1,25-Dihydroxyvitamin D3 prevents toluene diisocyanate-induced airway epithelial barrier disruption

International Journal of Molecular Medicine

Volumn 36, Issue 1, 2015, Pages 263-270

  Li, Wenjia ^a   Dong, Hangming ^a   Zhao, Haijin ^a   Song, Jiafu ^a   Tang, Haixiong ^a   Yao, Lihong ^a   Liu, Laiyu ^a   Tong, Wancheng ^a   Zou, Mengchen ^a   Zou, Fei ^a   Cai, Shaoxi ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

1,25 Dihydroxyvitamin D3; Asthma; Barrier integrity; Bronchial epithelial cells; Toluene 2,4 diisocyanate

Indexed keywords

CALCITRIOL; CLAUDIN 1; CLAUDIN 2; GAMMA INTERFERON; HUMAN SERUM ALBUMIN; IMMUNOGLOBULIN E; INTERLEUKIN 4; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OCCLUDIN; PROTEIN ZO1; TOLUENE DIISOCYANATE; UVOMORULIN; CADHERIN; MITOGEN ACTIVATED PROTEIN KINASE; TJP1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; BRONCHUS MUCOSA; CELL CULTURE; CELL INFILTRATION; CELL MEMBRANE PERMEABILITY; CELL VIABILITY; CONTROLLED STUDY; ELECTRIC RESISTANCE; ENZYME PHOSPHORYLATION; EOSINOPHIL; EPITHELIUM CELL; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOREACTIVITY; IN VITRO STUDY; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RESPIRATORY EPITHELIUM; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; BIOSYNTHESIS; BLOOD; CELL LINE; DRUG EFFECTS; HUMAN; IMMUNOLOGY; IMPEDANCE; INFLAMMATION; METABOLISM; PATHOLOGY; RESPIRATORY TRACT MUCOSA; TIGHT JUNCTION;

ANIMALS; ASTHMA; CADHERINS; CALCITRIOL; CELL LINE; CELL MEMBRANE PERMEABILITY; ELECTRIC IMPEDANCE; EOSINOPHILS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; IMMUNOGLOBULIN E; INFLAMMATION; INTERFERON-GAMMA; INTERLEUKIN-4; MALE; MICE; MICE, INBRED BALB C; NEUTROPHIL INFILTRATION; OCCLUDIN; RESPIRATORY MUCOSA; TIGHT JUNCTIONS; TOLUENE 2,4-DIISOCYANATE; ZONULA OCCLUDENS-1 PROTEIN;

EID: 84930360992     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2015.2214     Document Type: Article

References (31)

1. Holgate ST: The airway epithelium is central to the pathogenesis of asthma. Allergol Int 57: 1-10, 2008.
2. Nawijn MC, Hackett TL, Postma DS, van Oosterhout AJ and Heijink IH: E-cadherin: Gatekeeper of airway mucosa and allergic sensitization. Trends Immunol 32: 248-255, 2011.
3. de Boer WI, Sharma HS, Baelemans SM, Hoogsteden HC, Lambrecht BN and Braunstahl GJ: Altered expression of epithelial junctional proteins in atopic asthma: Possible role in inflammation. Can J Physiol Pharmacol 86: 105-112, 2008.
4. Xiao C, Puddicombe SM, Field S, et al: Defective epithelial barrier function in asthma. J Allergy Clin Immunol 128: 549-556, 2011.
5. Post S, Nawijn MC, Hackett TL, Baranowska M, Gras R, van Oosterhout AJ and Heijink IH: The composition of house dust mite is critical for mucosal barrier dysfunction and allergic sensitisation. Thorax 67: 488-495, 2012.
6. Paul G, Brehm JM, Alcorn JF, Holguín F, Aujla SJ and Celedón JC: Vitamin D and asthma. Am J Respir Crit Care Med 185: 124-132, 2012.
7. Zhao H, Peng H, Cai SX, Li W, Zou F and Tong W: Toluene diisocyanate enhances human bronchial epithelial cells' permeability partly through the vascular endothelial growth factor pathway. Clin Exp Allergy 39: 1532-1539, 2009.
8. Song J, Zhao H, Dong H, Zhang D, Zou M, Tang H, Liu L, Liang Z, Lv Y, Zou F and Cai S: Mechanism of E-cadherin redistribution in bronchial airway epithelial cells in a TDI-induced asthma model. Toxicol Lett 220: 8-14, 2013.
9. Son M, Lee M, Kim YT, Youn JK and Park H: Heterogeneity of IgE response to TDI-HSA conjugates by ELISA in toluene diisocyanate (TDI)-induced occupational asthma (OA) patients. J Korean Med Sci 13: 147-152, 1998.
10. Wan H, Winton HL, Soeller C, Stewart GA, Thompson PJ, Gruenert DC, Cannell MB, Garrod DR and Robinson C: Tight junction properties of the immortalized human bronchial epithelial cell lines Calu-3 and 16HBE14o-. Eur Respir J 15: 1058-1068, 2000.
11. 3 in the mucosal injury and epithelial barrier disruption in DSS-induced acute colitis in mice. BMC Gastroenterol 12: 57, 2012.
12. Petecchia L, Sabatini F, Varesio L, Camoirano A, Usai C, Pezzolo A and Rossi GA: Bronchial airway epithelial cell damage following exposure to cigarette smoke includes disassembly of tight junction components mediated by the extracellular signal-regulated kinase 1/2 pathway. Chest 135: 1502-1512, 2009.
13. Sekiyama A, Gon Y, Terakado M, Takeshita I, Kozu Y, Maruoka S, Matsumoto K and Hashimoto S: Glucocorticoids enhance airway epithelial barrier integrity. Int Immunopharmacol 12: 350-357, 2012.
14. Tarlo SM and Lemiere C: Occupational asthma. N Engl J Med 370: 640-649, 2014.
15. Ban M, Morel G, Langonné I, Huguet N, Pépin E and Binet S: TDI can induce respiratory allergy with Th2-dominated response in mice. Toxicology 218: 39-47, 2006.
16. De Vooght V, Smulders S, Haenen S, Belmans J, Opdenakker G, Verbeken E, Nemery B, Hoet PH and Vanoirbeek JA: Neutrophil and eosinophil granulocytes as key players in a mouse model of chemical-induced asthma. Toxicol Sci 131: 406-418, 2013.
17. Piirilä PL, Meuronen A, Majuri ML, Luukkonen R, Mäntylä T, Wolff HJ, Nordman H, Alenius H and Laitinen A: Inflammation and functional outcome in diisocyanate-induced asthma after cessation of exposure. Allergy 63: 583-591, 2008.
18. Talini D, Novelli F, Bacci E, Costa F, Dente FL, Di Franco A, Malagrinò L, Vagaggini B and Paggiaro P: Mild improvement in symptoms and pulmonary function in a long-term follow-up of patients with toluene diisocyanate-induced asthma. Int Arch Allergy Immunol 161: 189-194, 2013.
19. Gorman S, Weeden CE, Tan DH, Scott NM, Hart J, Foong RE, Mok D, Stephens N, Zosky G and Hart PH: Reversible control by vitamin D of granulocytes and bacteria in the lungs of mice: An ovalbumin-induced model of allergic airway disease. PLoS One 8: e67823, 2013.
20. Agrawal T, Gupta GK and Agrawal DK: Vitamin D supplementation reduces airway hyperresponsiveness and allergic airway inflammation in a murine model. Clin Exp Allergy 43: 672-683, 2013.
21. Samrah S, Khatib I, Omari M, Khassawneh B, Momany S, Daoud A, Malkawi M and Khader Y: Vitamin D deficiency and level of asthma control in women from North of Jordan: A casecontrol study. J Asthma 51: 832-838, 2014.
22. Griffin MD, Xing N and Kumar R: Vitamin D and its analogs as regulators of immune activation and antigen presentation. Annu Rev Nutr 23: 117-145, 2003.
23. Herr C, Shaykhiev R and Bals R: The role of cathelicidin and defensins in pulmonary inflammatory diseases. Expert Opin Biol Ther 7: 1449-1461, 2007.
24. Hawrylowicz CM and O'Garra A: Potential role of interleukin- 10-secreting regulatory T cells in allergy and asthma. Nat Rev Immunol 5: 271-283, 2005.
25. Urry Z, Xystrakis E, Richards DF, McDonald J, Sattar Z, Cousins DJ, Corrigan CJ, Hickman E, Brown Z and Hawrylowicz CM: Ligation of TLR9 induced on human IL-10-secreting Tregs by 1alpha,25-dihydroxyvitamin D3 abrogates regulatory function. J Clin Invest 119: 387-398, 2009.
26. Barrat FJ, Cua DJ, Boonstra A, Richards DF, Crain C, Savelkoul HF, de Waal-Malefyt R, Coffman RL, Hawrylowicz CM and O'Garra A: In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J Exp Med 195: 603-616, 2002.
27. Xystrakis E, Kusumakar S, Boswell S, et al: Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoidresistant asthma patients. J Clin Invest 116: 146-155, 2006.
28. Kreindler JL, Steele C, Nguyen N, et al: Vitamin D3 attenuates Th2 responses to Aspergillus fumigatus mounted by CD4+ T cells from cystic fibrosis patients with allergic bronchopulmonary aspergillosis. J Clin Invest 120: 3242-3254, 2010.
29. Mahon BD, Wittke A, Weaver V and Cantorna MT: The targets of vitamin D depend on the differentiation and activation status of CD4 positive T cells. J Cell Biochem 89: 922-932, 2003.
30. Georas SN and Rezaee F: Epithelial barrier function: At the front line of asthma immunology and allergic airway inflammation. J Allergy Clin Immunol 134: 509-520, 2014.
31. Yin Z, Pintea V, Lin Y, Hammock BD and Watsky MA: Vitamin D enhances corneal epithelial barrier function. Invest Ophthalmol Vis Sci 52: 7359-7364, 2011.