PML induces compaction, TRF2 depletion and DNA damage signaling at telomeres and promotes their alternative lengthening

Journal of Cell Science

Volumn 128, Issue 10, 2015, Pages 1887-1900

  Osterwald, Sarah ^a   Deeg, Katharina I ^a   Chung, Inn ^a,c   Parisotto, Daniel ^a,d   Wörz, Stefan ^b   Rohr, Karl ^b   Erfle, Holger ^b   Rippe, Karsten ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

ALT; ALT associated PML nuclear body; Alternative lengthening of telomeres; APB; DNA repair; PML nuclear bodies

Indexed keywords

ATM PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 2; PROMYELOCYTIC LEUKEMIA PROTEIN; SUMO 3 PROTEIN; TELOMERIC REPEAT BINDING FACTOR 2; NUCLEAR PROTEIN; PML PROTEIN, HUMAN; TERF2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; DNA DAMAGE; DNA REPAIR; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IMAGE ANALYSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SUMOYLATION; TELOMERE; TELOMERE HOMEOSTASIS; TELOMERE SHORTENING; GENETICS; METABOLISM; PROMYELOCYTIC LEUKEMIA; TUMOR CELL LINE;

CELL LINE, TUMOR; DNA DAMAGE; DNA REPAIR; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; NUCLEAR PROTEINS; SIGNAL TRANSDUCTION; TELOMERE; TELOMERIC REPEAT BINDING PROTEIN 2; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 84930257589     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.148296     Document Type: Article

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