Temsirolimus promotes autophagic clearance of amyloid-β and provides protective effects in cellular and animal models of Alzheimer's disease

Pharmacological Research

Volumn 81, Issue , 2014, Pages 54-63

  Jiang, Teng ^a   Yu, Jin Tai ^a,b,c   Zhu, Xi Chen ^a   Tan, Meng Shan ^c   Wang, Hui Fu ^a   Cao, Lei ^a   Zhang, Qiao Quan ^a   Shi, Jian Quan ^d   Gao, Li ^d   Qin, Hao ^a   Zhang, Ying Dong ^d   Tan, Lan ^a,b,c  

^a NANJING MEDICAL UNIVERSITY   (China)

^b QINGDAO UNIVERSITY   (China)

^c OCEAN UNIVERSITY OF CHINA   (China)

^d NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Alzheimer's disease; Amyloid ; Autophagy; Spatial cognitive deficits; Temsirolimus

Indexed keywords

3 METHYLADENINE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; AUTOPHAGY PROTEIN 5; MAMMALIAN TARGET OF RAPAMYCIN; PRESENILIN 1; SMALL INTERFERING RNA; TEMSIROLIMUS; ANTINEOPLASTIC AGENT; MTOR PROTEIN, HUMAN; NEUROPROTECTIVE AGENT; RAPAMYCIN; TARGET OF RAPAMYCIN KINASE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL STRAIN HEK293; COGNITIVE DEFECT; CONTROLLED STUDY; HIPPOCAMPUS; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPATIAL LEARNING; SPATIAL MEMORY; TRANSGENIC MOUSE; ANALOGS AND DERIVATIVES; ANIMAL; BRAIN; DISEASE MODEL; DRUG EFFECTS; GENETICS; HEK293 CELL LINE; MAZE TEST; MEMORY; METABOLISM;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; ANTINEOPLASTIC AGENTS; AUTOPHAGY; BRAIN; DISEASE MODELS, ANIMAL; HEK293 CELLS; HUMANS; MALE; MAZE LEARNING; MEMORY; MICE, TRANSGENIC; NEUROPROTECTIVE AGENTS; SIROLIMUS; TOR SERINE-THREONINE KINASES;

EID: 84896338549     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2014.02.008     Document Type: Article

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