Toluene diisocyanate enhances human bronchial epithelial cells' permeability partly through the vascular endothelial growth factor pathway

Clinical and Experimental Allergy

Volumn 39, Issue 10, 2009, Pages 1532-1539

  Zhao, H ^a   Peng, H ^a,b   Cai, S X ^a   Li, W ^a   Zou, F ^a   Tong, W ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b GUANGDONG MEDICAL UNIVERSITY   (China)

Author keywords

Asthma; Cell permeability; Human bronchial epithelial (HBE) cells; Toluene 2,4 diisocyanate (TDI); Vascular endothelial growth factor (VEGF)

Indexed keywords

FLUORESCEIN ISOTHIOCYANATE DEXTRAN; HUMAN SERUM ALBUMIN; NEUTRALIZING ANTIBODY; TOLUENE DIISOCYANATE; VASCULOTROPIN;

ARTICLE; BRONCHUS MUCOSA; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RESPIRATORY SYSTEM; TIGHT JUNCTION; TRANSMISSION ELECTRON MICROSCOPY;

ANTIBODIES, MONOCLONAL; ASTHMA; BRONCHI; CELL LINE; CELL MEMBRANE; EPITHELIAL CELLS; HUMANS; PERMEABILITY; RESPIRATORY MUCOSA; SERUM ALBUMIN; TOLUENE 2,4-DIISOCYANATE; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 70349089634     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2009.03300.x     Document Type: Article

References (32)

1. Holgate ST. The airway epithelium is central to the pathogenesis of asthma. Allergol Int 2008 57 : 1 10.
2. Sajjan U, Wang Q, Zhao Y, Gruenert DC, Hershenson MB. Rhinovirus disrupts the barrier function of polarized airway epithelial cells. Am J Respir Crit Care Med 2008 178 : 1271 1281.
3. Olivera DS, Boggs SE, Beenhouwer C, Aden J, Knall C. Cellular mechanisms of mainstream cigarette smoke-induced lung epithelial tight junction permeability changes in vitro. Inhal Toxicol 2007 19 : 13 22.
4. Brown WE, Burkert AL. Biomarkers of toluene diisocyanate exposure. Appl Occup Environ Hyg 2002 17 : 840 845.
5. Mapp CE, Boschetto P, Maestrelli P, Fabbri LM. Occupational asthma. Am J Respir Crit Care Med 2005 172 : 280 305.
6. Redlich CA, Wisnewski AV, Gordon T. Mouse models of diisocyanate asthma. Am J Respir Cell Mol Biol 2002 27 : 385 390.
7. Wisnewski AV, Srivastava R, Herick C et al. Identification of human lung and skin proteins conjugated with hexamethylene diisocyanate in vitro and in vivo. Am J Respir Crit Care Med 2000 162 : 2330 2336.
8. Lange RW, Lantz RC, Stolz DB et al. Toluene diisocyanate colocalizes with tubulin on cilia of differentiated human airway epithelial cells. Toxicol Sci 1999 50 : 64 71.
9. Ogawa H, Inoue S, Ogushi F, Ogura H, Nakamura Y. Toluene diisocyanate (TDI) induces production of inflammatory cytokines and chemokines by bronchial epithelial cells via the epidermal growth factor receptor and p38 mitogen-activated protein kinase pathways. Exp Lung Res 2006 32 : 245 262.
10. Lee CG, Link H, Baluk P et al. Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. Nat Med 2004 10 : 1095 1103.
11. Lee YC, Kwak YG, Song CH. Contribution of vascular endothelial growth factor to airway hyperresponsiveness and inflammation in a murine model of toluene diisocyanate-induced asthma. J Immunol 2002 168 : 3595 3600.
12. Ahn MH, Park BJ, Kwon JH et al. Asp-Tyr-Leu-Lys tetrapeptide inhibits airway inflammation in 2 toluene 4-diisocyanate-induced asthma mice. Clin Exp Allergy 2008 38 : 1025 1032.
13. Horvath G, Wanner A. Inhaled corticosteroids: effects on the airway vasculature in bronchial asthma. Eur Respir J 2006 27 : 172 187.
14. Rothenberg ME. VEGF obstructs the lungs. Nat Med 2004 10 : 1041 1042.
15. Choi JH, Suh YJ, Lee SK, Suh CH, Nahm DH, Park HS. Acute and chronic changes of vascular endothelial growth factor (VEGF) in induced sputum of toluene diisocyanate (TDI)-induced asthma patients. J Korean Med Sci 2004 19 : 359 363.
16. Koyama S, Tsukadaira E, Haniuda M et al. Vascular endothelial growth factor mRNA and protein expression in airway epithelial cell lines in vitro. Eur Respir J 2002 20 : 1449 1456.
17. Son M, Lee M, Kim YT, Youn JK, Park H. Heterogeneity of IgE response to TDI-HSA conjugates by ELISA in toluene diisocyanate (TDI)-induced occupational asthma (OA) patients. J Korean Med Sci 1998 13 : 147 152.
18. Modesto RR, Pesce AJ. Use of tolyl diisocyanate for the preparation of a peroxidase-labelled antibody conjugate. Quantitation of the amount of diisocyanate bound. Biochem Biophys Acta 1973 295 : 283 295.
19. Ye YM, Kim CW, Kim HR et al. Biophysical determinant of toluene diisocyanate antigenicity associated with exposure and asthma. J Allergy Clin Immunol 2006 118 : 885 891.
20. Man Y, Hart VJ, Ring CJ, Sanjar S, West MR. Loss of epithelial integrity resulting from E-cadherin dysfunction predisposes airway epithelial cells to adenoviral infection. Am J Respir Cell Mol Biol 2000 23 : 610 617.
21. Apicella MA, Ketterer M, Lee FK, Zhou D, Rice PA, Blake MS. The pathogenesis of gonococcal urethritis in men: confocal and immunoelectron microscopic analysis of urethral exudates from men infected with Neisseria gonorrhoeae. J Infect Dis 1996 173 : 636 646.
22. Kim TS, Nakagawa T, Kitajiri S et al. Disruption and restoration of cell-cell junctions in mouse vestibular epithelia following aminoglycoside treatment. Hear Res 2005 205 : 201 209.
23. Peng HJ, Cai SX, Zhao HJ, Li WJ, Tong WC. Toluene diisocyanate increases vascular endothelial growth factor expression in human bronchial epithelial cells. Nan Fang Yi Ke Da Xue Xue Bao 2008 28 : 209 212.
24. de Boer WI, Sharma HS, Baelemans SM, Hoogsteden HC, Lambrecht BN, Braunstahl GJ. Altered expression of epithelial junctional proteins in atopic asthma: possible role in inflammation. Can J Physiol Pharmacol 2008 86 : 105 112.
25. Antony AB, Tepper RS, Mohammed KA. Cockroach extract antigen increases bronchial airway epithelial permeability. J Allergy Clin Immunol 2002 110 : 589 595.
26. Matter K, Balda MS. Signalling to and from tight junctions. Nat Rev Mol Cell Biol 2003 4 : 225 236.
27. Kilani MM, Mohammed KA, Nasreen N et al. Respiratory syncytial virus causes. Increased bronchial epithelial permeability. Chest 2004 126 : 186 191.
28. Mohammed KA, Nasreen N, Hardwick J, Logie CS, Patterson CE, Antony VB. Bacterial induction of pleural mesothelial monolayer barrier dysfunction. Am J Physiol Lung Cell Mol Physiol 2001 281 : 119 125.
29. Tong JP, Lam DS, Chan WM, Choy KW, Chan KP, Pang CP. Effects of triamcinolone on the expression of VEGF and PEDF in human retinal pigment epithelial and human umbilical vein endothelial cells. Mol Vis 2006 4 : 1490 1495.
30. Scharte M, Han X, Bertges DJ, Fink MP, Delude RL. Cytokines induce HIF-1 DNA binding and the expression of HIF-1-dependent genes in cultured rat enterocytes. Am J Physiol Gastrointest Liver Physiol 2003 284 : 373 384.
31. Wang W, Dentler WL, Borchardt RT et al. VEGF increases BMEC monolayer permeability by affecting occludin expression and tight junction assembly. Am J Physiol Heart Circ Physiol 2001 280 : H434 40.
32. Sun H, Breslin JW, Zhu J, Yuan SY, Wu MH. Rho and ROCK signaling in VEGF-induced microvascular endothelial hyperpermeability. Microcirculation 2006 13 : 237 247.