A three-dimensional colocalization RNA interference screening platform to elucidate the alternative lengthening of telomeres pathway

Biotechnology Journal

Volumn 7, Issue 1, 2012, Pages 103-116

  Osterwald, Sarah ^a   Wörz, Stefan ^b   Reymann, Jürgen ^b   Sieckmann, Frank ^c   Rohr, Karl ^b   Erfle, Holger ^b   Rippe, Karsten ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c Leica Microsystems CMS GmbH   (Germany)

Author keywords

3D colocalization; ALT; Automatic image analysis; RNAi screen; Telomeres

Indexed keywords

ALT; AUTOMATIC IMAGE ANALYSIS; COLOCALIZATION; RNAI SCREEN; TELOMERES;

CELLS; DISEASES; FLUORESCENCE; FLUORESCENCE MICROSCOPY; GENE THERAPY; IMAGE ANALYSIS; ONCOLOGY; RELIABILITY ANALYSIS; RNA;

THREE DIMENSIONAL;

53BP1 PROTEIN; ATM PROTEIN; CELL PROTEIN; ISOPROTEIN; MMS21 PROTEIN; PROMYELOCYTIC LEUKEMIA PROTEIN; PROMYELOCYTIC LEUKEMIA PROTEIN ISOFORM III; PROMYELOCYTIC LEUKEMIA PROTEIN ISOFORM V; PROMYELOCYTIC LEUKEMIA PROTEIN ISOFORM VI; SMALL INTERFERING RNA; SP100 PROTEIN; TELOMERIC REPEAT BINDING FACTOR 2; UNCLASSIFIED DRUG;

ALTERNATIVE TELOMERE LENGTHENING; APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL NUCLEUS INCLUSION BODY; CELLULAR DISTRIBUTION; CONFOCAL FLUORESCENCE MICROSCOPY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; GENE SILENCING; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; IMAGE ANALYSIS; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RNA INTERFERENCE; SUMOYLATION; TELOMERE;

CELL CYCLE; CELL LINE, TUMOR; GENE KNOCKDOWN TECHNIQUES; HELA CELLS; HUMANS; IMAGING, THREE-DIMENSIONAL; INTRANUCLEAR INCLUSION BODIES; LEUKEMIA, PROMYELOCYTIC, ACUTE; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; NUCLEAR PROTEINS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TELOMERASE; TELOMERE;

EID: 81355123151     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201000474     Document Type: Article

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