-related autophagy alterations in the brain of senescence accelerated mouse prone 8 (SAMP8) mice. Exp Gerontol 46, 533-541.
    • (2011) Exp Gerontol , vol.46 , pp. 533-541
    • Ma, Q.1    Qiang, J.2    Gu, P.3    Wang, Y.4    Geng, Y.5    Wang, M.6
  • 16
    • 54549091125 scopus 로고    scopus 로고
    • Systems biology: Metabo-nomics
    • Nicholson JK, Lindon JC (2008) Systems biology: Metabo-nomics. Nature 455, 1054-1056.
    • (2008) Nature , vol.455 , pp. 1054-1056
    • Nicholson, J.K.1    Lindon, J.C.2
  • 17
    • 80051704393 scopus 로고    scopus 로고
    • Quantitative metabolomics based on gas chromatography mass spectrometry: Status and perspectives
    • Koek MM, Jellema RH, van der Greef J, Tas AC, Han-kemeier T (2011) Quantitative metabolomics based on gas chromatography mass spectrometry: Status and perspectives. Metabolomics 7, 307-328.
    • (2011) Metabolomics , vol.7 , pp. 307-328
    • Koek, M.M.1    Jellema, R.H.2    Van Der Greef, J.3    Tas, A.C.4    Han-Kemeier, T.5
  • 20
    • 77949556929 scopus 로고    scopus 로고
    • Age-related changesinmetabolic profilesofrat hippocampus and cortices
    • Paban V, Fauvelle F, Alescio-Lautier B (2010) Age-related changesinmetabolic profilesofrat hippocampus and cortices. Eur J Neurosci 31, 1063-1073.
    • (2010) Eur J Neurosci , vol.31 , pp. 1063-1073
    • Paban, V.1    Fauvelle, F.2    Alescio-Lautier, B.3
  • 21
    • 64049103209 scopus 로고    scopus 로고
    • Metabonomic alterations in hippocampus, temporal and prefrontal cortex with age in rats
    • Zhang X, Liu H, Wu J, Liu M, Wang Y (2009) Metabonomic alterations in hippocampus, temporal and prefrontal cortex with age in rats. Neurochem Int 54, 481-487.
    • (2009) Neurochem Int , vol.54 , pp. 481-487
    • Zhang, X.1    Liu, H.2    Wu, J.3    Liu, M.4    Wang, Y.5
  • 23
    • 0035083555 scopus 로고    scopus 로고
    • Cholesterol metabolism in the brain
    • Dietschy JM, Turley SD (2001) Cholesterol metabolism in the brain. Curr Opin Lipidol 12, 105-112.
    • (2001) Curr Opin Lipidol , vol.12 , pp. 105-112
    • Dietschy, J.M.1    Turley, S.D.2
  • 26
    • 84870783499 scopus 로고    scopus 로고
    • Lipid metabolism and neuroinflam-mation in Alzheimer's disease: A role for liver X receptors
    • Kang J, Rivest S (2012) Lipid metabolism and neuroinflam-mation in Alzheimer's disease: A role for liver X receptors. Endocr Rev 33, 715-746.
    • (2012) Endocr Rev , vol.33 , pp. 715-746
    • Kang, J.1    Rivest, S.2
  • 27
    • 84867579493 scopus 로고    scopus 로고
    • Statins have therapeutic potential for the treatment of Alzheimer's disease, likely via protection of the neurovascular unit in the AD brain
    • Kurata T, Kawai H, Miyazaki K, Kozuki M, Morimoto N, Ohta Y, Ikeda Y, Abe K (2012) Statins have therapeutic potential for the treatment of Alzheimer's disease, likely via protection of the neurovascular unit in the AD brain. J Neurol Sci 322, 59-63.
    • (2012) J Neurol Sci , vol.322 , pp. 59-63
    • Kurata, T.1    Kawai, H.2    Miyazaki, K.3    Kozuki, M.4    Morimoto, N.5    Ohta, Y.6    Ikeda, Y.7    Abe, K.8
  • 28
    • 80155191187 scopus 로고    scopus 로고
    • Statins: The role in the treatment and prevention of Alzheimer's neu-rodegeneration
    • Pac-Soo C, Lloyd DG, Vizcaychipi MP, Ma D (2011) Statins: The role in the treatment and prevention of Alzheimer's neu-rodegeneration. J Alzheimers Dis 27, 1-10.
    • (2011) J Alzheimers Dis , vol.27 , pp. 1-10
    • Pac-Soo, C.1    Lloyd, D.G.2    Vizcaychipi, M.P.3    Ma, D.4
  • 29
    • 79959858679 scopus 로고    scopus 로고
    • Glycerophospholipids and glycerophospholipid-derived lipid mediators: A complex meshwork in Alzheimer's disease pathology
    • Frisardi V, Panza F, Seripa D, Farooqui T, Farooqui AA (2011) Glycerophospholipids and glycerophospholipid-derived lipid mediators: A complex meshwork in Alzheimer's disease pathology. Prog Lipid Res 50, 313-330.
    • (2011) Prog Lipid Res , vol.50 , pp. 313-330
    • Frisardi, V.1    Panza, F.2    Seripa, D.3    Farooqui, T.4    Farooqui, A.A.5
  • 30
    • 76849108962 scopus 로고    scopus 로고
    • Fatty acid composition of frontal, temporal and parietal neocortex in the normal human brain and in Alzheimer's disease
    • Fraser T, Tayler H, Love S (2010) Fatty acid composition of frontal, temporal and parietal neocortex in the normal human brain and in Alzheimer's disease. Neurochem Res 35, 503-513.
    • (2010) Neurochem Res , vol.35 , pp. 503-513
    • Fraser, T.1    Tayler, H.2    Love, S.3
  • 31
    • 79954613332 scopus 로고    scopus 로고
    • Oleic acid ameliorates amyloidosis in cellular and mouse models of Alzheimer's disease
    • Amtul Z, Westaway D, Cechetto DF, Rozmahel RF (2011) Oleic acid ameliorates amyloidosis in cellular and mouse models of Alzheimer's disease. Brain Pathol 21, 321-329.
    • (2011) Brain Pathol , vol.21 , pp. 321-329
    • Amtul, Z.1    Westaway, D.2    Cechetto, D.F.3    Rozmahel, R.F.4
  • 32
    • 0026891186 scopus 로고
    • Amino acid metabolism in neurodegen-erative diseases
    • Nakamura S (1992) [Amino acid metabolism in neurodegen-erative diseases]. Nihon Rinsho 50, 1637-1642.
    • (1992) Nihon Rinsho , vol.50 , pp. 1637-1642
    • Nakamura, S.1
  • 34
    • 84885424849 scopus 로고    scopus 로고
    • Alzheimer's disease: Amino acid levels and brain metabolic status
    • Gueli MC, Taibi G (2013) Alzheimer's disease: Amino acid levels and brain metabolic status. Neurol Sci 34, 1575-1579.
    • (2013) Neurol Sci , vol.34 , pp. 1575-1579
    • Gueli, M.C.1    Taibi, G.2
  • 35
    • 84903154904 scopus 로고    scopus 로고
    • Recent advances in the application of metabolomics to Alzheimer's disease
    • doi: 10.1016/j.bbadis.2013.06.014
    • Trushina E, Mielke MM (2013) Recent advances in the application of metabolomics to Alzheimer's disease. Biochim Biophys Acta, doi: 10.1016/j.bbadis.2013.06.014
    • (2013) Biochim Biophys Acta
    • Trushina, E.1    Mielke, M.M.2


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